The network for 'dna catabolic process endonucleolytic' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

dna catabolic process endonucleolytic

The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides.

Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
SLX4SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)0.942
MLH1mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)0.866
MSH2mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)0.820
EXOSC3exosome component 30.814
BCL2B-cell CLL/lymphoma 20.693
SLX1BSLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)0.589
EME1essential meiotic endonuclease 1 homolog 1 (S. pombe)0.586
MRE11AMRE11 meiotic recombination 11 homolog A (S. cerevisiae)0.474
BAK1BCL2-antagonist/killer 10.468
BCL2L11BCL2-like 11 (apoptosis facilitator)0.339
BCL2L1BCL2-like 10.320
CASP9caspase 9, apoptosis-related cysteine peptidase0.291
BAXBCL2-associated X protein0.264
EXOSC2exosome component 20.247
POU5F1POU class 5 homeobox 10.227
RAD51L1RAD51-like 1 (S. cerevisiae)0.224
BRCA1breast cancer 1, early onset0.219
EXOSC7exosome component 70.194
H2AFXH2A histone family, member X0.170
EXOSC4exosome component 40.169
APAF1apoptotic peptidase activating factor 10.160
DIS3LDIS3 mitotic control homolog (S. cerevisiae)-like0.149
MSH6mutS homolog 6 (E. coli)0.146
DIS3DIS3 mitotic control homolog (S. cerevisiae)0.136
FANCD2Fanconi anemia, complementation group D20.121
RAD51RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)0.115
XRCC4X-ray repair complementing defective repair in Chinese hamster cells 40.113
ERCC4excision repair cross-complementing rodent repair deficiency, complementation group 40.112
EXOSC9exosome component 90.108
C20orf94chromosome 20 open reading frame 940.102
EXOSC1exosome component 10.101
MCL1myeloid cell leukemia sequence 1 (BCL2-related)0.086
PMAIP1phorbol-12-myristate-13-acetate-induced protein 10.072
RAD50RAD50 homolog (S. cerevisiae)0.069
LIG4ligase IV, DNA, ATP-dependent0.064
EIF2C1eukaryotic translation initiation factor 2C, 10.063
XIAPX-linked inhibitor of apoptosis0.059
PSMA3proteasome (prosome, macropain) subunit, alpha type, 30.057
C19orf39chromosome 19 open reading frame 390.056
EIF2C2eukaryotic translation initiation factor 2C, 20.054
BRCA2breast cancer 2, early onset0.054
BIDBH3 interacting domain death agonist0.054
NBNnibrin0.051
MYCNv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.050
TERF2telomeric repeat binding factor 20.047
TNRC6Atrinucleotide repeat containing 6A0.047
EXOSC5exosome component 50.046
C4orf14chromosome 4 open reading frame 140.042
EXOSC10exosome component 100.040
CHEK2CHK2 checkpoint homolog (S. pombe)0.038
EXOSC8exosome component 80.037
XAB2XPA binding protein 20.035
ZSWIM7zinc finger, SWIM-type containing 70.034
BADBCL2-associated agonist of cell death0.033
XRCC6X-ray repair complementing defective repair in Chinese hamster cells 60.032
PRMT6protein arginine methyltransferase 60.032
RAD18RAD18 homolog (S. cerevisiae)0.030
RBL2retinoblastoma-like 2 (p130)0.030
H3F3CH3 histone, family 3C0.029
MUS81MUS81 endonuclease homolog (S. cerevisiae)0.028
RPA1replication protein A1, 70kDa0.028
XRCC3X-ray repair complementing defective repair in Chinese hamster cells 30.028
ERCC1excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)0.028
MDC1mediator of DNA-damage checkpoint 10.026
BBC3BCL2 binding component 30.026
RNR2l-rRNA0.025
RNF144Bring finger protein 144B0.025
PALB2partner and localizer of BRCA20.024
E2F1E2F transcription factor 10.023
SOX2SRY (sex determining region Y)-box 20.023
CDT1chromatin licensing and DNA replication factor 10.023
TP53tumor protein p530.023
CHEK1CHK1 checkpoint homolog (S. pombe)0.023
ERCC6excision repair cross-complementing rodent repair deficiency, complementation group 60.022
DNAJA3DnaJ (Hsp40) homolog, subfamily A, member 30.022
TNRC6Ctrinucleotide repeat containing 6C0.022
PARP2poly (ADP-ribose) polymerase 20.022
BIKBCL2-interacting killer (apoptosis-inducing)0.022
RBL1retinoblastoma-like 1 (p107)0.021
BLMBloom syndrome, RecQ helicase-like0.020
ARandrogen receptor0.020
POLD3polymerase (DNA-directed), delta 3, accessory subunit0.020
IGF2BP1insulin-like growth factor 2 mRNA binding protein 10.019
ATMataxia telangiectasia mutated0.019
HUWE1HECT, UBA and WWE domain containing 10.019
XRCC5X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)0.019
RAD52RAD52 homolog (S. cerevisiae)0.019
NUDT3nudix (nucleoside diphosphate linked moiety X)-type motif 30.018
POLR3Kpolymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa0.018
BRIP1BRCA1 interacting protein C-terminal helicase 10.018
TARBP2TAR (HIV-1) RNA binding protein 20.018
MSH3mutS homolog 3 (E. coli)0.018
XPCxeroderma pigmentosum, complementation group C0.017
WRNWerner syndrome, RecQ helicase-like0.017
TNRC6Btrinucleotide repeat containing 6B0.017
PPIApeptidylprolyl isomerase A (cyclophilin A)0.017
TERF2IPtelomeric repeat binding factor 2, interacting protein0.017
BECN1beclin 1, autophagy related0.016
ONECUT1one cut homeobox 10.016
MDM2Mdm2 p53 binding protein homolog (mouse)0.015
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Ras85DRas oncogene at 85D0.016
l(2)gllethal (2) giant larvae0.014
eIF-4EEukaryotic initiation factor 4E0.013
DlDelta0.012
NNotch0.011
auxauxillin0.011
tgotango0.011
TorTarget of rapamycin0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Casp4caspase 4, apoptosis-related cysteine peptidase0.969
DffbDNA fragmentation factor, beta subunit0.847
Gbp5guanylate binding protein 50.831
PycardPYD and CARD domain containing0.795
Casp1caspase 10.705
Aim2absent in melanoma 20.567
Il18interleukin 180.360
Rb1retinoblastoma 10.343
Tlr4toll-like receptor 40.248
Apaf1apoptotic peptidase activating factor 10.192
FaddFas (TNFRSF6)-associated via death domain0.168
Bak1BCL2-antagonist/killer 10.137
Brca1breast cancer 10.133
Plin1perilipin 10.116
Pms2postmeiotic segregation increased 2 (S. cerevisiae)0.089
Prkab1protein kinase, AMP-activated, beta 1 non-catalytic subunit0.081
Ints7integrator complex subunit 70.081
Cox5acytochrome c oxidase, subunit Va0.079
Uqcrbubiquinol-cytochrome c reductase binding protein0.077
WrnWerner syndrome homolog (human)0.076
Hellshelicase, lymphoid specific0.076
Cideccell death-inducing DFFA-like effector c0.070
Droshadrosha, ribonuclease type III0.068
Nlrp3NLR family, pyrin domain containing 30.066
Mcm7minichromosome maintenance deficient 7 (S. cerevisiae)0.065
Prkdcprotein kinase, DNA activated, catalytic polypeptide0.065
BidBH3 interacting domain death agonist0.064
Ndufab1NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 10.063
Uqcrc2ubiquinol cytochrome c reductase core protein 20.063
Bub1budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae)0.063
Ptpn11protein tyrosine phosphatase, non-receptor type 110.062
Il1binterleukin 1 beta0.061
Tgfbr2transforming growth factor, beta receptor II0.056
Hif1ahypoxia inducible factor 1, alpha subunit0.055
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.053
Alx1ALX homeobox 10.052
Ripk3receptor-interacting serine-threonine kinase 30.051
Mcm10minichromosome maintenance deficient 10 (S. cerevisiae)0.048
Stk11serine/threonine kinase 110.047
Mlh1mutL homolog 1 (E. coli)0.046
Casp8caspase 80.046
Eif2ak2eukaryotic translation initiation factor 2-alpha kinase 20.045
Rbl1retinoblastoma-like 1 (p107)0.043
Ints9integrator complex subunit 90.041
Iduaiduronidase, alpha-L-0.041
Gcshglycine cleavage system protein H (aminomethyl carrier)0.041
Plk4polo-like kinase 4 (Drosophila)0.039
Xpaxeroderma pigmentosum, complementation group A0.039
Cideacell death-inducing DNA fragmentation factor, alpha subunit-like effector A0.037
Fancd2Fanconi anemia, complementation group D20.035
Prkag1protein kinase, AMP-activated, gamma 1 non-catalytic subunit0.033
Plin4perilipin 40.033
Mybl2myeloblastosis oncogene-like 20.033
Vdac3voltage-dependent anion channel 30.032
Pole2polymerase (DNA directed), epsilon 2 (p59 subunit)0.032
Cfdcomplement factor D (adipsin)0.031
Casp3caspase 30.031
Ndufa12NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 120.030
Ndufa5NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 50.030
U2af1U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 10.029
Srsf9serine/arginine-rich splicing factor 90.029
Cbx7chromobox homolog 70.028
Apobec1apolipoprotein B mRNA editing enzyme, catalytic polypeptide 10.028
Mrpl13mitochondrial ribosomal protein L130.027
Sod2superoxide dismutase 2, mitochondrial0.027
Cdkn2ccyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)0.026
Tmpothymopoietin0.026
Hdac1histone deacetylase 10.025
Trip13thyroid hormone receptor interactor 130.025
Clic1chloride intracellular channel 10.025
Prim2DNA primase, p58 subunit0.024
Nudt1nudix (nucleoside diphosphate linked moiety X)-type motif 10.023
Casp7caspase 70.023
Dhfrdihydrofolate reductase0.023
Commd4COMM domain containing 40.023
Adigadipogenin0.023
MtbpMdm2, transformed 3T3 cell double minute p53 binding protein0.022
Taf3TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor0.022
Atrataxia telangiectasia and Rad3 related0.022
Cycscytochrome c, somatic0.022
Pola1polymerase (DNA directed), alpha 10.022
Safbscaffold attachment factor B0.022
Orc1origin recognition complex, subunit 10.022
FancmFanconi anemia, complementation group M0.022
Mastlmicrotubule associated serine/threonine kinase-like0.021
Atp5f1ATP synthase, H+ transporting, mitochondrial F0 complex, subunit B10.021
Wdhd1WD repeat and HMG-box DNA binding protein 10.021
Mcm8minichromosome maintenance deficient 8 (S. cerevisiae)0.021
Pparaperoxisome proliferator activated receptor alpha0.021
Dtldenticleless homolog (Drosophila)0.020
Chek2CHK2 checkpoint homolog (S. pombe)0.020
Xrcc6X-ray repair complementing defective repair in Chinese hamster cells 60.020
Cops7bCOP9 (constitutive photomorphogenic) homolog, subunit 7b (Arabidopsis thaliana)0.020
Mms22lMMS22-like, DNA repair protein0.020
Mre11ameiotic recombination 11 homolog A (S. cerevisiae)0.020
Prdx1peroxiredoxin 10.020
Hhathedgehog acyltransferase0.020
Gfm1G elongation factor, mitochondrial 10.019
Rad54lRAD54 like (S. cerevisiae)0.019
Nthl1nth (endonuclease III)-like 1 (E.coli)0.019
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
RAD1Rad1p0.884
MSH2Msh2p0.602
RAD14Rad14p0.169
RAD10Rad10p0.149
MSH3Msh3p0.109
SAW1Saw1p0.092
EXO1Exo1p0.047
DOT1Dot1p0.034
POL32Pol32p0.033
RAD5Rad5p0.029
MSH6Msh6p0.028
PSO2Pso2p0.027
YLR264C-Ahypothetical protein0.027
RAD53Rad53p0.026
SEN1Sen1p0.026
SRD1Srd1p0.025
YIR035Chypothetical protein0.023
LEU2Leu2p0.021
RAD59Rad59p0.021
YAR068Whypothetical protein0.021
YLR162Whypothetical protein0.021
APN1Apn1p0.021
RAD18Rad18p0.021
YOL038C-Ahypothetical protein0.020
URA3Ura3p0.020
MER1Mer1p0.020
YOR342Chypothetical protein0.019
ARG8Arg8p0.019
GYL1Gyl1p0.018
MEX67Mex67p0.018
CUP1-1Cup1-1p0.018
SLX4Slx4p0.017
ARP10Arp10p0.017
HOHop0.017
DBP5Dbp5p0.017
YLR042Chypothetical protein0.017
RAD54Rad54p0.017
POL2Pol2p0.017
MUS81Mus81p0.016
HXT3Hxt3p0.016
RPS6ARps6ap0.016
POL30Pol30p0.016
YBR013Chypothetical protein0.016
YAR066Whypothetical protein0.016
ATP6Atp6p0.015
POL31Pol31p0.015
URA6Ura6p0.015
YPR157Whypothetical protein0.015
YGR035Chypothetical protein0.015
YOL013W-Ahypothetical protein0.014
ZPS1Zps1p0.014
SAE2Sae2p0.014
CPD1Cpd1p0.014
SMM1Smm1p0.014
MF(ALPHA)2Mf(alpha)2p0.014
HST3Hst3p0.014
SUT2Sut2p0.014
RPS5Rps5p0.014
XRS2Xrs2p0.014
BSC1Bsc1p0.014
SPL2Spl2p0.014
HPF1Hpf1p0.014
AUA1Aua1p0.013
SCM4Scm4p0.013
RAD17Rad17p0.013
SSL2Ssl2p0.013
FMT1Fmt1p0.013
IZH4Izh4p0.013
CSL4Csl4p0.013
YPR096Chypothetical protein0.013
YHB1Yhb1p0.013
UPS3Ups3p0.013
OPT2Opt2p0.012
ALT2Alt2p0.012
TPC1Tpc1p0.012
CCA1Cca1p0.012
ARR2Arr2p0.012
YIL151Chypothetical protein0.012
YLR040Chypothetical protein0.012
TYE7Tye7p0.012
DIC1Dic1p0.012
TIR3Tir3p0.012
YAL037C-Ahypothetical protein0.012
COS12Cos12p0.012
RPS2Rps2p0.012
MMS21Mms21p0.012
YBL044Whypothetical protein0.012
RMI1Rmi1p0.012
HDA2Hda2p0.012
YMR317Whypothetical protein0.012
NRG2Nrg2p0.011
YKR075Chypothetical protein0.011
YOL014Whypothetical protein0.011
DUR1,2Dur1,2p0.011
YJL181Whypothetical protein0.011
RRP45Rrp45p0.011
PTR2Ptr2p0.011
REE1Ree1p0.011
PRS2Prs2p0.011
CAR1Car1p0.011