The network for 'interleukin 6 production' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

interleukin 6 production

The appearance of interleukin-6 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

NameDescriptionProbabilityFunc Analog Organism
IRAK2interleukin-1 receptor-associated kinase 21.000
MYD88myeloid differentiation primary response gene (88)1.000
IRAK1interleukin-1 receptor-associated kinase 10.997
TRAF6TNF receptor-associated factor 60.993
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.985
TNFAIP3tumor necrosis factor, alpha-induced protein 30.977
RIPK2receptor-interacting serine-threonine kinase 20.874
IL1R1interleukin 1 receptor, type I0.853
MAP2K4mitogen-activated protein kinase kinase 40.844
BIRC3baculoviral IAP repeat containing 30.728
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.707
TICAM2toll-like receptor adaptor molecule 20.687
NLRC4NLR family, CARD domain containing 40.681
TLR2toll-like receptor 20.600
MAPK14mitogen-activated protein kinase 140.509
IL6interleukin 6 (interferon, beta 2)0.469
IL8interleukin 80.464
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.458
LAMP1lysosomal-associated membrane protein 10.447
TLR4toll-like receptor 40.443
TRAF1TNF receptor-associated factor 10.396
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.384
ARRB1arrestin, beta 10.364
CXCL2chemokine (C-X-C motif) ligand 20.332
IRAK3interleukin-1 receptor-associated kinase 30.330
ZNF496zinc finger protein 4960.316
IL10RAinterleukin 10 receptor, alpha0.291
SNTA1syntrophin, alpha 1 (dystrophin-associated protein A1, 59kDa, acidic component)0.289
SOD2superoxide dismutase 2, mitochondrial0.271
TRADDTNFRSF1A-associated via death domain0.271
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.260
IL22RA2interleukin 22 receptor, alpha 20.246
IL6Rinterleukin 6 receptor0.236
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.233
HLA-Amajor histocompatibility complex, class I, A0.220
MAFAv-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)0.212
ZC3H12Azinc finger CCCH-type containing 12A0.211
GATA2GATA binding protein 20.205
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.180
CD14CD14 molecule0.168
HLA-Cmajor histocompatibility complex, class I, C0.166
CCL20chemokine (C-C motif) ligand 200.164
SOCS3suppressor of cytokine signaling 30.158
CPNE6copine VI (neuronal)0.142
JUNjun proto-oncogene0.137
TNFRSF1Atumor necrosis factor receptor superfamily, member 1A0.137
TRAF2TNF receptor-associated factor 20.135
FZD1frizzled homolog 1 (Drosophila)0.134
CEBPDCCAAT/enhancer binding protein (C/EBP), delta0.134
TNFtumor necrosis factor0.132
TNFRSF1Btumor necrosis factor receptor superfamily, member 1B0.132
PELI3pellino homolog 3 (Drosophila)0.130
SETD8SET domain containing (lysine methyltransferase) 80.129
IL1Binterleukin 1, beta0.128
CXCL3chemokine (C-X-C motif) ligand 30.122
IL1RAPinterleukin 1 receptor accessory protein0.121
SMAD3SMAD family member 30.119
HSP90AA1heat shock protein 90kDa alpha (cytosolic), class A member 10.105
LAPTM5lysosomal protein transmembrane 50.101
TRAF3TNF receptor-associated factor 30.099
HLA-Gmajor histocompatibility complex, class I, G0.098
B2Mbeta-2-microglobulin0.094
AXLAXL receptor tyrosine kinase0.091
BIRC2baculoviral IAP repeat containing 20.088
MEFVMediterranean fever0.087
HLA-Fmajor histocompatibility complex, class I, F0.084
HSPB1heat shock 27kDa protein 10.079
IRAK4interleukin-1 receptor-associated kinase 40.077
PYDC2pyrin domain containing 20.076
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.075
C19orf50chromosome 19 open reading frame 500.071
UBASH3Bubiquitin associated and SH3 domain containing B0.070
SYKspleen tyrosine kinase0.064
HSF1heat shock transcription factor 10.064
MARK2MAP/microtubule affinity-regulating kinase 20.063
NOD2nucleotide-binding oligomerization domain containing 20.063
IL22RA1interleukin 22 receptor, alpha 10.063
IRF7interferon regulatory factor 70.059
TOLLIPtoll interacting protein0.058
HDAC9histone deacetylase 90.057
IL4Rinterleukin 4 receptor0.056
HLA-Emajor histocompatibility complex, class I, E0.056
GNMTglycine N-methyltransferase0.056
LILRB1leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 10.055
JAK1Janus kinase 10.055
IL1RNinterleukin 1 receptor antagonist0.054
MAPKAPK3mitogen-activated protein kinase-activated protein kinase 30.054
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.053
SQSTM1sequestosome 10.053
ICAM1intercellular adhesion molecule 10.052
TAB1TGF-beta activated kinase 1/MAP3K7 binding protein 10.052
TCF12transcription factor 120.051
PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)0.049
IL6STinterleukin 6 signal transducer (gp130, oncostatin M receptor)0.048
LYNv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.047
TRIM34tripartite motif containing 340.046
DUSP1dual specificity phosphatase 10.045
EPORerythropoietin receptor0.044
FCGR2BFc fragment of IgG, low affinity IIb, receptor (CD32)0.043
MYH9myosin, heavy chain 9, non-muscle0.041
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Tnftumor necrosis factor0.999
Myd88myeloid differentiation primary response gene 880.982
Tlr4toll-like receptor 40.948
Traf6TNF receptor-associated factor 60.945
Cd44CD44 antigen0.941
Il1r1interleukin 1 receptor, type I0.897
Casp4caspase 4, apoptosis-related cysteine peptidase0.882
Nlrp3NLR family, pyrin domain containing 30.870
Il10interleukin 100.860
Lyz2lysozyme 20.828
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.802
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.754
Map3k14mitogen-activated protein kinase kinase kinase 140.718
Ikzf1IKAROS family zinc finger 10.687
Ifnginterferon gamma0.614
Arrb2arrestin, beta 20.547
Chrna3cholinergic receptor, nicotinic, alpha polypeptide 30.527
Irak4interleukin-1 receptor-associated kinase 40.512
Otx2orthodenticle homolog 2 (Drosophila)0.508
Map3k7mitogen-activated protein kinase kinase kinase 70.455
Cd40CD40 antigen0.453
Lifleukemia inhibitory factor0.427
Inpp5dinositol polyphosphate-5-phosphatase D0.410
Tnfrsf9tumor necrosis factor receptor superfamily, member 90.407
Il4interleukin 40.403
Tnfrsf11atumor necrosis factor receptor superfamily, member 11a0.378
Ccl2chemokine (C-C motif) ligand 20.370
Map3k8mitogen-activated protein kinase kinase kinase 80.308
Stat3signal transducer and activator of transcription 30.298
Lhx1LIM homeobox protein 10.292
Pax2paired box gene 20.283
Arrb1arrestin, beta 10.259
Trim30dtripartite motif-containing 30D0.230
FgrGardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog0.213
Tnfaip3tumor necrosis factor, alpha-induced protein 30.213
Birc3baculoviral IAP repeat-containing 30.212
Gli2GLI-Kruppel family member GLI20.208
Hcsthematopoietic cell signal transducer0.208
Ifnar1interferon (alpha and beta) receptor 10.206
Pik3ap1phosphoinositide-3-kinase adaptor protein 10.203
Gdnfglial cell line derived neurotrophic factor0.199
Prf1perforin 1 (pore forming protein)0.198
Ikbkginhibitor of kappaB kinase gamma0.182
TcraT-cell receptor alpha chain0.177
Nos2nitric oxide synthase 2, inducible0.176
Il6interleukin 60.174
Hspa5heat shock protein 50.172
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.171
Emx2empty spiracles homolog 2 (Drosophila)0.171
Socs1suppressor of cytokine signaling 10.167
Pax6paired box gene 60.162
Gpr132G protein-coupled receptor 1320.162
Il11interleukin 110.159
MefvMediterranean fever0.158
FasFas (TNF receptor superfamily member 6)0.155
Il2interleukin 20.145
Ccl4chemokine (C-C motif) ligand 40.142
Relreticuloendotheliosis oncogene0.141
Foxn1forkhead box N10.141
Rargretinoic acid receptor, gamma0.139
Chrnb4cholinergic receptor, nicotinic, beta polypeptide 40.130
Wt1Wilms tumor 1 homolog0.124
Ltbrlymphotoxin B receptor0.123
Il1rninterleukin 1 receptor antagonist0.122
Lhx3LIM homeobox protein 30.122
Ltalymphotoxin A0.121
Traf2TNF receptor-associated factor 20.107
Cd33CD33 antigen0.101
Il2rginterleukin 2 receptor, gamma chain0.094
Stat5bsignal transducer and activator of transcription 5B0.093
Mmp8matrix metallopeptidase 80.092
Il22interleukin 220.092
Gfra1glial cell line derived neurotrophic factor family receptor alpha 10.090
Ptgirprostaglandin I receptor (IP)0.090
Nfam1Nfat activating molecule with ITAM motif 10.090
Emx1empty spiracles homolog 1 (Drosophila)0.089
Mmp9matrix metallopeptidase 90.089
Pitx2paired-like homeodomain transcription factor 20.088
Casp1caspase 10.087
Rag2recombination activating gene 20.087
Asprv1aspartic peptidase, retroviral-like 10.087
Dok1docking protein 10.082
Cd19CD19 antigen0.082
Dkk1dickkopf homolog 1 (Xenopus laevis)0.081
CblbCasitas B-lineage lymphoma b0.081
Itgalintegrin alpha L0.080
Nodalnodal0.080
Il1f9interleukin 1 family, member 90.079
Snai1snail homolog 1 (Drosophila)0.078
Mavsmitochondrial antiviral signaling protein0.077
Gp1baglycoprotein 1b, alpha polypeptide0.076
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.075
BtkBruton agammaglobulinemia tyrosine kinase0.075
Fgf8fibroblast growth factor 80.075
Trim12atripartite motif-containing 12A0.075
C78513EST C785130.075
Klrb1bkiller cell lectin-like receptor subfamily B member 1B0.074
Trem3triggering receptor expressed on myeloid cells 30.074
Il1rl1interleukin 1 receptor-like 10.074
Tbk1TANK-binding kinase 10.073
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Zfp36zinc finger protein 360.147
Casp12caspase 120.112
Icam1intercellular adhesion molecule 10.058
Fosl2fos-like antigen 20.058
Npffr2neuropeptide FF receptor 20.056
Cycscytochrome c, somatic0.054
Hspe1heat shock protein 1 (chaperonin 10)0.053
Errfi1ERBB receptor feedback inhibitor 10.052
Sox17SRY (sex determining region Y)-box 170.049
Dusp1dual specificity phosphatase 10.048
Cxcl1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.045
Ccl4chemokine (C-C motif) ligand 40.044
Cx3cr1chemokine (C-X3-C motif) receptor 10.043
Fgfr2fibroblast growth factor receptor 20.041
Adora2aadenosine A2a receptor0.039
Cxcl2chemokine (C-X-C motif) ligand 20.036
Grm6glutamate receptor, metabotropic 60.033
Irak3interleukin-1 receptor-associated kinase 30.032
JunJun oncogene0.032
Slc14a2solute carrier family 14 (urea transporter), member 20.032
Gzmkgranzyme K0.031
Mcpt3mast cell peptidase 30.030
Ptafrplatelet-activating factor receptor0.029
Plaurplasminogen activator, urokinase receptor0.029
Slc25a5solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 50.029
C5ar1complement component 5a receptor 10.029
Serpine1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.028
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.027
Junbjun B proto-oncogene0.026
Alox5arachidonate 5-lipoxygenase0.026
Atp2a3ATPase, Ca++ transporting, ubiquitous0.025
Ccl3chemokine (C-C motif) ligand 30.024
Csf1colony stimulating factor 1 (macrophage)0.024
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.024
FaslgFas ligand (TNF superfamily, member 6)0.023
Ripk1receptor (TNFRSF)-interacting serine-threonine kinase 10.023
Shc1SHC (Src homology 2 domain containing) transforming protein 10.023
Slc13a2solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 20.023
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.023
FgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.022
Cxcl6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.021
Sh2b3SH2B adaptor protein 30.021
Lpllipoprotein lipase0.020
Ms4a2membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)0.020
Cacng5calcium channel, voltage-dependent, gamma subunit 50.019
Glis2GLIS family zinc finger 20.019
Ptger2prostaglandin E receptor 2 (subtype EP2)0.019
LOC24906RoBo-10.019
Itpr2inositol 1,4,5-triphosphate receptor, type 20.019
Crhr1corticotropin releasing hormone receptor 10.019
Myd88myeloid differentiation primary response gene 880.019
Rhbdl1rhomboid, veinlet-like 1 (Drosophila)0.019
Aqp5aquaporin 50.018
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.018
Olr416olfactory receptor 4160.018
Ier2immediate early response 20.018
Chrna7cholinergic receptor, nicotinic, alpha 70.018
Ier3immediate early response 30.017
Socs3suppressor of cytokine signaling 30.017
Ghrgrowth hormone receptor0.017
Cntn1contactin 10.017
Stat3signal transducer and activator of transcription 30.017
Plscr1phospholipid scramblase 10.016
Ptprz1protein tyrosine phosphatase, receptor-type, Z polypeptide 10.016
Ppyr1pancreatic polypeptide receptor 10.016
Il6interleukin 60.016
Hand1heart and neural crest derivatives expressed 10.016
HhipHedgehog-interacting protein0.016
Steap4STEAP family member 40.015
LOC100360403ATP-binding cassette, sub-family C, member 9-like0.015
Slc25a24solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 240.015
Gja4gap junction protein, alpha 40.015
Ltbrlymphotoxin beta receptor (TNFR superfamily, member 3)0.015
Dok1docking protein 10.015
Kcng3potassium voltage-gated channel, subfamily G, member 30.015
Gfpt1glutamine fructose-6-phosphate transaminase 10.015
NrarpNotch-regulated ankyrin repeat protein0.015
Hlfhepatic leukemia factor0.015
Mmp12matrix metallopeptidase 120.014
Cyp27b1cytochrome P450, family 27, subfamily b, polypeptide 10.014
Kcnj4potassium inwardly-rectifying channel, subfamily J, member 40.014
Ece1endothelin converting enzyme 10.014
Scn4asodium channel, voltage-gated, type IV, alpha subunit0.013
Serpina3nserine (or cysteine) peptidase inhibitor, clade A, member 3N0.013
Zfp36l1zinc finger protein 36, C3H type-like 10.013
Phkg1phosphorylase kinase, gamma 10.013
Ciitaclass II, major histocompatibility complex, transactivator0.013
Unc93b1unc-93 homolog B1 (C. elegans)0.013
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.013
Chrm2cholinergic receptor, muscarinic 20.013
Acrv1acrosomal vesicle protein 10.013
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.013
RGD1561143similar to cell surface receptor FDFACT0.013
Klf4Kruppel-like factor 4 (gut)0.013
Fgbfibrinogen beta chain0.012
Rhobras homolog gene family, member B0.012
Abcg1ATP-binding cassette, subfamily G (WHITE), member 10.012
Tnfsf4tumor necrosis factor (ligand) superfamily, member 40.012
Il4interleukin 40.012
Atf3activating transcription factor 30.012
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism