The network for 'pathway restricted smad protein phosphorylation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

pathway restricted smad protein phosphorylation

The process of introducing a phosphate group on to a pathway restricted SMAD protein. A pathway restricted SMAD protein is an effector protein that acts directly downstream of the transforming growth factor family receptor.

NameDescriptionProbabilityFunc Analog Organism
TGFBR2transforming growth factor, beta receptor II (70/80kDa)1.000
TGFB1transforming growth factor, beta 11.000
BMPR1Abone morphogenetic protein receptor, type IA0.999
SMAD1SMAD family member 10.998
SMURF2SMAD specific E3 ubiquitin protein ligase 20.997
BMP2bone morphogenetic protein 20.996
SMN1survival of motor neuron 1, telomeric0.990
FSTL1follistatin-like 10.986
SMAD7SMAD family member 70.986
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.985
TGFBR1transforming growth factor, beta receptor 10.940
TGFB3transforming growth factor, beta 30.935
SMAD2SMAD family member 20.915
BMPR1Bbone morphogenetic protein receptor, type IB0.857
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.828
FKBP1AFK506 binding protein 1A, 12kDa0.793
SKILSKI-like oncogene0.747
SMAD3SMAD family member 30.723
NRP1neuropilin 10.615
HUWE1HECT, UBA and WWE domain containing 10.493
GDF5growth differentiation factor 50.478
WFIKKN1WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 10.444
LRP6low density lipoprotein receptor-related protein 60.316
SMAD5SMAD family member 50.285
ENGendoglin0.264
BMP4bone morphogenetic protein 40.198
TGFB2transforming growth factor, beta 20.168
ACVR1activin A receptor, type I0.165
SMAD6SMAD family member 60.142
RBFOX2RNA binding protein, fox-1 homolog (C. elegans) 20.121
PCGF2polycomb group ring finger 20.098
PRKG1protein kinase, cGMP-dependent, type I0.098
THBS1thrombospondin 10.096
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.082
FSTfollistatin0.081
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.074
RXRAretinoid X receptor, alpha0.068
SMAD4SMAD family member 40.061
NEURL4neuralized homolog 4 (Drosophila)0.052
BRAPBRCA1 associated protein0.051
MAPK8mitogen-activated protein kinase 80.050
ADARB1adenosine deaminase, RNA-specific, B10.050
DCP1BDCP1 decapping enzyme homolog B (S. cerevisiae)0.050
ACVR2Bactivin A receptor, type IIB0.050
HEYLhairy/enhancer-of-split related with YRPW motif-like0.049
COL2A1collagen, type II, alpha 10.048
NRP2neuropilin 20.047
PDLIM4PDZ and LIM domain 40.045
ACVR1Bactivin A receptor, type IB0.041
ZFYVE9zinc finger, FYVE domain containing 90.039
MYO6myosin VI0.039
RBFOX1RNA binding protein, fox-1 homolog (C. elegans) 10.037
TGFBR3transforming growth factor, beta receptor III0.036
DIP2ADIP2 disco-interacting protein 2 homolog A (Drosophila)0.034
CBX6chromobox homolog 60.034
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.034
RNFT1ring finger protein, transmembrane 10.033
SOX7SRY (sex determining region Y)-box 70.033
OTUD5OTU domain containing 50.033
PMEPA1prostate transmembrane protein, androgen induced 10.032
ACVR2Aactivin A receptor, type IIA0.030
DCP1ADCP1 decapping enzyme homolog A (S. cerevisiae)0.030
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.030
CXXC5CXXC finger protein 50.030
INHBAinhibin, beta A0.030
ZMYND11zinc finger, MYND-type containing 110.029
PTOV1prostate tumor overexpressed 10.029
NLKnemo-like kinase0.028
PRRC2Bproline-rich coiled-coil 2B0.027
GEMIN6gem (nuclear organelle) associated protein 60.027
MKL2MKL/myocardin-like 20.027
QKIquaking homolog, KH domain RNA binding (mouse)0.026
APLP1amyloid beta (A4) precursor-like protein 10.026
SKIv-ski sarcoma viral oncogene homolog (avian)0.026
CBX8chromobox homolog 80.025
PDGFCplatelet derived growth factor C0.025
NOGnoggin0.024
VEGFCvascular endothelial growth factor C0.024
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.024
HOXC8homeobox C80.023
ACBD3acyl-CoA binding domain containing 30.023
ZBED5zinc finger, BED-type containing 50.023
RHOXF2Rhox homeobox family, member 20.022
USP7ubiquitin specific peptidase 7 (herpes virus-associated)0.022
PITX1paired-like homeodomain 10.022
FZD7frizzled homolog 7 (Drosophila)0.022
INHBBinhibin, beta B0.022
NEDD9neural precursor cell expressed, developmentally down-regulated 90.022
PHF1PHD finger protein 10.021
FOXF1forkhead box F10.021
TFPItissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)0.021
CCDC50coiled-coil domain containing 500.021
FOXF2forkhead box F20.020
BMP6bone morphogenetic protein 60.020
BAMBIBMP and activin membrane-bound inhibitor homolog (Xenopus laevis)0.020
BMP7bone morphogenetic protein 70.019
SPG20spastic paraplegia 20 (Troyer syndrome)0.019
FCHO2FCH domain only 20.019
RPS6KA5ribosomal protein S6 kinase, 90kDa, polypeptide 50.019
JAG1jagged 10.019
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
bmp2bbone morphogenetic protein 2b1.000
bmp4bone morphogenetic protein 41.000
acvr2bactivin receptor IIb0.647
wnt10awingless-type MMTV integration site family, member 10a0.630
dkk1bdickkopf 1b0.551
dact2dapper homolog 2, antagonist of beta-catenin (xenopus)0.472
gpr126G protein-coupled receptor 1260.419
acvr2aactivin receptor IIa0.354
bambiaBMP and activin membrane-bound inhibitor (Xenopus laevis) homolog a0.328
osr1odd-skipped related 1 (Drosophila)0.294
dharmadharma0.236
bmp2abone morphogenetic protein 2a0.228
bmpr2abone morphogenetic protein receptor, type II a (serine/threonine kinase)0.208
bmp3bone morphogenetic protein 30.207
sh3gl1bSH3-domain GRB2-like 1b0.174
tll1tolloid-like 10.162
twist1atwist1a0.159
bmpr1abbone morphogenetic protein receptor, type 1ab0.158
pnxposterior neuron-specific homeobox0.152
ergv-ets erythroblastosis virus E26 oncogene like (avian)0.150
pcdh8protocadherin 80.146
bmp7bbone morphogenetic protein 7b0.138
msxbmuscle segment homeobox B0.130
hmx4H6 family homeobox 40.124
sfrp1bsecreted frizzled-related protein 1b0.120
raf1av-raf-1 murine leukemia viral oncogene homolog 1a0.120
spns2spinster homolog 2 (Drosophila)0.115
mapk3mitogen-activated protein kinase 30.114
efnb2aephrin B2a0.113
mapk4mitogen-activated protein kinase 40.107
ets1av-ets erythroblastosis virus E26 oncogene homolog 1a0.106
inhainhibin, alpha0.105
runx1runt-related transcription factor 10.101
rxrbbretinoid x receptor, beta b0.100
hspa12bheat shock protein 12B0.096
fbn2bfibrillin 2b0.093
acta2actin, alpha 2, smooth muscle, aorta0.092
fzd9bfrizzled homolog 9b0.089
msxdmuscle segment homeobox D0.087
ednraendothelin receptor type A0.087
scinlascinderin like a0.086
slc6a6solute carrier family 6 (neurotransmitter transporter, taurine), member 60.082
sox11bSRY-box containing gene 11b0.081
rargaretinoic acid receptor gamma a0.080
og9xOG9 homeobox gene0.078
spry4sprouty (Drosophila) homolog 40.075
cdh17cadherin 17, LI cadherin (liver-intestine)0.075
tgfb3transforming growth factor, beta 30.074
restRE1-silencing transcription factor0.071
si:ch211-173o4.2si:ch211-173o4.20.066
inhbabinhibin, beta Ab0.065
gdf9growth differentiation factor 90.061
rargbretinoic acid receptor, gamma b0.061
inhbaainhibin, beta Aa0.061
fgf20afibroblast growth factor 20a0.059
plxnb2aplexin b2a0.058
lmo4aLIM domain only 4a0.057
smad9MAD homolog 9 (Drosophila)0.057
oepone-eyed pinhead0.057
cpla2cytosolic phospholipase a20.056
ihhaIndian hedgehog homolog a0.055
wnt11rwingless-type MMTV integration site family, member 11, related0.053
crip2cysteine-rich protein 20.053
antxr1anthrax toxin receptor 10.051
tbx5aT-box 5a0.051
lhcgrluteinizing hormone/choriogonadotropin receptor0.050
sdc2syndecan 20.049
tgfb2transforming growth factor, beta 20.049
tbx2bT-box 2b0.048
foxo3bforkhead box O3b0.047
flt4fms-related tyrosine kinase 40.046
eve1even-skipped-like10.046
nkx2.5NK2 transcription factor related 50.045
ldb2aLIM-domain binding factor 2a0.044
nog3noggin 30.042
cdh5cadherin 50.042
tbx22T-box 220.042
chdchordin0.041
plcg1phospholipase C, gamma 10.041
dusp5dual specificity phosphatase 50.040
ext1bexostoses (multiple) 1b0.039
tie1endothelium-specific receptor tyrosine kinase 10.038
igf3insulin-like growth factor 30.038
aplnraapelin receptor a0.037
zgc:63629zgc:636290.037
nfatc1nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 10.037
wnt8awingless-type MMTV integration site family, member 8a0.037
zgc:77051zgc:770510.036
wnt5bwingless-type MMTV integration site family, member 5b0.035
notum3notum 30.035
ventventral expressed homeobox0.035
rbp4retinol binding protein 4, plasma0.034
nrg2aneuregulin 2a0.034
mapk1mitogen-activated protein kinase 10.033
lama4laminin, alpha 40.033
sgk1serum/glucocorticoid regulated kinase 10.032
tln1talin 10.032
mxtx2mix-type homeobox gene 20.031
fasFas (TNF receptor superfamily, member 6)0.031
chrna2acholinergic receptor, nicotinic, alpha polypeptide 2a (neuronal)0.031
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
MadMothers against dpp0.999
Ras85DRas oncogene at 85D0.945
saxsaxophone0.777
sogshort gastrulation0.586
DadDaughters against dpp0.560
gbbglass bottom boat0.518
dallydivision abnormally delayed0.344
MedMedea0.261
comtcomatose0.242
tkvthickveins0.235
myoglianinCG1838 gene product from transcript CG1838-RD0.135
shnschnurri0.124
ash2absent, small, or homeotic discs 20.103
Plc21CPhospholipase C at 21C0.097
TlToll0.094
wunwunen0.068
ttvtout-velu0.057
PP2A-B'CG7913 gene product from transcript CG7913-RK0.044
EgfrEpidermal growth factor receptor0.041
alaristaless0.039
kaykayak0.035
SaraSmad anchor for receptor activation0.034
mysmyospheroid0.031
crbcrumbs0.031
witwishful thinking0.027
Nrx-1Neurexin 10.027
Atg1Autophagy-specific gene 10.027
Pi3K92ECG4141 gene product from transcript CG4141-RB0.026
Pk61CProtein kinase 61C0.026
knknot0.025
dawdawdle0.025
hhhedgehog0.025
cicubitus interruptus0.024
Smg1CG32743 gene product from transcript CG32743-RA0.024
G-salpha60AG protein salpha 60A0.023
brpbruchpilot0.022
stnBstoned B0.022
Sac1CG9128 gene product from transcript CG9128-RB0.021
tldtolloid0.020
kek1kekkon-10.020
n-sybn-synaptobrevin0.020
dppdecapentaplegic0.018
slmbsupernumerary limbs0.017
bynbrachyenteron0.017
EcREcdysone receptor0.016
toktolkin0.016
ActbetaActivin-beta0.016
SelDSelenide,water dikinase0.016
sydsunday driver0.015
unc-104CG8566 gene product from transcript CG8566-RB0.015
Fak56DFocal Adhesion Kinase0.014
CG8709CG8709 gene product from transcript CG8709-RK0.014
dshdishevelled0.014
NFATNFAT homolog0.014
hpohippo0.013
pumpumilio0.013
GluRIIAGlutamate receptor IIA0.013
CaMKIICalcium/calmodulin-dependent protein kinase II0.013
Pde8Phosphodiesterase 80.013
nwknervous wreck0.013
laplike-AP1800.012
diadiaphanous0.012
rhorhomboid0.012
drkdownstream of receptor kinase0.012
scbscab0.012
Stat92ESignal-transducer and activator of transcription protein at 92E0.011
ash1absent, small, or homeotic discs 10.011
Nrx-IVNeurexin IV0.011
hiwhighwire0.011
pntpointed0.011
Cyp18a1Cytochrome P450-18a10.011
highikaru genki0.011
CG32154CG32154 gene product from transcript CG32154-RA0.010
Nup160Nucleoporin 1600.010
fjfour-jointed0.010
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Tgfbr2transforming growth factor, beta receptor II0.997
Smad4MAD homolog 4 (Drosophila)0.971
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.926
Apcadenomatosis polyposis coli0.909
Smad3MAD homolog 3 (Drosophila)0.905
Bmp4bone morphogenetic protein 40.864
Nodalnodal0.709
Acvr1activin A receptor, type 10.685
Bmp7bone morphogenetic protein 70.578
Smad1MAD homolog 1 (Drosophila)0.538
Smad2MAD homolog 2 (Drosophila)0.514
Tgfbr1transforming growth factor, beta receptor I0.507
Tgfb2transforming growth factor, beta 20.407
Axin1axin 10.317
Map3k7mitogen-activated protein kinase kinase kinase 70.299
Bmpr1abone morphogenetic protein receptor, type 1A0.292
Fstfollistatin0.225
Bmp2bone morphogenetic protein 20.186
Bmpr2bone morphogenic protein receptor, type II (serine/threonine kinase)0.178
Smad7MAD homolog 7 (Drosophila)0.160
Fgfr1fibroblast growth factor receptor 10.160
Acvrl1activin A receptor, type II-like 10.153
Gli3GLI-Kruppel family member GLI30.150
Hand1heart and neural crest derivatives expressed transcript 10.097
Smosmoothened homolog (Drosophila)0.088
Smad6MAD homolog 6 (Drosophila)0.082
Wfikkn2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.080
Hand2heart and neural crest derivatives expressed transcript 20.079
Foxc1forkhead box C10.079
Erbb2ipErbb2 interacting protein0.075
Prkg1protein kinase, cGMP-dependent, type I0.070
Cdh5cadherin 50.069
Amhr2anti-Mullerian hormone type 2 receptor0.065
Engendoglin0.061
Prrx1paired related homeobox 10.058
Gata4GATA binding protein 40.056
Ror2receptor tyrosine kinase-like orphan receptor 20.051
Foxf1aforkhead box F1a0.051
Acvr2bactivin receptor IIB0.049
Ctnnb1catenin (cadherin associated protein), beta 10.047
Gdf5growth differentiation factor 50.047
Shhsonic hedgehog0.046
Csf1colony stimulating factor 1 (macrophage)0.046
Tcte3t-complex-associated testis expressed 30.046
Fgfr3fibroblast growth factor receptor 30.043
Timp2tissue inhibitor of metalloproteinase 20.042
Lrp2low density lipoprotein receptor-related protein 20.039
Lumlumican0.038
Fgfr2fibroblast growth factor receptor 20.038
Ptch1patched homolog 10.037
Gpc3glypican 30.036
Msx2homeobox, msh-like 20.036
Hoxa11homeobox A110.035
Hic1hypermethylated in cancer 10.035
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.035
Epas1endothelial PAS domain protein 10.032
Itga8integrin alpha 80.031
Acvr2aactivin receptor IIA0.030
Nos3nitric oxide synthase 3, endothelial cell0.030
Rspo2R-spondin 2 homolog (Xenopus laevis)0.030
Kif3akinesin family member 3A0.030
Prrx2paired related homeobox 20.028
Ext1exostoses (multiple) 10.027
Tcfap2atranscription factor AP-2, alpha0.027
Tgfbr3transforming growth factor, beta receptor III0.027
Smurf1SMAD specific E3 ubiquitin protein ligase 10.026
Zeb1zinc finger E-box binding homeobox 10.026
Il6stinterleukin 6 signal transducer0.026
Fgf8fibroblast growth factor 80.026
Gdf1growth differentiation factor 10.026
Sox17SRY-box containing gene 170.026
Tie1tyrosine kinase with immunoglobulin-like and EGF-like domains 10.025
Esr1estrogen receptor 1 (alpha)0.024
Ptpn11protein tyrosine phosphatase, non-receptor type 110.024
Ptk2PTK2 protein tyrosine kinase 20.024
Meox2mesenchyme homeobox 20.024
Ptprbprotein tyrosine phosphatase, receptor type, B0.024
Fzd1frizzled homolog 1 (Drosophila)0.024
Tdgf1teratocarcinoma-derived growth factor 10.023
Foxc2forkhead box C20.022
Fzd7frizzled homolog 7 (Drosophila)0.022
Otx2orthodenticle homolog 2 (Drosophila)0.022
Hhexhematopoietically expressed homeobox0.021
Gata6GATA binding protein 60.021
Thbdthrombomodulin0.021
Rargretinoic acid receptor, gamma0.020
Fbn1fibrillin 10.019
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.019
Gdf6growth differentiation factor 60.019
Shesrc homology 2 domain-containing transforming protein E0.018
Jag1jagged 10.018
Yap1yes-associated protein 10.017
Thbs1thrombospondin 10.017
Vldlrvery low density lipoprotein receptor0.017
Cdoncell adhesion molecule-related/down-regulated by oncogenes0.017
Fzd4frizzled homolog 4 (Drosophila)0.017
Ece1endothelin converting enzyme 10.016
Gdf3growth differentiation factor 30.016
Lgr4leucine-rich repeat-containing G protein-coupled receptor 40.015
Rnf111ring finger 1110.015
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Tgfbr2transforming growth factor, beta receptor II0.047
Smad7SMAD family member 70.023
Fgfr1Fibroblast growth factor receptor 10.022
Sod3superoxide dismutase 3, extracellular0.020
Tbl1xr1transducin (beta)-like 1 X-linked receptor 10.020
Metmet proto-oncogene0.019
Arntaryl hydrocarbon receptor nuclear translocator0.017
Castcalpastatin0.017
Nek9NIMA (never in mitosis gene a)- related kinase 90.016
Lamc1laminin, gamma 10.015
Calcrlcalcitonin receptor-like0.015
Myh9myosin, heavy chain 9, non-muscle0.014
Elf1E74-like factor 10.014
Igfbp5insulin-like growth factor binding protein 50.014
Pecam1platelet/endothelial cell adhesion molecule 10.014
Fbln5fibulin 50.013
Tceb3transcription elongation factor B (SIII), polypeptide 30.013
Efnb1ephrin B10.013
Adam10ADAM metallopeptidase domain 100.013
Cald1caldesmon 10.013
Lims1LIM and senescent cell antigen-like domains 10.013
Pkn2protein kinase N20.013
Ptpn12protein tyrosine phosphatase, non-receptor type 120.013
Ece1endothelin converting enzyme 10.012
Prkchprotein kinase C, eta0.012
Socs3suppressor of cytokine signaling 30.012
Flt1FMS-related tyrosine kinase 10.012
Stx2syntaxin 20.012
Itpr2inositol 1,4,5-triphosphate receptor, type 20.012
Col12a1collagen, type XII, alpha 10.012
Bgnbiglycan0.012
Unc5bunc-5 homolog B (C. elegans)0.011
SnrkSNF related kinase0.011
Socs2suppressor of cytokine signaling 20.010
Tcf12transcription factor 120.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism