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Multiple Organisms

epoxygenase p450 pathway

The chemical reactions and pathways by which arachidonic acid is converted to other compounds including epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids.

NameDescriptionProbabilityFunc Analog Organism
CYP2C9cytochrome P450, family 2, subfamily C, polypeptide 91.000
CYP2A6cytochrome P450, family 2, subfamily A, polypeptide 61.000
CYP2C19cytochrome P450, family 2, subfamily C, polypeptide 190.989
CYP4F2cytochrome P450, family 4, subfamily F, polypeptide 20.948
CYP4A11cytochrome P450, family 4, subfamily A, polypeptide 110.947
CYP3A43cytochrome P450, family 3, subfamily A, polypeptide 430.929
CYP2C18cytochrome P450, family 2, subfamily C, polypeptide 180.872
ADH6alcohol dehydrogenase 6 (class V)0.815
CYP3A4cytochrome P450, family 3, subfamily A, polypeptide 40.779
CYP4F12cytochrome P450, family 4, subfamily F, polypeptide 120.704
CYP2B6cytochrome P450, family 2, subfamily B, polypeptide 60.660
GLYATglycine-N-acyltransferase0.498
SLC10A1solute carrier family 10 (sodium/bile acid cotransporter family), member 10.498
C8Bcomplement component 8, beta polypeptide0.455
MAT1Amethionine adenosyltransferase I, alpha0.414
SULT1B1sulfotransferase family, cytosolic, 1B, member 10.404
CYP4F3cytochrome P450, family 4, subfamily F, polypeptide 30.380
CYP3A5cytochrome P450, family 3, subfamily A, polypeptide 50.342
C8Acomplement component 8, alpha polypeptide0.324
C6complement component 60.293
OTCornithine carbamoyltransferase0.262
FETUBfetuin B0.259
AGXT2alanine--glyoxylate aminotransferase 20.243
CYP2D6cytochrome P450, family 2, subfamily D, polypeptide 60.243
ALDOBaldolase B, fructose-bisphosphate0.228
NAT2N-acetyltransferase 2 (arylamine N-acetyltransferase)0.223
HRGhistidine-rich glycoprotein0.218
FMO4flavin containing monooxygenase 40.209
G6PCglucose-6-phosphatase, catalytic subunit0.201
CYP1A2cytochrome P450, family 1, subfamily A, polypeptide 20.200
CFHR4complement factor H-related 40.195
CYP2A7cytochrome P450, family 2, subfamily A, polypeptide 70.193
DAOD-amino-acid oxidase0.184
F9coagulation factor IX0.157
AADACarylacetamide deacetylase (esterase)0.153
HALhistidine ammonia-lyase0.130
ABCC2ATP-binding cassette, sub-family C (CFTR/MRP), member 20.125
KNG1kininogen 10.125
CYP2C8cytochrome P450, family 2, subfamily C, polypeptide 80.124
CYP2E1cytochrome P450, family 2, subfamily E, polypeptide 10.120
SULT2A1sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 10.116
HMGCS23-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)0.114
CYP3A7cytochrome P450, family 3, subfamily A, polypeptide 70.112
GPLD1glycosylphosphatidylinositol specific phospholipase D10.107
GBA3glucosidase, beta, acid 3 (cytosolic)0.097
GSTA3glutathione S-transferase alpha 30.094
C4BPAcomplement component 4 binding protein, alpha0.092
LAMC3laminin, gamma 30.092
BHMTbetaine--homocysteine S-methyltransferase0.092
CYP4F11cytochrome P450, family 4, subfamily F, polypeptide 110.091
UGT1A3UDP glucuronosyltransferase 1 family, polypeptide A30.086
PLGplasminogen0.083
SERPINC1serpin peptidase inhibitor, clade C (antithrombin), member 10.081
CA5Acarbonic anhydrase VA, mitochondrial0.081
FUT6fucosyltransferase 6 (alpha (1,3) fucosyltransferase)0.077
PFKFB16-phosphofructo-2-kinase/fructose-2,6-biphosphatase 10.072
AKR1C4aldo-keto reductase family 1, member C4 (chlordecone reductase; 3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol dehydrogenase 4)0.071
F13Bcoagulation factor XIII, B polypeptide0.071
DIO1deiodinase, iodothyronine, type I0.068
ITIH4inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein)0.067
HPXhemopexin0.061
APCSamyloid P component, serum0.060
HAO1hydroxyacid oxidase (glycolate oxidase) 10.060
HPD4-hydroxyphenylpyruvate dioxygenase0.059
SLC2A2solute carrier family 2 (facilitated glucose transporter), member 20.058
MASP2mannan-binding lectin serine peptidase 20.057
ADRA1Aadrenergic, alpha-1A-, receptor0.057
RDH16retinol dehydrogenase 16 (all-trans)0.056
DNASE1L3deoxyribonuclease I-like 30.055
UGT2B15UDP glucuronosyltransferase 2 family, polypeptide B150.055
ABCB11ATP-binding cassette, sub-family B (MDR/TAP), member 110.053
CNGA1cyclic nucleotide gated channel alpha 10.052
XDHxanthine dehydrogenase0.051
HGDhomogentisate 1,2-dioxygenase0.050
SLC22A1solute carrier family 22 (organic cation transporter), member 10.049
DPYSdihydropyrimidinase0.046
MTTPmicrosomal triglyceride transfer protein0.046
APOC3apolipoprotein C-III0.045
SULT1E1sulfotransferase family 1E, estrogen-preferring, member 10.045
TTPAtocopherol (alpha) transfer protein0.044
ARG1arginase, liver0.043
LECT2leukocyte cell-derived chemotaxin 20.043
ADH1Calcohol dehydrogenase 1C (class I), gamma polypeptide0.042
AKR1D1aldo-keto reductase family 1, member D1 (delta 4-3-ketosteroid-5-beta-reductase)0.041
SERPINA6serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 60.041
PAHphenylalanine hydroxylase0.041
KRT4keratin 40.040
BAATbile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)0.040
CYP1A1cytochrome P450, family 1, subfamily A, polypeptide 10.040
LPAlipoprotein, Lp(a)0.039
ANXA10annexin A100.039
FABP1fatty acid binding protein 1, liver0.039
SLC28A1solute carrier family 28 (sodium-coupled nucleoside transporter), member 10.038
ADH4alcohol dehydrogenase 4 (class II), pi polypeptide0.037
PCK1phosphoenolpyruvate carboxykinase 1 (soluble)0.037
MEP1Bmeprin A, beta0.037
CCL16chemokine (C-C motif) ligand 160.037
APOC4apolipoprotein C-IV0.037
NR1I2nuclear receptor subfamily 1, group I, member 20.037
UGT1A1UDP glucuronosyltransferase 1 family, polypeptide A10.037
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Cyp2b1cytochrome P450, family 2, subfamily b, polypeptide 10.941
Cyp2d2cytochrome P450, family 2, subfamily d, polypeptide 20.874
Abcc6ATP-binding cassette, subfamily C (CFTR/MRP), member 60.854
Cyp2d3cytochrome P450, family 2, subfamily d, polypeptide 30.781
Ugt2bUDP glycosyltransferase 2 family, polypeptide B0.755
Cyp2c13cytochrome P450, family 2, subfamily c, polypeptide 130.684
Cyp2a1cytochrome P450, family 2, subfamily a, polypeptide 10.672
Cyp2b2cytochrome P450, family 2, subfamily b, polypeptide 20.666
Sult1c3sulfotransferase family, cytosolic, 1C, member 30.612
Cyp3a23/3a1cytochrome P450, family 3, subfamily a, polypeptide 23/polypeptide 10.581
Cyp7a1cytochrome P450, family 7, subfamily a, polypeptide 10.487
Cyp2b3cytochrome P450, family 2, subfamily b, polypeptide 30.454
Akr1c18aldo-keto reductase family 1, member C180.451
Cyp1a2cytochrome P450, family 1, subfamily a, polypeptide 20.409
Dpysdihydropyrimidinase0.388
Cyp4a10cytochrome P450, family 4, subfamily a, polypeptide 100.330
A1i3alpha-1-inhibitor III0.325
Apobapolipoprotein B0.259
Sult1e1sulfotransferase family 1E, estrogen-preferring, member 10.209
Cyp3a2cytochrome P450, family 3, subfamily a, polypeptide 20.208
Azgp1alpha-2-glycoprotein 1, zinc-binding0.206
Hsd17b6hydroxysteroid (17-beta) dehydrogenase 60.203
Cyp3a18cytochrome P450, family 3, subfamily a, polypeptide 180.188
Trhr2thyrotropin releasing hormone receptor 20.187
Cyp4f1cytochrome P450, family 4, subfamily f, polypeptide 10.179
Cyp4a8cytochrome P450, family 4, subfamily a, polypeptide 80.172
Slc22a7solute carrier family 22 (organic anion transporter), member 70.169
Sult1c2sulfotransferase family, cytosolic, 1C, member 20.162
Sult1b1sulfotransferase family, cytosolic, 1B, member 10.152
Cyp4f4cytochrome P450, family 4, subfamily f, polypeptide 40.142
Mettl7bmethyltransferase like 7B0.141
Cyp2c22cytochrome P450, family 2, subfamily c, polypeptide 220.140
LOC494499LOC494499 protein0.138
Haao3-hydroxyanthranilate 3,4-dioxygenase0.126
Cyp2e1cytochrome P450, family 2, subfamily e, polypeptide 10.122
Ugt2b1UDP glucuronosyltransferase 2 family, polypeptide B10.121
Mosc1MOCO sulphurase C-terminal domain containing 10.113
Cyp1a1cytochrome P450, family 1, subfamily a, polypeptide 10.102
Gnmtglycine N-methyltransferase0.101
Cyp2b15cytochrome P450, family 2, subfamily b, polypeptide 150.100
Abcb11ATP-binding cassette, subfamily B (MDR/TAP), member 110.097
Cyp2d4cytochrome P450, family 2, subfamily d, polypeptide 40.095
Crygfcrystallin, gamma F0.095
Gckrglucokinase (hexokinase 4) regulator0.089
Cyp4a2cytochrome P450, family 4, subfamily a, polypeptide 20.087
Ugt2b5UDP glucuronosyltransferase 2 family, polypeptide B50.086
Serpina3kserine (or cysteine) peptidase inhibitor, clade A, member 3K0.080
Olr1701olfactory receptor 17010.074
G6pcglucose-6-phosphatase, catalytic subunit0.073
Slc23a1solute carrier family 23 (nucleobase transporters), member 10.072
Ces1ecarboxylesterase 1E0.066
Cyp2f4cytochrome P450, family 2, subfamily f, polypeptide 40.058
Ces1ccarboxylesterase 1C0.057
LOC100365112carboxylesterase-like0.056
Colqcollagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase0.054
LOC299282Serine protease inhibitor0.053
Cyp2c23cytochrome P450, family 2, subfamily c, polypeptide 230.052
Adh1alcohol dehydrogenase 1 (class I)0.049
Otcornithine carbamoyltransferase0.047
Kmokynurenine 3-monooxygenase (kynurenine 3-hydroxylase)0.047
Slco1a4solute carrier organic anion transporter family, member 1a40.046
Serpina1serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10.045
Pacs1phosphofurin acidic cluster sorting protein 10.045
Pck1phosphoenolpyruvate carboxykinase 1 (soluble)0.044
Olr59olfactory receptor 590.044
Slc10a1solute carrier family 10 (sodium/bile acid cotransporter family), member 10.040
Pigrpolymeric immunoglobulin receptor0.039
Dhfrdihydrofolate reductase0.037
Gsta5glutathione S-transferase Yc2 subunit0.037
Cyp11a1cytochrome P450, family 11, subfamily a, polypeptide 10.036
Fgbfibrinogen beta chain0.035
Hsd3b5hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 50.034
Cps1carbamoyl-phosphate synthetase 10.034
Gsta2glutathione S-transferase A20.032
Nr0b2nuclear receptor subfamily 0, group B, member 20.031
Kcnj1potassium inwardly-rectifying channel, subfamily J, member 10.031
Khkketohexokinase0.030
Ugt2b37UDP-glucuronosyltransferase 2 family, member 370.030
Apoa2apolipoprotein A-II0.029
Hpd4-hydroxyphenylpyruvate dioxygenase0.028
Klkb1kallikrein B, plasma 10.028
Ahsgalpha-2-HS-glycoprotein0.027
Inmtindolethylamine N-methyltransferase0.027
Rxrgretinoid X receptor gamma0.027
Car5acarbonic anhydrase 5a, mitochondrial0.026
Mbl2mannose-binding lectin (protein C) 20.024
Cyp27b1cytochrome P450, family 27, subfamily b, polypeptide 10.023
Fgfr4fibroblast growth factor receptor 40.023
Fdxrferredoxin reductase0.023
L3mbtl3l(3)mbt-like 3 (Drosophila)0.023
Cnga3cyclic nucleotide gated channel alpha 30.022
Cyp4f6cytochrome P450, family 4, subfamily f, polypeptide 60.022
Cyp4b1cytochrome P450, family 4, subfamily b, polypeptide 10.022
Plgplasminogen0.021
LOC100361864UDP-glucuronosyltransferase 2B3-like0.020
RT1-M5RT1 class Ib, locus M50.020
Gabrr2gamma-aminobutyric acid (GABA) receptor, rho 20.020
Slco1b3solute carrier organic anion transporter family, member 1b30.019
Sval2seminal vesicle antigen-like 20.019
Grb7growth factor receptor bound protein 70.019
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism