The network for 'heart trabecula morphogenesis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

heart trabecula morphogenesis

The process of shaping a trabecula in the heart. A trabecula is a small, often microscopic, tissue element in the form of a small beam, strut or rod, which generally has a mechanical function. Trabecula are usually but not necessarily, composed of dense collagenous tissue.

NameDescriptionProbabilityFunc Analog Organism
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.225
EGFRepidermal growth factor receptor0.169
SPENspen homolog, transcriptional regulator (Drosophila)0.070
TBX5T-box 50.064
VCPvalosin containing protein0.060
ATXN1Lataxin 1-like0.047
ANGPT2angiopoietin 20.046
MKL1megakaryoblastic leukemia (translocation) 10.046
SMARCB1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 10.040
NOTCH3notch 30.039
SMARCC1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.038
FHL3four and a half LIM domains 30.030
ACVR1Bactivin A receptor, type IB0.027
GRB7growth factor receptor-bound protein 70.024
JAG1jagged 10.023
MAML1mastermind-like 1 (Drosophila)0.023
SMARCA2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 20.022
ANGPT1angiopoietin 10.021
HIF1Ahypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)0.021
ARID1AAT rich interactive domain 1A (SWI-like)0.019
SMARCD1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 10.018
NSFL1CNSFL1 (p97) cofactor (p47)0.018
NCOR2nuclear receptor corepressor 20.017
EPAS1endothelial PAS domain protein 10.016
RPL34ribosomal protein L340.016
ERBB4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.015
TRRAPtransformation/transcription domain-associated protein0.014
SP1Sp1 transcription factor0.014
ITGA7integrin, alpha 70.013
GATA4GATA binding protein 40.013
MYOD1myogenic differentiation 10.013
TGFBR1transforming growth factor, beta receptor 10.013
VAV2vav 2 guanine nucleotide exchange factor0.013
CFL1cofilin 1 (non-muscle)0.012
CDK19cyclin-dependent kinase 190.012
SMARCC2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 20.012
XIAPX-linked inhibitor of apoptosis0.012
MYOGmyogenin (myogenic factor 4)0.012
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.012
YY1YY1 transcription factor0.011
SMAD9SMAD family member 90.011
FOXO1forkhead box O10.011
ERGv-ets erythroblastosis virus E26 oncogene homolog (avian)0.011
PIK3R2phosphoinositide-3-kinase, regulatory subunit 2 (beta)0.011
MED10mediator complex subunit 100.011
ITGA3integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)0.011
CYR61cysteine-rich, angiogenic inducer, 610.010
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.010
EGLN3egl nine homolog 3 (C. elegans)0.010
BTF3basic transcription factor 30.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
erbb3bv-erb-b2 erythroblastic leukemia viral oncogene homolog 3b0.770
erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog0.317
nrg1neuregulin 10.107
fabp11afatty acid binding protein 11a0.040
flt1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.040
plcg1phospholipase C, gamma 10.037
prdm5PR domain containing 50.031
notch3notch homolog 30.030
erbb3av-erb-b2 erythroblastic leukemia viral oncogene homolog 3a0.028
axin1axin 10.027
dzip1DAZ interacting protein 10.022
card14caspase recruitment domain family, member 140.022
oepone-eyed pinhead0.020
tbx1T-box 10.019
smyhc2slow myosin heavy chain 20.018
osr2odd-skipped related 2 (Drosophila)0.017
gyltl1bglycosyltransferase-like 1b0.016
ripk2receptor-interacting serine-threonine kinase 20.016
fancd2Fanconi anemia, complementation group D20.016
myh6myosin, heavy polypeptide 6, cardiac muscle, alpha0.016
slc24a5solute carrier family 24, member 50.016
restRE1-silencing transcription factor0.016
tbx16T-box gene 160.016
disp1dispatched homolog 1 (Drosophila)0.016
mibmind bomb0.016
nkx2.5NK2 transcription factor related 50.015
nfatc1nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 10.015
rbfox1lRNA binding protein, fox-1 homolog (C. elegans) 1-like0.015
pno1partner of NOB1 homolog (S. cerevisiae)0.014
kbpkif1-binding protein0.014
tbx20T-box 200.014
slc8a1asolute carrier family 8 (sodium/calcium exchanger), member 1a0.014
tgfb3transforming growth factor, beta 30.014
hey2hairy/enhancer-of-split related with YRPW motif 20.013
etv2ets variant gene 20.013
me2malic enzyme 2, NAD(+)-dependent, mitochondrial0.013
appl1adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 10.013
fbn2bfibrillin 2b0.013
gpr182G protein-coupled receptor 1820.013
ptprjaprotein tyrosine phosphatase, receptor type, J a0.013
rsl24d1ribosomal L24 domain containing 10.013
nrarpanotch-regulated ankyrin repeat protein a0.013
aplnraapelin receptor a0.013
kdrlkinase insert domain receptor like0.012
plekha7pleckstrin homology domain containing, family A member 70.012
med12mediator of RNA polymerase II transcription, subunit 12 homolog0.012
egfraepidermal growth factor receptor a (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)0.012
foxb1.1forkhead box B1.10.012
tmprss4atransmembrane protease, serine 4a0.012
cldn5bclaudin 5b0.012
mical2amicrotubule associated monoxygenase, calponin and LIM domain containing 2a0.011
mitfamicrophthalmia-associated transcription factor a0.011
tnnt2atroponin T2a, cardiac0.011
b4galt5UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 50.011
gtpbp4GTP binding protein 40.011
kdrkinase insert domain receptor (a type III receptor tyrosine kinase)0.011
aplnrbapelin receptor b0.010
styk1serine/threonine/tyrosine kinase 10.010
cdh5cadherin 50.010
relv-rel reticuloendotheliosis viral oncogene homolog0.010
pou5f1POU domain, class 5, transcription factor 10.010
sox10SRY-box containing gene 100.010
zbtb4zinc finger and BTB domain containing 40.010
ptk6aPTK6 protein tyrosine kinase 6a0.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Notch1Notch gene homolog 1 (Drosophila)1.000
Jag1jagged 10.999
Hand2heart and neural crest derivatives expressed transcript 20.997
Ptpn11protein tyrosine phosphatase, non-receptor type 110.976
Hand1heart and neural crest derivatives expressed transcript 10.958
Dll1delta-like 1 (Drosophila)0.955
Foxc2forkhead box C20.941
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.927
Itgb1integrin beta 1 (fibronectin receptor beta)0.906
Gata4GATA binding protein 40.885
Pitx2paired-like homeodomain transcription factor 20.885
Nfatc4nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 40.858
Foxc1forkhead box C10.830
Kdrkinase insert domain protein receptor0.814
Efnb2ephrin B20.802
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.760
Shhsonic hedgehog0.759
Tbx1T-box 10.737
Sox10SRY-box containing gene 100.723
Fgf8fibroblast growth factor 80.690
Dll4delta-like 4 (Drosophila)0.663
Vegfavascular endothelial growth factor A0.644
Isl1ISL1 transcription factor, LIM/homeodomain0.642
Sox18SRY-box containing gene 180.637
Pax3paired box gene 30.617
Psen1presenilin 10.616
Smarcc1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.543
Smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.541
Hif1ahypoxia inducible factor 1, alpha subunit0.541
Arid1bAT rich interactive domain 1B (SWI-like)0.525
Phox2bpaired-like homeobox 2b0.523
Klf3Kruppel-like factor 3 (basic)0.511
Flt4FMS-like tyrosine kinase 40.494
Fgfr1fibroblast growth factor receptor 10.489
Chd7chromodomain helicase DNA binding protein 70.470
Eya1eyes absent 1 homolog (Drosophila)0.423
Nfatc2nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 20.413
Psen2presenilin 20.401
Tgfb2transforming growth factor, beta 20.382
Ntf3neurotrophin 30.361
Cdh5cadherin 50.337
Mesp1mesoderm posterior 10.312
Pecam1platelet/endothelial cell adhesion molecule 10.306
Gata6GATA binding protein 60.295
Ptprbprotein tyrosine phosphatase, receptor type, B0.292
Shesrc homology 2 domain-containing transforming protein E0.290
Ptrfpolymerase I and transcript release factor0.276
Gfra1glial cell line derived neurotrophic factor family receptor alpha 10.275
Epas1endothelial PAS domain protein 10.270
Sall4sal-like 4 (Drosophila)0.266
Vangl2vang-like 2 (van gogh, Drosophila)0.253
Bmp4bone morphogenetic protein 40.247
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.245
Ednrbendothelin receptor type B0.231
Tgfbr2transforming growth factor, beta receptor II0.227
Acvrl1activin A receptor, type II-like 10.221
Rb1retinoblastoma 10.221
Egfl7EGF-like domain 70.218
Nkx2-6NK2 transcription factor related, locus 6 (Drosophila)0.216
Kcnq1potassium voltage-gated channel, subfamily Q, member 10.214
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.200
Lama4laminin, alpha 40.191
Gscgoosecoid homeobox0.184
Prrx1paired related homeobox 10.182
Gdf6growth differentiation factor 60.180
Hoxa1homeobox A10.178
Adamts9a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 90.176
Gdf5growth differentiation factor 50.175
Acvr1activin A receptor, type 10.170
Arid1aAT rich interactive domain 1A (SWI-like)0.166
Nfatc3nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 30.164
Lama5laminin, alpha 50.155
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.155
Fgd5FYVE, RhoGEF and PH domain containing 50.153
Esamendothelial cell-specific adhesion molecule0.144
Gdf3growth differentiation factor 30.141
Loxlysyl oxidase0.139
Pax1paired box gene 10.137
Cited2Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 20.137
Gbx2gastrulation brain homeobox 20.136
Msx1homeobox, msh-like 10.136
Itga5integrin alpha 5 (fibronectin receptor alpha)0.129
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.125
Col4a1collagen, type IV, alpha 10.121
Pitx1paired-like homeodomain transcription factor 10.121
Heylhairy/enhancer-of-split related with YRPW motif-like0.117
Zic3zinc finger protein of the cerebellum 30.114
Vcpvalosin containing protein0.109
Hey2hairy/enhancer-of-split related with YRPW motif 20.105
Ednraendothelin receptor type A0.105
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.105
Notch2Notch gene homolog 2 (Drosophila)0.102
Gpc3glypican 30.097
Foxh1forkhead box H10.094
Foxe1forkhead box E10.093
Adcy4adenylate cyclase 40.092
Zeb1zinc finger E-box binding homeobox 10.091
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism