The network for 'striated muscle adaptation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

striated muscle adaptation

Any process in which striated muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities.

NameDescriptionProbabilityFunc Analog Organism
MYOZ1myozenin 10.961
TNNI1troponin I type 1 (skeletal, slow)0.932
TNNC1troponin C type 1 (slow)0.888
CASP8caspase 8, apoptosis-related cysteine peptidase0.853
SRFserum response factor (c-fos serum response element-binding transcription factor)0.673
ACTA1actin, alpha 1, skeletal muscle0.649
ACTN2actinin, alpha 20.638
TRIM63tripartite motif containing 630.603
TNNI2troponin I type 2 (skeletal, fast)0.602
CSRP3cysteine and glycine-rich protein 3 (cardiac LIM protein)0.419
MRPL41mitochondrial ribosomal protein L410.415
FLNCfilamin C, gamma0.217
TNNT2troponin T type 2 (cardiac)0.147
GFM1G elongation factor, mitochondrial 10.136
TBX5T-box 50.111
TNNT1troponin T type 1 (skeletal, slow)0.101
ANKRD2ankyrin repeat domain 2 (stretch responsive muscle)0.091
CASP10caspase 10, apoptosis-related cysteine peptidase0.090
ITPR3inositol 1,4,5-trisphosphate receptor, type 30.087
EP300E1A binding protein p3000.084
CALCAcalcitonin-related polypeptide alpha0.084
PPP3R1protein phosphatase 3, regulatory subunit B, alpha0.083
MYH7myosin, heavy chain 7, cardiac muscle, beta0.081
PKD2polycystic kidney disease 2 (autosomal dominant)0.073
HDAC4histone deacetylase 40.072
TNNI3troponin I type 3 (cardiac)0.064
HIST1H4Fhistone cluster 1, H4f0.060
MBNL1muscleblind-like (Drosophila)0.059
MYOZ2myozenin 20.056
TRPC3transient receptor potential cation channel, subfamily C, member 30.056
IRF2interferon regulatory factor 20.056
HDAC9histone deacetylase 90.053
TNNT3troponin T type 3 (skeletal, fast)0.052
NOMO1NODAL modulator 10.051
KLF13Kruppel-like factor 130.050
TRIM55tripartite motif containing 550.044
CKMcreatine kinase, muscle0.044
DLG2discs, large homolog 2 (Drosophila)0.043
ATP2A1ATPase, Ca++ transporting, cardiac muscle, fast twitch 10.043
TRIM54tripartite motif containing 540.043
MYLPFmyosin light chain, phosphorylatable, fast skeletal muscle0.042
COASYCoA synthase0.042
NR3C1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.040
CBLBCas-Br-M (murine) ecotropic retroviral transforming sequence b0.040
DCAF6DDB1 and CUL4 associated factor 60.040
USP14ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)0.038
RICTORRPTOR independent companion of MTOR, complex 20.037
HDAC5histone deacetylase 50.036
TRPC4transient receptor potential cation channel, subfamily C, member 40.035
CCDC85Bcoiled-coil domain containing 85B0.035
TNNC2troponin C type 2 (fast)0.033
MKL1megakaryoblastic leukemia (translocation) 10.033
HAND2heart and neural crest derivatives expressed 20.033
MYL2myosin, light chain 2, regulatory, cardiac, slow0.032
MYH6myosin, heavy chain 6, cardiac muscle, alpha0.031
TRIM43tripartite motif containing 430.030
MAPK8mitogen-activated protein kinase 80.030
HIST1H3Bhistone cluster 1, H3b0.030
LMCD1LIM and cysteine-rich domains 10.029
TNFRSF10Btumor necrosis factor receptor superfamily, member 10b0.029
DLG1discs, large homolog 1 (Drosophila)0.028
TOM1L1target of myb1 (chicken)-like 10.027
TNFSF10tumor necrosis factor (ligand) superfamily, member 100.027
PDK1pyruvate dehydrogenase kinase, isozyme 10.027
TRPC6transient receptor potential cation channel, subfamily C, member 60.027
SGCAsarcoglycan, alpha (50kDa dystrophin-associated glycoprotein)0.026
LDB3LIM domain binding 30.025
TCAPtitin-cap (telethonin)0.025
MYF5myogenic factor 50.025
C16orf74chromosome 16 open reading frame 740.025
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.024
TRPC5transient receptor potential cation channel, subfamily C, member 50.024
ITPR1inositol 1,4,5-trisphosphate receptor, type 10.023
OBSCNobscurin, cytoskeletal calmodulin and titin-interacting RhoGEF0.023
COX6A2cytochrome c oxidase subunit VIa polypeptide 20.022
ZEB2zinc finger E-box binding homeobox 20.022
PPP1R12Aprotein phosphatase 1, regulatory (inhibitor) subunit 12A0.022
MYBPC2myosin binding protein C, fast type0.022
GMEB1glucocorticoid modulatory element binding protein 10.021
PDPK13-phosphoinositide dependent protein kinase-10.021
OSMoncostatin M0.021
BTKBruton agammaglobulinemia tyrosine kinase0.021
MYL3myosin, light chain 3, alkali; ventricular, skeletal, slow0.020
PTP4A3protein tyrosine phosphatase type IVA, member 30.020
MYH1myosin, heavy chain 1, skeletal muscle, adult0.020
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.020
MYBPC3myosin binding protein C, cardiac0.020
SGCGsarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)0.020
ACTC1actin, alpha, cardiac muscle 10.019
SYNPO2Lsynaptopodin 2-like0.019
TRRAPtransformation/transcription domain-associated protein0.018
TOP1topoisomerase (DNA) I0.018
MTORmechanistic target of rapamycin (serine/threonine kinase)0.018
MYOGmyogenin (myogenic factor 4)0.018
ANKRD1ankyrin repeat domain 1 (cardiac muscle)0.018
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
wupAwings up A0.520
Tm2Tropomyosin 20.302
MhcMyosin heavy chain0.096
Lk6CG17342 gene product from transcript CG17342-RA0.071
stmAstambha A0.056
Actnalpha actinin0.056
CanBCalcineurin B0.043
Cf2Chorion factor 20.040
Act88FActin 88F0.036
ImpIGF-II mRNA-binding protein0.033
Atg1Autophagy-specific gene 10.027
Rya-r44FRyanodine receptor 44F0.024
Mlc2Myosin light chain 20.024
vvlventral veins lacking0.023
Pp2B-14DProtein phosphatase 2B at 14D0.022
CG8709CG8709 gene product from transcript CG8709-RK0.022
emcextra macrochaetae0.022
Nf1Neurofibromin 10.021
zfh1Zn finger homeodomain 10.020
crolcrooked legs0.019
Mlp84BMuscle LIM protein at 84B0.019
Nf-YANuclear factor Y-box A0.019
MntCG13316 gene product from transcript CG13316-RD0.018
Su(z)2Suppressor of zeste 20.018
Zasp66Z band alternatively spliced PDZ-motif protein 660.018
sinaseven in absentia0.017
Eip75BEcdysone-induced protein 75B0.017
Pk61CProtein kinase 61C0.016
l(2)05510lethal (2) 055100.016
Smg5CG8954 gene product from transcript CG8954-RA0.015
InRInsulin-like receptor0.015
Zasp52Z band alternatively spliced PDZ-motif protein 520.014
VAChTCG32848 gene product from transcript CG32848-RA0.014
DdcDopa decarboxylase0.014
svpseven up0.013
CkIIalphaCasein kinase II alpha subunit0.013
CanA1Calcineurin A10.013
DadDaughters against dpp0.013
TobCG9214 gene product from transcript CG9214-RA0.012
blowblown fuse0.012
Snap25Synapse protein 250.012
dvedefective proventriculus0.012
MicalMolecule interacting with CasL0.012
KaiRIACG18039 gene product from transcript CG18039-RA0.012
rolsrolling pebbles0.012
alpha-AdaptinCG4260 gene product from transcript CG4260-RA0.012
Eip63F-1Ecdysone-induced protein 63F 10.011
abbaanother B-box affiliate0.011
howheld out wings0.011
Hr4CG16902 gene product from transcript CG16902-RC0.011
CG5177CG5177 gene product from transcript CG5177-RA0.011
TpnC73FTroponin C at 73F0.011
CG9650CG9650 gene product from transcript CG9650-RG0.011
CG10743CG10743 gene product from transcript CG10743-RB0.010
coroCG9446 gene product from transcript CG9446-RC0.010
Tak1TGF-beta activated kinase 10.010
Pink1PTEN-induced putative kinase 10.010
Rab23CG2108 gene product from transcript CG2108-RA0.010
nAcRalpha-80Bnicotinic Acetylcholine Receptor alpha 80B0.010
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Hrchistidine rich calcium binding protein0.920
Jag1jagged 10.872
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.813
Pitx2paired-like homeodomain transcription factor 20.734
Zfpm2zinc finger protein, multitype 20.700
Trim55tripartite motif-containing 550.617
Tnnt3troponin T3, skeletal, fast0.576
Ank1ankyrin 1, erythroid0.459
Tgfb2transforming growth factor, beta 20.398
Tnnc2troponin C2, fast0.395
Ryr1ryanodine receptor 1, skeletal muscle0.391
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.378
Kcnma1potassium large conductance calcium-activated channel, subfamily M, alpha member 10.365
Pax7paired box gene 70.322
Casq1calsequestrin 10.321
Eya1eyes absent 1 homolog (Drosophila)0.312
Actc1actin, alpha, cardiac muscle 10.271
Nos3nitric oxide synthase 3, endothelial cell0.268
Tnni2troponin I, skeletal, fast 20.264
Actn3actinin alpha 30.237
Actn2actinin alpha 20.228
Ldb3LIM domain binding 30.216
Fbxo32F-box protein 320.189
Nfatc3nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 30.185
Spna1spectrin alpha 10.180
Myl1myosin, light polypeptide 10.175
Klf4Kruppel-like factor 4 (gut)0.167
Slc4a1solute carrier family 4 (anion exchanger), member 10.167
Cacnb4calcium channel, voltage-dependent, beta 4 subunit0.160
Hdac4histone deacetylase 40.145
Tal1T-cell acute lymphocytic leukemia 10.143
Notch1Notch gene homolog 1 (Drosophila)0.135
Rhobras homolog gene family, member B0.135
Adam19a disintegrin and metallopeptidase domain 19 (meltrin beta)0.133
Nppanatriuretic peptide type A0.125
Yap1yes-associated protein 10.123
Mybphmyosin binding protein H0.119
Klf3Kruppel-like factor 3 (basic)0.119
Myh1myosin, heavy polypeptide 1, skeletal muscle, adult0.119
Efnb2ephrin B20.118
Mll5myeloid/lymphoid or mixed-lineage leukemia 50.115
Gtf2ird1general transcription factor II I repeat domain-containing 10.115
Casq2calsequestrin 20.111
Rock2Rho-associated coiled-coil containing protein kinase 20.110
Eporerythropoietin receptor0.109
Spnb2spectrin beta 20.106
Tnnt2troponin T2, cardiac0.105
Mef2amyocyte enhancer factor 2A0.105
Nfatc4nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 40.101
Ptpn14protein tyrosine phosphatase, non-receptor type 140.096
Nrapnebulin-related anchoring protein0.095
Ppp3r1protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I)0.091
Thrbthyroid hormone receptor beta0.090
Chrna1cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)0.090
Ntf3neurotrophin 30.088
Gfi1bgrowth factor independent 1B0.087
Myom2myomesin 20.084
Xirp1xin actin-binding repeat containing 10.083
Myh3myosin, heavy polypeptide 3, skeletal muscle, embryonic0.083
Ankrd2ankyrin repeat domain 2 (stretch responsive muscle)0.082
Hbb-b1hemoglobin, beta adult major chain0.082
Tnni1troponin I, skeletal, slow 10.079
Tcf15transcription factor 150.078
Rxraretinoid X receptor alpha0.077
Srpk3serine/arginine-rich protein specific kinase 30.075
Mylpfmyosin light chain, phosphorylatable, fast skeletal muscle0.073
Ptpn11protein tyrosine phosphatase, non-receptor type 110.070
Pygmmuscle glycogen phosphorylase0.066
Dlg4discs, large homolog 4 (Drosophila)0.065
Ckmcreatine kinase, muscle0.064
Mybpc3myosin binding protein C, cardiac0.063
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.062
Gabrb3gamma-aminobutyric acid (GABA) A receptor, subunit beta 30.061
Wfikkn2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.061
Arandrogen receptor0.060
Iduaiduronidase, alpha-L-0.059
Cacng1calcium channel, voltage-dependent, gamma subunit 10.059
Myoz1myozenin 10.058
Hey2hairy/enhancer-of-split related with YRPW motif 20.057
Zswim6zinc finger, SWIM domain containing 60.057
Skiski sarcoma viral oncogene homolog (avian)0.057
Kcnj11potassium inwardly rectifying channel, subfamily J, member 110.056
Myh8myosin, heavy polypeptide 8, skeletal muscle, perinatal0.054
Csrp3cysteine and glycine-rich protein 30.053
Cacnb2calcium channel, voltage-dependent, beta 2 subunit0.053
Crhr2corticotropin releasing hormone receptor 20.053
Atp2a1ATPase, Ca++ transporting, cardiac muscle, fast twitch 10.050
Pax3paired box gene 30.050
Hdac5histone deacetylase 50.050
Tnnt1troponin T1, skeletal, slow0.049
Map3k5mitogen-activated protein kinase kinase kinase 50.049
Slc12a2solute carrier family 12, member 20.049
Myod1myogenic differentiation 10.049
Cdh23cadherin 23 (otocadherin)0.048
Hdac7histone deacetylase 70.048
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism