The network for 'mesodermal cell fate commitment' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

mesodermal cell fate commitment

The cell differentiation process that results in commitment of a cell to become part of the mesoderm.

NameDescriptionProbabilityFunc Analog Organism
FGF1fibroblast growth factor 1 (acidic)1.000
BMPR1Abone morphogenetic protein receptor, type IA1.000
PBX1pre-B-cell leukemia homeobox 10.999
BMP2bone morphogenetic protein 20.999
MEIS1Meis homeobox 10.998
FGFR1fibroblast growth factor receptor 10.990
SETD8SET domain containing (lysine methyltransferase) 80.987
FOXD3forkhead box D30.987
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.986
JAG1jagged 10.984
LRP6low density lipoprotein receptor-related protein 60.941
SMAD3SMAD family member 30.935
FGF10fibroblast growth factor 100.917
FZD1frizzled homolog 1 (Drosophila)0.914
NEDD4neural precursor cell expressed, developmentally down-regulated 40.909
SMAD2SMAD family member 20.891
NOTCH3notch 30.882
SMAD5SMAD family member 50.879
RBPJrecombination signal binding protein for immunoglobulin kappa J region0.807
WWP2WW domain containing E3 ubiquitin protein ligase 20.768
SOX2SRY (sex determining region Y)-box 20.744
HOXA10homeobox A100.688
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.671
FGF7fibroblast growth factor 70.652
MEIS2Meis homeobox 20.640
HIC1hypermethylated in cancer 10.509
SMURF1SMAD specific E3 ubiquitin protein ligase 10.483
FSTL1follistatin-like 10.466
FRS2fibroblast growth factor receptor substrate 20.461
SMAD7SMAD family member 70.400
NFIBnuclear factor I/B0.389
MAML1mastermind-like 1 (Drosophila)0.362
NEDD9neural precursor cell expressed, developmentally down-regulated 90.334
NOTCH2notch 20.301
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.291
GLIS2GLIS family zinc finger 20.279
LATlinker for activation of T cells0.271
ZFYVE9zinc finger, FYVE domain containing 90.263
FGFR2fibroblast growth factor receptor 20.262
KRT8keratin 80.255
TLE1transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)0.195
ICKintestinal cell (MAK-like) kinase0.181
HOXA5homeobox A50.180
ZMYND11zinc finger, MYND-type containing 110.165
JUPjunction plakoglobin0.160
FBXL15F-box and leucine-rich repeat protein 150.152
BBS1Bardet-Biedl syndrome 10.135
FBLN1fibulin 10.135
HOXB7homeobox B70.135
FZD8frizzled homolog 8 (Drosophila)0.125
FGF2fibroblast growth factor 2 (basic)0.124
CTGFconnective tissue growth factor0.117
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.116
DLL1delta-like 1 (Drosophila)0.116
ETS2v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)0.111
JAG2jagged 20.101
MKL2MKL/myocardin-like 20.100
BMP4bone morphogenetic protein 40.093
CREBBPCREB binding protein0.092
FOXC1forkhead box C10.088
MAST4microtubule associated serine/threonine kinase family member 40.086
NLKnemo-like kinase0.086
TNIKTRAF2 and NCK interacting kinase0.082
HOXD9homeobox D90.081
MYH10myosin, heavy chain 10, non-muscle0.080
SIX1SIX homeobox 10.079
NOSTRINnitric oxide synthase trafficker0.076
HOXA13homeobox A130.074
PSEN1presenilin 10.069
PLCG1phospholipase C, gamma 10.069
HOXA9homeobox A90.069
ARandrogen receptor0.067
FOXC2forkhead box C2 (MFH-1, mesenchyme forkhead 1)0.067
FGF8fibroblast growth factor 8 (androgen-induced)0.065
RHOBras homolog gene family, member B0.063
CTNNBIP1catenin, beta interacting protein 10.059
TCF4transcription factor 40.056
SMAD9SMAD family member 90.056
GATA5GATA binding protein 50.055
FOXF2forkhead box F20.053
FZD2frizzled homolog 2 (Drosophila)0.052
SFRP1secreted frizzled-related protein 10.050
ADARB1adenosine deaminase, RNA-specific, B10.050
SYKspleen tyrosine kinase0.049
HNF1AHNF1 homeobox A0.049
NPAS1neuronal PAS domain protein 10.045
HOXA11homeobox A110.044
SKIv-ski sarcoma viral oncogene homolog (avian)0.044
HOXB5homeobox B50.044
BTRCbeta-transducin repeat containing0.044
TP73tumor protein p730.043
BMPR1Bbone morphogenetic protein receptor, type IB0.043
FGFR3fibroblast growth factor receptor 30.043
CDH2cadherin 2, type 1, N-cadherin (neuronal)0.043
HOXB13homeobox B130.042
SIM2single-minded homolog 2 (Drosophila)0.042
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.042
HOXA7homeobox A70.040
MSX1msh homeobox 10.040
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
tbx1T-box 10.945
bmp4bone morphogenetic protein 40.859
eya1eyes absent homolog 10.857
hnf1baHNF1 homeobox Ba0.815
flhfloating head0.765
wnt4awingless-type MMTV integration site family, member 4a0.699
hoxb3ahomeo box B3a0.655
gli1GLI-Kruppel family member 10.622
wnt3wingless-type MMTV integration site family, member 30.613
fgf3fibroblast growth factor 30.549
shhasonic hedgehog a0.508
pax2apaired box gene 2a0.474
wnt2bbwingless-type MMTV integration site family, member 2Bb0.473
wnt5bwingless-type MMTV integration site family, member 5b0.472
wnt9awingless-type MMTV integration site family, member 9A0.457
hoxa2bhomeo box A2b0.441
notch3notch homolog 30.429
hoxd4ahomeo box D4a0.428
oepone-eyed pinhead0.393
bmp2bbone morphogenetic protein 2b0.383
msxcmuscle segment homeobox C0.376
dlx2adistal-less homeobox gene 2a0.356
dkk1bdickkopf 1b0.340
tbx18T-box 180.332
ndr2nodal-related 20.310
wnt3awingless-type MMTV integration site family, member 3A0.305
wnt8bwingless-type MMTV integration site family, member 8b0.300
fgf10afibroblast growth factor 10a0.289
foxi1forkhead box I10.276
her5hairy-related 50.272
six4bsine oculis homeobox homolog 4b0.269
bocbrother of CDO0.266
foxd5forkhead box D50.253
ventventral expressed homeobox0.238
hoxa3ahomeo box A3a0.231
cdx4caudal type homeo box transcription factor 40.231
dab1adisabled homolog 1a (Drosophila)0.230
mibmind bomb0.218
restRE1-silencing transcription factor0.218
zic1zic family member 1 (odd-paired homolog, Drosophila)0.216
spns2spinster homolog 2 (Drosophila)0.211
sox3SRY-box containing gene 30.210
alas2aminolevulinate, delta-, synthetase 20.195
gbx2gastrulation brain homeo box 20.195
slit3slit (Drosophila) homolog 30.193
notch1anotch homolog 1a0.190
pax8paired box gene 80.173
vedventrally expressed dharma/bozozok antagonist0.172
wif1wnt inhibitory factor 10.172
tbx5aT-box 5a0.169
wnt1wingless-type MMTV integration site family, member 10.166
hoxa11ahomeo box A11a0.164
bmpr1aabone morphogenetic protein receptor, type 1aa0.162
smosmoothened homolog (Drosophila)0.160
ephb4beph receptor B4b0.156
cyp26b1cytochrome P450, family 26, subfamily b, polypeptide 10.153
tll1tolloid-like 10.151
epha7eph receptor A70.149
neo1neogenin 10.146
foxb1.2forkhead box B1.20.145
snai1bsnail homolog 1b (Drosophila)0.139
sox2SRY-box containing gene 20.137
admpanti-dorsalizing morphogenic protein0.137
lhx5LIM homeobox 50.133
flot2aflotillin 2a0.129
wnt2wingless-type MMTV integration site family member 20.123
irx5airoquois homeobox protein 5a0.120
pcdh8protocadherin 80.116
tbx16T-box gene 160.115
gata3GATA-binding protein 30.115
hoxc6ahomeo box C6a0.112
irx1airoquois homeobox protein 1, a0.111
hoxd13ahomeo box D13a0.109
hoxb2ahomeo box B2a0.107
hmx4H6 family homeobox 40.102
mab21l2mab-21-like 20.101
spry2sprouty homolog 20.099
sox21aSRY-box containing gene 21a0.096
hhiphedgehog interacting protein0.093
bmp7abone morphogenetic protein 7a0.091
six2asine oculis-related homeobox 2a0.090
six1bsine oculis homeobox homolog 1b0.089
lhx1bLIM homeobox 1b0.088
wnt10awingless-type MMTV integration site family, member 10a0.088
plagl2pleiomorphic adenoma gene-like 20.087
hoxd11ahomeo box D11a0.084
gyltl1bglycosyltransferase-like 1b0.084
atoh1aatonal homolog 1a0.083
tp63tumor protein p630.082
bmp2abone morphogenetic protein 2a0.081
fzd10frizzled homolog 100.079
foxn4forkhead box N40.078
foxh1forkhead box H10.076
hoxb1bhomeo box B1b0.075
hmx3homeo box (H6 family) 30.074
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
slp1sloppy paired 10.719
abd-Aabdominal A0.620
stumpsCG31317 gene product from transcript CG31317-RC0.536
cicubitus interruptus0.388
Abd-BAbdominal B0.292
E(spl)Enhancer of split0.276
CG14869CG14869 gene product from transcript CG14869-RB0.116
eyaeyes absent0.099
fkhfork head0.079
zfh1Zn finger homeodomain 10.072
HLH54FCG5005 gene product from transcript CG5005-RA0.069
slp2sloppy paired 20.051
LanB2Laminin B20.050
emcextra macrochaetae0.042
zfh2Zn finger homeodomain 20.041
CG34139CG34139 gene product from transcript CG34139-RD0.039
sogshort gastrulation0.027
CG18806CG18806 gene product from transcript CG18806-RA0.025
HLHm5E(spl) region transcript m50.024
eveeven skipped0.024
lmdlame duck0.023
HmgcrHMG Coenzyme A reductase0.023
NotumCG13076 gene product from transcript CG13076-RB0.022
gcmglial cells missing0.021
NijANinjurin A0.020
Mef2Myocyte enhancer factor 20.016
bshbrain-specific homeobox0.016
EgfrEpidermal growth factor receptor0.016
opaodd paired0.015
cdicenter divider0.015
jebjelly belly0.015
Lim1CG11354 gene product from transcript CG11354-RA0.013
PoxnPox neuro0.012
ftzfushi tarazu0.012
C15CG7937 gene product from transcript CG7937-RA0.012
slmbsupernumerary limbs0.011
bibbig brain0.011
pdm2POU domain protein 20.011
fasfaint sausage0.010
zpgzero population growth0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Shhsonic hedgehog1.000
Pax2paired box gene 21.000
Fgfr2fibroblast growth factor receptor 21.000
Ctnnb1catenin (cadherin associated protein), beta 11.000
Gli3GLI-Kruppel family member GLI31.000
Fgfr1fibroblast growth factor receptor 10.999
Hoxa11homeobox A110.998
Foxc1forkhead box C10.997
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.997
Fgf8fibroblast growth factor 80.997
Bmp4bone morphogenetic protein 40.997
Pbx1pre B-cell leukemia transcription factor 10.993
Eya1eyes absent 1 homolog (Drosophila)0.990
Sox9SRY-box containing gene 90.989
Otx2orthodenticle homolog 2 (Drosophila)0.986
Hoxd11homeobox D110.984
Tbx1T-box 10.983
Isl1ISL1 transcription factor, LIM/homeodomain0.982
Pitx2paired-like homeodomain transcription factor 20.980
Hand1heart and neural crest derivatives expressed transcript 10.978
Foxc2forkhead box C20.978
Alx4aristaless-like homeobox 40.978
Vangl2vang-like 2 (van gogh, Drosophila)0.968
Dlx5distal-less homeobox 50.962
Hoxa1homeobox A10.957
Pax3paired box gene 30.954
Sox2SRY-box containing gene 20.952
Hoxd13homeobox D130.947
Hmx3H6 homeobox 30.945
Msx2homeobox, msh-like 20.924
Rargretinoic acid receptor, gamma0.916
Msx1homeobox, msh-like 10.906
Lef1lymphoid enhancer binding factor 10.901
Smad3MAD homolog 3 (Drosophila)0.899
Hoxa13homeobox A130.897
Efnb2ephrin B20.870
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.867
Hand2heart and neural crest derivatives expressed transcript 20.838
Prrx1paired related homeobox 10.820
Wnt3awingless-related MMTV integration site 3A0.810
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.808
Smad6MAD homolog 6 (Drosophila)0.791
Gdnfglial cell line derived neurotrophic factor0.782
Jag1jagged 10.776
Chd7chromodomain helicase DNA binding protein 70.771
Ntf3neurotrophin 30.759
Gli2GLI-Kruppel family member GLI20.746
Wnt4wingless-related MMTV integration site 40.722
Hoxa9homeobox A90.715
Ror2receptor tyrosine kinase-like orphan receptor 20.711
Gata4GATA binding protein 40.693
Foxd2forkhead box D20.691
Lhx1LIM homeobox protein 10.685
Tgfb2transforming growth factor, beta 20.675
Tcfap2atranscription factor AP-2, alpha0.671
Pax8paired box gene 80.670
Bmp7bone morphogenetic protein 70.661
Dkk1dickkopf homolog 1 (Xenopus laevis)0.650
Gbx2gastrulation brain homeobox 20.626
Tbx2T-box 20.598
Prrx2paired related homeobox 20.596
Meox2mesenchyme homeobox 20.572
Foxh1forkhead box H10.571
Gdf5growth differentiation factor 50.555
Hoxa2homeobox A20.555
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.520
Lmx1aLIM homeobox transcription factor 1 alpha0.516
Hes1hairy and enhancer of split 1 (Drosophila)0.513
Fgf3fibroblast growth factor 30.512
Pou3f3POU domain, class 3, transcription factor 30.510
Apcadenomatosis polyposis coli0.498
Bmpr1abone morphogenetic protein receptor, type 1A0.478
Bcl2B-cell leukemia/lymphoma 20.468
Retret proto-oncogene0.434
Sfrp2secreted frizzled-related protein 20.431
Gata3GATA binding protein 30.423
Fgfr3fibroblast growth factor receptor 30.406
Zic3zinc finger protein of the cerebellum 30.389
Igdcc3immunoglobulin superfamily, DCC subclass, member 30.376
Fgf15fibroblast growth factor 150.372
Hoxa10homeobox A100.362
Barx1BarH-like homeobox 10.322
Wnt6wingless-related MMTV integration site 60.322
Tbx15T-box 150.314
Acvr1activin A receptor, type 10.306
Foxa2forkhead box A20.301
Efna4ephrin A40.289
Sox3SRY-box containing gene 30.278
Ptenphosphatase and tensin homolog0.277
Fgf10fibroblast growth factor 100.266
Tbx6T-box 60.262
Smad4MAD homolog 4 (Drosophila)0.261
Etv4ets variant gene 4 (E1A enhancer binding protein, E1AF)0.253
Pitx3paired-like homeodomain transcription factor 30.251
Alx3aristaless-like homeobox 30.238
Zeb1zinc finger E-box binding homeobox 10.237
Psen1presenilin 10.231
Gscgoosecoid homeobox0.229
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism