The network for 'establishment or maintenance of epithelial cell apical basal polarity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

establishment or maintenance of epithelial cell apical basal polarity

Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell.

NameDescriptionProbabilityFunc Analog Organism
GDAguanine deaminase0.997
MAPTmicrotubule-associated protein tau0.992
DVL1dishevelled, dsh homolog 1 (Drosophila)0.982
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.981
LCKlymphocyte-specific protein tyrosine kinase0.972
APCadenomatous polyposis coli0.963
DVL3dishevelled, dsh homolog 3 (Drosophila)0.941
ARHGDIARho GDP dissociation inhibitor (GDI) alpha0.939
PRKAB2protein kinase, AMP-activated, beta 2 non-catalytic subunit0.938
CD3ECD3e molecule, epsilon (CD3-TCR complex)0.927
ARHGAP1Rho GTPase activating protein 10.914
PARD6Apar-6 partitioning defective 6 homolog alpha (C. elegans)0.912
CSNK1Ecasein kinase 1, epsilon0.870
MARK2MAP/microtubule affinity-regulating kinase 20.858
CD247CD247 molecule0.845
PRKAB1protein kinase, AMP-activated, beta 1 non-catalytic subunit0.823
CD44CD44 molecule (Indian blood group)0.815
PRKAA1protein kinase, AMP-activated, alpha 1 catalytic subunit0.766
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.755
RHOAras homolog gene family, member A0.717
RHOCras homolog gene family, member C0.715
PKP2plakophilin 20.696
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.661
MPP5membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)0.617
INADLInaD-like (Drosophila)0.614
SNF8SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae)0.549
MCCmutated in colorectal cancers0.535
ARHGEF2Rho/Rac guanine nucleotide exchange factor (GEF) 20.535
FLNAfilamin A, alpha0.522
PRKAG1protein kinase, AMP-activated, gamma 1 non-catalytic subunit0.505
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.465
LRRK2leucine-rich repeat kinase 20.459
VCLvinculin0.458
PXNpaxillin0.456
TJP2tight junction protein 2 (zona occludens 2)0.415
LATlinker for activation of T cells0.405
JUPjunction plakoglobin0.363
CHMP1Achromatin modifying protein 1A0.362
LGALS1lectin, galactoside-binding, soluble, 10.360
LIN7Clin-7 homolog C (C. elegans)0.347
SFNstratifin0.337
ROCK1Rho-associated, coiled-coil containing protein kinase 10.331
DLG1discs, large homolog 1 (Drosophila)0.326
PARD3par-3 partitioning defective 3 homolog (C. elegans)0.304
CEP250centrosomal protein 250kDa0.303
ELLelongation factor RNA polymerase II0.299
RHOGras homolog gene family, member G (rho G)0.296
PHLPP1PH domain and leucine rich repeat protein phosphatase 10.289
AXIN1axin 10.289
NEDD4Lneural precursor cell expressed, developmentally down-regulated 4-like0.289
SMAD2SMAD family member 20.281
DVL2dishevelled, dsh homolog 2 (Drosophila)0.270
ERBB2IPerbb2 interacting protein0.265
EZRezrin0.256
KIF5Bkinesin family member 5B0.247
UBE2R2ubiquitin-conjugating enzyme E2R 20.247
DCUN1D1DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)0.244
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.241
SORBS3sorbin and SH3 domain containing 30.239
CEP164centrosomal protein 164kDa0.233
CAPZA2capping protein (actin filament) muscle Z-line, alpha 20.229
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.227
ARHGEF7Rho guanine nucleotide exchange factor (GEF) 70.213
ZNF512Bzinc finger protein 512B0.205
CDH5cadherin 5, type 2 (vascular endothelium)0.195
PTPN22protein tyrosine phosphatase, non-receptor type 22 (lymphoid)0.194
RTKNrhotekin0.191
WASF2WAS protein family, member 20.186
HDAC7histone deacetylase 70.185
ACACAacetyl-CoA carboxylase alpha0.184
STK11serine/threonine kinase 110.171
PRKAG2protein kinase, AMP-activated, gamma 2 non-catalytic subunit0.165
EMP3epithelial membrane protein 30.161
PRKCIprotein kinase C, iota0.160
BADBCL2-associated agonist of cell death0.158
CSNK1Dcasein kinase 1, delta0.153
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.152
BTBD10BTB (POZ) domain containing 100.149
UBE3Aubiquitin protein ligase E3A0.139
CDC73cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.134
MAP4K5mitogen-activated protein kinase kinase kinase kinase 50.132
TWF2twinfilin, actin-binding protein, homolog 2 (Drosophila)0.130
TBC1D10ATBC1 domain family, member 10A0.129
JUBjub, ajuba homolog (Xenopus laevis)0.128
PKP4plakophilin 40.127
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.126
CSNK1A1casein kinase 1, alpha 10.123
TRIP6thyroid hormone receptor interactor 60.121
ZYXzyxin0.120
ARHGAP5Rho GTPase activating protein 50.118
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.118
PPP1CBprotein phosphatase 1, catalytic subunit, beta isozyme0.117
EXOC5exocyst complex component 50.111
SLC1A2solute carrier family 1 (glial high affinity glutamate transporter), member 20.108
IREB2iron-responsive element binding protein 20.107
MAP3K3mitogen-activated protein kinase kinase kinase 30.106
SH3BP2SH3-domain binding protein 20.105
SMAD3SMAD family member 30.102
MARK1MAP/microtubule affinity-regulating kinase 10.100
FYNFYN oncogene related to SRC, FGR, YES0.098
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
nid-1Protein NID-10.094
sur-5Protein SUR-50.069
pyc-1Protein PYC-10.043
gei-4Protein GEI-40.036
par-1Protein PAR-10.036
CELE_T04H1.2Protein T04H1.20.033
chd-7Protein CHD-70.029
F21A10.2Protein F21A10.20.028
ain-1Protein AIN-10.018
fasn-1Protein FASN-10.015
elo-2Protein ELO-20.014
T26C12.1Protein T26C12.10.013
hlh-30Protein HLH-300.013
atg-2Protein ATG-20.013
lat-1Protein LAT-10.012
hbl-1Protein HBL-10.010
mrp-5Protein MRP-50.010
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
crb2acrumbs homolog 2a0.986
epb41l5erythrocyte membrane protein band 4.1 like 50.955
dag1dystroglycan 10.849
csadcysteine sulfinic acid decarboxylase0.502
prkciprotein kinase C, iota0.402
lrp2low density lipoprotein-related protein 20.256
guca1cguanylate cyclase activator 1C0.170
cdh2cadherin 2, neuronal0.167
mstnamyostatin a0.146
gro2groucho 20.144
mpp5amembrane protein, palmitoylated 5a (MAGUK p55 subfamily member 5a)0.143
pitpnbphosphotidylinositol transfer protein, beta0.139
ythdf1YTH domain family, member 10.124
scribscribbled homolog (Drosophila)0.123
crxcone-rod homeobox0.106
dlg4discs, large (Drosophila) homolog 4 and discs, large homolog 4 (Drosophila)0.104
hmgcrb3-hydroxy-3-methylglutaryl-Coenzyme A reductase b0.097
si:dkey-97i18.2si:dkey-97i18.20.096
mibmind bomb0.091
skianuclear oncoprotein skia0.087
opn4x1opsin 4x10.080
celsr2cadherin, EGF LAG seven-pass G-type receptor 2 and cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)0.078
lama1laminin, alpha 10.071
ppp1r12aprotein phosphatase 1, regulatory (inhibitor) subunit 12A0.068
homezhomeodomain leucine zipper gene0.068
celsr3cadherin, EGF LAG seven-pass G-type receptor 30.067
dtngdystrobrevin, gamma and dystrobrevin, gamma-like0.065
tcf7l1atranscription factor 7-like 1a (T-cell specific, HMG-box)0.064
pxnpaxillin0.064
acsl4aacyl-CoA synthetase long-chain family member 4a0.057
rrasrelated RAS viral (r-ras) oncogene homolog0.057
lamb1alaminin, beta 1a0.056
ptprfprotein tyrosine phosphatase, receptor type, F0.055
sall4sal-like 4 (Drosophila)0.054
fn1fibronectin 10.053
ywhabltyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide like0.053
zgc:63721zgc:637210.052
cxadrcoxsackie virus and adenovirus receptor0.050
frmd6FERM domain containing 60.050
fam43bfamily with sequence similarity 43, member B0.048
rp2retinitis pigmentosa 2 (X-linked recessive)0.048
bhmtbetaine-homocysteine methyltransferase0.045
prickle1aprickle-like 1 (Drosophila) a0.041
sema3aasemaphorin 3aa0.040
slc4a4asolute carrier family 4, member 4a0.040
wacaWW domain containing adaptor with coiled-coil a0.040
sb:cb472sb:cb4720.039
cntn1bcontactin 1b0.039
zgc:110298zgc:1102980.037
sema6dsema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D0.036
six4.3sine oculis homeobox homolog 4.30.036
myf5myogenic factor 50.036
perpPERP, TP53 apoptosis effector0.035
sdcbpsyndecan binding protein (syntenin)0.033
enpp6ectonucleotide pyrophosphatase/phosphodiesterase 60.033
tfectranscription factor EC0.033
hgfahepatocyte growth factor a0.033
axin1axin 10.032
LOC100003514protein kinase C alpha type-like0.032
crb3bcrumbs homolog 3b0.032
nrxn1aneurexin 1a0.032
casz1castor zinc finger 10.032
rtn4areticulon 4a0.031
zgc:114199zgc:1141990.031
castcalpastatin0.031
prkczprotein kinase C, zeta0.031
srcv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.031
si:ch211-272f3.4si:ch211-272f3.40.030
krt8keratin 80.029
apcadenomatosis polyposis coli0.029
arpc5bactin related protein 2/3 complex, subunit 5B0.028
vclvinculin0.028
kif7kinesin family member 70.027
LOC100331502melanopsin-B-like0.026
zfpl1zinc finger protein-like 10.026
lman2lectin, mannose-binding 20.026
zgc:153148zgc:1531480.026
lamc1laminin, gamma 10.026
mxi1max interacting protein0.026
synj1synaptojanin 10.025
nrasneuroblastoma RAS viral (v-ras) oncogene homolog0.025
pacsin3protein kinase C and casein kinase substrate in neurons 30.025
nphs1lnephrosis 1, congenital, Finnish type (nephrin)-like0.024
olfm1bolfactomedin 1b0.024
LOC100007758novel protein similar to vertebrate SLIT and NTRK-like family, member 3 (SLITRK3)0.023
ehd1EH-domain containing 10.023
dopey1dopey family member 10.023
itga5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.023
tm9sf2transmembrane 9 superfamily member 20.022
lmx1b.2LIM homeobox transcription factor 1, beta 20.022
si:ch211-134j6.3si:ch211-134j6.30.022
dlg1discs, large (Drosophila) homolog 10.022
fgfrl1afibroblast growth factor receptor-like 1a0.022
cyfip2cytoplasmic FMR1 interacting protein 20.022
si:rp71-1p14.10si:rp71-1p14.100.021
utrnutrophin0.021
ptk2.1protein tyrosine kinase 2a0.021
dvl3dishevelled, dsh homolog 3 (Drosophila)0.021
chmchoroideremia0.021
crb3acrumbs homolog 3a0.021
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
fzfrizzled0.641
crbcrumbs0.545
GugGrunge0.347
fjfour-jointed0.332
dsdachsous0.224
ftfat0.220
Lis-1Lissencephaly-10.177
Dhc64CDynein heavy chain 64C0.160
coracoracle0.143
pkprickle0.142
dlg1discs large 10.138
kugkugelei0.123
frcfringe connection0.118
DlicDynein light intermediate chain0.105
trctricornered0.096
stanstarry night0.086
sktlskittles0.082
bazbazooka0.078
Rac1CG2248 gene product from transcript CG2248-RA0.076
RalaRas-related protein0.075
VangVan Gogh0.061
exexpanded0.056
ric8aCG15797 gene product from transcript CG15797-RA0.054
Wnt4Wnt oncogene analog 40.050
klarklarsicht0.047
hpohippo0.047
scribscribbled0.047
kstkarst0.045
KhcKinesin heavy chain0.043
msnmisshapen0.043
snostrawberry notch0.041
dgodiego0.041
aPKCatypical protein kinase C0.041
Cdc42CG12530 gene product from transcript CG12530-RA0.040
mysmyospheroid0.038
l(2)gllethal (2) giant larvae0.037
fngfringe0.037
Nrx-IVNeurexin IV0.037
DDichaete0.036
Sop2Suppressor of profilin 20.035
MYPT-75DCG6896 gene product from transcript CG6896-RA0.034
Rbsn-5Rabenosyn-50.034
LIMK1LIM-kinase10.031
Vps28Vacuolar protein sorting 280.030
ttktramtrack0.029
CG32556CG32556 gene product from transcript CG32556-RB0.029
sggshaggy0.029
sanoserrano0.029
fryfurry0.029
Vhlvon Hippel-Lindau0.029
CG13144CG13144 gene product from transcript CG13144-RA0.028
mewmultiple edematous wings0.028
grhgrainy head0.027
flrflare0.026
gammaCopgamma-coatomer protein0.025
PknProtein kinase related to protein kinase N0.024
schlankCG3576 gene product from transcript CG3576-RB0.024
bsblistered0.024
cpbcapping protein beta0.023
vps2CG14542 gene product from transcript CG14542-RA0.023
nctnicastrin0.023
cdicenter divider0.022
DmnDynamitin0.022
ininturned0.022
stcksteamer duck0.021
par-6CG5884 gene product from transcript CG5884-RA0.021
CG11138CG11138 gene product from transcript CG11138-RC0.021
fz2frizzled 20.020
CG34168CG34168 gene product from transcript CG34168-RA0.020
CG31740CG31740 gene product from transcript CG31740-RA0.020
ChcClathrin heavy chain0.019
KrnKeren0.019
diadiaphanous0.019
JraJun-related antigen0.019
Gef26CG9491 gene product from transcript CG9491-RB0.018
dbodiablo0.018
mirrmirror0.018
sinahsina homologue0.018
ImpE1Ecdysone-inducible gene E10.018
CG6116CG6116 gene product from transcript CG6116-RA0.018
Rab2Rab-protein 20.018
Vps20Vacuolar protein sorting 200.018
rokRho-kinase0.017
ykiyorkie0.017
JIL-1CG6297 gene product from transcript CG6297-RA0.017
ghoghost0.017
PldPhospholipase D0.017
bunbunched0.017
kaykayak0.017
PatjCG12021 gene product from transcript CG12021-RC0.017
termterminus0.016
mfrnmitoferrin0.016
Myd88CG2078 gene product from transcript CG2078-RA0.016
RRoughened0.016
HopHsp70/Hsp90 organizing protein homolog0.016
UsfCG17592 gene product from transcript CG17592-RB0.016
bowlbrother of odd with entrails limited0.016
bcdbicoid0.016
drmdrumstick0.016
inscinscuteable0.015
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Vangl2vang-like 2 (van gogh, Drosophila)0.998
Dvl2dishevelled 2, dsh homolog (Drosophila)0.881
Pax6paired box gene 60.836
Neurod1neurogenic differentiation 10.698
Crb2crumbs homolog 2 (Drosophila)0.693
Dvl3dishevelled 3, dsh homolog (Drosophila)0.466
Dvl1dishevelled, dsh homolog 1 (Drosophila)0.427
Retret proto-oncogene0.412
MecomMDS1 and EVI1 complex locus0.403
Cd151CD151 antigen0.395
Otx2orthodenticle homolog 2 (Drosophila)0.350
Neurod4neurogenic differentiation 40.340
Ascl1achaete-scute complex homolog 1 (Drosophila)0.336
Gdnfglial cell line derived neurotrophic factor0.284
Neurog2neurogenin 20.267
Pdx1pancreatic and duodenal homeobox 10.229
Itga3integrin alpha 30.222
Atoh7atonal homolog 7 (Drosophila)0.214
Vangl1vang-like 1 (van gogh, Drosophila)0.213
Prph2peripherin 20.197
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.194
Caskcalcium/calmodulin-dependent serine protein kinase (MAGUK family)0.173
Sox11SRY-box containing gene 110.166
Emx2empty spiracles homolog 2 (Drosophila)0.166
Foxc2forkhead box C20.157
Tbrachyury0.153
Erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.148
Irs2insulin receptor substrate 20.145
Lmx1bLIM homeobox transcription factor 1 beta0.118
Kiss1KiSS-1 metastasis-suppressor0.116
Wdr1WD repeat domain 10.114
Phox2bpaired-like homeobox 2b0.099
Ldb1LIM domain binding 10.097
Lhx1LIM homeobox protein 10.093
Ptk7PTK7 protein tyrosine kinase 70.092
Dab1disabled homolog 1 (Drosophila)0.090
Hand1heart and neural crest derivatives expressed transcript 10.088
Runx1t1runt-related transcription factor 1; translocated to, 1 (cyclin D-related)0.088
Emx1empty spiracles homolog 1 (Drosophila)0.083
Shhsonic hedgehog0.082
Tcfap2atranscription factor AP-2, alpha0.080
Ptf1apancreas specific transcription factor, 1a0.077
Pitx2paired-like homeodomain transcription factor 20.076
Inainternexin neuronal intermediate filament protein, alpha0.075
Pax3paired box gene 30.073
Col4a3collagen, type IV, alpha 30.072
Rac1RAS-related C3 botulinum substrate 10.071
Arxaristaless related homeobox0.071
Wt1Wilms tumor 1 homolog0.064
Lhx9LIM homeobox protein 90.061
Ush1gUsher syndrome 1G homolog (human)0.060
Pou4f2POU domain, class 4, transcription factor 20.058
Insm1insulinoma-associated 10.057
Igdcc3immunoglobulin superfamily, DCC subclass, member 30.055
Itgb1integrin beta 1 (fibronectin receptor beta)0.053
Nr5a1nuclear receptor subfamily 5, group A, member 10.052
Cdkn1bcyclin-dependent kinase inhibitor 1B0.047
Tlx3T-cell leukemia, homeobox 30.045
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.044
Lhx3LIM homeobox protein 30.043
Gata6GATA binding protein 60.043
Crb1crumbs homolog 1 (Drosophila)0.043
Nkx3-2NK3 homeobox 20.041
Srrm4serine/arginine repetitive matrix 40.040
Pax2paired box gene 20.038
Dlg3discs, large homolog 3 (Drosophila)0.036
Etv4ets variant gene 4 (E1A enhancer binding protein, E1AF)0.036
Sox2SRY-box containing gene 20.034
Lhcgrluteinizing hormone/choriogonadotropin receptor0.034
Snai1snail homolog 1 (Drosophila)0.033
Nkd1naked cuticle 1 homolog (Drosophila)0.033
Gscgoosecoid homeobox0.032
Mmp24matrix metallopeptidase 240.031
Rag2recombination activating gene 20.031
Vegfavascular endothelial growth factor A0.031
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.030
Bmp4bone morphogenetic protein 40.030
Dlgap1discs, large (Drosophila) homolog-associated protein 10.030
Wwtr1WW domain containing transcription regulator 10.029
Myh10myosin, heavy polypeptide 10, non-muscle0.029
Kiss1rKISS1 receptor0.028
Myh9myosin, heavy polypeptide 9, non-muscle0.028
Smad2MAD homolog 2 (Drosophila)0.028
Gata1GATA binding protein 10.027
Fzd1frizzled homolog 1 (Drosophila)0.027
Lamb1laminin B10.027
Pou4f3POU domain, class 4, transcription factor 30.027
Fgf8fibroblast growth factor 80.026
Cdx2caudal type homeobox 20.025
Zic2zinc finger protein of the cerebellum 20.025
Nkx6-1NK6 homeobox 10.025
Smad4MAD homolog 4 (Drosophila)0.024
Lhx6LIM homeobox protein 60.024
En1engrailed 10.024
Onecut1one cut domain, family member 10.024
Hoxa1homeobox A10.024
Gbx2gastrulation brain homeobox 20.023
Foxd1forkhead box D10.023
Crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.023
Shank2SH3/ankyrin domain gene 20.023
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism