The network for 'toll like receptor 2 signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

toll like receptor 2 signaling pathway

Any series of molecular signals generated as a consequence of binding to toll-like receptor 2.

NameDescriptionProbabilityFunc Analog Organism
MYD88myeloid differentiation primary response gene (88)1.000
BIRC3baculoviral IAP repeat containing 31.000
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 11.000
IRAK1interleukin-1 receptor-associated kinase 10.999
TRAF6TNF receptor-associated factor 60.999
IRAK2interleukin-1 receptor-associated kinase 20.998
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.998
TRAF1TNF receptor-associated factor 10.991
BIRC2baculoviral IAP repeat containing 20.977
TRAF3TNF receptor-associated factor 30.950
RIPK2receptor-interacting serine-threonine kinase 20.950
IRAK3interleukin-1 receptor-associated kinase 30.916
PELI3pellino homolog 3 (Drosophila)0.832
TRAF2TNF receptor-associated factor 20.751
CASP8caspase 8, apoptosis-related cysteine peptidase0.715
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.536
TNIP1TNFAIP3 interacting protein 10.491
ZC3H12Azinc finger CCCH-type containing 12A0.452
TNFAIP3tumor necrosis factor, alpha-induced protein 30.427
IRAK4interleukin-1 receptor-associated kinase 40.326
TLR4toll-like receptor 40.317
SQSTM1sequestosome 10.304
RIPK3receptor-interacting serine-threonine kinase 30.268
FADDFas (TNFRSF6)-associated via death domain0.200
FASFas (TNF receptor superfamily, member 6)0.188
MAP3K14mitogen-activated protein kinase kinase kinase 140.148
TRADDTNFRSF1A-associated via death domain0.147
CAV1caveolin 1, caveolae protein, 22kDa0.135
TANKTRAF family member-associated NFKB activator0.132
CASP9caspase 9, apoptosis-related cysteine peptidase0.106
IRF7interferon regulatory factor 70.099
PTPRAprotein tyrosine phosphatase, receptor type, A0.096
CD40CD40 molecule, TNF receptor superfamily member 50.081
CASP7caspase 7, apoptosis-related cysteine peptidase0.078
USP15ubiquitin specific peptidase 150.076
TRIM38tripartite motif containing 380.073
ZC3H12Czinc finger CCCH-type containing 12C0.068
CASP10caspase 10, apoptosis-related cysteine peptidase0.064
TOLLIPtoll interacting protein0.060
CFLARCASP8 and FADD-like apoptosis regulator0.059
MALT1mucosa associated lymphoid tissue lymphoma translocation gene 10.056
PELI2pellino homolog 2 (Drosophila)0.054
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.051
TLR2toll-like receptor 20.044
CAV2caveolin 20.038
SAMHD1SAM domain and HD domain 10.036
TNFRSF10Atumor necrosis factor receptor superfamily, member 10a0.035
NOD2nucleotide-binding oligomerization domain containing 20.034
PELI1pellino homolog 1 (Drosophila)0.034
ARAFv-raf murine sarcoma 3611 viral oncogene homolog0.032
RIPK4receptor-interacting serine-threonine kinase 40.031
TNFtumor necrosis factor0.031
PTPN22protein tyrosine phosphatase, non-receptor type 22 (lymphoid)0.030
USP4ubiquitin specific peptidase 4 (proto-oncogene)0.030
CARD11caspase recruitment domain family, member 110.028
INADLInaD-like (Drosophila)0.026
KRT8keratin 80.025
RBCK1RanBP-type and C3HC4-type zinc finger containing 10.023
TMEM173transmembrane protein 1730.023
CCDC50coiled-coil domain containing 500.023
TNFRSF10Btumor necrosis factor receptor superfamily, member 10b0.023
ANXA1annexin A10.022
ID1inhibitor of DNA binding 1, dominant negative helix-loop-helix protein0.021
STK11serine/threonine kinase 110.021
IL1R1interleukin 1 receptor, type I0.020
IKBKEinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon0.020
UBE2D1ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)0.019
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.019
TRAF3IP1TNF receptor-associated factor 3 interacting protein 10.017
TRAF3IP2TRAF3 interacting protein 20.017
GIT2G protein-coupled receptor kinase interacting ArfGAP 20.017
NOD1nucleotide-binding oligomerization domain containing 10.017
BCL10B-cell CLL/lymphoma 100.016
JAK1Janus kinase 10.016
STRADASTE20-related kinase adaptor alpha0.015
SPOPspeckle-type POZ protein0.015
STAP2signal transducing adaptor family member 20.015
PTK2BPTK2B protein tyrosine kinase 2 beta0.014
PROCRprotein C receptor, endothelial0.014
TICAM1toll-like receptor adaptor molecule 10.014
TNFRSF1Atumor necrosis factor receptor superfamily, member 1A0.013
TAB3TGF-beta activated kinase 1/MAP3K7 binding protein 30.013
CD14CD14 molecule0.013
TICAM2toll-like receptor adaptor molecule 20.013
TNFSF10tumor necrosis factor (ligand) superfamily, member 100.011
TNFAIP8tumor necrosis factor, alpha-induced protein 80.011
ZBP1Z-DNA binding protein 10.011
MLKLmixed lineage kinase domain-like0.011
DOCK8dedicator of cytokinesis 80.011
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Myd88myeloid differentiation primary response gene 880.956
Traf6TNF receptor-associated factor 60.607
Ptk2PTK2 protein tyrosine kinase 20.333
Inpp5dinositol polyphosphate-5-phosphatase D0.185
Ikzf1IKAROS family zinc finger 10.178
Irak4interleukin-1 receptor-associated kinase 40.127
Ptprcprotein tyrosine phosphatase, receptor type, C0.126
WasWiskott-Aldrich syndrome homolog (human)0.112
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.105
MefvMediterranean fever0.099
FybFYN binding protein0.096
Cd44CD44 antigen0.094
CblCasitas B-lineage lymphoma0.065
Il2rbinterleukin 2 receptor, beta chain0.058
Map3k8mitogen-activated protein kinase kinase kinase 80.058
Cd247CD247 antigen0.057
Hcls1hematopoietic cell specific Lyn substrate 10.050
Pik3ap1phosphoinositide-3-kinase adaptor protein 10.049
PycardPYD and CARD domain containing0.047
Siglecesialic acid binding Ig-like lectin E0.045
Icam1intercellular adhesion molecule 10.044
Dok1docking protein 10.043
Plcg2phospholipase C, gamma 20.040
BlnkB-cell linker0.039
Dok2docking protein 20.037
Il1binterleukin 1 beta0.032
Casp4caspase 4, apoptosis-related cysteine peptidase0.031
Prkceprotein kinase C, epsilon0.030
Tiraptoll-interleukin 1 receptor (TIR) domain-containing adaptor protein0.030
Grb2growth factor receptor bound protein 20.030
Zap70zeta-chain (TCR) associated protein kinase0.029
Cd40CD40 antigen0.028
Tnfaip3tumor necrosis factor, alpha-induced protein 30.027
Il1rninterleukin 1 receptor antagonist0.026
TifaTRAF-interacting protein with forkhead-associated domain0.026
Ncr1natural cytotoxicity triggering receptor 10.026
Ptpreprotein tyrosine phosphatase, receptor type, E0.025
Irak3interleukin-1 receptor-associated kinase 30.025
BC013712cDNA sequence BC0137120.023
Il1ainterleukin 1 alpha0.022
Il1r1interleukin 1 receptor, type I0.022
Csf1colony stimulating factor 1 (macrophage)0.022
Fpr1formyl peptide receptor 10.022
Pik3r1phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)0.022
Ooepoocyte expressed protein homolog (dog)0.021
Ccr6chemokine (C-C motif) receptor 60.020
Il2rginterleukin 2 receptor, gamma chain0.018
Itsn1intersectin 1 (SH3 domain protein 1A)0.017
Clnkcytokine-dependent hematopoietic cell linker0.017
Cd300lfCD300 antigen like family member F0.016
Cd19CD19 antigen0.016
Pilrb1paired immunoglobin-like type 2 receptor beta 10.016
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.016
Ccl4chemokine (C-C motif) ligand 40.015
Ptk2bPTK2 protein tyrosine kinase 2 beta0.015
Itgalintegrin alpha L0.015
Cd4CD4 antigen0.015
Cd28CD28 antigen0.015
Tlr4toll-like receptor 40.015
Trem3triggering receptor expressed on myeloid cells 30.014
Pou2af1POU domain, class 2, associating factor 10.014
Lcklymphocyte protein tyrosine kinase0.013
Skap2src family associated phosphoprotein 20.013
Cd8aCD8 antigen, alpha chain0.012
Unc93b1unc-93 homolog B1 (C. elegans)0.012
FynFyn proto-oncogene0.012
Nlrp3NLR family, pyrin domain containing 30.011
Il1f9interleukin 1 family, member 90.011
Fcgr2bFc receptor, IgG, low affinity IIb0.011
SpibSpi-B transcription factor (Spi-1/PU.1 related)0.011
Cd300ldCD300 molecule-like family member d0.011
Fpr2formyl peptide receptor 20.011
Ebi3Epstein-Barr virus induced gene 30.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism