The network for 'proteoglycan catabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

proteoglycan catabolic process

The chemical reactions and pathways resulting in the breakdown of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans.

NameDescriptionProbabilityFunc Analog Organism
HMGCL3-hydroxymethyl-3-methylglutaryl-CoA lyase0.174
USP4ubiquitin specific peptidase 4 (proto-oncogene)0.160
COMPcartilage oligomeric matrix protein0.120
COL6A1collagen, type VI, alpha 10.093
ACANaggrecan0.085
DOCK7dedicator of cytokinesis 70.085
MPP1membrane protein, palmitoylated 1, 55kDa0.083
CHPFchondroitin polymerizing factor0.080
MLL4myeloid/lymphoid or mixed-lineage leukemia 40.078
ZNF431zinc finger protein 4310.074
PIK3R5phosphoinositide-3-kinase, regulatory subunit 50.074
SUMO3SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae)0.069
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.069
KLHL5kelch-like 5 (Drosophila)0.063
A1BGalpha-1-B glycoprotein0.058
COL4A2collagen, type IV, alpha 20.054
COL13A1collagen, type XIII, alpha 10.053
MMP14matrix metallopeptidase 14 (membrane-inserted)0.050
EXT2exostosin 20.047
BMP1bone morphogenetic protein 10.047
PHF17PHD finger protein 170.046
EMILIN2elastin microfibril interfacer 20.043
NGFRnerve growth factor receptor0.042
PDE4DIPphosphodiesterase 4D interacting protein0.040
TMSB4Xthymosin beta 4, X-linked0.037
CRIP2cysteine-rich protein 20.037
DDAH2dimethylarginine dimethylaminohydrolase 20.036
TUBA1Atubulin, alpha 1a0.033
WISP1WNT1 inducible signaling pathway protein 10.032
CHRDchordin0.027
MKRN1makorin ring finger protein 10.025
LOXL1lysyl oxidase-like 10.024
ADAMTS12ADAM metallopeptidase with thrombospondin type 1 motif, 120.023
COL4A5collagen, type IV, alpha 50.023
P2RX2purinergic receptor P2X, ligand-gated ion channel, 20.023
MFAP2microfibrillar-associated protein 20.022
CRHR1corticotropin releasing hormone receptor 10.022
DMPKdystrophia myotonica-protein kinase0.021
MAST2microtubule associated serine/threonine kinase 20.021
TUBB3tubulin, beta 30.020
CARHSP1calcium regulated heat stable protein 1, 24kDa0.020
GPR124G protein-coupled receptor 1240.020
HOXD8homeobox D80.020
CCND2cyclin D20.019
FSTL1follistatin-like 10.019
SLIT2slit homolog 2 (Drosophila)0.019
CCNA1cyclin A10.018
OSTF1osteoclast stimulating factor 10.017
WDR73WD repeat domain 730.017
UBTD1ubiquitin domain containing 10.016
GLI2GLI family zinc finger 20.016
CCDC40coiled-coil domain containing 400.016
NMT2N-myristoyltransferase 20.015
SLC30A3solute carrier family 30 (zinc transporter), member 30.015
ALAS1aminolevulinate, delta-, synthase 10.015
APLP1amyloid beta (A4) precursor-like protein 10.015
AMNamnionless homolog (mouse)0.014
SCARF2scavenger receptor class F, member 20.014
CSADcysteine sulfinic acid decarboxylase0.014
PHLDA3pleckstrin homology-like domain, family A, member 30.014
ELNelastin0.014
KCNJ5potassium inwardly-rectifying channel, subfamily J, member 50.013
TDGF1teratocarcinoma-derived growth factor 10.013
ADAM12ADAM metallopeptidase domain 120.013
RGS4regulator of G-protein signaling 40.013
UNC5Bunc-5 homolog B (C. elegans)0.013
PTPRUprotein tyrosine phosphatase, receptor type, U0.013
SYDE1synapse defective 1, Rho GTPase, homolog 1 (C. elegans)0.013
GDPD4glycerophosphodiester phosphodiesterase domain containing 40.013
CD248CD248 molecule, endosialin0.013
NKD2naked cuticle homolog 2 (Drosophila)0.013
FKBP10FK506 binding protein 10, 65 kDa0.013
COL1A1collagen, type I, alpha 10.013
CXorf36chromosome X open reading frame 360.013
ITGA11integrin, alpha 110.013
DUS2Ldihydrouridine synthase 2-like, SMM1 homolog (S. cerevisiae)0.012
HADHBhydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit0.012
PLXNA3plexin A30.012
HSF2BPheat shock transcription factor 2 binding protein0.012
BMP8Abone morphogenetic protein 8a0.012
TRIM46tripartite motif containing 460.012
MXRA8matrix-remodelling associated 80.012
ODZ4odz, odd Oz/ten-m homolog 4 (Drosophila)0.012
APCDD1Ladenomatosis polyposis coli down-regulated 1-like0.012
KCNJ4potassium inwardly-rectifying channel, subfamily J, member 40.012
COL5A3collagen, type V, alpha 30.012
TSPAN9tetraspanin 90.012
CPNE7copine VII0.012
A2Malpha-2-macroglobulin0.012
PTGISprostaglandin I2 (prostacyclin) synthase0.011
COL6A2collagen, type VI, alpha 20.011
AJAP1adherens junctions associated protein 10.011
MRC2mannose receptor, C type 20.011
MAGEL2MAGE-like 20.011
LAMA1laminin, alpha 10.011
PRNDprion protein 2 (dublet)0.011
HCN2hyperpolarization activated cyclic nucleotide-gated potassium channel 20.011
FBN3fibrillin 30.011
GPR176G protein-coupled receptor 1760.011
SNTG2syntrophin, gamma 20.011
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism