The network for 'axis elongation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

axis elongation

The developmental growth that results in the elongation of a line that defines polarity or symmetry in an anatomical structure.

NameDescriptionProbabilityFunc Analog Organism
FGFR2fibroblast growth factor receptor 21.000
HDAC2histone deacetylase 20.945
FGF1fibroblast growth factor 1 (acidic)0.889
FGFR1fibroblast growth factor receptor 10.879
BMPR1Abone morphogenetic protein receptor, type IA0.870
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.853
FGF10fibroblast growth factor 100.840
FSTL1follistatin-like 10.785
CDK19cyclin-dependent kinase 190.776
FZD1frizzled homolog 1 (Drosophila)0.593
DVL1dishevelled, dsh homolog 1 (Drosophila)0.516
S100A4S100 calcium binding protein A40.448
PARD6Apar-6 partitioning defective 6 homolog alpha (C. elegans)0.374
RHOAras homolog gene family, member A0.371
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.364
BBS2Bardet-Biedl syndrome 20.354
SMAD2SMAD family member 20.342
MED24mediator complex subunit 240.327
ZFYVE9zinc finger, FYVE domain containing 90.313
TP53tumor protein p530.301
LRRK2leucine-rich repeat kinase 20.249
ARHGEF12Rho guanine nucleotide exchange factor (GEF) 120.239
ZMYND11zinc finger, MYND-type containing 110.227
JAM3junctional adhesion molecule 30.225
FGF7fibroblast growth factor 70.224
MED29mediator complex subunit 290.216
EXOC7exocyst complex component 70.213
FRS2fibroblast growth factor receptor substrate 20.207
DVL3dishevelled, dsh homolog 3 (Drosophila)0.185
DKK1dickkopf homolog 1 (Xenopus laevis)0.185
MBNL1muscleblind-like (Drosophila)0.182
GSK3Bglycogen synthase kinase 3 beta0.171
AXIN1axin 10.165
PRKCIprotein kinase C, iota0.148
BBS1Bardet-Biedl syndrome 10.146
FGF2fibroblast growth factor 2 (basic)0.133
PCM1pericentriolar material 10.131
KLHL2kelch-like 2, Mayven (Drosophila)0.129
FZD7frizzled homolog 7 (Drosophila)0.129
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.129
MAGEA2melanoma antigen family A, 20.126
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.122
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.120
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.119
CSNK1Dcasein kinase 1, delta0.118
WT1Wilms tumor 10.117
TRRAPtransformation/transcription domain-associated protein0.116
CEP164centrosomal protein 164kDa0.115
LRP6low density lipoprotein receptor-related protein 60.114
FGF8fibroblast growth factor 8 (androgen-induced)0.109
TGFB2transforming growth factor, beta 20.108
SPRY1sprouty homolog 1, antagonist of FGF signaling (Drosophila)0.103
FZD8frizzled homolog 8 (Drosophila)0.102
BBS7Bardet-Biedl syndrome 70.099
ERRFI1ERBB receptor feedback inhibitor 10.098
SIN3ASIN3 homolog A, transcription regulator (yeast)0.097
MDFIMyoD family inhibitor0.094
COL14A1collagen, type XIV, alpha 10.093
TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)0.092
RIN1Ras and Rab interactor 10.090
HDAC3histone deacetylase 30.089
TTC8tetratricopeptide repeat domain 80.089
GLIS2GLIS family zinc finger 20.084
MED13mediator complex subunit 130.082
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.080
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.079
BBS9Bardet-Biedl syndrome 90.078
F11RF11 receptor0.078
RAPGEF1Rap guanine nucleotide exchange factor (GEF) 10.074
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.072
WFIKKN1WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 10.072
CSNK1Ecasein kinase 1, epsilon0.070
ATP2B1ATPase, Ca++ transporting, plasma membrane 10.068
THBS1thrombospondin 10.067
SPRY4sprouty homolog 4 (Drosophila)0.065
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.065
MED28mediator complex subunit 280.063
TGFBR1transforming growth factor, beta receptor 10.063
CDH11cadherin 11, type 2, OB-cadherin (osteoblast)0.061
ARL6ADP-ribosylation factor-like 60.061
PPP2R1Aprotein phosphatase 2, regulatory subunit A, alpha0.061
ARandrogen receptor0.060
DIP2ADIP2 disco-interacting protein 2 homolog A (Drosophila)0.058
PAX2paired box 20.057
PRPF3PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae)0.057
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.057
YAP1Yes-associated protein 10.056
CITED2Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 20.055
TBL1XR1transducin (beta)-like 1 X-linked receptor 10.054
FGF3fibroblast growth factor 30.053
FGFR3fibroblast growth factor receptor 30.052
MED16mediator complex subunit 160.051
OSBPL8oxysterol binding protein-like 80.051
SMURF2SMAD specific E3 ubiquitin protein ligase 20.050
AMMECR1Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 10.050
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
bmp2bbone morphogenetic protein 2b0.705
hnf1baHNF1 homeobox Ba0.687
bmp4bone morphogenetic protein 40.625
bonbonnie and clyde0.602
wnt5bwingless-type MMTV integration site family, member 5b0.568
wnt11wingless-type MMTV integration site family, member 110.552
tbx1T-box 10.502
osr2odd-skipped related 2 (Drosophila)0.453
pax2apaired box gene 2a0.385
mibmind bomb0.355
cdh2cadherin 2, neuronal0.310
bmp2abone morphogenetic protein 2a0.290
fn1fibronectin 10.282
aldh1a2aldehyde dehydrogenase 1 family, member A20.253
flhfloating head0.239
oepone-eyed pinhead0.224
hoxd4ahomeo box D4a0.200
wnt3awingless-type MMTV integration site family, member 3A0.188
dact1dapper homolog 1, antagonist of beta-catenin (xenopus)0.161
smad9MAD homolog 9 (Drosophila)0.160
brd4bromodomain containing 40.156
tbx5aT-box 5a0.147
bmpr1aabone morphogenetic protein receptor, type 1aa0.145
notch1anotch homolog 1a0.145
osr1odd-skipped related 1 (Drosophila)0.136
lratblecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b)0.133
eya1eyes absent homolog 10.131
fgf3fibroblast growth factor 30.129
shhbsonic hedgehog b0.128
raraaretinoic acid receptor, alpha a0.124
tbx16T-box gene 160.113
wnt9bwingless-type MMTV integration site family, member 9B0.102
eomesaeomesodermin homolog a0.095
smad5MAD homolog 5 (Drosophila)0.092
shhasonic hedgehog a0.086
eng1aengrailed 1a0.085
wnt4awingless-type MMTV integration site family, member 4a0.083
wnt8awingless-type MMTV integration site family, member 8a0.082
ventventral expressed homeobox0.080
bambibBMP and activin membrane-bound inhibitor homolog (Xenopus laevis) b0.075
pou5f1POU domain, class 5, transcription factor 10.070
jag2jagged 20.068
ptch2patched 20.068
wnt8bwingless-type MMTV integration site family, member 8b0.064
foxp1bforkhead box P1b0.064
restRE1-silencing transcription factor0.064
nkx3.2NK3 homeobox 20.062
ftr82finTRIM family, member 820.060
pkd2polycystic kidney disease 20.058
col2a1acollagen type II, alpha-1a0.057
eaf2ELL associated factor 20.055
dlx2adistal-less homeobox gene 2a0.054
pcdh8protocadherin 80.054
cfl2lcofilin 2, like0.053
fgf8afibroblast growth factor 8 a0.052
nkd2naked cuticle homolog 2 and naked 2a0.052
cdx1bcaudal type homeobox 1 b0.051
smosmoothened homolog (Drosophila)0.050
her5hairy-related 50.050
nipblbnovel protein similar to vertebrate Nipped-B homolog and nipped-b homolog b (Drosophila)0.049
map2k4amitogen-activated protein kinase kinase 4a0.049
hgfahepatocyte growth factor a0.048
vangl2vang-like 2 (van gogh, Drosophila)0.047
msxcmuscle segment homeobox C0.046
hoxa9bhomeo box A9b0.044
gli1GLI-Kruppel family member 10.044
acvr1lactivin A receptor, type I like0.044
slc30a7solute carrier family 30 (zinc transporter), member 70.042
cdh1cadherin 1, epithelial0.042
gpc4glypican 40.041
bmpr1abbone morphogenetic protein receptor, type 1ab0.040
col11a2collagen type XI alpha-20.040
rarabretinoic acid receptor, alpha b0.039
pard6gbpar-6 partitioning defective 6 homolog gamma B (C. elegans)0.038
sema3dsemaphorin 3d0.037
fzd10frizzled homolog 100.037
foxi1forkhead box I10.036
lnx2bligand of numb-protein X 2b0.036
tgfb3transforming growth factor, beta 30.035
tbx18T-box 180.034
fzd8bfrizzled homolog 8b0.034
entpd3ectonucleoside triphosphate diphosphohydrolase 30.033
six2asine oculis-related homeobox 2a0.033
klf2bKruppel-like factor 2b0.033
pdzk1PDZ domain containing 10.033
vsx1visual system homeobox 1 homolog, chx10-like0.031
prkar1aaprotein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) a0.031
sept6septin 60.030
ndr2nodal-related 20.030
lrp2low density lipoprotein-related protein 20.029
col11a1acollagen, type XI, alpha 1a0.029
lmx1b.1LIM homeobox transcription factor 1, beta 10.028
wnt9awingless-type MMTV integration site family, member 9A0.028
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
stumpsCG31317 gene product from transcript CG31317-RC0.378
Ptp69DProtein tyrosine phosphatase 69D0.189
eyaeyes absent0.154
wbwing blister0.114
Wnt5Wnt oncogene analog 50.091
Src64BSrc oncogene at 64B0.077
argosCG4531 gene product from transcript CG4531-RA0.070
nrv2nervana 20.060
Wnt4Wnt oncogene analog 40.056
cicubitus interruptus0.054
Cdc42CG12530 gene product from transcript CG12530-RA0.053
dallydivision abnormally delayed0.044
jingCG9397 gene product from transcript CG9397-RI0.037
Wnt2Wnt oncogene analog 20.037
ShcSHC-adaptor protein0.033
CG14869CG14869 gene product from transcript CG14869-RB0.032
Fas3Fasciclin 30.030
bibbig brain0.030
zfh1Zn finger homeodomain 10.030
aopanterior open0.029
Tak1TGF-beta activated kinase 10.028
dosdaughter of sevenless0.027
MrtfMyocardin-related transcription factor0.025
PtpmegCG1228 gene product from transcript CG1228-RD0.025
kirrekin of irre0.025
CBPsarcoplasmic calcium-binding protein0.024
par-1CG8201 gene product from transcript CG8201-RA0.024
vvlventral veins lacking0.023
svpseven up0.023
fz2frizzled 20.022
Su(var)3-7Suppressor of variegation 3-70.022
Sema-1aCG18405 gene product from transcript CG18405-RD0.022
mewmultiple edematous wings0.021
maskmultiple ankyrin repeats single KH domain0.021
nkdnaked cuticle0.021
Traf4TNF-receptor-associated factor 40.021
HmgcrHMG Coenzyme A reductase0.020
phlpole hole0.019
grhgrainy head0.019
elavembryonic lethal abnormal vision0.019
PebProtein ejaculatory bulb0.018
G-oalpha47AG protein oalpha 47A0.017
Fak56DFocal Adhesion Kinase0.017
trioCG18214 gene product from transcript CG18214-RA0.017
Lim3CG10699 gene product from transcript CG10699-RB0.017
CG8526CG8526 gene product from transcript CG8526-RA0.017
CG9650CG9650 gene product from transcript CG9650-RG0.017
reporeversed polarity0.017
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Shhsonic hedgehog1.000
Gli3GLI-Kruppel family member GLI30.997
Vangl2vang-like 2 (van gogh, Drosophila)0.997
Fgf8fibroblast growth factor 80.996
Fgfr2fibroblast growth factor receptor 20.995
Tcfap2atranscription factor AP-2, alpha0.946
Foxc1forkhead box C10.938
Bmp4bone morphogenetic protein 40.929
Pax3paired box gene 30.886
Prrx1paired related homeobox 10.875
Hand1heart and neural crest derivatives expressed transcript 10.872
Dvl3dishevelled 3, dsh homolog (Drosophila)0.853
Tbx3T-box 30.846
Fgfr3fibroblast growth factor receptor 30.840
Pitx2paired-like homeodomain transcription factor 20.816
Hoxd13homeobox D130.796
Ror2receptor tyrosine kinase-like orphan receptor 20.748
Dkk1dickkopf homolog 1 (Xenopus laevis)0.747
Alx4aristaless-like homeobox 40.730
Sfrp2secreted frizzled-related protein 20.707
Dvl2dishevelled 2, dsh homolog (Drosophila)0.685
Meox2mesenchyme homeobox 20.680
Gli2GLI-Kruppel family member GLI20.641
Msx1homeobox, msh-like 10.637
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.614
Rargretinoic acid receptor, gamma0.576
Tbx2T-box 20.576
Fgf10fibroblast growth factor 100.566
Msx2homeobox, msh-like 20.543
Pou3f3POU domain, class 3, transcription factor 30.516
Wnt5awingless-related MMTV integration site 5A0.505
Wnt3awingless-related MMTV integration site 3A0.502
Lrp6low density lipoprotein receptor-related protein 60.478
Dvl1dishevelled, dsh homolog 1 (Drosophila)0.468
Bmp7bone morphogenetic protein 70.458
Sox11SRY-box containing gene 110.457
Esrrbestrogen related receptor, beta0.451
Smosmoothened homolog (Drosophila)0.435
Pax8paired box gene 80.431
Tgfb2transforming growth factor, beta 20.429
Pax9paired box gene 90.393
Spry2sprouty homolog 2 (Drosophila)0.389
Hand2heart and neural crest derivatives expressed transcript 20.386
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.382
Pax2paired box gene 20.377
Egfrepidermal growth factor receptor0.377
Tbx15T-box 150.356
Tgfatransforming growth factor alpha0.331
Spry4sprouty homolog 4 (Drosophila)0.328
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.306
Hes1hairy and enhancer of split 1 (Drosophila)0.303
Gas1growth arrest specific 10.282
Sall4sal-like 4 (Drosophila)0.274
Pbx1pre B-cell leukemia transcription factor 10.264
Pax7paired box gene 70.263
Fgf3fibroblast growth factor 30.262
Foxf1aforkhead box F1a0.260
Alx3aristaless-like homeobox 30.247
Zeb1zinc finger E-box binding homeobox 10.247
Runx2runt related transcription factor 20.238
Fgfr1fibroblast growth factor receptor 10.231
Fzd8frizzled homolog 8 (Drosophila)0.225
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.225
Eya1eyes absent 1 homolog (Drosophila)0.219
Lrp2low density lipoprotein receptor-related protein 20.216
IhhIndian hedgehog0.215
Twist2twist homolog 2 (Drosophila)0.214
Efna4ephrin A40.213
Cbx5chromobox homolog 5 (Drosophila HP1a)0.184
Rxraretinoid X receptor alpha0.181
Fgf18fibroblast growth factor 180.178
Dact1dapper homolog 1, antagonist of beta-catenin (xenopus)0.176
Nr2f1nuclear receptor subfamily 2, group F, member 10.173
Prrx2paired related homeobox 20.168
Pcsk5proprotein convertase subtilisin/kexin type 50.157
Smad6MAD homolog 6 (Drosophila)0.148
Ror1receptor tyrosine kinase-like orphan receptor 10.148
Six4sine oculis-related homeobox 4 homolog (Drosophila)0.148
Pou5f1POU domain, class 5, transcription factor 10.147
Rarbretinoic acid receptor, beta0.144
Bbs2Bardet-Biedl syndrome 2 (human)0.143
Sox9SRY-box containing gene 90.142
Tcf21transcription factor 210.142
Amhr2anti-Mullerian hormone type 2 receptor0.138
Pitx1paired-like homeodomain transcription factor 10.132
Foxc2forkhead box C20.130
Sox7SRY-box containing gene 70.130
Otx2orthodenticle homolog 2 (Drosophila)0.126
Hoxa13homeobox A130.126
Dlx5distal-less homeobox 50.120
Igdcc3immunoglobulin superfamily, DCC subclass, member 30.116
Hspg2perlecan (heparan sulfate proteoglycan 2)0.112
Tcf15transcription factor 150.109
Hoxa11homeobox A110.103
En1engrailed 10.103
Six6sine oculis-related homeobox 6 homolog (Drosophila)0.102
Bmp2bone morphogenetic protein 20.101
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Rbm42RNA binding motif protein 420.033
Mgpmatrix Gla protein0.028
Prrx1paired related homeobox 10.026
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.021
Mllt4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.021
Nrp2neuropilin 20.018
Ptpn12protein tyrosine phosphatase, non-receptor type 120.018
Prkaa1protein kinase, AMP-activated, alpha 1 catalytic subunit0.018
Rasa1RAS p21 protein activator (GTPase activating protein) 10.017
Aebp1AE binding protein 10.017
Sf3b4splicing factor 3b, subunit 40.015
Ednrbendothelin receptor type B0.014
Prkchprotein kinase C, eta0.014
Ppm1gprotein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform0.013
Metmet proto-oncogene0.013
Cdc42bpaCDC42 binding protein kinase alpha0.013
Postnperiostin, osteoblast specific factor0.013
Strnstriatin, calmodulin binding protein0.012
Ube3aubiquitin protein ligase E3A0.012
Lphn2latrophilin 20.012
Plod2procollagen lysine, 2-oxoglutarate 5-dioxygenase 20.012
Pdlim5PDZ and LIM domain 50.011
Acvr1activin A receptor, type I0.011
Gnai2guanine nucleotide binding protein (G protein), alpha inhibiting 20.011
Csnk2a2casein kinase 2, alpha prime polypeptide0.011
RGD1565927similar to 4631422O05Rik protein0.011
Rab14RAB14, member RAS oncogene family0.011
Lamc1laminin, gamma 10.011
Ctskcathepsin K0.010
Spp1secreted phosphoprotein 10.010
Npwneuropeptide W0.010
Maneamannosidase, endo-alpha0.010
Cdc2l5cell division cycle 2-like 5 (cholinesterase-related cell division controller)0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism