The network for 'dna synthesis involved in dna repair' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

dna synthesis involved in dna repair

Synthesis of DNA that proceeds from the broken 3' single-strand DNA end uses the homologous intact duplex as the template.

NameDescriptionProbabilityFunc Analog Organism
POLD3polymerase (DNA-directed), delta 3, accessory subunit0.880
PCNAproliferating cell nuclear antigen0.876
RPA1replication protein A1, 70kDa0.854
PARP1poly (ADP-ribose) polymerase 10.509
CHAF1Achromatin assembly factor 1, subunit A (p150)0.445
RAD52RAD52 homolog (S. cerevisiae)0.373
POLA2polymerase (DNA directed), alpha 2 (70kD subunit)0.353
RPA3replication protein A3, 14kDa0.324
BRIP1BRCA1 interacting protein C-terminal helicase 10.246
RAD51RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)0.245
RPA2replication protein A2, 32kDa0.216
XRCC6X-ray repair complementing defective repair in Chinese hamster cells 60.211
EP300E1A binding protein p3000.198
MDC1mediator of DNA-damage checkpoint 10.173
LIG1ligase I, DNA, ATP-dependent0.095
BRCA1breast cancer 1, early onset0.078
UHRF2ubiquitin-like with PHD and ring finger domains 20.077
RAD18RAD18 homolog (S. cerevisiae)0.075
TERF2telomeric repeat binding factor 20.063
CDT1chromatin licensing and DNA replication factor 10.063
CDKN1Bcyclin-dependent kinase inhibitor 1B (p27, Kip1)0.047
POLD1polymerase (DNA directed), delta 1, catalytic subunit 125kDa0.046
WRNWerner syndrome, RecQ helicase-like0.038
POLA1polymerase (DNA directed), alpha 1, catalytic subunit0.036
H2AFXH2A histone family, member X0.035
CHAF1Bchromatin assembly factor 1, subunit B (p60)0.034
RAD51L3RAD51-like 3 (S. cerevisiae)0.034
DNMT1DNA (cytosine-5-)-methyltransferase 10.030
ING2inhibitor of growth family, member 20.029
CDK2cyclin-dependent kinase 20.028
FOXM1forkhead box M10.027
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.024
MUS81MUS81 endonuclease homolog (S. cerevisiae)0.024
SMC1Astructural maintenance of chromosomes 1A0.023
MSH6mutS homolog 6 (E. coli)0.017
CDKN2Bcyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)0.015
TOP3Atopoisomerase (DNA) III alpha0.015
CCND3cyclin D30.014
MCM5minichromosome maintenance complex component 50.013
CDK6cyclin-dependent kinase 60.013
DDX11DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 110.013
TIMELESStimeless homolog (Drosophila)0.012
E2F1E2F transcription factor 10.012
KAT2BK(lysine) acetyltransferase 2B0.011
CKS1BCDC28 protein kinase regulatory subunit 1B0.011
PPP1CCprotein phosphatase 1, catalytic subunit, gamma isozyme0.011
EXO1exonuclease 10.011
MCM2minichromosome maintenance complex component 20.011
BRCA2breast cancer 2, early onset0.010
LMNB2lamin B20.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
mus205mutagen-sensitive 2050.968
mus101mutagen-sensitive 1010.922
mus308mutagen-sensitive 3080.903
mei-9meiotic 90.776
mus201mutagen-sensitive 2010.728
DNApol-etaCG7143 gene product from transcript CG7143-RA0.668
RecQ5homolog of RecQ0.652
Brca2Breast cancer 2, early onset homolog0.623
mei-41meiotic 410.508
CG5524CG5524 gene product from transcript CG5524-RA0.403
nbsCG6754 gene product from transcript CG6754-RC0.372
spn-Aspindle A0.359
mus309mutagen-sensitive 3090.359
mus301mutagen-sensitive 3010.313
spn-Bspindle B0.308
mus304mutagen-sensitive 3040.291
RecQ4CG7487 gene product from transcript CG7487-RA0.287
mus210mutagen-sensitive 2100.254
rad50CG6339 gene product from transcript CG6339-RD0.247
mus312mutagen-sensitive 3120.090
IrbpInverted repeat-binding protein0.066
Mnn1Menin 10.041
Rev1CG12189 gene product from transcript CG12189-RA0.038
Smc5CG32438 gene product from transcript CG32438-RE0.031
Chrac-14CG13399 gene product from transcript CG13399-RA0.029
tefutelomere fusion0.013
Ercc1CG10215 gene product from transcript CG10215-RA0.012
mei-218meiotic 2180.011
CG4680CG4680 gene product from transcript CG4680-RA0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Srsf10serine/arginine-rich splicing factor 100.014
Zfp62zinc finger protein 620.012
Kcnq2potassium voltage-gated channel, subfamily Q, member 20.012
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism