The network for 'positive regulation of cysteine type endopeptidase activity involved in apoptotic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of cysteine type endopeptidase activity involved in apoptotic process

Any process that activates or increases the activity of a cysteine-type endopeptidase involved in the apoptotic process.

NameDescriptionProbabilityFunc Analog Organism
CASP8caspase 8, apoptosis-related cysteine peptidase1.000
BCL2B-cell CLL/lymphoma 21.000
MDM2Mdm2 p53 binding protein homolog (mouse)1.000
CFLARCASP8 and FADD-like apoptosis regulator0.998
CASP10caspase 10, apoptosis-related cysteine peptidase0.998
CREBBPCREB binding protein0.997
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.996
FASFas (TNF receptor superfamily, member 6)0.996
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.995
TP53tumor protein p530.994
FADDFas (TNFRSF6)-associated via death domain0.994
S100BS100 calcium binding protein B0.990
BCL2L1BCL2-like 10.990
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.989
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.986
TNFRSF10Atumor necrosis factor receptor superfamily, member 10a0.982
BIDBH3 interacting domain death agonist0.981
TNFRSF10Btumor necrosis factor receptor superfamily, member 10b0.978
XIAPX-linked inhibitor of apoptosis0.974
SMAD1SMAD family member 10.972
HIF1Ahypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)0.971
CASP9caspase 9, apoptosis-related cysteine peptidase0.969
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.963
RIPK2receptor-interacting serine-threonine kinase 20.960
BAXBCL2-associated X protein0.960
CASP2caspase 2, apoptosis-related cysteine peptidase0.951
S100A6S100 calcium binding protein A60.944
CASP3caspase 3, apoptosis-related cysteine peptidase0.937
POU5F1POU class 5 homeobox 10.934
BCL2L11BCL2-like 11 (apoptosis facilitator)0.925
MCL1myeloid cell leukemia sequence 1 (BCL2-related)0.923
HSP90AA1heat shock protein 90kDa alpha (cytosolic), class A member 10.906
TNFRSF1Atumor necrosis factor receptor superfamily, member 1A0.904
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.903
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.902
SUMO1SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)0.893
HIPK2homeodomain interacting protein kinase 20.861
SMAD3SMAD family member 30.837
SMAD4SMAD family member 40.829
NLRC4NLR family, CARD domain containing 40.821
MAPK8mitogen-activated protein kinase 80.811
TRAF2TNF receptor-associated factor 20.806
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.802
RB1retinoblastoma 10.790
EIF3Leukaryotic translation initiation factor 3, subunit L0.781
TRAF1TNF receptor-associated factor 10.780
BIRC3baculoviral IAP repeat containing 30.770
APAF1apoptotic peptidase activating factor 10.764
FYNFYN oncogene related to SRC, FGR, YES0.757
S100A1S100 calcium binding protein A10.755
RXRAretinoid X receptor, alpha0.729
SQSTM1sequestosome 10.718
NR4A1nuclear receptor subfamily 4, group A, member 10.717
S100A4S100 calcium binding protein A40.714
TNFSF10tumor necrosis factor (ligand) superfamily, member 100.694
TNFRSF6Btumor necrosis factor receptor superfamily, member 6b, decoy0.683
BMP2bone morphogenetic protein 20.682
CDK2cyclin-dependent kinase 20.668
PYCARDPYD and CARD domain containing0.665
CYR61cysteine-rich, angiogenic inducer, 610.653
VDAC2voltage-dependent anion channel 20.645
ARandrogen receptor0.636
DAXXdeath-domain associated protein0.636
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme0.629
SMAD7SMAD family member 70.621
TGFB1transforming growth factor, beta 10.615
SUMO2SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)0.608
CARD11caspase recruitment domain family, member 110.606
ESR1estrogen receptor 10.605
HMGB2high mobility group box 20.584
PAX3paired box 30.583
SKILSKI-like oncogene0.582
BIRC2baculoviral IAP repeat containing 20.574
SP1Sp1 transcription factor0.572
NCLnucleolin0.569
SUMO3SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae)0.568
HMGB1high mobility group box 10.563
FKBP1AFK506 binding protein 1A, 12kDa0.562
CRADDCASP2 and RIPK1 domain containing adaptor with death domain0.560
EPAS1endothelial PAS domain protein 10.543
SMN1survival of motor neuron 1, telomeric0.538
BCAP31B-cell receptor-associated protein 310.532
HCKhemopoietic cell kinase0.522
S100A14S100 calcium binding protein A140.513
POU3F2POU class 3 homeobox 20.509
SMAD2SMAD family member 20.506
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.502
PIAS4protein inhibitor of activated STAT, 40.499
FASLGFas ligand (TNF superfamily, member 6)0.493
TNFRSF1Btumor necrosis factor receptor superfamily, member 1B0.489
HNF4Ahepatocyte nuclear factor 4, alpha0.485
BAK1BCL2-antagonist/killer 10.466
TRADDTNFRSF1A-associated via death domain0.463
VDAC1voltage-dependent anion channel 10.450
NCOR2nuclear receptor corepressor 20.445
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.420
ENGendoglin0.417
CAV1caveolin 1, caveolae protein, 22kDa0.388
PPP1CCprotein phosphatase 1, catalytic subunit, gamma isozyme0.385
SYKspleen tyrosine kinase0.381
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
bcl2B-cell leukemia/lymphoma 20.724
mcl1amyeloid cell leukemia sequence 1a0.583
mcl1bmyeloid cell leukemia sequence 1b0.459
badBCL2-antagonist of cell death0.420
bidaBH3 interacting domain death agonist0.317
eif3haeukaryotic translation initiation factor 3, subunit H, a0.212
stc1lstanniocalcin 1, like0.193
baxabcl2-associated X protein, a0.177
sulf1sulfatase 10.145
bbc3BCL2 binding component 30.140
LOC567131calcitonin gene-related peptide type 1 receptor-like0.108
cct5chaperonin containing TCP1, subunit 5 (epsilon)0.106
tfe3btranscription factor binding to IGHM enhancer 3b0.101
rpsaribosomal protein SA0.085
socs3asuppressor of cytokine signaling 3a0.077
bactin1bactin10.076
caspacaspase a0.072
bcl2l1bcl2-like 10.069
gnb2l1guanine nucleotide binding protein (G protein), beta polypeptide 2-like 10.069
plxnb2aplexin b2a0.065
dhfrdihydrofolate reductase0.064
serpinb1serpin peptidase inhibitor, clade B (ovalbumin), member 10.060
casp8caspase 8, apoptosis-related cysteine peptidase0.059
bcl2l10BCL2-like 10 (apoptosis facilitator)0.058
foxo3bforkhead box O3b0.056
satb2SATB homeobox 20.050
mycamyelocytomatosis oncogene a0.047
irf6interferon regulatory factor 60.046
duoxdual oxidase0.046
junjun proto-oncogene0.044
cct6achaperonin containing TCP1, subunit 6A (zeta 1)0.044
adipor1badiponectin receptor 1b0.043
mre11ameiotic recombination 11 homolog A (S. cerevisiae)0.040
pmaip1phorbol-12-myristate-13-acetate-induced protein 10.040
ranras-related nuclear protein0.040
ptgs1prostaglandin-endoperoxide synthase 10.040
ahcyS-adenosylhomocysteine hydrolase0.040
faddFas (tnfrsf6)-associated via death domain0.039
eif3s2eukaryotic translation initiation factor 3, subunit 2 beta0.038
ogg18-oxoguanine DNA glycosylase0.038
hmgb2ahigh-mobility group box 2a0.036
fanciFanconi anemia, complementation group I0.036
zgc:64114zgc:641140.035
pabpc1apoly A binding protein, cytoplasmic 1 a0.035
eif3beukaryotic translation initiation factor 3, subunit B0.035
pcnaproliferating cell nuclear antigen0.034
crfa31.2IL-4RA-like protein 20.034
lass2LAG1 homolog, ceramide synthase 2 (S. cerevisiae)0.034
fechferrochelatase0.034
ptgs2aprostaglandin-endoperoxide synthase 2a0.032
s100a10bS100 calcium binding protein A10b0.032
igfbp1ainsulin-like growth factor binding protein 1a0.032
zgc:92237zgc:922370.031
eif3deukaryotic translation initiation factor 3, subunit D0.031
hnrnpa0heterogeneous nuclear ribonucleoprotein A00.031
tlr9toll-like receptor 90.031
gtpbp4GTP binding protein 40.031
ctgfconnective tissue growth factor0.031
chac1ChaC, cation transport regulator-like 10.030
per2period homolog 2 (Drosophila)0.030
immtinner membrane protein, mitochondrial (mitofilin)0.029
rpl7aribosomal protein L7a0.029
fasFas (TNF receptor superfamily, member 6)0.028
tnfsf10l2tumor necrosis factor (ligand) superfamily, member 10 like 20.028
eif4a3eukaryotic translation initiation factor 4A, isoform 30.028
f2rl1.2coagulation factor II (thrombin) receptor-like 1.20.027
gata5GATA-binding protein 50.027
mdm2transformed 3T3 cell double minute 2 homolog (mouse)0.027
ndufv1NADH dehydrogenase (ubiquinone) flavoprotein 10.025
zgc:66317zgc:663170.025
pitrm1pitrilysin metalloproteinase 10.025
si:ch211-235f6.2si:ch211-235f6.20.025
limk1LIM domain kinase 10.025
metmet proto-oncogene (hepatocyte growth factor receptor)0.025
eif3eaeukaryotic translation initiation factor 3, subunit E, a0.024
dhddsdehydrodolichyl diphosphate synthase0.024
ppiapeptidylprolyl isomerase A (cyclophilin A)0.024
LOC100535854ubiquitin carboxyl-terminal hydrolase CYLD-like0.023
hoxa4ahomeo box A4a0.023
rps11ribosomal protein S110.023
mycl1bv-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian) b0.023
rps3aribosomal protein S3A0.023
dnmt5DNA (cytosine-5-)-methyltransferase 50.022
egr1early growth response 10.022
chchd10coiled-coil-helix-coiled-coil-helix domain containing 100.022
pkp2plakophilin 20.022
lap3leucine aminopeptidase 30.021
adipor2adiponectin receptor 20.021
tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.021
trpv6transient receptor potential cation channel, subfamily V, member 60.021
cflarCASP8 and FADD-like apoptosis regulator0.021
mical3flavoprotein oxidoreductase MICAL30.021
cebpdCCAAT/enhancer binding protein (C/EBP), delta0.020
psma6bproteasome (prosome, macropain) subunit, alpha type, 6b0.020
kitlgbkit ligand b0.020
dlx3bdistal-less homeobox gene 3b0.020
dip2cDIP2 disco-interacting protein 2 homolog C (Drosophila)0.020
LOC566020Gig2-like protein DreO0.020
si:rp71-39b20.7si:rp71-39b20.70.020
fbxo32F-box protein 320.020
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Dcp-1Death caspase-10.978
ththread0.957
imdimmune deficiency0.908
grimCG4345 gene product from transcript CG4345-RA0.756
AGO2Argonaute 20.706
DreddDeath related ced-3/Nedd2-like protein0.593
CG9772CG9772 gene product from transcript CG9772-RB0.575
jarjaguar0.561
CG2469CG2469 gene product from transcript CG2469-RB0.533
PliPellino0.518
NcNedd2-like caspase0.479
rprreaper0.470
Df31Decondensation factor 310.426
B52CG10851 gene product from transcript CG10851-RB0.383
alphalphabet0.343
keykenny0.320
RASSF8CG5053 gene product from transcript CG5053-RA0.280
XNPCG4548 gene product from transcript CG4548-RA0.265
BG4CG12297 gene product from transcript CG12297-RA0.264
parkparkin0.247
cazcabeza0.240
His3.3AHistone H3.3A0.239
Aats-glyGlycyl-tRNA synthetase0.221
djdon juan0.221
bchsblue cheese0.213
jingCG9397 gene product from transcript CG9397-RI0.208
EndoGEndonuclease G0.203
Pkd2Polycystic kidney disease gene-20.203
yuriyuri gagarin0.197
msl-1male-specific lethal 10.193
ird5immune response deficient 50.189
Sox14Sox box protein 140.176
lealeak0.175
mus209mutagen-sensitive 2090.168
spag4sperm-associated antigen 40.167
His3.3BHistone H3.3B0.163
HtrA2CG8464 gene product from transcript CG8464-RA0.155
rinrasputin0.149
CG34110CG34110 gene product from transcript CG34110-RC0.146
RnrLRibonucleoside diphosphate reductase large subunit0.144
RelRelish0.143
Art4Arginine methyltransferase 40.142
CG5155CG5155 gene product from transcript CG5155-RA0.142
Roc1bCG16988 gene product from transcript CG16988-RA0.140
wtswarts0.135
ArkApaf-1-related-killer0.135
Eip74EFEcdysone-induced protein 74EF0.131
CG7033CG7033 gene product from transcript CG7033-RC0.130
p53CG33336 gene product from transcript CG33336-RB0.128
CG5384CG5384 gene product from transcript CG5384-RA0.117
Trxr-1Thioredoxin reductase-10.115
CG13597CG13597 gene product from transcript CG13597-RA0.109
PGRP-LEPeptidoglycan recognition protein LE0.102
CG10630CG10630 gene product from transcript CG10630-RA0.102
CG6412CG6412 gene product from transcript CG6412-RA0.100
CG5355CG5355 gene product from transcript CG5355-RA0.097
Cyt-c-dCytochrome c distal0.095
IceCG7788 gene product from transcript CG7788-RA0.088
Mst77FMale-specific transcript 77F0.086
Mcm7Minichromosome maintenance 70.085
Hsp27Heat shock protein 270.084
CG7998CG7998 gene product from transcript CG7998-RA0.082
nocteno circadian temperature entrainment0.081
CG12214CG12214 gene product from transcript CG12214-RB0.080
CG11399CG11399 gene product from transcript CG11399-RB0.080
WRNexoWRN exonuclease0.078
CG11347CG11347 gene product from transcript CG11347-RE0.077
pr-set7CG3307 gene product from transcript CG3307-RC0.076
drprdraper0.075
fs(2)ltoPP43female sterile (2) ltoPP430.069
mus201mutagen-sensitive 2010.068
sklsickle0.067
zfh2Zn finger homeodomain 20.067
commcommissureless0.066
hipkhomeodomain interacting protein kinase0.066
CG5741CG5741 gene product from transcript CG5741-RC0.065
CG42630CG42630 gene product from transcript CG42630-RA0.064
eyeyeless0.064
lmglemming0.061
Prosalpha6TProteasome alpha6T subunit0.059
CG3875CG3875 gene product from transcript CG3875-RA0.058
EgmEnigma0.058
dupdouble parked0.057
mgemaggie0.056
CG14614CG14614 gene product from transcript CG14614-RA0.055
CG8223CG8223 gene product from transcript CG8223-RA0.054
slislit0.054
CG9384CG9384 gene product from transcript CG9384-RA0.052
CYLDcylindromatosis0.052
rowrelative of woc0.051
Glut1Glucose transporter 10.050
CG4030CG4030 gene product from transcript CG4030-RA0.049
scramb2scramblase 20.048
rnorhinoceros0.047
ATPsyn-Cf6ATPase coupling factor 60.047
FK506-bp2FK506-binding protein 20.046
CG7564CG7564 gene product from transcript CG7564-RA0.046
Arr2Arrestin 20.044
Mi-2CG8103 gene product from transcript CG8103-RA0.044
Sod2Superoxide dismutase 2 (Mn)0.043
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Trp53transformation related protein 530.998
Il6stinterleukin 6 signal transducer0.966
Ptgs2prostaglandin-endoperoxide synthase 20.952
Tnftumor necrosis factor0.933
Tlr4toll-like receptor 40.908
Stat5bsignal transducer and activator of transcription 5B0.892
Il10interleukin 100.863
Stat5asignal transducer and activator of transcription 5A0.844
Cd44CD44 antigen0.825
Casp4caspase 4, apoptosis-related cysteine peptidase0.793
Il1r1interleukin 1 receptor, type I0.753
Casp1caspase 10.752
SkilSKI-like0.700
Leprleptin receptor0.664
Socs1suppressor of cytokine signaling 10.663
FasFas (TNF receptor superfamily member 6)0.636
Mcl1myeloid cell leukemia sequence 10.594
Stat3signal transducer and activator of transcription 30.592
S100a9S100 calcium binding protein A9 (calgranulin B)0.587
Kitkit oncogene0.586
BaxBCL2-associated X protein0.576
Bcl2B-cell leukemia/lymphoma 20.573
Rararetinoic acid receptor, alpha0.483
Gdnfglial cell line derived neurotrophic factor0.433
Gli2GLI-Kruppel family member GLI20.433
Ikzf1IKAROS family zinc finger 10.426
Myd88myeloid differentiation primary response gene 880.422
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.416
Stat6signal transducer and activator of transcription 60.406
Socs3suppressor of cytokine signaling 30.392
Stat1signal transducer and activator of transcription 10.387
Tgfb1transforming growth factor, beta 10.385
Wnt3awingless-related MMTV integration site 3A0.375
Lyz2lysozyme 20.367
Ifnginterferon gamma0.361
Ptprcprotein tyrosine phosphatase, receptor type, C0.360
Cycscytochrome c, somatic0.347
PycardPYD and CARD domain containing0.346
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.346
Gbp5guanylate binding protein 50.328
Pax3paired box gene 30.323
Esr2estrogen receptor 2 (beta)0.321
Irf9interferon regulatory factor 90.320
Wnt10bwingless related MMTV integration site 10b0.305
FaddFas (TNFRSF6)-associated via death domain0.299
Ppp1ccprotein phosphatase 1, catalytic subunit, gamma isoform0.283
Nos2nitric oxide synthase 2, inducible0.277
Map3k14mitogen-activated protein kinase kinase kinase 140.275
Ilkintegrin linked kinase0.269
Il2rginterleukin 2 receptor, gamma chain0.247
Dkk1dickkopf homolog 1 (Xenopus laevis)0.232
Ncoa3nuclear receptor coactivator 30.215
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.212
S100a8S100 calcium binding protein A8 (calgranulin A)0.203
Wnt4wingless-related MMTV integration site 40.199
WwoxWW domain-containing oxidoreductase0.199
Sirt1sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)0.197
E2f1E2F transcription factor 10.185
Htthuntingtin0.176
Arandrogen receptor0.162
Spna1spectrin alpha 10.158
Il7interleukin 70.157
Mdm4transformed mouse 3T3 cell double minute 40.155
Rb1retinoblastoma 10.153
Vdrvitamin D receptor0.148
Vhlvon Hippel-Lindau tumor suppressor0.147
Ctnnb1catenin (cadherin associated protein), beta 10.146
XiapX-linked inhibitor of apoptosis0.144
Rbl1retinoblastoma-like 1 (p107)0.140
Coro1bcoronin, actin binding protein 1B0.137
Ptch2patched homolog 20.137
Igbp1immunoglobulin (CD79A) binding protein 10.136
Ptpn2protein tyrosine phosphatase, non-receptor type 20.134
Ppargperoxisome proliferator activated receptor gamma0.131
Nos3nitric oxide synthase 3, endothelial cell0.131
Tnfsf11tumor necrosis factor (ligand) superfamily, member 110.128
Klf6Kruppel-like factor 60.127
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.126
Cdk4cyclin-dependent kinase 40.125
Ighimmunoglobulin heavy chain complex0.118
Mapk14mitogen-activated protein kinase 140.117
Ccr1chemokine (C-C motif) receptor 10.115
Irf1interferon regulatory factor 10.115
Mmp9matrix metallopeptidase 90.114
Lepleptin0.114
Tcf3transcription factor 30.110
Rps3ribosomal protein S30.110
Lystlysosomal trafficking regulator0.109
Msh2mutS homolog 2 (E. coli)0.108
Casp8caspase 80.107
Tnfsf14tumor necrosis factor (ligand) superfamily, member 140.107
Apcadenomatosis polyposis coli0.106
Pmaip1phorbol-12-myristate-13-acetate-induced protein 10.104
Nlrp3NLR family, pyrin domain containing 30.102
Mfn2mitofusin 20.101
Trp73transformation related protein 730.101
Ccnd1cyclin D10.101
Wt1Wilms tumor 1 homolog0.100
Hif1ahypoxia inducible factor 1, alpha subunit0.099
Nphs2nephrosis 2 homolog, podocin (human)0.099
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism