The network for 'tissue regeneration' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

tissue regeneration

The regrowth of lost or destroyed tissues.

NameDescriptionProbabilityFunc Analog Organism
HDAC2histone deacetylase 20.979
JAG1jagged 10.969
HDAC1histone deacetylase 10.964
FGFR2fibroblast growth factor receptor 20.938
EGFRepidermal growth factor receptor0.921
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.910
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.734
ESR1estrogen receptor 10.731
SHC1SHC (Src homology 2 domain containing) transforming protein 10.653
FN1fibronectin 10.632
DHX30DEAH (Asp-Glu-Ala-His) box polypeptide 300.580
HSP90AA1heat shock protein 90kDa alpha (cytosolic), class A member 10.575
TP63tumor protein p630.564
PLAUplasminogen activator, urokinase0.557
FGBfibrinogen beta chain0.534
KRT17keratin 170.528
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.484
SUZ12suppressor of zeste 12 homolog (Drosophila)0.461
PTPN11protein tyrosine phosphatase, non-receptor type 110.453
CASP10caspase 10, apoptosis-related cysteine peptidase0.446
LATlinker for activation of T cells0.429
KDM1Alysine (K)-specific demethylase 1A0.421
VDAC1voltage-dependent anion channel 10.415
FKBP1AFK506 binding protein 1A, 12kDa0.408
SIN3ASIN3 homolog A, transcription regulator (yeast)0.400
CHD4chromodomain helicase DNA binding protein 40.393
PLATplasminogen activator, tissue0.367
CASP8caspase 8, apoptosis-related cysteine peptidase0.355
KRT18keratin 180.349
RBBP4retinoblastoma binding protein 40.332
EEDembryonic ectoderm development0.330
KRT14keratin 140.326
PTPN1protein tyrosine phosphatase, non-receptor type 10.317
CD74CD74 molecule, major histocompatibility complex, class II invariant chain0.310
SERPINE1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.298
ATP6V1G1ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G10.297
KRT19keratin 190.257
IGFBP3insulin-like growth factor binding protein 30.246
S100A10S100 calcium binding protein A100.234
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.231
MTA3metastasis associated 1 family, member 30.231
PIK3R2phosphoinositide-3-kinase, regulatory subunit 2 (beta)0.230
TERF2telomeric repeat binding factor 20.227
MAPK1mitogen-activated protein kinase 10.227
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.214
FANCAFanconi anemia, complementation group A0.208
RBBP7retinoblastoma binding protein 70.207
COL1A2collagen, type I, alpha 20.200
GRB10growth factor receptor-bound protein 100.196
SMAD7SMAD family member 70.190
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.189
FRS2fibroblast growth factor receptor substrate 20.187
FGAfibrinogen alpha chain0.181
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.178
JAK2Janus kinase 20.175
IGF2Rinsulin-like growth factor 2 receptor0.173
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.173
APOA1apolipoprotein A-I0.167
THBS1thrombospondin 10.164
ZHX1zinc fingers and homeoboxes 10.162
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.162
MDM2Mdm2 p53 binding protein homolog (mouse)0.159
FYNFYN oncogene related to SRC, FGR, YES0.148
FASFas (TNF receptor superfamily, member 6)0.146
POU5F1POU class 5 homeobox 10.138
FGF2fibroblast growth factor 2 (basic)0.135
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.133
NEDD4neural precursor cell expressed, developmentally down-regulated 40.130
FGF1fibroblast growth factor 1 (acidic)0.130
TGFB3transforming growth factor, beta 30.129
CSKc-src tyrosine kinase0.129
DDR2discoidin domain receptor tyrosine kinase 20.127
TNFRSF10Atumor necrosis factor receptor superfamily, member 10a0.127
INSRinsulin receptor0.127
NSFN-ethylmaleimide-sensitive factor0.126
RBPJrecombination signal binding protein for immunoglobulin kappa J region0.125
MBD3methyl-CpG binding domain protein 30.124
IQGAP1IQ motif containing GTPase activating protein 10.122
ITGB1BP3integrin beta 1 binding protein 30.121
CDC20cell division cycle 20 homolog (S. cerevisiae)0.121
TJP1tight junction protein 1 (zona occludens 1)0.120
KRT6Akeratin 6A0.120
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.120
FAM162Afamily with sequence similarity 162, member A0.119
GATAD2BGATA zinc finger domain containing 2B0.117
FBLN1fibulin 10.113
NTRK1neurotrophic tyrosine kinase, receptor, type 10.112
CAV1caveolin 1, caveolae protein, 22kDa0.111
GADD45Agrowth arrest and DNA-damage-inducible, alpha0.111
FAF1Fas (TNFRSF6) associated factor 10.110
PRKRAprotein kinase, interferon-inducible double stranded RNA dependent activator0.109
FGGfibrinogen gamma chain0.107
APOC3apolipoprotein C-III0.106
SPARCsecreted protein, acidic, cysteine-rich (osteonectin)0.104
BLMBloom syndrome, RecQ helicase-like0.101
TNFRSF10Btumor necrosis factor receptor superfamily, member 10b0.101
CSTAcystatin A (stefin A)0.100
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
sox10SRY-box containing gene 100.989
erbb3bv-erb-b2 erythroblastic leukemia viral oncogene homolog 3b0.981
eya1eyes absent homolog 10.912
fgfr1afibroblast growth factor receptor 1a0.792
evx1even-skipped homeobox 10.761
tbx1T-box 10.690
col1a1acollagen, type I, alpha 1a0.680
egr2bearly growth response 2b0.655
tcf7l2transcription factor 7-like 2 (T-cell specific, HMG-box)0.647
cxcr4bchemokine (C-X-C motif), receptor 4b0.610
wnt5bwingless-type MMTV integration site family, member 5b0.592
wnt10awingless-type MMTV integration site family, member 10a0.586
kdrlkinase insert domain receptor like0.581
lef1lymphocyte enhancer binding factor 10.563
emx3empty spiracles homeobox 30.546
wnt11rwingless-type MMTV integration site family, member 11, related0.538
dkk1bdickkopf 1b0.527
mmp2matrix metalloproteinase 20.515
col2a1acollagen type II, alpha-1a0.484
runx1runt-related transcription factor 10.474
foxd3forkhead box D30.469
anxa1aannexin A1a0.466
snai1bsnail homolog 1b (Drosophila)0.451
hmx4H6 family homeobox 40.437
krml2.2Kreisler (mouse) maf-related leucine zipper homolog 2.20.410
mibmind bomb0.405
efnb3bephrin B3b0.352
sox11aSRY-box containing gene 11a0.343
runx2brunt-related transcription factor 2b0.341
cyp26b1cytochrome P450, family 26, subfamily b, polypeptide 10.339
robo3roundabout homolog 30.333
mbpmyelin basic protein0.329
smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.328
dbx1adeveloping brain homeobox 1a0.301
mllmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.301
ptf1apancreas specific transcription factor, 1a0.297
csnk1a1casein kinase 1, alpha 10.296
krit1KRIT1, ankyrin repeat containing0.288
nkx2.2aNK2 transcription factor related 2a0.288
anxa1bannexin A1b0.274
cdh1cadherin 1, epithelial0.271
pitx3paired-like homeodomain transcription factor 30.269
wnt4awingless-type MMTV integration site family, member 4a0.267
col1a2collagen, type I, alpha 20.258
gata3GATA-binding protein 30.254
erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog0.253
wnt9bwingless-type MMTV integration site family, member 9B0.240
atoh1aatonal homolog 1a0.235
vcanaversican a0.234
pitx2paired-like homeodomain transcription factor 20.223
sox11bSRY-box containing gene 11b0.221
gata4GATA-binding protein 40.221
sfrp1asecreted frizzled-related protein 1a0.217
tbx5aT-box 5a0.210
slc4a2asolute carrier family 4, anion exchanger, member 2a0.210
fbn2bfibrillin 2b0.205
nanos3nanos homolog 30.205
tagln2transgelin 20.204
spns2spinster homolog 2 (Drosophila)0.190
postnperiostin, osteoblast specific factor0.184
tnfrsfatumor necrosis factor receptor superfamily, member a0.180
bmp1abone morphogenetic protein 1a0.179
id1inhibitor of DNA binding 10.177
foxg1aforkhead box G1a0.177
ptenbphosphatase and tensin homolog B (mutated in multiple advanced cancers 1)0.176
ptpn6protein tyrosine phosphatase, non-receptor type 60.172
cdkn1ccyclin-dependent kinase inhibitor 1C (p57, Kip2)0.171
lmx1b.1LIM homeobox transcription factor 1, beta 10.171
junbjun B proto-oncogene0.170
wnt2bbwingless-type MMTV integration site family, member 2Bb0.169
dnmt7DNA (cytosine-5-)-methyltransferase 70.169
tnctenascin C0.169
foxn4forkhead box N40.169
ctskcathepsin K0.168
fn1bfibronectin 1b0.167
hdac1histone deacetylase 10.167
ripk2receptor-interacting serine-threonine kinase 20.166
fzd7afrizzled homolog 7a0.164
pkp1plakophilin 10.161
krt4keratin 40.160
grhl2bgrainyhead-like 2b (Drosophila)0.157
tgfb1atransforming growth factor, beta 1a0.154
alpialkaline phosphatase, intestinal0.152
nrg2aneuregulin 2a0.152
lhx2bLIM homeobox 2b0.150
tll1tolloid-like 10.150
nfkbiaanuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a0.148
odz4odd Oz/ten-m homolog 40.145
crybb1crystallin, beta B10.143
col19a1collagen, type XIX, alpha 10.143
gli2aGLI-Kruppel family member GLI2a0.142
hnf1baHNF1 homeobox Ba0.142
cx39.9connexin 39.90.142
neurog1neurogenin 10.142
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Abd-BAbdominal B0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Trp53transformation related protein 530.931
Fgfr2fibroblast growth factor receptor 20.762
Ctnnb1catenin (cadherin associated protein), beta 10.733
Mapk14mitogen-activated protein kinase 140.717
Rxraretinoid X receptor alpha0.694
Trp63transformation related protein 630.658
Egfrepidermal growth factor receptor0.643
Krt17keratin 170.641
Shhsonic hedgehog0.628
Tbx1T-box 10.549
Smad3MAD homolog 3 (Drosophila)0.547
Ptpn11protein tyrosine phosphatase, non-receptor type 110.529
Ezh2enhancer of zeste homolog 2 (Drosophila)0.515
Rargretinoic acid receptor, gamma0.500
Foxn1forkhead box N10.457
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.395
Gopcgolgi associated PDZ and coiled-coil motif containing0.381
Retret proto-oncogene0.365
Ptgs2prostaglandin-endoperoxide synthase 20.356
Fgf10fibroblast growth factor 100.322
Pax3paired box gene 30.318
Pitx2paired-like homeodomain transcription factor 20.315
Gli3GLI-Kruppel family member GLI30.315
Krt6akeratin 6A0.300
Hes1hairy and enhancer of split 1 (Drosophila)0.298
Grb10growth factor receptor bound protein 100.287
Fgf8fibroblast growth factor 80.274
Mybphmyosin binding protein H0.258
Jarid2jumonji, AT rich interactive domain 20.250
Pax1paired box gene 10.248
Ntf3neurotrophin 30.242
Foxc1forkhead box C10.231
Wnt3awingless-related MMTV integration site 3A0.223
Krt5keratin 50.218
Krt14keratin 140.213
Sox2SRY-box containing gene 20.205
Smad6MAD homolog 6 (Drosophila)0.188
Efnb2ephrin B20.186
Krt35keratin 350.185
Ptk7PTK7 protein tyrosine kinase 70.182
Krt72-pskeratin 72, pseudogene0.179
Gpc3glypican 30.176
Fzd1frizzled homolog 1 (Drosophila)0.170
Atoh7atonal homolog 7 (Drosophila)0.170
Nos3nitric oxide synthase 3, endothelial cell0.169
Pax7paired box gene 70.167
Psapl1prosaposin-like 10.167
Tgfb2transforming growth factor, beta 20.164
Pkp1plakophilin 10.158
Tbx3T-box 30.140
Wnt5awingless-related MMTV integration site 5A0.137
Fbln1fibulin 10.136
Barx2BarH-like homeobox 20.136
Wnt7awingless-related MMTV integration site 7A0.133
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.130
Efna4ephrin A40.125
Ctsdcathepsin D0.122
Neurog2neurogenin 20.121
Isl1ISL1 transcription factor, LIM/homeodomain0.118
Pax2paired box gene 20.118
Itgb1integrin beta 1 (fibronectin receptor beta)0.116
Shc1src homology 2 domain-containing transforming protein C10.115
Vegfavascular endothelial growth factor A0.114
Krtdapkeratinocyte differentiation associated protein0.113
Hspa9heat shock protein 90.112
Erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.111
Hoxd13homeobox D130.110
Cldn3claudin 30.108
Gdnfglial cell line derived neurotrophic factor0.108
Sox4SRY-box containing gene 40.106
Tcfap2ctranscription factor AP-2, gamma0.106
Hdac1histone deacetylase 10.103
Hoxa2homeobox A20.103
Esr1estrogen receptor 1 (alpha)0.103
Sprr1asmall proline-rich protein 1A0.101
Lrp2low density lipoprotein receptor-related protein 20.101
Emx1empty spiracles homolog 1 (Drosophila)0.100
Tgfatransforming growth factor alpha0.100
Gli2GLI-Kruppel family member GLI20.100
Pax8paired box gene 80.098
Krt33bkeratin 33B0.096
Apoeapolipoprotein E0.092
Pax6paired box gene 60.091
Mta2metastasis-associated gene family, member 20.089
Myf5myogenic factor 50.088
Nphp4nephronophthisis 4 (juvenile) homolog (human)0.087
Fgf5fibroblast growth factor 50.086
Ptch2patched homolog 20.086
Sfrp2secreted frizzled-related protein 20.086
Phox2bpaired-like homeobox 2b0.085
Bmp4bone morphogenetic protein 40.085
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.085
Twist1twist homolog 1 (Drosophila)0.084
Myl2myosin, light polypeptide 2, regulatory, cardiac, slow0.084
Dkk1dickkopf homolog 1 (Xenopus laevis)0.084
Sox9SRY-box containing gene 90.082
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Anxa2annexin A20.535
Nefmneurofilament, medium polypeptide0.408
Aebp1AE binding protein 10.372
Neflneurofilament, light polypeptide0.323
Fgfr2fibroblast growth factor receptor 20.275
Krt18keratin 180.246
Hmox1heme oxygenase (decycling) 10.211
Anxa5annexin A50.203
Igfbp5insulin-like growth factor binding protein 50.177
Pzppregnancy-zone protein0.161
Gabrpgamma-aminobutyric acid (GABA-A) receptor, pi0.141
Aldoaaldolase A, fructose-bisphosphate0.141
Runx1runt-related transcription factor 10.134
Emp1epithelial membrane protein 10.132
Smad7SMAD family member 70.130
Anxa1annexin A10.129
Tgm1transglutaminase 1, K polypeptide0.122
Pkm2pyruvate kinase, muscle0.120
Ankrd1ankyrin repeat domain 1 (cardiac muscle)0.119
Timp3TIMP metallopeptidase inhibitor 30.112
Gja1gap junction protein, alpha 10.112
Nbl1neuroblastoma, suppression of tumorigenicity 10.111
S1pr2sphingosine-1-phosphate receptor 20.109
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.105
Ccl2chemokine (C-C motif) ligand 20.098
Plauplasminogen activator, urokinase0.098
P2rx7purinergic receptor P2X, ligand-gated ion channel, 70.097
Spp1secreted phosphoprotein 10.096
Mgpmatrix Gla protein0.096
Icam1intercellular adhesion molecule 10.093
Cd44Cd44 molecule0.091
Acta2smooth muscle alpha-actin0.091
Cd9CD9 molecule0.090
Fgfr1Fibroblast growth factor receptor 10.086
Col12a1collagen, type XII, alpha 10.084
Hspb1heat shock protein 10.083
Nab1Ngfi-A binding protein 10.082
Socs3suppressor of cytokine signaling 30.077
Olfml2bolfactomedin-like 2B0.074
Prrx1paired related homeobox 10.074
Cd37CD37 molecule0.073
Nefhneurofilament, heavy polypeptide0.073
Cd14CD14 molecule0.072
Tgfbr2transforming growth factor, beta receptor II0.069
Stxbp1syntaxin binding protein 10.067
Ldhalactate dehydrogenase A0.065
Ednrbendothelin receptor type B0.064
Gapdhglyceraldehyde-3-phosphate dehydrogenase0.063
Sod3superoxide dismutase 3, extracellular0.063
Col3a1collagen, type III, alpha 10.060
Myh9myosin, heavy chain 9, non-muscle0.059
Tgfb1transforming growth factor, beta 10.058
Pecam1platelet/endothelial cell adhesion molecule 10.056
Lgals3lectin, galactoside-binding, soluble, 30.056
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.055
RT1-M5RT1 class Ib, locus M50.054
Phkg1phosphorylase kinase, gamma 10.054
Prkchprotein kinase C, eta0.053
Serpine2serine (or cysteine) peptidase inhibitor, clade E, member 20.053
Lamc1laminin, gamma 10.052
Kif2ckinesin family member 2C0.051
Ccdc80coiled-coil domain containing 800.051
Tgfb3transforming growth factor, beta 30.050
Notch2Notch homolog 2 (Drosophila)0.049
Jak2Janus kinase 20.049
Gja4gap junction protein, alpha 40.049
Itgb4integrin, beta 40.049
Pygmphosphorylase, glycogen, muscle0.049
Jak1Janus kinase 10.048
Irs1insulin receptor substrate 10.047
Sparcsecreted protein, acidic, cysteine-rich (osteonectin)0.047
Soat1sterol O-acyltransferase 10.046
Itpr2inositol 1,4,5-triphosphate receptor, type 20.045
Fn1fibronectin 10.045
Ccr5chemokine (C-C motif) receptor 50.044
Egr3early growth response 30.044
Cdh6cadherin 60.044
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.044
Ptger2prostaglandin E receptor 2 (subtype EP2)0.043
C2cd4dC2 calcium-dependent domain containing 4D0.043
Calcbcalcitonin-related polypeptide, beta0.042
Pax8paired box 80.041
Ptprcprotein tyrosine phosphatase, receptor type, C0.041
Flt1FMS-related tyrosine kinase 10.040
Lcn2lipocalin 20.040
Serpina3nserine (or cysteine) peptidase inhibitor, clade A, member 3N0.040
Smad1SMAD family member 10.040
Rrm2ribonucleotide reductase M20.039
Dusp7dual specificity phosphatase 70.039
Ednraendothelin receptor type A0.038
Olr737olfactory receptor 7370.038
Tcp11t-complex protein 110.038
Mfap4microfibrillar-associated protein 40.038
Casq1calsequestrin 1 (fast-twitch, skeletal muscle)0.038
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism