The network for 'regulation of transmission of nerve impulse' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of transmission of nerve impulse

Any process that modulates the frequency, rate or extent of transmission of a nerve impulse, the sequential electrochemical polarization and depolarization that travels across the membrane of a neuron in response to stimulation.

NameDescriptionProbabilityFunc Analog Organism
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.971
HTR2C5-hydroxytryptamine (serotonin) receptor 2C0.850
GABRA5gamma-aminobutyric acid (GABA) A receptor, alpha 50.813
GRIA1glutamate receptor, ionotropic, AMPA 10.698
SLC24A2solute carrier family 24 (sodium/potassium/calcium exchanger), member 20.693
GABRA3gamma-aminobutyric acid (GABA) A receptor, alpha 30.673
HTR2A5-hydroxytryptamine (serotonin) receptor 2A0.665
GABRA4gamma-aminobutyric acid (GABA) A receptor, alpha 40.642
OPRK1opioid receptor, kappa 10.631
ITGA6integrin, alpha 60.618
GRM1glutamate receptor, metabotropic 10.571
CDH8cadherin 8, type 20.568
GABRG2gamma-aminobutyric acid (GABA) A receptor, gamma 20.517
GRIK1glutamate receptor, ionotropic, kainate 10.499
SNTG1syntrophin, gamma 10.492
SLC17A6solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 60.491
ELAVL2ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B)0.464
RIT2Ras-like without CAAX 20.440
GPC5glypican 50.438
UGT2B7UDP glucuronosyltransferase 2 family, polypeptide B70.426
GRIA2glutamate receptor, ionotropic, AMPA 20.420
CACNG3calcium channel, voltage-dependent, gamma subunit 30.419
SV2Csynaptic vesicle glycoprotein 2C0.413
NTRK3neurotrophic tyrosine kinase, receptor, type 30.406
CDH10cadherin 10, type 2 (T2-cadherin)0.394
SNAP91synaptosomal-associated protein, 91kDa homolog (mouse)0.394
KCNJ3potassium inwardly-rectifying channel, subfamily J, member 30.385
SLC1A2solute carrier family 1 (glial high affinity glutamate transporter), member 20.374
GABRA1gamma-aminobutyric acid (GABA) A receptor, alpha 10.358
RALYLRALY RNA binding protein-like0.355
MTNR1Amelatonin receptor 1A0.342
SLC1A6solute carrier family 1 (high affinity aspartate/glutamate transporter), member 60.340
TAC1tachykinin, precursor 10.334
SLITRK3SLIT and NTRK-like family, member 30.310
SYT13synaptotagmin XIII0.304
SLC12A5solute carrier family 12 (potassium/chloride transporter), member 50.302
NEUROD2neurogenic differentiation 20.298
SCN2Asodium channel, voltage-gated, type II, alpha subunit0.297
NRXN1neurexin 10.289
NPYneuropeptide Y0.287
ADCYAP1adenylate cyclase activating polypeptide 1 (pituitary)0.271
STXBP5Lsyntaxin binding protein 5-like0.270
GLRA3glycine receptor, alpha 30.261
DAB1disabled homolog 1 (Drosophila)0.258
SYN2synapsin II0.257
MMP1matrix metallopeptidase 1 (interstitial collagenase)0.244
KCNA1potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)0.243
DCCdeleted in colorectal carcinoma0.240
KCND2potassium voltage-gated channel, Shal-related subfamily, member 20.238
GNG4guanine nucleotide binding protein (G protein), gamma 40.238
VSTM2AV-set and transmembrane domain containing 2A0.236
GRM3glutamate receptor, metabotropic 30.219
DRD5dopamine receptor D50.200
CHGBchromogranin B (secretogranin 1)0.197
KCNB1potassium voltage-gated channel, Shab-related subfamily, member 10.193
GABRB3gamma-aminobutyric acid (GABA) A receptor, beta 30.187
GRM5glutamate receptor, metabotropic 50.187
MGAT4Cmannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)0.187
PDIA3protein disulfide isomerase family A, member 30.184
RIMS1regulating synaptic membrane exocytosis 10.181
PEX5Lperoxisomal biogenesis factor 5-like0.181
MYO16myosin XVI0.181
CACNB4calcium channel, voltage-dependent, beta 4 subunit0.180
FABP7fatty acid binding protein 7, brain0.179
GLRA1glycine receptor, alpha 10.177
KCNJ10potassium inwardly-rectifying channel, subfamily J, member 100.173
DDX25DEAD (Asp-Glu-Ala-Asp) box polypeptide 250.172
NELL1NEL-like 1 (chicken)0.171
GABRQgamma-aminobutyric acid (GABA) receptor, theta0.169
GABRR1gamma-aminobutyric acid (GABA) receptor, rho 10.169
ADAM18ADAM metallopeptidase domain 180.167
RGS7regulator of G-protein signaling 70.162
RIMS2regulating synaptic membrane exocytosis 20.155
GRIA4glutamate receptor, ionotrophic, AMPA 40.147
GABRB1gamma-aminobutyric acid (GABA) A receptor, beta 10.145
CNKSR2connector enhancer of kinase suppressor of Ras 20.143
GLRA2glycine receptor, alpha 20.141
TNRtenascin R (restrictin, janusin)0.138
CD63CD63 molecule0.137
MCF2MCF.2 cell line derived transforming sequence0.137
KCNQ3potassium voltage-gated channel, KQT-like subfamily, member 30.137
NHLH2nescient helix loop helix 20.133
GABRA6gamma-aminobutyric acid (GABA) A receptor, alpha 60.133
SERPINI2serpin peptidase inhibitor, clade I (pancpin), member 20.132
WSCD2WSC domain containing 20.126
PURGpurine-rich element binding protein G0.125
ZMAT4zinc finger, matrin-type 40.122
ATP2B3ATPase, Ca++ transporting, plasma membrane 30.121
FGF12fibroblast growth factor 120.121
KCNMB2potassium large conductance calcium-activated channel, subfamily M, beta member 20.118
LRRTM4leucine rich repeat transmembrane neuronal 40.118
GPR22G protein-coupled receptor 220.117
GABRG3gamma-aminobutyric acid (GABA) A receptor, gamma 30.117
PRKCGprotein kinase C, gamma0.116
TACR1tachykinin receptor 10.116
ACCN1amiloride-sensitive cation channel 1, neuronal0.115
SEZ6Lseizure related 6 homolog (mouse)-like0.114
SSTR2somatostatin receptor 20.111
PMP2peripheral myelin protein 20.110
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
esr1estrogen receptor 10.258
avplarginine vasopressin-like0.249
mc4rmelanocortin 4 receptor0.051
uts1urotensin 10.036
paqr7bprogestin and adipoQ receptor family member VII, b0.036
mchr1amelanin-concentrating hormone receptor 1a0.030
sst3somatostatin 30.021
sst6somatostatin 60.018
htr1bd5-hydroxytryptamine (serotonin) receptor 1bd0.016
slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.016
c1qtnf4C1q and tumor necrosis factor related protein 40.016
ncam2neural cell adhesion molecule 20.015
or115-10odorant receptor, family F, subfamily 115, member 100.014
prok2prokineticin 20.014
htr1aa5-hydroxytryptamine (serotonin) receptor 1A a0.014
pomcaproopiomelanocortin a0.013
gnrh3gonadotropin-releasing hormone 30.013
slc22a7bsolute carrier family 22 (organic anion transporter), member 7b0.012
th2tyrosine hydroxylase 20.011
gad2glutamate decarboxylase 20.011
cadm2acell adhesion molecule 2a0.011
ghsragrowth hormone secretagogue receptor a0.010
chrm2acholinergic receptor, muscarinic 2a0.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Col3a1collagen, type III, alpha 10.092
Col1a2collagen, type I, alpha 20.062
Nid1nidogen 10.056
Col14a1collagen, type XIV, alpha 10.055
Wisp1WNT1 inducible signaling pathway protein 10.049
Col5a2collagen, type V, alpha 20.043
Hcrtr2hypocretin (orexin) receptor 20.041
Col1a1collagen, type I, alpha 10.040
Ptk2PTK2 protein tyrosine kinase 20.037
Plin4perilipin 40.030
Itih3inter-alpha trypsin inhibitor, heavy chain 30.030
Col6a3collagen, type VI, alpha 30.026
Thbs1thrombospondin 10.024
Col4a1collagen, type IV, alpha 10.023
Tskstestis-specific serine kinase substrate0.021
Sctrsecretin receptor0.019
Slc34a1solute carrier family 34 (sodium phosphate), member 10.019
Dsc3desmocollin 30.018
Ptgs2prostaglandin-endoperoxide synthase 20.018
Serping1serine (or cysteine) peptidase inhibitor, clade G, member 10.017
Pcsk5proprotein convertase subtilisin/kexin type 50.017
Htr1a5-hydroxytryptamine (serotonin) receptor 1A0.017
Clec4fC-type lectin domain family 4, member f0.016
Col6a2collagen, type VI, alpha 20.016
Fstl1follistatin-like 10.016
Sox3SRY-box containing gene 30.016
Cyr61cysteine rich protein 610.015
Col4a2collagen, type IV, alpha 20.014
Col6a1collagen, type VI, alpha 10.014
Bmp1bone morphogenetic protein 10.014
Pcolceprocollagen C-endopeptidase enhancer protein0.013
Ren1renin 1 structural0.013
Adamts1a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 10.013
Mmp3matrix metallopeptidase 30.013
Hchemolytic complement0.013
Col18a1collagen, type XVIII, alpha 10.012
Thbs2thrombospondin 20.012
Igfbp4insulin-like growth factor binding protein 40.012
Folr2folate receptor 2 (fetal)0.011
Slc12a1solute carrier family 12, member 10.011
Otporthopedia homolog (Drosophila)0.011
Aqp2aquaporin 20.011
Col4a3collagen, type IV, alpha 30.010
Igfbp6insulin-like growth factor binding protein 60.010
Hhatlhedgehog acyltransferase-like0.010
Adra1badrenergic receptor, alpha 1b0.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism