The network for 'potassium ion transmembrane transport' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

potassium ion transmembrane transport

A process in which a potassium ion is transported from one side of a membrane to the other.

NameDescriptionProbabilityFunc Analog Organism
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide1.000
YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide1.000
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide1.000
KCNIP2Kv channel interacting protein 21.000
DLG4discs, large homolog 4 (Drosophila)1.000
KCNB1potassium voltage-gated channel, Shab-related subfamily, member 10.998
KCNQ1potassium voltage-gated channel, KQT-like subfamily, member 10.997
SMURF2SMAD specific E3 ubiquitin protein ligase 20.996
KCNE1potassium voltage-gated channel, Isk-related family, member 10.995
ACTN2actinin, alpha 20.995
CAB39calcium binding protein 390.987
KCND2potassium voltage-gated channel, Shal-related subfamily, member 20.987
KCNA5potassium voltage-gated channel, shaker-related subfamily, member 50.981
MTMR12myotubularin related protein 120.975
ABCC8ATP-binding cassette, sub-family C (CFTR/MRP), member 80.972
KCNA1potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)0.959
SMAD4SMAD family member 40.926
LIN7Blin-7 homolog B (C. elegans)0.915
YWHAQtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.907
CD177CD177 molecule0.903
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.902
KCNA4potassium voltage-gated channel, shaker-related subfamily, member 40.882
GRIN2Bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.804
PDLIM1PDZ and LIM domain 10.791
CHRNA4cholinergic receptor, nicotinic, alpha 40.762
MTM1myotubularin 10.715
YWHAHtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.713
S100BS100 calcium binding protein B0.692
GRIN2Aglutamate receptor, ionotropic, N-methyl D-aspartate 2A0.659
NEDD4Lneural precursor cell expressed, developmentally down-regulated 4-like0.618
MAP3K3mitogen-activated protein kinase kinase kinase 30.555
SSTR2somatostatin receptor 20.551
RAF1v-raf-1 murine leukemia viral oncogene homolog 10.513
CAMK2Bcalcium/calmodulin-dependent protein kinase II beta0.506
GRIN2Cglutamate receptor, ionotropic, N-methyl D-aspartate 2C0.488
DLGAP1discs, large (Drosophila) homolog-associated protein 10.479
ZFYVE9zinc finger, FYVE domain containing 90.470
P2RX6purinergic receptor P2X, ligand-gated ion channel, 60.445
WWP1WW domain containing E3 ubiquitin protein ligase 10.443
HRH3histamine receptor H30.442
KCNF1potassium voltage-gated channel, subfamily F, member 10.435
MYOZ1myozenin 10.431
SMURF1SMAD specific E3 ubiquitin protein ligase 10.429
KCNJ3potassium inwardly-rectifying channel, subfamily J, member 30.414
KCNC1potassium voltage-gated channel, Shaw-related subfamily, member 10.412
KCNQ2potassium voltage-gated channel, KQT-like subfamily, member 20.401
ANKRD13Aankyrin repeat domain 13A0.393
ATP2B2ATPase, Ca++ transporting, plasma membrane 20.389
NEDD4neural precursor cell expressed, developmentally down-regulated 40.375
KCNJ11potassium inwardly-rectifying channel, subfamily J, member 110.370
AKAP12A kinase (PRKA) anchor protein 120.347
DLGAP2discs, large (Drosophila) homolog-associated protein 20.344
GLP1Rglucagon-like peptide 1 receptor0.309
ERBB4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.299
CRHR1corticotropin releasing hormone receptor 10.283
BSNbassoon (presynaptic cytomatrix protein)0.280
CCKBRcholecystokinin B receptor0.279
HTR2C5-hydroxytryptamine (serotonin) receptor 2C0.268
HOXA1homeobox A10.265
MTMR9myotubularin related protein 90.262
ATP2B3ATPase, Ca++ transporting, plasma membrane 30.253
SCNN1Bsodium channel, nonvoltage-gated 1, beta0.238
HCN2hyperpolarization activated cyclic nucleotide-gated potassium channel 20.235
WNK4WNK lysine deficient protein kinase 40.218
VSTM2AV-set and transmembrane domain containing 2A0.213
WWP2WW domain containing E3 ubiquitin protein ligase 20.208
RYR2ryanodine receptor 2 (cardiac)0.203
CXXC5CXXC finger protein 50.200
GNAO1guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O0.200
CACNA1Ecalcium channel, voltage-dependent, R type, alpha 1E subunit0.198
SMAD5SMAD family member 50.197
BAI1brain-specific angiogenesis inhibitor 10.196
ADAMTSL4ADAMTS-like 40.196
CDK5R2cyclin-dependent kinase 5, regulatory subunit 2 (p39)0.192
CACNA1Bcalcium channel, voltage-dependent, N type, alpha 1B subunit0.187
PDE4DIPphosphodiesterase 4D interacting protein0.184
HTR2A5-hydroxytryptamine (serotonin) receptor 2A0.183
HCN4hyperpolarization activated cyclic nucleotide-gated potassium channel 40.179
SMAD2SMAD family member 20.179
KCNJ10potassium inwardly-rectifying channel, subfamily J, member 100.173
SEZ6Lseizure related 6 homolog (mouse)-like0.170
PLK3polo-like kinase 30.170
KCNH1potassium voltage-gated channel, subfamily H (eag-related), member 10.169
CDC25Bcell division cycle 25 homolog B (S. pombe)0.166
SMAD9SMAD family member 90.160
KCNJ9potassium inwardly-rectifying channel, subfamily J, member 90.158
KCNB2potassium voltage-gated channel, Shab-related subfamily, member 20.156
SLC6A7solute carrier family 6 (neurotransmitter transporter, L-proline), member 70.154
RHBDL1rhomboid, veinlet-like 1 (Drosophila)0.152
FOXD3forkhead box D30.151
PKD1polycystic kidney disease 1 (autosomal dominant)0.151
ADAM11ADAM metallopeptidase domain 110.147
DPP6dipeptidyl-peptidase 60.145
OPRD1opioid receptor, delta 10.145
SYN2synapsin II0.142
GLRA1glycine receptor, alpha 10.142
KCTD17potassium channel tetramerisation domain containing 170.141
NEUROD2neurogenic differentiation 20.140
GAD2glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa)0.139
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
dyc-1Protein DYC-10.060
dys-1Protein DYS-10.054
cpx-1Protein CPX-10.028
dyb-1Protein DYB-10.025
CELE_Y69H2.1Protein Y69H2.10.023
gpb-1Protein GPB-10.018
egl-2Protein EGL-20.018
pkg-1Protein PKG-10.017
gly-5Protein GLY-50.017
C34C12.6Protein C34C12.60.016
CELE_Y64G10A.7Protein Y64G10A.70.016
sipa-1Protein SIPA-10.015
clp-1Protein CLP-10.015
stn-1Protein STN-10.015
C06G1.5Protein C06G1.50.015
par-1Protein PAR-10.013
tbc-4Protein TBC-40.011
nep-26Protein NEP-260.011
Y48G1C.7Protein Y48G1C.70.011
mboa-1Protein MBOA-10.010
abts-1Protein ABTS-10.010
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
atp1b2aATPase, Na+/K+ transporting, beta 2a polypeptide0.224
atp1b1bATPase, Na+/K+ transporting, beta 1b polypeptide0.222
atp1b2bATPase, Na+/K+ transporting, beta 2b polypeptide0.196
slc12a2solute carrier family 12 (potassium/chloride transporters), member 20.154
atp1a2aATPase, Na+/K+ transporting, alpha 2a polypeptide0.152
LOC570775protein argonaute-1-like0.090
slc12a3solute carrier family 12 (sodium/chloride transporters), member 30.088
atp1a1a.4ATPase, Na+/K+ transporting, alpha 1a.4 polypeptide0.076
atp1a1a.2ATPase, Na+/K+ transporting, alpha 1a.2 polypeptide0.073
s1pr2sphingosine-1-phosphate receptor 20.068
pvalb8parvalbumin 80.062
mybpc3myosin binding protein C, cardiac0.049
gpiaglucose phosphate isomerase a0.041
aqp8a.1aquaporin 8a, tandem duplicate 10.037
ppargc1alperoxisome proliferator-activated receptor gamma, coactivator 1 alpha like0.032
ptprkprotein tyrosine phosphatase, receptor type, K0.031
ca2carbonic anhydrase II0.030
ldb3aLIM-domain binding factor 3a0.029
atp1b1aATPase, Na+/K+ transporting, beta 1a polypeptide0.026
ahcyl1S-adenosylhomocysteine hydrolase-like 10.025
pgam2phosphoglycerate mutase 2 (muscle)0.022
kcnh1potassium voltage-gated channel, subfamily H (eag-related), member 10.021
xirp1xin actin-binding repeat containing 10.018
vamp2vesicle-associated membrane protein 20.018
gapdhsglyceraldehyde-3-phosphate dehydrogenase, spermatogenic0.017
ap1b1adaptor-related protein complex 1, beta 1 subunit0.017
atp1a1a.3ATPase, Na+/K+ transporting, alpha 1a.3 polypeptide0.017
slc4a2asolute carrier family 4, anion exchanger, member 2a0.017
nbl1neuroblastoma, suppression of tumorigenicity 10.017
cdh17cadherin 17, LI cadherin (liver-intestine)0.017
slc25a3asolute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3a0.017
cx41.8connexin 41.80.017
eef2l2eukaryotic translation elongation factor 2, like 20.016
actn3aactinin alpha 3a0.016
synj1synaptojanin 10.015
tnnt2atroponin T2a, cardiac0.015
vsg1vessel-specific 10.014
lmo1LIM domain only 10.013
cabp1calcium binding protein 10.013
trpc1transient receptor potential cation channel, subfamily C, member 10.013
myo7aamyosin VIIAa0.012
chrndcholinergic receptor, nicotinic, delta polypeptide0.012
edarectodysplasin A receptor0.012
soul4heme-binding protein soul40.011
esrrdestrogen-related receptor delta0.011
hnf1bbHNF1 homeobox Bb0.011
ints6integrator complex subunit 60.011
igfbp3insulin-like growth factor binding protein 30.011
actn1actinin, alpha 10.011
pcsk5aproprotein convertase subtilisin/kexin type 5a0.011
gpr126G protein-coupled receptor 1260.011
tyrp1btyrosinase-related protein 1b0.011
ocrloculocerebrorenal syndrome of Lowe0.011
foxi3bforkhead box I3b0.010
LOC100149148novel protein similar to myosin heavy chain 4 (myhc4)0.010
myhz1.2myosin, heavy polypeptide 1.2, skeletal muscle0.010
ppp3cbprotein phosphatase 3, catalytic subunit, beta isozyme0.010
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
AceAcetylcholine esterase0.017
CG4563CG4563 gene product from transcript CG4563-RA0.017
Klp64DKinesin-like protein at 64D0.016
CG10200CG10200 gene product from transcript CG10200-RB0.015
CG5890CG5890 gene product from transcript CG5890-RB0.014
GlcAT-PCG6207 gene product from transcript CG6207-RC0.014
CG14957CG14957 gene product from transcript CG14957-RA0.013
Irk2Inwardly rectifying potassium channel 20.012
Frq1Frequenin 10.011
Ilp2Insulin-like peptide 20.011
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Atp2b2ATPase, Ca++ transporting, plasma membrane 20.999
Kcnq1potassium voltage-gated channel, subfamily Q, member 10.997
Scn5asodium channel, voltage-gated, type V, alpha0.978
Kcnk3potassium channel, subfamily K, member 30.966
Kcnma1potassium large conductance calcium-activated channel, subfamily M, alpha member 10.953
Cdh23cadherin 23 (otocadherin)0.938
Kcna1potassium voltage-gated channel, shaker-related subfamily, member 10.902
Kcne1potassium voltage-gated channel, Isk-related subfamily, member 10.902
Mybpc3myosin binding protein C, cardiac0.863
Srrm4serine/arginine repetitive matrix 40.806
Kcna2potassium voltage-gated channel, shaker-related subfamily, member 20.781
Cacna2d1calcium channel, voltage-dependent, alpha2/delta subunit 10.755
Ywhabtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.745
Slc12a2solute carrier family 12, member 20.635
Cacnb2calcium channel, voltage-dependent, beta 2 subunit0.632
Slc26a4solute carrier family 26, member 40.626
Slc12a1solute carrier family 12, member 10.618
Ush1gUsher syndrome 1G homolog (human)0.615
Kcnj3potassium inwardly-rectifying channel, subfamily J, member 30.590
Smyd1SET and MYND domain containing 10.583
Grid2glutamate receptor, ionotropic, delta 20.579
Atp4aATPase, H+/K+ exchanging, gastric, alpha polypeptide0.568
Ryr2ryanodine receptor 2, cardiac0.563
Thrbthyroid hormone receptor beta0.457
Ldb3LIM domain binding 30.455
Camk2acalcium/calmodulin-dependent protein kinase II alpha0.453
Syt7synaptotagmin VII0.447
Grxcr1glutaredoxin, cysteine rich 10.432
Tbx3T-box 30.432
Crhr2corticotropin releasing hormone receptor 20.394
Kcna4potassium voltage-gated channel, shaker-related subfamily, member 40.379
Kcnj5potassium inwardly-rectifying channel, subfamily J, member 50.363
AI118078expressed sequence AI1180780.359
InadlInaD-like (Drosophila)0.334
Kcnj11potassium inwardly rectifying channel, subfamily J, member 110.331
Cacna1ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.321
Aff2AF4/FMR2 family, member 20.314
Dlg4discs, large homolog 4 (Drosophila)0.313
Myo6myosin VI0.306
Gpr12G-protein coupled receptor 120.296
Gja3gap junction protein, alpha 30.294
Ank1ankyrin 1, erythroid0.292
Hrchistidine rich calcium binding protein0.286
Gjd3gap junction protein, delta 30.284
Cntn1contactin 10.270
Slc12a5solute carrier family 12, member 50.243
Kcnb1potassium voltage gated channel, Shab-related subfamily, member 10.242
Tmc1transmembrane channel-like gene family 10.237
Cckbrcholecystokinin B receptor0.228
Wnk4WNK lysine deficient protein kinase 40.228
Scn8asodium channel, voltage-gated, type VIII, alpha0.226
Slc8a1solute carrier family 8 (sodium/calcium exchanger), member 10.220
Il16interleukin 160.216
Lama2laminin, alpha 20.215
Crxcone-rod homeobox containing gene0.208
Ckmt2creatine kinase, mitochondrial 20.207
Hrh2histamine receptor H20.204
Hsd3b4hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 40.203
Syn2synapsin II0.201
Oprk1opioid receptor, kappa 10.200
Adra1aadrenergic receptor, alpha 1a0.200
Tspo2translocator protein 20.196
Pcdh15protocadherin 150.193
Slc4a7solute carrier family 4, sodium bicarbonate cotransporter, member 70.192
Clrn1clarin 10.180
Kcna6potassium voltage-gated channel, shaker-related, subfamily, member 60.175
Rtn2reticulon 2 (Z-band associated protein)0.172
Capn9calpain 90.170
Adra2cadrenergic receptor, alpha 2c0.165
Cacnb4calcium channel, voltage-dependent, beta 4 subunit0.165
Abcc9ATP-binding cassette, sub-family C (CFTR/MRP), member 90.165
Pygmmuscle glycogen phosphorylase0.153
Gad2glutamic acid decarboxylase 20.142
Nptx1neuronal pentraxin 10.137
Nppanatriuretic peptide type A0.136
Chrm1cholinergic receptor, muscarinic 1, CNS0.136
Sparcl1SPARC-like 10.135
Six6sine oculis-related homeobox 6 homolog (Drosophila)0.134
Gabrb3gamma-aminobutyric acid (GABA) A receptor, subunit beta 30.133
Trpc4transient receptor potential cation channel, subfamily C, member 40.132
Kcnj10potassium inwardly-rectifying channel, subfamily J, member 100.132
Cntn3contactin 30.129
Kcnd2potassium voltage-gated channel, Shal-related family, member 20.128
Tbx5T-box 50.127
Rph3arabphilin 3A0.126
Elf5E74-like factor 50.126
Rgs6regulator of G-protein signaling 60.124
Kcnk9potassium channel, subfamily K, member 90.123
Cplx1complexin 10.122
Kcnj6potassium inwardly-rectifying channel, subfamily J, member 60.115
Myh6myosin, heavy polypeptide 6, cardiac muscle, alpha0.114
Pcsk4proprotein convertase subtilisin/kexin type 40.114
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.112
Amigo1adhesion molecule with Ig like domain 10.111
Rgs7regulator of G protein signaling 70.111
Chrm3cholinergic receptor, muscarinic 3, cardiac0.111
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
LOC100362824caveolin 2-like0.470
Chrna1cholinergic receptor, nicotinic, alpha 1 (muscle)0.211
Strnstriatin, calmodulin binding protein0.178
Lim2lens intrinsic membrane protein 20.147
Kcnk3potassium channel, subfamily K, member 30.145
Grin2bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.132
Grpgastrin releasing peptide0.125
Pde1bphosphodiesterase 1B, calmodulin-dependent0.119
Atp1b2ATPase, Na+/K+ transporting, beta 2 polypeptide0.117
Ghrlghrelin/obestatin prepropeptide0.116
Kcnh2potassium voltage-gated channel, subfamily H (eag-related), member 20.113
Rab3bRAB3B, member RAS oncogene family0.110
P2rx6purinergic receptor P2X, ligand-gated ion channel, 60.107
Slc6a11solute carrier family 6 (neurotransmitter transporter, GABA), member 110.097
MrgprfMAS-related GPR, member F0.092
Myh6myosin, heavy chain 6, cardiac muscle, alpha0.090
Drd1adopamine receptor D1A0.088
Ly6blymphocyte antigen 6 complex, locus B0.088
Catsper2cation channel, sperm associated 20.088
Ppp2r2cprotein phosphatase 2 (formerly 2A), regulatory subunit B, gamma isoform0.085
CartptCART prepropeptide0.084
Magmyelin-associated glycoprotein0.083
Gfra2GDNF family receptor alpha 20.079
LOC100360403ATP-binding cassette, sub-family C, member 9-like0.078
Pla2g2cphospholipase A2, group IIC0.078
Pcsk4proprotein convertase subtilisin/kexin type 40.066
Sh3gl2SH3-domain GRB2-like 20.066
Kcnd3potassium voltage-gated channel, Shal-related subfamily, member 30.065
Tagln3transgelin 30.062
Fitm1fat storage-inducing transmembrane protein 10.061
Sstr3somatostatin receptor 30.061
Cntn2contactin 2 (axonal)0.060
Grid2glutamate receptor, ionotropic, delta 20.060
Crhr1corticotropin releasing hormone receptor 10.060
Crybb3crystallin, beta B30.059
Slc2a3solute carrier family 2 (facilitated glucose transporter), member 30.059
Adrb1adrenergic, beta-1-, receptor0.059
Grm2glutamate receptor, metabotropic 20.058
Vamp1vesicle-associated membrane protein 10.057
Atp7bATPase, Cu++ transporting, beta polypeptide0.054
Pla2g5phospholipase A2, group V0.054
Calcacalcitonin-related polypeptide alpha0.053
Kcnq1potassium voltage-gated channel, KQT-like subfamily, member 10.053
Pde1cphosphodiesterase 1C0.053
RT1-M4RT1 class Ib, locus M40.053
Htr1d5-hydroxytryptamine (serotonin) receptor 1D0.052
Chrnb2cholinergic receptor, nicotinic, beta 2 (neuronal)0.051
Kcnh4potassium voltage-gated channel, subfamily H (eag-related), member 40.051
Neurod1neurogenic differentiation 10.051
Ucp3uncoupling protein 3 (mitochondrial, proton carrier)0.049
Opn4opsin 40.049
Kcnd2potassium voltage-gated channel, Shal-related subfamily, member 20.049
RGD1560871similar to plexin 10.048
Cnga2cyclic nucleotide gated channel alpha 20.048
Kcnc2potassium voltage gated channel, Shaw-related subfamily, member 20.047
Chrna4cholinergic receptor, nicotinic, alpha 40.047
Impg2interphotoreceptor matrix proteoglycan 20.046
Asipagouti signaling protein0.046
Rab20RAB20, member RAS oncogene family0.046
Chrndcholinergic receptor, nicotinic, delta0.045
Chrna7cholinergic receptor, nicotinic, alpha 70.045
Coro6coronin 60.044
Evi2aecotropic viral integration site 2A0.044
Atp2c2ATPase, Ca++ transporting, type 2C, member 20.043
Gpr150G protein-coupled receptor 1500.043
Hspb2heat shock protein beta 20.043
Lrrc4bleucine rich repeat containing 4B0.043
SeboxSEBOX homeobox0.042
Appamyloid beta (A4) precursor protein0.042
Pgam2phosphoglycerate mutase 2 (muscle)0.042
Hs3st2heparan sulfate (glucosamine) 3-O-sulfotransferase 20.042
Tmod2tropomodulin 20.042
Slc6a17solute carrier family 6 (neurotransmitter transporter), member 170.042
Rph3arabphilin 3A0.042
Chrna3cholinergic receptor, nicotinic, alpha 30.041
Cd46CD46 molecule, complement regulatory protein0.041
Myl7myosin, light chain 7, regulatory0.040
Spt1salivary protein 10.040
Kykyphoscoliosis peptidase0.040
Fgf14fibroblast growth factor 140.040
LOC685244similar to IQ motif and Sec7 domain 20.039
Foxe1forkhead box E1 (thyroid transcription factor 2)0.039
Chrnb1cholinergic receptor, nicotinic, beta 1 (muscle)0.039
Cacna1icalcium channel, voltage-dependent, T type, alpha 1I subunit0.039
Degs2degenerative spermatocyte homolog 2, lipid desaturase (Drosophila)0.038
Snap91synaptosomal-associated protein 910.037
Adcyap1r1adenylate cyclase activating polypeptide 1 receptor 10.037
Aif1lallograft inflammatory factor 1-like0.037
Fgf20fibroblast growth factor 200.036
Arcactivity-regulated cytoskeleton-associated protein0.036
Crxcone-rod homeobox0.036
Obscnobscurin, cytoskeletal calmodulin and titin-interacting RhoGEF0.036
Cyp11b1cytochrome P450, family 11, subfamily b, polypeptide 10.036
Lrp3low density lipoprotein receptor-related protein 30.036
Kcnh6potassium voltage-gated channel, subfamily H (eag-related), member 60.036
Rgs8regulator of G-protein signaling 80.036
Dnase1deoxyribonuclease I0.035
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism