The network for 'regulation of metaphase anaphase transition of cell cycle' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of metaphase anaphase transition of cell cycle

Any process that modulates the frequency, rate or extent of metaphase/anaphase transition of cell cycle.

NameDescriptionProbabilityFunc Analog Organism
CDC20cell division cycle 20 homolog (S. cerevisiae)0.999
CDC27cell division cycle 27 homolog (S. cerevisiae)0.999
CDK2cyclin-dependent kinase 20.995
BUB1Bbudding uninhibited by benzimidazoles 1 homolog beta (yeast)0.994
ANAPC7anaphase promoting complex subunit 70.972
BUB3budding uninhibited by benzimidazoles 3 homolog (yeast)0.969
CCNA2cyclin A20.954
MAD2L1MAD2 mitotic arrest deficient-like 1 (yeast)0.910
ANAPC4anaphase promoting complex subunit 40.896
CCNB1cyclin B10.874
CDC23cell division cycle 23 homolog (S. cerevisiae)0.836
BUB1budding uninhibited by benzimidazoles 1 homolog (yeast)0.799
CCT8chaperonin containing TCP1, subunit 8 (theta)0.743
RB1retinoblastoma 10.738
CKS1BCDC28 protein kinase regulatory subunit 1B0.597
SKP2S-phase kinase-associated protein 2 (p45)0.568
CHAF1Achromatin assembly factor 1, subunit A (p150)0.479
ANAPC11anaphase promoting complex subunit 110.444
MAD2L2MAD2 mitotic arrest deficient-like 2 (yeast)0.431
SMC6structural maintenance of chromosomes 60.405
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme0.395
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.387
RAD21RAD21 homolog (S. pombe)0.368
CDC26cell division cycle 26 homolog (S. cerevisiae)0.305
ORC1origin recognition complex, subunit 10.301
RBL1retinoblastoma-like 1 (p107)0.295
CUL2cullin 20.236
CCNE1cyclin E10.231
CREBBPCREB binding protein0.213
RBX1ring-box 1, E3 ubiquitin protein ligase0.210
NSMCE1non-SMC element 1 homolog (S. cerevisiae)0.210
PPP2R5Cprotein phosphatase 2, regulatory subunit B', gamma0.205
CUL1cullin 10.194
AURKBaurora kinase B0.193
CBX5chromobox homolog 50.187
CCNB2cyclin B20.158
CDC16cell division cycle 16 homolog (S. cerevisiae)0.155
CDKN1Bcyclin-dependent kinase inhibitor 1B (p27, Kip1)0.154
COPS5COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)0.146
SMC3structural maintenance of chromosomes 30.131
UHRF2ubiquitin-like with PHD and ring finger domains 20.131
CDKN3cyclin-dependent kinase inhibitor 30.123
SKP1S-phase kinase-associated protein 10.114
TFDP1transcription factor Dp-10.111
VHLvon Hippel-Lindau tumor suppressor0.103
PPP1CAprotein phosphatase 1, catalytic subunit, alpha isozyme0.099
CKS2CDC28 protein kinase regulatory subunit 20.091
CDT1chromatin licensing and DNA replication factor 10.091
PLK1polo-like kinase 10.078
SKA1spindle and kinetochore associated complex subunit 10.075
ANAPC1anaphase promoting complex subunit 10.071
DOT1LDOT1-like, histone H3 methyltransferase (S. cerevisiae)0.068
STAG1stromal antigen 10.065
CCND1cyclin D10.064
PPP2R2Aprotein phosphatase 2, regulatory subunit B, alpha0.058
PPP2R5Aprotein phosphatase 2, regulatory subunit B', alpha0.055
PPP2R1Bprotein phosphatase 2, regulatory subunit A, beta0.055
SKA3spindle and kinetochore associated complex subunit 30.053
PTTG1pituitary tumor-transforming 10.053
E2F1E2F transcription factor 10.052
RBL2retinoblastoma-like 2 (p130)0.050
TINF2TERF1 (TRF1)-interacting nuclear factor 20.049
NEK9NIMA (never in mitosis gene a)- related kinase 90.049
SPC24SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae)0.049
TCEB2transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)0.048
BRCA1breast cancer 1, early onset0.045
FXR2fragile X mental retardation, autosomal homolog 20.045
MYST1MYST histone acetyltransferase 10.045
SMC4structural maintenance of chromosomes 40.044
BRCA2breast cancer 2, early onset0.043
PAG1phosphoprotein associated with glycosphingolipid microdomains 10.043
BIRC5baculoviral IAP repeat containing 50.043
CDK1cyclin-dependent kinase 10.043
NDC80NDC80 homolog, kinetochore complex component (S. cerevisiae)0.042
KIF18Akinesin family member 18A0.041
NSMCE4Anon-SMC element 4 homolog A (S. cerevisiae)0.040
HERC2hect domain and RLD 20.040
BTRCbeta-transducin repeat containing0.038
SKA2spindle and kinetochore associated complex subunit 20.038
UHRF1ubiquitin-like with PHD and ring finger domains 10.037
COMMD1copper metabolism (Murr1) domain containing 10.037
USP7ubiquitin specific peptidase 7 (herpes virus-associated)0.037
INCENPinner centromere protein antigens 135/155kDa0.036
PARP3poly (ADP-ribose) polymerase family, member 30.036
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.036
COPS4COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis)0.036
ATRXalpha thalassemia/mental retardation syndrome X-linked0.035
ATMINATM interactor0.035
SGOL2shugoshin-like 2 (S. pombe)0.034
CASC5cancer susceptibility candidate 50.033
LRR1leucine rich repeat protein 10.033
TCEB1transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)0.032
SIRT2sirtuin 20.032
PPME1protein phosphatase methylesterase 10.032
ANKRD52ankyrin repeat domain 520.032
CUL5cullin 50.030
PRRC2Cproline-rich coiled-coil 2C0.030
ARIH2ariadne homolog 2 (Drosophila)0.030
FBXO5F-box protein 50.029
RBBP8retinoblastoma binding protein 80.029
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
rnr-1Protein RNR-10.022
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
CycB3Cyclin B30.796
Mcm10Sensitized chromosome inheritance modifier 190.757
gwlgreatwall0.646
CycACyclin A0.643
IswiImitation SWI0.563
CycBCyclin B0.563
Pp1-87BProtein phosphatase 1 at 87B0.543
cdc16CG6759 gene product from transcript CG6759-RA0.518
DrefDNA replication-related element factor0.462
Klp61FKinesin-like protein at 61F0.451
cmetCENP-meta0.426
hpohippo0.423
ncdnon-claret disjunctional0.409
tefutelomere fusion0.376
fzyfizzy0.374
poloCG12306 gene product from transcript CG12306-RA0.356
SMC2CG10212 gene product from transcript CG10212-RA0.312
pavpavarotti0.282
idaimaginal discs arrested0.267
dupdouble parked0.253
stgstring0.208
SseSeparase0.203
flflfalafel0.194
Cap-GCG34438 gene product from transcript CG34438-RF0.174
pimpimples0.160
nbsCG6754 gene product from transcript CG6754-RC0.158
Cdc37CG12019 gene product from transcript CG12019-RA0.150
bratbrain tumor0.133
BubR1Bub1-related kinase0.130
marsCG17064 gene product from transcript CG17064-RB0.100
Rpd3CG7471 gene product from transcript CG7471-RA0.099
ballballchen0.098
cavcaravaggio0.095
MybMyb oncogene-like0.090
thrthree rows0.087
prodproliferation disrupter0.081
cdc2CG5363 gene product from transcript CG5363-RA0.080
Cenp-CCG31258 gene product from transcript CG31258-RA0.073
NiPp1Nuclear inhibitor of Protein phosphatase 10.073
gammaTub23Cgamma-Tubulin at 23C0.069
piepineapple eye0.068
CG9772CG9772 gene product from transcript CG9772-RB0.066
aspabnormal spindle0.062
pashapartner of drosha0.061
cidcentromere identifier0.060
Cks30ACyclin-dependent kinase subunit 30A0.060
Orc2Origin recognition complex subunit 20.060
Kmn1kinetochore Mis12-Ndc80 network component 10.057
Bj1Bj1 protein0.055
Spc105RSpc105-related0.055
NELF-BCG32721 gene product from transcript CG32721-RA0.052
Su(H)Suppressor of Hairless0.051
borrborealin-related0.050
vtdverthandi0.048
pitaCG3941 gene product from transcript CG3941-RA0.044
eastenhanced adult sensory threshold0.043
Nuf2CG8902 gene product from transcript CG8902-RA0.043
DNApol-alpha60DNA polymerase alpha 60kD0.042
Dcr-1Dicer-10.041
IncenpInner centromere protein0.040
Rab23CG2108 gene product from transcript CG2108-RA0.038
Akt1CG4006 gene product from transcript CG4006-RA0.037
RnrSRibonucleoside diphosphate reductase small subunit0.036
betaTub60Dbeta-Tubulin at 60D0.034
nodno distributive disjunction0.034
aslasterless0.033
zwilchCG18729 gene product from transcript CG18729-RA0.033
cutletCG33122 gene product from transcript CG33122-RA0.033
UbcD2Ubiquitin conjugating enzyme 20.032
I-2Inhibitor-20.032
sleslender lobes0.031
CG4332CG4332 gene product from transcript CG4332-RA0.031
Grip75CG6176 gene product from transcript CG6176-RA0.031
mspsmini spindles0.031
gammaTub37Cgamma-Tubulin at 37C0.031
Cks85ACyclin-dependent kinase subunit 85A0.030
kukkugelkern0.030
Rpb4CG33520 gene product from transcript CG33520-RF0.030
ldslodestar0.030
Eps-15Epidermal growth factor receptor pathway substrate clone 150.029
alphaTub67Calpha-Tubulin at 67C0.029
CG8378CG8378 gene product from transcript CG8378-RA0.029
E(z)Enhancer of zeste0.029
shtdshattered0.028
DetDeterin0.028
CG6962CG6962 gene product from transcript CG6962-RA0.028
CG13625CG13625 gene product from transcript CG13625-RA0.027
Ras85DRas oncogene at 85D0.027
KP78bCG17216 gene product from transcript CG17216-RB0.027
PsaPuromycin sensitive aminopeptidase0.027
nxf2nuclear RNA export factor 20.027
atmsantimeros0.027
mus301mutagen-sensitive 3010.027
mad2CG17498 gene product from transcript CG17498-RA0.026
Ptp69DProtein tyrosine phosphatase 69D0.026
wispwispy0.026
Trf4-1CG11265 gene product from transcript CG11265-RE0.025
Su(var)2-10Suppressor of variegation 2-100.025
dapdacapo0.025
Orc6Origin recognition complex subunit 60.024
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Trp53transformation related protein 530.989
Ctnnb1catenin (cadherin associated protein), beta 10.701
Ccne1cyclin E10.626
Ccnb1cyclin B10.483
Prc1protein regulator of cytokinesis 10.371
Brca1breast cancer 10.334
Cdk1cyclin-dependent kinase 10.272
Cdk2cyclin-dependent kinase 20.256
Cenpecentromere protein E0.215
Ccna2cyclin A20.204
Ppp1ccprotein phosphatase 1, catalytic subunit, gamma isoform0.183
Spag5sperm associated antigen 50.182
Ptenphosphatase and tensin homolog0.172
Brca2breast cancer 20.160
Kif2ckinesin family member 2C0.145
Sgol1shugoshin-like 1 (S. pombe)0.134
Kif20akinesin family member 20A0.115
Ccnb2cyclin B20.087
Asf1bASF1 anti-silencing function 1 homolog B (S. cerevisiae)0.085
Nek2NIMA (never in mitosis gene a)-related expressed kinase 20.082
Ooepoocyte expressed protein homolog (dog)0.082
Apcadenomatosis polyposis coli0.079
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.079
Melkmaternal embryonic leucine zipper kinase0.071
Hmmrhyaluronan mediated motility receptor (RHAMM)0.066
Ube2cubiquitin-conjugating enzyme E2C0.056
Nbnnibrin0.051
Cdkn1bcyclin-dependent kinase inhibitor 1B0.049
Sgol2shugoshin-like 2 (S. pombe)0.045
Dlgap5discs, large (Drosophila) homolog-associated protein 50.045
Kif4kinesin family member 40.041
Suz12suppressor of zeste 12 homolog (Drosophila)0.040
Ncapd2non-SMC condensin I complex, subunit D20.040
Rad51ap1RAD51 associated protein 10.039
Bub1bbudding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)0.039
Mis18bp1MIS18 binding protein 10.037
Ccnfcyclin F0.036
C330027C09RikRIKEN cDNA C330027C09 gene0.036
Cdc25ccell division cycle 25 homolog C (S. pombe)0.036
Birc5baculoviral IAP repeat-containing 50.036
Plk1polo-like kinase 1 (Drosophila)0.035
Chek1checkpoint kinase 1 homolog (S. pombe)0.035
Cdca8cell division cycle associated 80.035
Kif11kinesin family member 110.033
Cdc20cell division cycle 20 homolog (S. cerevisiae)0.033
Cenpncentromere protein N0.032
BlmBloom syndrome, RecQ helicase-like0.031
Kif22kinesin family member 220.029
Kntc1kinetochore associated 10.028
Axin1axin 10.028
Cenpkcentromere protein K0.025
Tmpothymopoietin0.025
E2f8E2F transcription factor 80.025
Ppp1caprotein phosphatase 1, catalytic subunit, alpha isoform0.023
Cdkn2dcyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)0.021
Cenpfcentromere protein F0.021
Psen1presenilin 10.021
Wdhd1WD repeat and HMG-box DNA binding protein 10.021
Aurkbaurora kinase B0.021
Lin9lin-9 homolog (C. elegans)0.021
Gtse1G two S phase expressed protein 10.021
Gsk3bglycogen synthase kinase 3 beta0.020
Ect2ect2 oncogene0.020
Uhrf1ubiquitin-like, containing PHD and RING finger domains, 10.020
Suv39h2suppressor of variegation 3-9 homolog 2 (Drosophila)0.020
Acdadrenocortical dysplasia0.020
6720463M24RikRIKEN cDNA 6720463M24 gene0.020
Ckap2cytoskeleton associated protein 20.019
Ncapd3non-SMC condensin II complex, subunit D30.019
Mdm4transformed mouse 3T3 cell double minute 40.019
2810417H13RikRIKEN cDNA 2810417H13 gene0.018
Mybl2myeloblastosis oncogene-like 20.018
Cdca5cell division cycle associated 50.018
Ndc80NDC80 homolog, kinetochore complex component (S. cerevisiae)0.018
Aurkaaurora kinase A0.017
Cdkn3cyclin-dependent kinase inhibitor 30.017
Hist1h2aahistone cluster 1, H2aa0.016
Mdm2transformed mouse 3T3 cell double minute 20.016
Fignl1fidgetin-like 10.016
Cbx1chromobox homolog 1 (Drosophila HP1 beta)0.016
BrafBraf transforming gene0.016
Trp73transformation related protein 730.016
Dtldenticleless homolog (Drosophila)0.015
Cul4acullin 4A0.015
Hist2h4histone cluster 2, H40.014
Prkdcprotein kinase, DNA activated, catalytic polypeptide0.014
Exo1exonuclease 10.014
Ercc6lexcision repair cross-complementing rodent repair deficiency complementation group 6 - like0.014
Rb1retinoblastoma 10.014
Kiss1KiSS-1 metastasis-suppressor0.014
Tk1thymidine kinase 10.014
Mns1meiosis-specific nuclear structural protein 10.014
StilScl/Tal1 interrupting locus0.013
Gsg2germ cell-specific gene 20.013
Orc1origin recognition complex, subunit 10.013
Ube2nubiquitin-conjugating enzyme E2N0.013
Lig4ligase IV, DNA, ATP-dependent0.013
Ube2tubiquitin-conjugating enzyme E2T (putative)0.012
Msh2mutS homolog 2 (E. coli)0.012
Usp9xubiquitin specific peptidase 9, X chromosome0.012
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
PPH21Pph21p0.992
MTW1Mtw1p0.941
MAD2Mad2p0.934
SLK19Slk19p0.922
BUB1Bub1p0.905
CHL4Chl4p0.900
CDC20Cdc20p0.892
NSL1Nsl1p0.868
CSE4Cse4p0.867
DSN1Dsn1p0.772
PPH22Pph22p0.763
TID3Tid3p0.726
SLI15Sli15p0.712
SPC105Spc105p0.702
BUB3Bub3p0.673
SMC4Smc4p0.669
IML3Iml3p0.601
PPZ1Ppz1p0.559
MCM21Mcm21p0.559
CDC55Cdc55p0.544
MIF2Mif2p0.514
ZDS2Zds2p0.511
CDC26Cdc26p0.465
CDC27Cdc27p0.465
HHT1Hht1p0.462
DOC1Doc1p0.455
CDC16Cdc16p0.451
KIP1Kip1p0.448
YPI1Ypi1p0.446
ASE1Ase1p0.403
SPC24Spc24p0.395
MAD1Mad1p0.387
ZDS1Zds1p0.382
CDC23Cdc23p0.340
MAD3Mad3p0.313
CTF3Ctf3p0.309
PDS1Pds1p0.286
RTS1Rts1p0.284
NUF2Nuf2p0.268
IPL1Ipl1p0.220
CIN8Cin8p0.220
SMC2Smc2p0.210
OKP1Okp1p0.205
APC4Apc4p0.197
SWM1Swm1p0.189
MND2Mnd2p0.177
CBF2Cbf2p0.171
AME1Ame1p0.162
MPS1Mps1p0.160
CTF19Ctf19p0.145
GIP2Gip2p0.142
NNF1Nnf1p0.132
KIC1Kic1p0.125
MCM22Mcm22p0.121
DCC1Dcc1p0.118
TIP41Tip41p0.114
HHF2Hhf2p0.093
SPC25Spc25p0.092
FMP48Fmp48p0.090
ECO1Eco1p0.085
APC2Apc2p0.082
MMS21Mms21p0.081
YBP2Ybp2p0.079
PIG2Pig2p0.073
DAM1Dam1p0.069
SCM3Scm3p0.069
PSH1Psh1p0.067
SMC6Smc6p0.066
BRN1Brn1p0.058
CBF1Cbf1p0.051
CTF13Ctf13p0.049
SOL1Sol1p0.049
SDS22Sds22p0.048
RAD53Rad53p0.047
GAC1Gac1p0.047
CSM1Csm1p0.046
PCL10Pcl10p0.045
FIN1Fin1p0.043
CDH1Cdh1p0.042
BFA1Bfa1p0.040
CIN1Cin1p0.040
YKL075Chypothetical protein0.038
RAD61Rad61p0.038
PTI1Pti1p0.038
NBL1Nbl1p0.036
CRP1Crp1p0.035
MYO1Myo1p0.035
MAM1Mam1p0.034
IRC15Irc15p0.033
GLC7Glc7p0.031
YNL144Chypothetical protein0.030
SRD1Srd1p0.030
SGO1Sgo1p0.028
TGL2Tgl2p0.028
YOR059Chypothetical protein0.028
CAB3Cab3p0.027
SMC5Smc5p0.027
IME4Ime4p0.027
SPO12Spo12p0.026
CLB1Clb1p0.026