The network for 'endodermal cell fate commitment' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

endodermal cell fate commitment

The cell differentiation process that results in commitment of a cell to become part of the endoderm.

NameDescriptionProbabilityFunc Analog Organism
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)1.000
SP1Sp1 transcription factor1.000
FGF1fibroblast growth factor 1 (acidic)1.000
PAX3paired box 30.999
SMAD7SMAD family member 70.999
POU3F2POU class 3 homeobox 20.999
BMP2bone morphogenetic protein 20.998
SMAD2SMAD family member 20.996
BMPR1Abone morphogenetic protein receptor, type IA0.995
FOXD3forkhead box D30.993
SOX10SRY (sex determining region Y)-box 100.990
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.988
DVL3dishevelled, dsh homolog 3 (Drosophila)0.986
CDC73cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.986
RTF1Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.959
SMAD1SMAD family member 10.955
LEO1Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.941
FKBP1AFK506 binding protein 1A, 12kDa0.932
BMP7bone morphogenetic protein 70.925
JAG1jagged 10.887
SMAD4SMAD family member 40.882
DVL1dishevelled, dsh homolog 1 (Drosophila)0.869
CTR9Ctr9, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.850
SOX2SRY (sex determining region Y)-box 20.833
RANBP2RAN binding protein 20.807
LCKlymphocyte-specific protein tyrosine kinase0.758
SMAD3SMAD family member 30.743
NOTCH3notch 30.743
SMAD5SMAD family member 50.726
SYKspleen tyrosine kinase0.705
LRP6low density lipoprotein receptor-related protein 60.690
ZNF512Bzinc finger protein 512B0.686
CTNNBIP1catenin, beta interacting protein 10.669
FGFR2fibroblast growth factor receptor 20.662
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.650
TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)0.645
NOGnoggin0.602
WWP2WW domain containing E3 ubiquitin protein ligase 20.594
NEDD4neural precursor cell expressed, developmentally down-regulated 40.547
GDF5growth differentiation factor 50.522
CD3ECD3e molecule, epsilon (CD3-TCR complex)0.483
MEOX2mesenchyme homeobox 20.425
WT1Wilms tumor 10.400
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.386
FYNFYN oncogene related to SRC, FGR, YES0.363
AXIN1axin 10.357
FGF10fibroblast growth factor 100.335
FGFR3fibroblast growth factor receptor 30.329
CXXC5CXXC finger protein 50.321
MAML1mastermind-like 1 (Drosophila)0.310
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.293
SMAD6SMAD family member 60.272
HCKhemopoietic cell kinase0.262
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.256
SALL2sal-like 2 (Drosophila)0.250
CSNK1Ecasein kinase 1, epsilon0.240
PLCG1phospholipase C, gamma 10.235
FSTL1follistatin-like 10.228
NLKnemo-like kinase0.222
PAF1Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)0.221
TAB3TGF-beta activated kinase 1/MAP3K7 binding protein 30.218
CEP164centrosomal protein 164kDa0.215
MYBv-myb myeloblastosis viral oncogene homolog (avian)0.212
SMURF2SMAD specific E3 ubiquitin protein ligase 20.203
JAG2jagged 20.203
MARCKSL1MARCKS-like 10.194
FGF2fibroblast growth factor 2 (basic)0.191
PHLDA1pleckstrin homology-like domain, family A, member 10.189
SOX11SRY (sex determining region Y)-box 110.188
OTPorthopedia homeobox0.175
BBS10Bardet-Biedl syndrome 100.165
WDR61WD repeat domain 610.165
SHANK2SH3 and multiple ankyrin repeat domains 20.161
MDFIMyoD family inhibitor0.157
HCFC1host cell factor C1 (VP16-accessory protein)0.144
DSPdesmoplakin0.140
SKIv-ski sarcoma viral oncogene homolog (avian)0.139
POU3F1POU class 3 homeobox 10.137
HNF1AHNF1 homeobox A0.136
KLHL12kelch-like 12 (Drosophila)0.132
SOX1SRY (sex determining region Y)-box 10.119
WWP1WW domain containing E3 ubiquitin protein ligase 10.118
KLF5Kruppel-like factor 5 (intestinal)0.116
RBPJrecombination signal binding protein for immunoglobulin kappa J region0.116
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.116
HIPK2homeodomain interacting protein kinase 20.113
SOX21SRY (sex determining region Y)-box 210.111
TRAF4TNF receptor-associated factor 40.110
FOXC2forkhead box C2 (MFH-1, mesenchyme forkhead 1)0.109
TAB1TGF-beta activated kinase 1/MAP3K7 binding protein 10.106
LYNv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.096
ACAP3ArfGAP with coiled-coil, ankyrin repeat and PH domains 30.096
CD22CD22 molecule0.094
MSX1msh homeobox 10.092
FOXG1forkhead box G10.090
SPRR2Asmall proline-rich protein 2A0.089
GLIS2GLIS family zinc finger 20.089
SH3BP2SH3-domain binding protein 20.089
BMP4bone morphogenetic protein 40.088
SOX5SRY (sex determining region Y)-box 50.087
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
chdchordin0.998
flhfloating head0.745
tbx1T-box 10.605
emx3empty spiracles homeobox 30.589
col2a1acollagen type II, alpha-1a0.565
dlcdeltaC0.551
fgf8afibroblast growth factor 8 a0.528
tbx20T-box 200.513
tbx2bT-box 2b0.498
pcdh8protocadherin 80.478
fgf3fibroblast growth factor 30.476
tbx16T-box gene 160.465
fli1afriend leukemia integration 1a0.458
cdh1cadherin 1, epithelial0.447
notch3notch homolog 30.434
pax2apaired box gene 2a0.426
ntlano tail a0.414
jag2jagged 20.395
gata3GATA-binding protein 30.378
bmp2bbone morphogenetic protein 2b0.354
rarabretinoic acid receptor, alpha b0.331
bmp4bone morphogenetic protein 40.315
mespamesoderm posterior a0.294
mibmind bomb0.287
gbx2gastrulation brain homeo box 20.282
cdh2cadherin 2, neuronal0.254
foxg1aforkhead box G1a0.248
her1hairy-related 10.236
spry2sprouty homolog 20.230
ndr1nodal-related 10.208
fgfr4fibroblast growth factor receptor 40.207
sox3SRY-box containing gene 30.195
fgf17fibroblast growth factor 170.191
her7hairy and enhancer of split related-70.186
spry4sprouty (Drosophila) homolog 40.181
hand2heart and neural crest derivatives expressed transcript 20.180
mmp2matrix metalloproteinase 20.174
fgfr2fibroblast growth factor receptor 20.174
bmpr2bbone morphogenetic protein receptor, type II b (serine/threonine kinase)0.173
hey2hairy/enhancer-of-split related with YRPW motif 20.164
tll1tolloid-like 10.155
efnb2aephrin B2a0.154
oepone-eyed pinhead0.143
lhx1aLIM homeobox 1a0.143
osr2odd-skipped related 2 (Drosophila)0.139
kdrlkinase insert domain receptor like0.139
ventventral expressed homeobox0.133
tbx5aT-box 5a0.111
msxbmuscle segment homeobox B0.110
wnt5bwingless-type MMTV integration site family, member 5b0.108
gro2groucho 20.105
notch2notch homolog 20.103
sall4sal-like 4 (Drosophila)0.102
sox19bSRY-box containing gene 19b0.099
six4bsine oculis homeobox homolog 4b0.097
meis3myeloid ecotropic viral integration site 30.097
egr2aearly growth response 2a0.097
eomesaeomesodermin homolog a0.096
spns2spinster homolog 2 (Drosophila)0.096
snai1asnail homolog 1a (Drosophila)0.091
bmp7abone morphogenetic protein 7a0.091
cdx4caudal type homeo box transcription factor 40.090
traf4atnf receptor-associated factor 4a0.089
six3bsine oculis homeobox homolog 3b0.087
dusp6dual specificity phosphatase 60.085
isl1islet10.083
foxi1forkhead box I10.082
pitx2paired-like homeodomain transcription factor 20.082
igfbp3insulin-like growth factor binding protein 30.080
ephb4beph receptor B4b0.080
ndr2nodal-related 20.079
lft1lefty10.078
dharmadharma0.078
bonbonnie and clyde0.077
lhx1bLIM homeobox 1b0.074
igf1rbinsulin-like growth factor 1b receptor0.073
hmx4H6 family homeobox 40.072
prlprolactin0.071
btg2B-cell translocation gene 20.071
hoxd11ahomeo box D11a0.070
fn1fibronectin 10.068
rx3retinal homeobox gene 30.067
dccdeleted in colorectal carcinoma0.066
pdgfaaplatelet-derived growth factor alpha a0.064
pcdh10bprotocadherin 10b0.064
gata2aGATA-binding protein 2a0.063
bocbrother of CDO0.062
krml2.2Kreisler (mouse) maf-related leucine zipper homolog 2.20.061
hey1hairy/enhancer-of-split related with YRPW motif 10.060
aldh1a2aldehyde dehydrogenase 1 family, member A20.060
dlbdeltaB0.058
pou5f1POU domain, class 5, transcription factor 10.056
bmpr2abone morphogenetic protein receptor, type II a (serine/threonine kinase)0.056
twist1atwist1a0.056
tbx6T-box gene 60.055
hoxa11ahomeo box A11a0.055
ccm2cerebral cavernous malformation 20.053
hoxa10bhomeo box A10b0.053
eya1eyes absent homolog 10.053
nanos3nanos homolog 30.053
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
MadMothers against dpp0.989
tkvthickveins0.965
DadDaughters against dpp0.787
rhorhomboid0.719
smosmoothened0.648
dshdishevelled0.628
MedMedea0.581
cicubitus interruptus0.531
osaCG7467 gene product from transcript CG7467-RD0.481
numbCG3779 gene product from transcript CG3779-RB0.450
bnlbranchless0.409
shnschnurri0.354
tldtolloid0.299
grogroucho0.297
cactcactus0.254
putpunt0.244
eyaeyes absent0.237
ushu-shaped0.223
zfh2Zn finger homeodomain 20.215
EgfrEpidermal growth factor receptor0.202
Su(H)Suppressor of Hairless0.202
htlheartless0.190
emcextra macrochaetae0.185
Bre1CG10542 gene product from transcript CG10542-RA0.176
TlToll0.176
sbbscribbler0.175
enengrailed0.172
kelkelch0.140
AblAbl tyrosine kinase0.135
wgwingless0.134
fzfrizzled0.131
sogshort gastrulation0.130
armarmadillo0.126
CtBPC-terminal Binding Protein0.123
aopanterior open0.116
gekgenghis khan0.115
CG5591CG5591 gene product from transcript CG5591-RA0.109
Gef26CG9491 gene product from transcript CG9491-RB0.107
sglsugarless0.106
orboo18 RNA-binding protein0.101
saxsaxophone0.089
stysprouty0.083
phlpole hole0.083
LanALaminin A0.081
dockdreadlocks0.080
srstripe0.079
cswcorkscrew0.078
Mes2CG11100 gene product from transcript CG11100-RB0.077
cnocanoe0.077
Doc2Dorsocross20.077
vvlventral veins lacking0.075
wlswntless0.073
SaraSmad anchor for receptor activation0.072
sdscalloped0.072
edechinoid0.072
ttvtout-velu0.069
frcfringe connection0.067
myoglianinCG1838 gene product from transcript CG1838-RD0.066
sllslalom0.066
Ras64BRas oncogene at 64B0.065
nmonemo0.065
zfh1Zn finger homeodomain 10.063
srpserpent0.058
SmoxSmad on X0.058
stumpsCG31317 gene product from transcript CG31317-RC0.058
tsgtwisted gastrulation0.057
dapdacapo0.054
rapretina aberrant in pattern0.054
neurneuralized0.053
Btk29ABtk family kinase at 29A0.052
ovoCG6824 gene product from transcript CG6824-RE0.051
SosSon of sevenless0.051
porporcupine0.051
inscinscuteable0.048
sqzsqueeze0.048
Ras85DRas oncogene at 85D0.048
rstroughest0.048
scwscrew0.048
panpangolin0.046
RRoughened0.045
mirrmirror0.045
Sra-1specifically Rac1-associated protein 10.044
dallydivision abnormally delayed0.044
cgcombgap0.043
Gap1GTPase-activating protein 10.042
NijANinjurin A0.041
eaeaster0.041
knknot0.040
AxnAxin0.039
Irk2Inwardly rectifying potassium channel 20.039
G-oalpha47AG protein oalpha 47A0.039
UbqnUbiquilin0.039
Vap-33-1CG5014 gene product from transcript CG5014-RB0.039
ftz-f1ftz transcription factor 10.038
krzkurtz0.037
Fak56DFocal Adhesion Kinase0.036
hbshibris0.035
snostrawberry notch0.034
auxauxillin0.034
klarklarsicht0.034
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Shhsonic hedgehog1.000
Fgfr2fibroblast growth factor receptor 21.000
Otx2orthodenticle homolog 2 (Drosophila)1.000
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)1.000
Fgf8fibroblast growth factor 81.000
Pitx2paired-like homeodomain transcription factor 21.000
Bmp4bone morphogenetic protein 41.000
Foxc1forkhead box C11.000
Gli3GLI-Kruppel family member GLI31.000
Hand1heart and neural crest derivatives expressed transcript 11.000
Vangl2vang-like 2 (van gogh, Drosophila)1.000
Pax2paired box gene 21.000
Pax3paired box gene 31.000
Fgfr1fibroblast growth factor receptor 11.000
Chd7chromodomain helicase DNA binding protein 71.000
Hand2heart and neural crest derivatives expressed transcript 21.000
Six1sine oculis-related homeobox 1 homolog (Drosophila)1.000
Sox2SRY-box containing gene 21.000
Tcfap2atranscription factor AP-2, alpha1.000
Eya1eyes absent 1 homolog (Drosophila)1.000
Ctnnb1catenin (cadherin associated protein), beta 11.000
Foxc2forkhead box C21.000
Sox9SRY-box containing gene 90.999
Dlx5distal-less homeobox 50.999
Jag1jagged 10.999
Msx1homeobox, msh-like 10.999
Prrx1paired related homeobox 10.999
Tbx1T-box 10.999
Foxg1forkhead box G10.999
Tbx3T-box 30.999
Hoxa1homeobox A10.999
Alx4aristaless-like homeobox 40.998
Chrdchordin0.997
Rargretinoic acid receptor, gamma0.997
Nodalnodal0.996
Isl1ISL1 transcription factor, LIM/homeodomain0.995
Gbx2gastrulation brain homeobox 20.992
Smosmoothened homolog (Drosophila)0.989
Tgfb2transforming growth factor, beta 20.988
Hes1hairy and enhancer of split 1 (Drosophila)0.988
Pitx1paired-like homeodomain transcription factor 10.981
Gata4GATA binding protein 40.980
Bmp7bone morphogenetic protein 70.979
Wnt3awingless-related MMTV integration site 3A0.977
Efnb2ephrin B20.975
Lrp6low density lipoprotein receptor-related protein 60.971
Acvr1activin A receptor, type 10.970
Pou5f1POU domain, class 5, transcription factor 10.960
Msx2homeobox, msh-like 20.958
Nognoggin0.957
Sox11SRY-box containing gene 110.957
Ptpn11protein tyrosine phosphatase, non-receptor type 110.950
Dvl2dishevelled 2, dsh homolog (Drosophila)0.938
Lef1lymphoid enhancer binding factor 10.927
Emx1empty spiracles homolog 1 (Drosophila)0.920
Smad4MAD homolog 4 (Drosophila)0.901
Ednraendothelin receptor type A0.897
Smad6MAD homolog 6 (Drosophila)0.886
Bmpr1abone morphogenetic protein receptor, type 1A0.884
Runx2runt related transcription factor 20.876
Fgf10fibroblast growth factor 100.868
Hoxd13homeobox D130.863
Sall4sal-like 4 (Drosophila)0.850
Apcadenomatosis polyposis coli0.847
Gli2GLI-Kruppel family member GLI20.826
Smad1MAD homolog 1 (Drosophila)0.823
Gscgoosecoid homeobox0.823
Zeb1zinc finger E-box binding homeobox 10.812
Meox2mesenchyme homeobox 20.801
Rarbretinoic acid receptor, beta0.794
Bdnfbrain derived neurotrophic factor0.786
Fgfr3fibroblast growth factor receptor 30.772
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.769
Lhx1LIM homeobox protein 10.769
Dvl3dishevelled 3, dsh homolog (Drosophila)0.754
Nf1neurofibromatosis 10.742
Prrx2paired related homeobox 20.736
Psen1presenilin 10.717
Rxraretinoid X receptor alpha0.715
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.713
Ntf3neurotrophin 30.707
Alx3aristaless-like homeobox 30.706
Gata6GATA binding protein 60.701
Wnt1wingless-related MMTV integration site 10.669
Ror2receptor tyrosine kinase-like orphan receptor 20.664
Otx1orthodenticle homolog 1 (Drosophila)0.659
Zic3zinc finger protein of the cerebellum 30.647
Pou3f3POU domain, class 3, transcription factor 30.645
Emx2empty spiracles homolog 2 (Drosophila)0.644
Six4sine oculis-related homeobox 4 homolog (Drosophila)0.635
Dll1delta-like 1 (Drosophila)0.586
Lhx3LIM homeobox protein 30.574
Alx1ALX homeobox 10.556
Hoxa3homeobox A30.545
Hoxa2homeobox A20.539
Fgf3fibroblast growth factor 30.537
Hoxa13homeobox A130.509
Pax6paired box gene 60.497
Map3k7mitogen-activated protein kinase kinase kinase 70.489
En2engrailed 20.483
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism