The network for 'interleukin 8 production' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

interleukin 8 production

The appearance of interleukin-8 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

NameDescriptionProbabilityFunc Analog Organism
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.995
RIPK2receptor-interacting serine-threonine kinase 20.986
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.973
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.966
BIRC3baculoviral IAP repeat containing 30.950
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.918
MYD88myeloid differentiation primary response gene (88)0.914
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.908
C1QAcomplement component 1, q subcomponent, A chain0.876
MAP3K3mitogen-activated protein kinase kinase kinase 30.758
RELv-rel reticuloendotheliosis viral oncogene homolog (avian)0.728
RELBv-rel reticuloendotheliosis viral oncogene homolog B0.605
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.503
IL1R1interleukin 1 receptor, type I0.502
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.402
PLAUplasminogen activator, urokinase0.375
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.371
NLRC4NLR family, CARD domain containing 40.366
DLG1discs, large homolog 1 (Drosophila)0.336
ABI2abl-interactor 20.302
ANXA1annexin A10.284
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.231
CARD11caspase recruitment domain family, member 110.220
S100A10S100 calcium binding protein A100.212
VIMvimentin0.211
CRPC-reactive protein, pentraxin-related0.209
TNIP2TNFAIP3 interacting protein 20.209
CEBPGCCAAT/enhancer binding protein (C/EBP), gamma0.190
C1QCcomplement component 1, q subcomponent, C chain0.169
ZNF496zinc finger protein 4960.161
FCN2ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin)0.154
CASP8caspase 8, apoptosis-related cysteine peptidase0.132
C1QBcomplement component 1, q subcomponent, B chain0.130
TNFRSF1Atumor necrosis factor receptor superfamily, member 1A0.130
RHOAras homolog gene family, member A0.127
MAP3K8mitogen-activated protein kinase kinase kinase 80.125
SLMAPsarcolemma associated protein0.123
FASFas (TNF receptor superfamily, member 6)0.118
MAD2L2MAD2 mitotic arrest deficient-like 2 (yeast)0.116
KLF6Kruppel-like factor 60.115
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.111
ARRB1arrestin, beta 10.106
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.103
PPP1R15Aprotein phosphatase 1, regulatory (inhibitor) subunit 15A0.096
TNFAIP3tumor necrosis factor, alpha-induced protein 30.088
ITGB5integrin, beta 50.088
MEFVMediterranean fever0.087
BMPR1Bbone morphogenetic protein receptor, type IB0.085
C9orf89chromosome 9 open reading frame 890.078
IRAK1interleukin-1 receptor-associated kinase 10.078
BCL3B-cell CLL/lymphoma 30.073
DUSP1dual specificity phosphatase 10.073
MPOmyeloperoxidase0.072
SH3D19SH3 domain containing 190.071
TNIP1TNFAIP3 interacting protein 10.070
ACTG1actin, gamma 10.066
PYDC2pyrin domain containing 20.061
TRADDTNFRSF1A-associated via death domain0.061
TNFRSF1Btumor necrosis factor receptor superfamily, member 1B0.061
GOLGA2golgin A20.061
EMP1epithelial membrane protein 10.061
TSC22D4TSC22 domain family, member 40.059
MAP3K2mitogen-activated protein kinase kinase kinase 20.058
NLRP3NLR family, pyrin domain containing 30.057
S100A11S100 calcium binding protein A110.057
MARCOmacrophage receptor with collagenous structure0.055
TRAF1TNF receptor-associated factor 10.055
NFKBIEnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon0.055
TLR4toll-like receptor 40.054
DBPD site of albumin promoter (albumin D-box) binding protein0.054
JUNjun proto-oncogene0.054
KLF4Kruppel-like factor 4 (gut)0.052
TLR2toll-like receptor 20.051
TRAF6TNF receptor-associated factor 60.050
S100A9S100 calcium binding protein A90.048
CFLARCASP8 and FADD-like apoptosis regulator0.048
ASAP1ArfGAP with SH3 domain, ankyrin repeat and PH domain 10.046
ANXA4annexin A40.045
IKBKEinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon0.045
HDAC7histone deacetylase 70.045
IL1R2interleukin 1 receptor, type II0.044
BCL2A1BCL2-related protein A10.042
ORM1orosomucoid 10.042
CFL1cofilin 1 (non-muscle)0.041
GNMTglycine N-methyltransferase0.041
CYBBcytochrome b-245, beta polypeptide0.040
IFNGR1interferon gamma receptor 10.038
CD14CD14 molecule0.037
CASP10caspase 10, apoptosis-related cysteine peptidase0.037
SQSTM1sequestosome 10.037
NFKBIBnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta0.037
IGSF6immunoglobulin superfamily, member 60.036
CAMPcathelicidin antimicrobial peptide0.036
IRAK2interleukin-1 receptor-associated kinase 20.036
SMAD3SMAD family member 30.035
BIRC2baculoviral IAP repeat containing 20.035
SLC15A3solute carrier family 15, member 30.035
PTAFRplatelet-activating factor receptor0.035
SPRR2Asmall proline-rich protein 2A0.034
ATF3activating transcription factor 30.033
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Myd88myeloid differentiation primary response gene 880.994
Casp4caspase 4, apoptosis-related cysteine peptidase0.983
Casp1caspase 10.935
Ticam1toll-like receptor adaptor molecule 10.811
Lhx1LIM homeobox protein 10.677
Map3k8mitogen-activated protein kinase kinase kinase 80.596
Dkk1dickkopf homolog 1 (Xenopus laevis)0.570
Tlr2toll-like receptor 20.569
Nlrp3NLR family, pyrin domain containing 30.542
Dact1dapper homolog 1, antagonist of beta-catenin (xenopus)0.469
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.456
Gbp5guanylate binding protein 50.435
Cyldcylindromatosis (turban tumor syndrome)0.401
Cd14CD14 antigen0.373
Traf3TNF receptor-associated factor 30.303
Arrb2arrestin, beta 20.295
Pik3ap1phosphoinositide-3-kinase adaptor protein 10.289
Dysfdysferlin0.273
Otx1orthodenticle homolog 1 (Drosophila)0.264
Map3k3mitogen-activated protein kinase kinase kinase 30.248
Tlr4toll-like receptor 40.242
Socs3suppressor of cytokine signaling 30.233
Pax8paired box gene 80.207
Casp8caspase 80.203
Slc34a2solute carrier family 34 (sodium phosphate), member 20.196
Tbrachyury0.188
LitafLPS-induced TN factor0.178
Klf2Kruppel-like factor 2 (lung)0.170
Hif1ahypoxia inducible factor 1, alpha subunit0.170
Anxa3annexin A30.166
Sftpbsurfactant associated protein B0.164
Fzd8frizzled homolog 8 (Drosophila)0.162
Tnftumor necrosis factor0.155
Fzd10frizzled homolog 10 (Drosophila)0.153
Cyp26a1cytochrome P450, family 26, subfamily a, polypeptide 10.152
Wnt3awingless-related MMTV integration site 3A0.152
Ikbkginhibitor of kappaB kinase gamma0.151
Klf6Kruppel-like factor 60.150
Treml1triggering receptor expressed on myeloid cells-like 10.146
Mmp8matrix metallopeptidase 80.143
Cd44CD44 antigen0.137
Tnfaip3tumor necrosis factor, alpha-induced protein 30.137
Ripk1receptor (TNFRSF)-interacting serine-threonine kinase 10.136
Socs1suppressor of cytokine signaling 10.134
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.134
Acanaggrecan0.129
Asprv1aspartic peptidase, retroviral-like 10.129
Porcnporcupine homolog (Drosophila)0.121
Emx2empty spiracles homolog 2 (Drosophila)0.119
Pax2paired box gene 20.116
Cxcl1chemokine (C-X-C motif) ligand 10.116
Atf3activating transcription factor 30.115
3110079O15RikRIKEN cDNA 3110079O15 gene0.114
Il1r1interleukin 1 receptor, type I0.113
Nupr1nuclear protein 10.112
Ageradvanced glycosylation end product-specific receptor0.112
Osmroncostatin M receptor0.112
Wnt10awingless related MMTV integration site 10a0.111
Anxa2annexin A20.111
Plaurplasminogen activator, urokinase receptor0.111
Fut7fucosyltransferase 70.111
Trp73transformation related protein 730.109
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.108
Il1ainterleukin 1 alpha0.108
Wnt10bwingless related MMTV integration site 10b0.107
Lgals3lectin, galactose binding, soluble 30.105
Itgb2lintegrin beta 2-like0.102
Lcn2lipocalin 20.099
Rargretinoic acid receptor, gamma0.098
Il18interleukin 180.097
Ms4a3membrane-spanning 4-domains, subfamily A, member 30.097
Itchitchy, E3 ubiquitin protein ligase0.096
Foxn4forkhead box N40.095
Slpisecretory leukocyte peptidase inhibitor0.094
MgmtO-6-methylguanine-DNA methyltransferase0.093
Pou3f1POU domain, class 3, transcription factor 10.092
Fgf18fibroblast growth factor 180.092
FasFas (TNF receptor superfamily member 6)0.091
5830411N06RikRIKEN cDNA 5830411N06 gene0.090
CebpdCCAAT/enhancer binding protein (C/EBP), delta0.089
Amhanti-Mullerian hormone0.089
Foxa2forkhead box A20.089
Fgf8fibroblast growth factor 80.089
Foxl2forkhead box L20.089
Ngpneutrophilic granule protein0.088
Traf2TNF receptor-associated factor 20.087
Il13ra1interleukin 13 receptor, alpha 10.086
Dync1h1dynein cytoplasmic 1 heavy chain 10.086
Klf3Kruppel-like factor 3 (basic)0.086
Klklotho0.083
Krt86keratin 860.083
Wnt5bwingless-related MMTV integration site 5B0.082
NoboxNOBOX oogenesis homeobox0.082
Gdnfglial cell line derived neurotrophic factor0.082
Emx1empty spiracles homolog 1 (Drosophila)0.082
Plscr1phospholipid scramblase 10.080
Inhbbinhibin beta-B0.080
Cpceruloplasmin0.078
Cd177CD177 antigen0.077
Gli2GLI-Kruppel family member GLI20.076
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
C5ar1complement component 5a receptor 10.034
Ccl2chemokine (C-C motif) ligand 20.022
Olr1oxidized low density lipoprotein (lectin-like) receptor 10.020
Mgat2mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase0.018
Lilrb4leukocyte immunoglobulin-like receptor, subfamily B, member 40.017
Ccl3chemokine (C-C motif) ligand 30.014
Plod2procollagen lysine, 2-oxoglutarate 5-dioxygenase 20.013
Myd88myeloid differentiation primary response gene 880.013
Pla1aphospholipase A1 member A0.013
Atf3activating transcription factor 30.012
Casp1caspase 10.012
Bet1blocked early in transport 1 homolog (S. cerevisiae)0.012
Hckhemopoietic cell kinase0.011
Snap23synaptosomal-associated protein 230.011
Igsf6immunoglobulin superfamily, member 60.011
Cxcl1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.011
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism