The network for 'myeloid leukocyte differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

myeloid leukocyte differentiation

The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage.

NameDescriptionProbabilityFunc Analog Organism
CASP8caspase 8, apoptosis-related cysteine peptidase0.996
TAL1T-cell acute lymphocytic leukemia 10.975
TRAF1TNF receptor-associated factor 10.959
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.898
RUNX1runt-related transcription factor 10.886
ZNF43zinc finger protein 430.870
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.867
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.863
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.858
EGFRepidermal growth factor receptor0.846
XIAPX-linked inhibitor of apoptosis0.838
NCOA1nuclear receptor coactivator 10.816
BIRC3baculoviral IAP repeat containing 30.813
CCR5chemokine (C-C motif) receptor 50.795
NCOR2nuclear receptor corepressor 20.769
CASP3caspase 3, apoptosis-related cysteine peptidase0.752
CXCL9chemokine (C-X-C motif) ligand 90.722
CREBBPCREB binding protein0.700
PTPN6protein tyrosine phosphatase, non-receptor type 60.682
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.661
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.618
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.560
HNF4Ahepatocyte nuclear factor 4, alpha0.550
GRB2growth factor receptor-bound protein 20.510
LILRA6leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 60.507
RIPK2receptor-interacting serine-threonine kinase 20.501
CFLARCASP8 and FADD-like apoptosis regulator0.453
ESR1estrogen receptor 10.449
EP300E1A binding protein p3000.442
SP1Sp1 transcription factor0.436
SH2D4ASH2 domain containing 4A0.434
CXCL10chemokine (C-X-C motif) ligand 100.402
NOTCH1notch 10.399
TRAF2TNF receptor-associated factor 20.396
CAV1caveolin 1, caveolae protein, 22kDa0.393
CCR1chemokine (C-C motif) receptor 10.389
FASFas (TNF receptor superfamily, member 6)0.389
ANXA1annexin A10.389
TNFRSF10Btumor necrosis factor receptor superfamily, member 10b0.387
MDM2Mdm2 p53 binding protein homolog (mouse)0.376
ICAM1intercellular adhesion molecule 10.359
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.353
ZNF253zinc finger protein 2530.342
IFNGinterferon, gamma0.336
ARandrogen receptor0.334
CCR2chemokine (C-C motif) receptor 20.322
CASP4caspase 4, apoptosis-related cysteine peptidase0.315
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.305
CD40CD40 molecule, TNF receptor superfamily member 50.300
CCL5chemokine (C-C motif) ligand 50.294
ZNF273zinc finger protein 2730.292
KITv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog0.292
CCR7chemokine (C-C motif) receptor 70.264
PBX1pre-B-cell leukemia homeobox 10.257
IL8interleukin 80.253
RXRAretinoid X receptor, alpha0.245
PSEN1presenilin 10.236
CCL22chemokine (C-C motif) ligand 220.234
JUNjun proto-oncogene0.224
ZNF675zinc finger protein 6750.222
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.211
SOCS3suppressor of cytokine signaling 30.205
SETD8SET domain containing (lysine methyltransferase) 80.202
HIC1hypermethylated in cancer 10.200
TRAF5TNF receptor-associated factor 50.198
HOXB5homeobox B50.197
PTPN11protein tyrosine phosphatase, non-receptor type 110.196
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.194
CASP9caspase 9, apoptosis-related cysteine peptidase0.192
TNFRSF6Btumor necrosis factor receptor superfamily, member 6b, decoy0.188
GABPAGA binding protein transcription factor, alpha subunit 60kDa0.188
NCOR1nuclear receptor corepressor 10.187
CCL7chemokine (C-C motif) ligand 70.182
JUNBjun B proto-oncogene0.179
IL10RAinterleukin 10 receptor, alpha0.179
NRP1neuropilin 10.175
SIGLEC7sialic acid binding Ig-like lectin 70.174
TRAF3TNF receptor-associated factor 30.173
IL2RBinterleukin 2 receptor, beta0.172
CASP7caspase 7, apoptosis-related cysteine peptidase0.172
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.171
IL4Rinterleukin 4 receptor0.169
TNFRSF9tumor necrosis factor receptor superfamily, member 90.168
CXCL13chemokine (C-X-C motif) ligand 130.167
SPI1spleen focus forming virus (SFFV) proviral integration oncogene spi10.165
SLAMF8SLAM family member 80.165
VDRvitamin D (1,25- dihydroxyvitamin D3) receptor0.163
LATlinker for activation of T cells0.161
ITKIL2-inducible T-cell kinase0.157
CXCR3chemokine (C-X-C motif) receptor 30.156
IRF4interferon regulatory factor 40.156
SIN3ASIN3 homolog A, transcription regulator (yeast)0.149
LIFleukemia inhibitory factor (cholinergic differentiation factor)0.149
HOXA10homeobox A100.148
RARAretinoic acid receptor, alpha0.148
ZMYND11zinc finger, MYND-type containing 110.148
IL6interleukin 6 (interferon, beta 2)0.147
LILRB2leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 20.145
PMLpromyelocytic leukemia0.144
TNFRSF14tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)0.143
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
tal1T-cell acute lymphocytic leukemia 10.956
spi1spleen focus forming virus (SFFV) proviral integration oncogene spi10.854
fn1fibronectin 10.837
runx1runt-related transcription factor 10.818
hand2heart and neural crest derivatives expressed transcript 20.766
mpxmyeloid-specific peroxidase0.766
cmybtranscription factor cmyb0.762
ets1av-ets erythroblastosis virus E26 oncogene homolog 1a0.680
gata1aGATA binding protein 1a0.514
f2rcoagulation factor II (thrombin) receptor0.459
etv2ets variant gene 20.404
ikzf1IKAROS family zinc finger 1 (Ikaros)0.390
cdh5cadherin 50.382
gata6GATA-binding protein 60.342
hbbe3hemoglobin beta embryonic-30.335
mmp9matrix metalloproteinase 90.296
sox7SRY-box containing gene 70.286
pdcd2programmed cell death 20.285
klf2aKruppel-like factor 2a0.277
spi1lspleen focus forming virus (SFFV) proviral integration oncogene spi1 like0.274
tgfb3transforming growth factor, beta 30.269
cebpbCCAAT/enhancer binding protein (C/EBP), beta0.259
mef2cbmyocyte enhancer factor 2cb0.243
gata5GATA-binding protein 50.228
csf1racolony stimulating factor 1 receptor, a0.223
sulf1sulfatase 10.220
fzd7bfrizzled homolog 7b0.209
hhexhematopoietically expressed homeobox0.198
junjun proto-oncogene0.197
lmo2LIM domain only 2 (rhombotin-like 1)0.197
aco1aconitase 1, soluble0.182
rargaretinoic acid receptor gamma a0.180
nkx2.5NK2 transcription factor related 50.173
foxi3aforkhead box I3a0.169
tie1endothelium-specific receptor tyrosine kinase 10.169
krml2.2Kreisler (mouse) maf-related leucine zipper homolog 2.20.163
calcrlacalcitonin receptor-like a0.152
spry4sprouty (Drosophila) homolog 40.150
junbljun B proto-oncogene, like0.149
rag1recombination activating gene 10.140
scn1labsodium channel, voltage-gated, type I like, alpha b0.139
cdh1cadherin 1, epithelial0.137
lcp1lymphocyte cytosolic plastin 10.125
cebpaCCAAT/enhancer binding protein (C/EBP), alpha0.124
gata2aGATA-binding protein 2a0.115
tbx1T-box 10.114
fli1afriend leukemia integration 1a0.111
dusp5dual specificity phosphatase 50.111
junbjun B proto-oncogene0.109
her6hairy-related 60.106
fabp2fatty acid binding protein 2, intestinal0.104
tie2endothelium-specific receptor tyrosine kinase 20.094
irak4interleukin-1 receptor-associated kinase 40.094
foxp1bforkhead box P1b0.092
mycamyelocytomatosis oncogene a0.090
notch3notch homolog 30.088
cyp26c1cytochrome P450, family 26, subfamily C, polypeptide 10.085
slc25a37solute carrier family 25, member 370.085
id2ainhibitor of DNA binding 2, dominant negative helix-loop-helix protein, a0.082
tmprss4atransmembrane protease, serine 4a0.082
kitakit receptor a0.081
gadd45bagrowth arrest and DNA-damage-inducible, beta a0.080
cdh4cadherin 4, retinal0.074
osr1odd-skipped related 1 (Drosophila)0.074
dhrs3adehydrogenase/reductase (SDR family) member 3a0.073
vcanaversican a0.072
tmem88atransmembrane protein 88 a0.071
dctdopachrome tautomerase0.070
efnb2aephrin B2a0.070
atf3activating transcription factor 30.070
ntn1anetrin 1a0.068
crabp2acellular retinoic acid binding protein 2, a0.068
mmp13amatrix metalloproteinase 13a0.066
mychmyelocytomatosis oncogene homolog0.066
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.063
f2rl1.2coagulation factor II (thrombin) receptor-like 1.20.062
tcf12transcription factor 120.061
igf1insulin-like growth factor 10.061
fbp1bfructose-1,6-bisphosphatase 1b0.061
tagln2transgelin 20.058
spns2spinster homolog 2 (Drosophila)0.058
igf1rbinsulin-like growth factor 1b receptor0.058
flt1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.056
cpoxcoproporphyrinogen oxidase0.054
cxcl12bchemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1)0.054
raraaretinoic acid receptor, alpha a0.053
tgfb2transforming growth factor, beta 20.052
fgf17fibroblast growth factor 170.052
fn1bfibronectin 1b0.052
phlda2pleckstrin homology-like domain, family A, member 20.051
tpm4tropomyosin 40.050
mef2camyocyte enhancer factor 2ca0.050
foxd3forkhead box D30.050
erbb3bv-erb-b2 erythroblastic leukemia viral oncogene homolog 3b0.050
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Mapk14mitogen-activated protein kinase 140.997
Cd40CD40 antigen0.992
Gata4GATA binding protein 40.985
Tnftumor necrosis factor0.983
Ptenphosphatase and tensin homolog0.982
Tgfbr2transforming growth factor, beta receptor II0.981
Hand1heart and neural crest derivatives expressed transcript 10.977
Csf1colony stimulating factor 1 (macrophage)0.977
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.973
Ccr2chemokine (C-C motif) receptor 20.968
Tnfrsf9tumor necrosis factor receptor superfamily, member 90.966
Ikzf1IKAROS family zinc finger 10.966
Bmpr1abone morphogenetic protein receptor, type 1A0.959
Fgfr2fibroblast growth factor receptor 20.957
Gata1GATA binding protein 10.953
Tgfb1transforming growth factor, beta 10.950
Cd160CD160 antigen0.949
Map3k14mitogen-activated protein kinase kinase kinase 140.948
Ctnnb1catenin (cadherin associated protein), beta 10.938
Pax6paired box gene 60.933
Ptpn11protein tyrosine phosphatase, non-receptor type 110.922
Runx2runt related transcription factor 20.920
Atf2activating transcription factor 20.918
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.917
Notch1Notch gene homolog 1 (Drosophila)0.897
Ptf1apancreas specific transcription factor, 1a0.896
Pbx1pre B-cell leukemia transcription factor 10.894
Ccl2chemokine (C-C motif) ligand 20.892
Rarbretinoic acid receptor, beta0.886
Gata6GATA binding protein 60.880
Notch2Notch gene homolog 2 (Drosophila)0.878
Inpp5dinositol polyphosphate-5-phosphatase D0.859
Gnaqguanine nucleotide binding protein, alpha q polypeptide0.854
Efnb2ephrin B20.852
Eporerythropoietin receptor0.851
Tnfsf11tumor necrosis factor (ligand) superfamily, member 110.847
Smad4MAD homolog 4 (Drosophila)0.844
Csf2colony stimulating factor 2 (granulocyte-macrophage)0.843
Robo1roundabout homolog 1 (Drosophila)0.824
Il2rginterleukin 2 receptor, gamma chain0.815
Bmp4bone morphogenetic protein 40.807
Mdm2transformed mouse 3T3 cell double minute 20.806
Ascl1achaete-scute complex homolog 1 (Drosophila)0.799
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.799
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.793
Chukconserved helix-loop-helix ubiquitous kinase0.792
CblCasitas B-lineage lymphoma0.789
Tcf4transcription factor 40.788
Gli2GLI-Kruppel family member GLI20.785
Smad3MAD homolog 3 (Drosophila)0.781
Shc1src homology 2 domain-containing transforming protein C10.780
Il2rbinterleukin 2 receptor, beta chain0.780
Ldb3LIM domain binding 30.776
Socs1suppressor of cytokine signaling 10.773
Sox11SRY-box containing gene 110.770
Ccr1chemokine (C-C motif) receptor 10.769
Tnfrsf4tumor necrosis factor receptor superfamily, member 40.768
JunJun oncogene0.765
Pthlhparathyroid hormone-like peptide0.763
Neurod1neurogenic differentiation 10.757
Vdrvitamin D receptor0.752
Inhbainhibin beta-A0.752
Rargretinoic acid receptor, gamma0.750
Id1inhibitor of DNA binding 10.750
Id3inhibitor of DNA binding 30.750
Lyz2lysozyme 20.749
Ephb2Eph receptor B20.748
Fut7fucosyltransferase 70.744
Bcl3B-cell leukemia/lymphoma 30.739
Nhlh1nescient helix loop helix 10.736
Msx1homeobox, msh-like 10.713
Rbl2retinoblastoma-like 20.707
Hoxa5homeobox A50.705
Csf1rcolony stimulating factor 1 receptor0.704
Tcf21transcription factor 210.700
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.700
Sfpi1SFFV proviral integration 10.698
Thrathyroid hormone receptor alpha0.695
Pik3caphosphatidylinositol 3-kinase, catalytic, alpha polypeptide0.694
Cxcr4chemokine (C-X-C motif) receptor 40.688
Tgfb2transforming growth factor, beta 20.688
Rspo2R-spondin 2 homolog (Xenopus laevis)0.685
Batf3basic leucine zipper transcription factor, ATF-like 30.682
Snai1snail homolog 1 (Drosophila)0.679
Sox9SRY-box containing gene 90.666
Ifnginterferon gamma0.662
Kitlkit ligand0.642
C3ar1complement component 3a receptor 10.639
Stat5asignal transducer and activator of transcription 5A0.638
Vegfavascular endothelial growth factor A0.638
Psen1presenilin 10.635
Foxc2forkhead box C20.620
Foxp3forkhead box P30.617
Ltblymphotoxin B0.616
Prkceprotein kinase C, epsilon0.615
Tnfrsf11atumor necrosis factor receptor superfamily, member 11a0.614
Irf9interferon regulatory factor 90.610
Jak3Janus kinase 30.606
S1pr2sphingosine-1-phosphate receptor 20.604
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Btg2BTG family, member 20.393
FgrGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.314
Sirpasignal-regulatory protein alpha0.255
Junbjun B proto-oncogene0.236
Fcn1ficolin (collagen/fibrinogen domain containing) 10.203
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.186
Rassf5Ras association (RalGDS/AF-6) domain family member 50.160
Cxcl3chemokine (C-X-C motif) ligand 30.154
Il2rbinterleukin 2 receptor, beta0.152
Zfp36zinc finger protein 360.137
Dusp1dual specificity phosphatase 10.131
Acap1ArfGAP with coiled-coil, ankyrin repeat and PH domains 10.131
Jak1Janus kinase 10.125
Ptafrplatelet-activating factor receptor0.123
Cfpcomplement factor properdin0.122
Slco2a1solute carrier organic anion transporter family, member 2a10.119
Plauplasminogen activator, urokinase0.113
Klf4Kruppel-like factor 4 (gut)0.110
Csf1colony stimulating factor 1 (macrophage)0.097
Myh9myosin, heavy chain 9, non-muscle0.093
Ptprcprotein tyrosine phosphatase, receptor type, C0.091
Il1rninterleukin 1 receptor antagonist0.091
Atf3activating transcription factor 30.090
Bcl2B-cell CLL/lymphoma 20.088
Cd2Cd2 molecule0.086
Egr1early growth response 10.080
Smad1SMAD family member 10.079
Ccl4chemokine (C-C motif) ligand 40.078
Il1r1interleukin 1 receptor, type I0.075
Spink3serine peptidase inhibitor, Kazal type 30.073
Tgfbr3transforming growth factor, beta receptor III0.065
Il8rbinterleukin 8 receptor, beta0.062
Ppp1r15aprotein phosphatase 1, regulatory (inhibitor) subunit 15A0.062
Arrb1arrestin, beta 10.062
Prdm1PR domain containing 1, with ZNF domain0.061
Ier2immediate early response 20.059
Cpa3carboxypeptidase A3, mast cell0.057
Prf1perforin 1 (pore forming protein)0.057
Gzmkgranzyme K0.057
Neurl3neuralized homolog 3 (Drosophila)0.056
CblCas-Br-M (murine) ecotropic retroviral transforming sequence0.055
Bmp6bone morphogenetic protein 60.054
Ms4a2membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)0.054
Reg3bregenerating islet-derived 3 beta0.054
Syt2synaptotagmin II0.054
Nme1non-metastatic cells 1, protein (NM23A) expressed in0.053
Guca2aguanylate cyclase activator 2a (guanylin)0.052
Myo1dmyosin ID0.052
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.050
B4galt1UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 10.048
Sellselectin L0.048
Gpx6glutathione peroxidase 60.047
Ccr2chemokine (C-C motif) receptor 20.047
TyrobpTyro protein tyrosine kinase binding protein0.047
Ciitaclass II, major histocompatibility complex, transactivator0.047
Socs3suppressor of cytokine signaling 30.047
Pfkfb26-phosphofructo-2-kinase/fructose-2,6-biphosphatase 20.047
Il2rginterleukin 2 receptor, gamma0.046
Mark2MAP/microtubule affinity-regulating kinase 20.046
Bcl3B-cell CLL/lymphoma 30.045
Il1binterleukin 1 beta0.043
Cxcl1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.043
Dcaf17DDB1 and CUL4 associated factor 170.043
Cst7cystatin F (leukocystatin)0.042
Sf1splicing factor 10.042
Pde3aphosphodiesterase 3A, cGMP inhibited0.042
Tmem88transmembrane protein 880.042
Gfra2GDNF family receptor alpha 20.040
Stx11syntaxin 110.040
Dag1dystroglycan 1 (dystrophin-associated glycoprotein 1)0.039
Tie1tyrosine kinase with immunoglobulin-like and EGF-like domains 10.039
Psgb1pregnancy-specific beta 1-glycoprotein0.039
Klrd1killer cell lectin-like receptor, subfamily D, member 10.038
Rgs1regulator of G-protein signaling 10.038
CebpgCCAAT/enhancer binding protein (C/EBP), gamma0.038
LOC687797similar to tumor suppressor candidate 50.038
Nr5a2nuclear receptor subfamily 5, group A, member 20.037
Olr1696olfactory receptor 16960.037
Tmem86atransmembrane protein 86A0.037
Sema3asema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A0.037
Gimap4GTPase, IMAP family member 40.037
Ccl3chemokine (C-C motif) ligand 30.036
Igfalsinsulin-like growth factor binding protein, acid labile subunit0.035
LOC100361706lambda-chain C1-region-like0.035
Actn4actinin alpha 40.035
Slco2b1solute carrier organic anion transporter family, member 2b10.034
Ccl6chemokine (C-C motif) ligand 60.034
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.034
Foxs1forkhead box S10.034
Tgfbr2transforming growth factor, beta receptor II0.033
Kcnh5potassium voltage-gated channel, subfamily H (eag-related), member 50.033
Ostcoligosaccharyltransferase complex subunit0.033
Gja4gap junction protein, alpha 40.033
Tomm6translocase of outer mitochondrial membrane 6 homolog (yeast)0.033
Dad1defender against cell death 10.032
Ncf4neutrophil cytosolic factor 40.032
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism