The network for 'regulation of syncytium formation by plasma membrane fusion' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of syncytium formation by plasma membrane fusion

Any process that modulates the frequency, rate or extent of the formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells.

NameDescriptionProbabilityFunc Analog Organism
ABI2abl-interactor 20.943
PTK2PTK2 protein tyrosine kinase 20.880
CASP8caspase 8, apoptosis-related cysteine peptidase0.709
ATP6V1E1ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E10.611
SLC7A5solute carrier family 7 (cationic amino acid transporter, y+ system), member 50.569
BCAR1breast cancer anti-estrogen resistance 10.424
STAT6signal transducer and activator of transcription 6, interleukin-4 induced0.382
ASAP1ArfGAP with SH3 domain, ankyrin repeat and PH domain 10.355
SRFserum response factor (c-fos serum response element-binding transcription factor)0.340
PTRFpolymerase I and transcript release factor0.333
ATP6V1DATPase, H+ transporting, lysosomal 34kDa, V1 subunit D0.303
MAD2L2MAD2 mitotic arrest deficient-like 2 (yeast)0.270
CSRP3cysteine and glycine-rich protein 3 (cardiac LIM protein)0.261
ATP6V1AATPase, H+ transporting, lysosomal 70kDa, V1 subunit A0.259
ATP6V0BATPase, H+ transporting, lysosomal 21kDa, V0 subunit b0.226
MAP2K3mitogen-activated protein kinase kinase 30.224
CXCL11chemokine (C-X-C motif) ligand 110.224
MAPK1mitogen-activated protein kinase 10.214
IL2RGinterleukin 2 receptor, gamma0.207
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.196
ANKFY1ankyrin repeat and FYVE domain containing 10.174
ATP6V0D1ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d10.171
CASP10caspase 10, apoptosis-related cysteine peptidase0.145
SH3D19SH3 domain containing 190.143
LASS2LAG1 homolog, ceramide synthase 20.119
INPP5Dinositol polyphosphate-5-phosphatase, 145kDa0.114
MED31mediator complex subunit 310.113
TNFSF10tumor necrosis factor (ligand) superfamily, member 100.108
MAP2K1mitogen-activated protein kinase kinase 10.103
DLG1discs, large homolog 1 (Drosophila)0.103
CBLBCas-Br-M (murine) ecotropic retroviral transforming sequence b0.090
ATP6V1FATPase, H+ transporting, lysosomal 14kDa, V1 subunit F0.086
GIT2G protein-coupled receptor kinase interacting ArfGAP 20.083
HOXA1homeobox A10.080
JAK1Janus kinase 10.078
LIMS1LIM and senescent cell antigen-like domains 10.077
IQGAP1IQ motif containing GTPase activating protein 10.072
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.070
IGFBP3insulin-like growth factor binding protein 30.070
IL13RA1interleukin 13 receptor, alpha 10.069
MAPK3mitogen-activated protein kinase 30.069
UBQLN4ubiquilin 40.069
IFNGR1interferon gamma receptor 10.067
CSF2RBcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.063
CXCL9chemokine (C-X-C motif) ligand 90.060
YARStyrosyl-tRNA synthetase0.058
ATP6V1G1ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G10.054
GARSglycyl-tRNA synthetase0.052
DUSP3dual specificity phosphatase 30.051
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.051
MAPKAPK2mitogen-activated protein kinase-activated protein kinase 20.050
NCK2NCK adaptor protein 20.049
CLTBclathrin, light chain B0.049
FN1fibronectin 10.049
ZFP36L1zinc finger protein 36, C3H type-like 10.045
WARStryptophanyl-tRNA synthetase0.045
PLEKHB2pleckstrin homology domain containing, family B (evectins) member 20.044
STK10serine/threonine kinase 100.043
TNFRSF10Atumor necrosis factor receptor superfamily, member 10a0.043
LRRK2leucine-rich repeat kinase 20.043
MFSD1major facilitator superfamily domain containing 10.043
ITGAVintegrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)0.042
SDCBPsyndecan binding protein (syntenin)0.040
TRIB3tribbles homolog 3 (Drosophila)0.039
MYOD1myogenic differentiation 10.039
BBS10Bardet-Biedl syndrome 100.039
FSTL3follistatin-like 3 (secreted glycoprotein)0.039
CD44CD44 molecule (Indian blood group)0.036
ATP6AP1ATPase, H+ transporting, lysosomal accessory protein 10.036
CARScysteinyl-tRNA synthetase0.036
TMBIM6transmembrane BAX inhibitor motif containing 60.035
COL1A1collagen, type I, alpha 10.034
TGFB1I1transforming growth factor beta 1 induced transcript 10.034
TNFRSF10Btumor necrosis factor receptor superfamily, member 10b0.033
SARSseryl-tRNA synthetase0.033
DPP4dipeptidyl-peptidase 40.033
LAPTM4Alysosomal protein transmembrane 4 alpha0.032
PTPN12protein tyrosine phosphatase, non-receptor type 120.032
ZNF426zinc finger protein 4260.031
MYOGmyogenin (myogenic factor 4)0.030
MKNK1MAP kinase interacting serine/threonine kinase 10.030
SLC7A1solute carrier family 7 (cationic amino acid transporter, y+ system), member 10.030
DUSP7dual specificity phosphatase 70.029
PTPN23protein tyrosine phosphatase, non-receptor type 230.029
PEA15phosphoprotein enriched in astrocytes 150.028
ARL8BADP-ribosylation factor-like 8B0.028
STAT5Asignal transducer and activator of transcription 5A0.028
CXCL13chemokine (C-X-C motif) ligand 130.027
MAFGv-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)0.027
ATP6V1C1ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C10.027
CXCR3chemokine (C-X-C motif) receptor 30.027
IGFBP6insulin-like growth factor binding protein 60.027
SDF2stromal cell-derived factor 20.027
TRIM43tripartite motif containing 430.026
PDLIM7PDZ and LIM domain 7 (enigma)0.026
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.026
UBDubiquitin D0.026
MYBPHmyosin binding protein H0.025
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
vha-8Protein VHA-80.406
vha-14Protein VHA-140.112
vha-4Protein VHA-40.085
vha-9Protein VHA-90.078
vha-15Protein VHA-150.070
vha-13Protein VHA-130.068
vha-3Protein VHA-30.059
vha-16Protein VHA-160.034
vha-1Protein VHA-10.032
unc-78Protein UNC-780.028
aqp-11Protein AQP-110.028
pssy-1Protein PSSY-10.022
CELE_Y53C10A.5Protein Y53C10A.50.021
acl-1Protein ACL-10.020
idh-1Protein IDH-10.019
F13E6.5Protein F13E6.50.019
sft-4Protein SFT-40.018
emo-1Protein EMO-10.018
erm-1Protein ERM-10.017
vha-10Protein VHA-100.013
ucr-2.2Protein UCR-2.20.013
C24A3.2Protein C24A3.20.013
vha-17Protein VHA-170.012
Y62E10A.13Protein Y62E10A.130.011
nhr-142Protein NHR-1420.011
crm-1Protein CRM-10.011
C10E2.6Protein C10E2.60.011
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
myod1myogenic differentiation 10.993
cxcl12bchemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1)0.952
myf5myogenic factor 50.708
aldh1a2aldehyde dehydrogenase 1 family, member A20.631
dhrs3adehydrogenase/reductase (SDR family) member 3a0.420
atp6v1e1bATPase, H+ transporting, lysosomal, V1 subunit E isoform 1b0.246
id2ainhibitor of DNA binding 2, dominant negative helix-loop-helix protein, a0.243
hspb1heat shock protein, alpha-crystallin-related, 10.200
pax3apaired box gene 3a0.149
ndfip1Nedd4 family interacting protein 10.118
dpysl3dihydropyrimidinase-like 30.115
efemp2EGF-containing fibulin-like extracellular matrix protein 20.113
pcdh10bprotocadherin 10b0.112
irx3biroquois homeobox protein 3b0.100
glulaglutamate-ammonia ligase (glutamine synthase) a0.098
meis3myeloid ecotropic viral integration site 30.093
sh3gl2SH3-domain GRB2-like 20.091
lfnglunatic fringe homolog0.091
atp6v1g1ATPase, H+ transporting, V1 subunit G isoform 10.090
hand2heart and neural crest derivatives expressed transcript 20.088
jam2bjunctional adhesion molecule 2b0.082
atp6v1fATPase, H+ transporting, V1 subunit F0.077
laptm4blysosomal associated protein transmembrane 4 beta0.075
samsn1aSAM domain, SH3 domain and nuclear localisation signals, 1a0.073
ctsccathepsin C0.071
osr2odd-skipped related 2 (Drosophila)0.067
eno1enolase 1, (alpha)0.066
dusp2dual specificity phosphatase 20.064
egr2bearly growth response 2b0.063
sema3dsemaphorin 3d0.063
LOC566969similar to MOX-2 protein0.061
fstl1afollistatin-like 1a0.058
olig4oligodendrocyte transcription factor 40.055
osr1odd-skipped related 1 (Drosophila)0.055
pcdh8protocadherin 80.054
fstl1bfollistatin-like 1b0.054
jam3bjunctional adhesion molecule 3b0.053
lbx2ladybird homeobox homolog 2 (Drosophila)0.053
lmo4aLIM domain only 4a0.050
atp6v1dATPase, H+ transporting, V1 subunit D and ATPase, H+ transporting, V1 subunit D0.050
dusp6dual specificity phosphatase 60.050
nptnaneuroplastin a0.049
tcea2transcription elongation factor A (SII), 20.049
rbfox1lRNA binding protein, fox-1 homolog (C. elegans) 1-like0.048
gmfgglia maturation factor, gamma0.047
krml2.2Kreisler (mouse) maf-related leucine zipper homolog 2.20.046
tnnt1troponin T1, skeletal, slow0.046
hsp90a.1heat shock protein 90-alpha 10.045
arfip2aADP-ribosylation factor interacting protein 2a0.044
rogdirogdi homolog (Drosophila)0.043
mpp1membrane protein, palmitoylated 10.042
ckbbcreatine kinase, brain b0.041
stac3SH3 and cysteine rich domain 30.040
ctssb.2cathepsin S, b.20.038
etv2ets variant gene 20.038
ctsfcathepsin F0.038
jam2ajunctional adhesion molecule 2a0.038
acvr1bactivin A receptor, type IB0.036
vgll2bvestigial like 2b0.036
lrrc15leucine rich repeat containing 150.036
hoxb5ahomeo box B5a0.036
flncbfilamin C, gamma b (actin binding protein 280)0.036
pdzrn3PDZ domain containing RING finger 3 and PDZ domain containing ring finger 30.035
gngt2bguanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 2b0.035
myf6myogenic factor 60.034
slc3a2solute carrier family 3, member 20.034
nkx6.1NK6 transcription factor related, locus 1 (Drosophila)0.034
frzbfrizzled-related protein0.034
uncx4.1Unc4.1 homeobox (C. elegans)0.033
zfand5azinc finger, AN1-type domain 5a0.033
ntn2netrin 20.032
id1inhibitor of DNA binding 10.032
sulf2lsulfatase 2, like0.032
calm2acalmodulin 2a (phosphorylase kinase, delta)0.032
rgs13regulator of G-protein signaling 130.030
pax3bpaired box gene 3b0.030
atp6v1aATPase, H+ transporting, lysosomal V1 subunit A0.030
efnb2aephrin B2a0.029
spi1spleen focus forming virus (SFFV) proviral integration oncogene spi10.029
scg3secretogranin III0.028
ak3adenylate kinase 30.028
meox1mesenchyme homeobox 10.028
cndp2CNDP dipeptidase 2 (metallopeptidase M20 family)0.027
cd63Cd63 antigen0.027
LOC100002342carboxypeptidase A6-like0.027
prtgaprotogenin homolog a (Gallus gallus)0.027
calm1acalmodulin 1a0.027
LOC557062hypothetical protein LOC5570620.026
rgs4regulator of G-protein signalling 40.026
hspd1heat shock 60kD protein 1 (chaperonin)0.026
yes1v-yes-1 Yamaguchi sarcoma viral oncogene homolog 10.026
zmynd11zinc finger, MYND domain containing 110.025
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
snssticks and stones0.990
kirrekin of irre0.983
Vrp1Verprolin 10.675
lbeladybird early0.594
eveeven skipped0.340
blowblown fuse0.307
rolsrolling pebbles0.161
Mp20Muscle protein 200.143
foxoforkhead box, sub-group O0.106
LamCLamin C0.099
X11LCG5675 gene product from transcript CG5675-RB0.070
Wnt4Wnt oncogene analog 40.063
Act57BActin 57B0.062
slp1sloppy paired 10.030
HeyHairy/E(spl)-related with YRPW motif0.028
singsingles bar0.027
Mlp84BMuscle LIM protein at 84B0.023
swshort wing0.021
NotumCG13076 gene product from transcript CG13076-RB0.017
ParpPoly-(ADP-ribose) polymerase0.016
Cpr72EaCuticular protein 72Ea0.015
CG5794CG5794 gene product from transcript CG5794-RB0.013
Pvf2PDGF- and VEGF-related factor 20.013
cdicenter divider0.013
Mef2Myocyte enhancer factor 20.012
lmdlame duck0.011
CG34350CG34350 gene product from transcript CG34350-RA0.011
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Map3k14mitogen-activated protein kinase kinase kinase 140.964
Stat3signal transducer and activator of transcription 30.956
Csf2rb2colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)0.753
Ifnginterferon gamma0.724
Tnftumor necrosis factor0.717
Crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.623
Ccl2chemokine (C-C motif) ligand 20.554
Il10interleukin 100.529
Stat5bsignal transducer and activator of transcription 5B0.493
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.399
Ccl7chemokine (C-C motif) ligand 70.375
Irf9interferon regulatory factor 90.332
Il1rninterleukin 1 receptor antagonist0.330
Il6interleukin 60.324
Cxcl1chemokine (C-X-C motif) ligand 10.313
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.305
Tnfrsf9tumor necrosis factor receptor superfamily, member 90.280
Stat6signal transducer and activator of transcription 60.273
Il1binterleukin 1 beta0.250
Cd28CD28 antigen0.237
Nfatc4nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 40.227
Il2interleukin 20.218
Stat5asignal transducer and activator of transcription 5A0.205
FasFas (TNF receptor superfamily member 6)0.196
Mapkapk2MAP kinase-activated protein kinase 20.170
Cxcl2chemokine (C-X-C motif) ligand 20.164
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.162
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.151
Selpselectin, platelet0.145
Il4rainterleukin 4 receptor, alpha0.137
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.135
Iigp1interferon inducible GTPase 10.130
Pax7paired box gene 70.128
Arhgef7Rho guanine nucleotide exchange factor (GEF7)0.123
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.113
Casp4caspase 4, apoptosis-related cysteine peptidase0.108
C3ar1complement component 3a receptor 10.107
Ccl20chemokine (C-C motif) ligand 200.105
Irg1immunoresponsive gene 10.100
Gbp2guanylate binding protein 20.100
Il7interleukin 70.096
Myd88myeloid differentiation primary response gene 880.094
Saa3serum amyloid A 30.093
Il1r1interleukin 1 receptor, type I0.091
Cxcl13chemokine (C-X-C motif) ligand 130.089
Ch25hcholesterol 25-hydroxylase0.089
Ccr1chemokine (C-C motif) receptor 10.088
Nfatc3nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 30.087
Csf2colony stimulating factor 2 (granulocyte-macrophage)0.083
Ubdubiquitin D0.081
Lyz2lysozyme 20.079
Serpina3nserine (or cysteine) peptidase inhibitor, clade A, member 3N0.078
Msr1macrophage scavenger receptor 10.077
Skor1SKI family transcriptional corepressor 10.077
Tlr4toll-like receptor 40.073
Zfp36zinc finger protein 360.073
Clec4dC-type lectin domain family 4, member d0.072
Myf5myogenic factor 50.071
Atf2activating transcription factor 20.070
Irgm1immunity-related GTPase family M member 10.068
Cd14CD14 antigen0.068
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.068
Irgm2immunity-related GTPase family M member 20.066
Igtpinterferon gamma induced GTPase0.065
Cd40CD40 antigen0.065
Ltalymphotoxin A0.063
MefvMediterranean fever0.062
Mapk14mitogen-activated protein kinase 140.061
Lmx1bLIM homeobox transcription factor 1 beta0.060
Mapk8ip3mitogen-activated protein kinase 8 interacting protein 30.059
Tlr2toll-like receptor 20.058
Bcl3B-cell leukemia/lymphoma 30.055
Mapk9mitogen-activated protein kinase 90.055
Foxp3forkhead box P30.054
Osmroncostatin M receptor0.054
Icosinducible T-cell co-stimulator0.054
Ciitaclass II transactivator0.052
Ccl12chemokine (C-C motif) ligand 120.052
Myo1cmyosin IC0.051
Socs1suppressor of cytokine signaling 10.050
Mmp3matrix metallopeptidase 30.050
Gzmbgranzyme B0.049
Tgm2transglutaminase 2, C polypeptide0.048
Mmp12matrix metallopeptidase 120.048
Slc11a1solute carrier family 11 (proton-coupled divalent metal ion transporters), member 10.046
Ifitm3interferon induced transmembrane protein 30.045
Trem3triggering receptor expressed on myeloid cells 30.045
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.045
Nphs2nephrosis 2 homolog, podocin (human)0.045
Smad3MAD homolog 3 (Drosophila)0.044
Ccl5chemokine (C-C motif) ligand 50.043
Mvpmajor vault protein0.043
LitafLPS-induced TN factor0.043
Cxcr5chemokine (C-X-C motif) receptor 50.043
Serpine1serine (or cysteine) peptidase inhibitor, clade E, member 10.043
Il12binterleukin 12b0.041
Relreticuloendotheliosis oncogene0.041
Myod1myogenic differentiation 10.041
Csf1colony stimulating factor 1 (macrophage)0.040
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism