The network for 'cell fate commitment involved in formation of primary germ layer' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cell fate commitment involved in formation of primary germ layer

The commitment of cells to specific cell fates of the endoderm, ectoderm, or mesoderm as a part of gastrulation.

NameDescriptionProbabilityFunc Analog Organism
POU3F2POU class 3 homeobox 20.985
SMAD7SMAD family member 70.984
BMP2bone morphogenetic protein 20.971
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.966
PAX3paired box 30.962
FGF1fibroblast growth factor 1 (acidic)0.926
PBX1pre-B-cell leukemia homeobox 10.917
FYNFYN oncogene related to SRC, FGR, YES0.912
BMPR1Abone morphogenetic protein receptor, type IA0.907
LCKlymphocyte-specific protein tyrosine kinase0.784
DVL3dishevelled, dsh homolog 3 (Drosophila)0.773
SETD8SET domain containing (lysine methyltransferase) 80.738
SP1Sp1 transcription factor0.720
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.605
MEIS1Meis homeobox 10.598
SMAD3SMAD family member 30.495
CSNK1Ecasein kinase 1, epsilon0.471
LRP6low density lipoprotein receptor-related protein 60.455
SMAD2SMAD family member 20.380
POU5F1POU class 5 homeobox 10.351
SOX2SRY (sex determining region Y)-box 20.345
FZD1frizzled homolog 1 (Drosophila)0.327
SMAD5SMAD family member 50.299
SMAD4SMAD family member 40.296
BBS10Bardet-Biedl syndrome 100.265
FOXD3forkhead box D30.257
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.255
BMP7bone morphogenetic protein 70.230
WNT3Awingless-type MMTV integration site family, member 3A0.219
JAG1jagged 10.214
SOX10SRY (sex determining region Y)-box 100.188
NOGnoggin0.176
APCadenomatous polyposis coli0.166
DVL1dishevelled, dsh homolog 1 (Drosophila)0.166
RTF1Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.161
WWP2WW domain containing E3 ubiquitin protein ligase 20.154
AXIN1axin 10.147
LEO1Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.122
FKBP1AFK506 binding protein 1A, 12kDa0.115
FGFR1fibroblast growth factor receptor 10.108
TCF7L2transcription factor 7-like 2 (T-cell specific, HMG-box)0.103
FSTL1follistatin-like 10.101
CREBBPCREB binding protein0.099
CTNNBIP1catenin, beta interacting protein 10.097
SMURF1SMAD specific E3 ubiquitin protein ligase 10.089
NLKnemo-like kinase0.088
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)0.088
ARandrogen receptor0.086
SMAD1SMAD family member 10.086
HOXA10homeobox A100.078
HIC1hypermethylated in cancer 10.078
MEIS2Meis homeobox 20.077
WT1Wilms tumor 10.066
HCKhemopoietic cell kinase0.066
EP300E1A binding protein p3000.064
NOTCH3notch 30.064
SMAD6SMAD family member 60.063
LRRK2leucine-rich repeat kinase 20.060
RPS6KA6ribosomal protein S6 kinase, 90kDa, polypeptide 60.060
MEOX2mesenchyme homeobox 20.054
SYKspleen tyrosine kinase0.051
PAF1Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)0.047
GSK3Bglycogen synthase kinase 3 beta0.045
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.045
FOXC2forkhead box C2 (MFH-1, mesenchyme forkhead 1)0.043
PLCG1phospholipase C, gamma 10.042
HOXA9homeobox A90.035
ZFYVE9zinc finger, FYVE domain containing 90.034
FZD8frizzled homolog 8 (Drosophila)0.032
MAP3K7mitogen-activated protein kinase kinase kinase 70.031
NEDD4neural precursor cell expressed, developmentally down-regulated 40.030
SFRP1secreted frizzled-related protein 10.030
BTRCbeta-transducin repeat containing0.029
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.027
WNT5Awingless-type MMTV integration site family, member 5A0.027
SOX21SRY (sex determining region Y)-box 210.026
RBPJrecombination signal binding protein for immunoglobulin kappa J region0.025
GLIS2GLIS family zinc finger 20.025
HNF1AHNF1 homeobox A0.024
SOX9SRY (sex determining region Y)-box 90.024
SOX11SRY (sex determining region Y)-box 110.022
INHBBinhibin, beta B0.022
PSTPIP1proline-serine-threonine phosphatase interacting protein 10.022
DUSP1dual specificity phosphatase 10.022
FOXE1forkhead box E1 (thyroid transcription factor 2)0.021
MYBv-myb myeloblastosis viral oncogene homolog (avian)0.020
FGF2fibroblast growth factor 2 (basic)0.020
GDF5growth differentiation factor 50.020
SIM2single-minded homolog 2 (Drosophila)0.020
NDPNorrie disease (pseudoglioma)0.019
FOXC1forkhead box C10.019
TCF4transcription factor 40.018
GRB2growth factor receptor-bound protein 20.018
OTPorthopedia homeobox0.018
MSX1msh homeobox 10.017
ZNF512Bzinc finger protein 512B0.016
SH3KBP1SH3-domain kinase binding protein 10.016
FOXF2forkhead box F20.015
FGF8fibroblast growth factor 8 (androgen-induced)0.015
FGFR2fibroblast growth factor receptor 20.015
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
pop-1Protein POP-10.998
elt-6Protein ELT-60.988
egl-18Protein EGL-180.987
pha-4Protein PHA-40.921
nhr-67Protein NHR-670.911
zip-7Protein ZIP-70.910
eya-1Protein EYA-10.874
hlh-1Protein HLH-10.821
lin-29Protein LIN-290.764
hlh-2Protein HLH-20.699
egl-13Protein EGL-130.674
fkh-2Protein FKH-20.666
hnd-1Protein HND-10.660
bar-1Protein BAR-10.650
nhr-2Protein NHR-20.610
pry-1Protein PRY-10.604
trim-9Protein TRIM-90.530
pes-1Protein PES-10.526
unc-62Protein UNC-620.485
egl-46Protein EGL-460.400
mls-2Protein MLS-20.400
lin-12Protein LIN-120.355
cnd-1Protein CND-10.277
hlh-14Protein HLH-140.269
cam-1Protein CAM-10.269
lin-17Protein LIN-170.265
cwn-2Protein CWN-20.245
odd-2Protein ODD-20.238
mab-5Protein MAB-50.235
nhr-25Protein NHR-250.232
egl-38Protein EGL-380.212
sma-6Protein SMA-60.210
eor-1Protein EOR-10.192
med-1Protein MED-10.180
egl-15Protein EGL-150.168
ceh-27Protein CEH-270.153
elt-2Protein ELT-20.143
unc-130Protein UNC-1300.130
CELE_C27D8.3Protein C27D8.30.122
rig-5Protein RIG-50.116
ztf-2Protein ZTF-20.113
mnp-1Protein MNP-10.112
egl-36Protein EGL-360.105
tbx-8Protein TBX-80.102
camt-1Protein CAMT-10.098
egl-30Protein EGL-300.095
peb-1Protein PEB-10.093
str-200Protein STR-2000.090
T20D4.19Protein T20D4.190.089
egl-5Protein EGL-50.087
ten-1Protein TEN-10.087
ceh-43Protein CEH-430.084
sem-2Protein SEM-20.084
let-60Protein LET-600.083
irx-1Protein IRX-10.082
Y65A5A.1Protein Y65A5A.10.082
med-2Protein MED-20.080
brp-1Protein BRP-10.080
syd-2Protein SYD-20.078
swsn-1Protein SWSN-10.078
sma-9Protein SMA-90.075
C40A11.6Protein C40A11.60.074
vab-3Protein VAB-30.072
ceh-16Protein CEH-160.071
ceh-36Protein CEH-360.070
F40G9.6Protein F40G9.60.066
ref-2Protein REF-20.065
tbx-9Protein TBX-90.062
dhs-14Protein DHS-140.061
F11D5.1Protein F11D5.10.061
twk-25Protein TWK-250.060
lag-1Protein LAG-10.060
sem-5Protein SEM-50.059
sos-1Protein SOS-10.059
T04D3.5Protein T04D3.50.059
T28F4.1Protein T28F4.10.057
best-18Protein BEST-180.056
gadr-3Protein GADR-30.055
sel-7Protein SEL-70.055
ceh-34Protein CEH-340.055
flt-1Protein FLT-10.054
CELE_C05B5.4Protein C05B5.40.054
flh-1Protein FLH-10.053
phat-5Protein PHAT-50.053
hlh-3Protein HLH-30.050
atg-7Protein ATG-70.049
gad-1Protein GAD-10.048
sem-4Protein SEM-40.048
unc-73Protein UNC-730.048
T04F8.7Protein T04F8.70.048
fbxc-34Protein FBXC-340.048
dmd-8Protein DMD-80.047
unc-53Protein UNC-530.047
php-3Protein PHP-30.047
B0035.6Protein B0035.60.045
klf-2Protein KLF-20.045
fbxb-40Protein FBXB-400.045
lin-7Protein LIN-70.045
btb-9Protein BTB-90.044
pax-3Protein PAX-30.044
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
chdchordin1.000
ndr2nodal-related 20.977
fgf3fibroblast growth factor 30.973
ventventral expressed homeobox0.964
flhfloating head0.960
tbx1T-box 10.947
hnf1baHNF1 homeobox Ba0.939
eya1eyes absent homolog 10.938
pax2apaired box gene 2a0.924
smad1MAD homolog 1 (Drosophila)0.903
fgfr1afibroblast growth factor receptor 1a0.902
dharmadharma0.878
gli1GLI-Kruppel family member 10.850
sox3SRY-box containing gene 30.843
bmp4bone morphogenetic protein 40.807
fgf17fibroblast growth factor 170.791
bmpr1aabone morphogenetic protein receptor, type 1aa0.785
tbx16T-box gene 160.741
sox9bSRY-box containing gene 9b0.741
wnt5bwingless-type MMTV integration site family, member 5b0.728
dlcdeltaC0.660
shhasonic hedgehog a0.655
wnt2bbwingless-type MMTV integration site family, member 2Bb0.640
oepone-eyed pinhead0.638
dkk1bdickkopf 1b0.623
btg2B-cell translocation gene 20.618
evx1even-skipped homeobox 10.615
bocbrother of CDO0.605
foxg1aforkhead box G1a0.581
runx2brunt-related transcription factor 2b0.581
tbx20T-box 200.575
spry2sprouty homolog 20.564
pcdh8protocadherin 80.553
meis3myeloid ecotropic viral integration site 30.552
notch3notch homolog 30.550
ephb4beph receptor B4b0.547
tll1tolloid-like 10.546
notch2notch homolog 20.538
vedventrally expressed dharma/bozozok antagonist0.536
dusp6dual specificity phosphatase 60.532
vsx1visual system homeobox 1 homolog, chx10-like0.529
epb4.1l4erythrocyte protein band 4.1-like 40.520
mmp2matrix metalloproteinase 20.514
wnt11rwingless-type MMTV integration site family, member 11, related0.512
mibmind bomb0.506
atoh1aatonal homolog 1a0.500
bmp2bbone morphogenetic protein 2b0.497
cdh2cadherin 2, neuronal0.484
fgf10afibroblast growth factor 10a0.483
gli2aGLI-Kruppel family member GLI2a0.476
fn1fibronectin 10.459
wnt8bwingless-type MMTV integration site family, member 8b0.443
wnt10awingless-type MMTV integration site family, member 10a0.442
sox1aSRY-box containing gene 1a0.425
msxcmuscle segment homeobox C0.419
fzd5frizzled homolog 50.417
axin1axin 10.407
ndr1nodal-related 10.400
fgf8afibroblast growth factor 8 a0.392
foxh1forkhead box H10.387
hoxa2bhomeo box A2b0.382
jag2jagged 20.377
ptch1patched 10.368
hoxa11ahomeo box A11a0.353
lhx2bLIM homeobox 2b0.352
dlddeltaD0.337
pou5f1POU domain, class 5, transcription factor 10.326
etv2ets variant gene 20.321
tcf7l2transcription factor 7-like 2 (T-cell specific, HMG-box)0.306
hmx4H6 family homeobox 40.299
bmpr2bbone morphogenetic protein receptor, type II b (serine/threonine kinase)0.298
lef1lymphocyte enhancer binding factor 10.290
gbx2gastrulation brain homeo box 20.290
foxb1.2forkhead box B1.20.290
nanos3nanos homolog 30.287
lama5laminin, alpha 50.280
her7hairy and enhancer of split related-70.274
sox2SRY-box containing gene 20.273
ntlano tail a0.272
wnt3awingless-type MMTV integration site family, member 3A0.266
foxn4forkhead box N40.266
hmx3homeo box (H6 family) 30.262
spry4sprouty (Drosophila) homolog 40.262
vangl2vang-like 2 (van gogh, Drosophila)0.254
hhiphedgehog interacting protein0.253
cdx4caudal type homeo box transcription factor 40.246
sox32SRY-box containing gene 320.244
plagl2pleiomorphic adenoma gene-like 20.241
nkx2.2aNK2 transcription factor related 2a0.231
mespbmesoderm posterior b0.223
egr2aearly growth response 2a0.221
pou3f3bPOU class 3 homeobox 3b0.220
wnt9awingless-type MMTV integration site family, member 9A0.219
emx3empty spiracles homeobox 30.208
pax8paired box gene 80.197
lfnglunatic fringe homolog0.187
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.181
snai1bsnail homolog 1b (Drosophila)0.178
med12mediator of RNA polymerase II transcription, subunit 12 homolog0.176
twist1atwist1a0.174
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
cicubitus interruptus0.998
wgwingless0.985
tintinman0.973
dppdecapentaplegic0.863
MadMothers against dpp0.824
slp1sloppy paired 10.693
abd-Aabdominal A0.625
shnschnurri0.567
ushu-shaped0.528
EgfrEpidermal growth factor receptor0.472
eyaeyes absent0.437
E(spl)Enhancer of split0.419
UbxUltrabithorax0.412
tldtolloid0.384
lzlozenge0.323
enengrailed0.301
binbiniou0.270
twitwist0.267
hkbhuckebein0.264
sflsulfateless0.191
panpangolin0.186
argosCG4531 gene product from transcript CG4531-RA0.183
sbbscribbler0.171
smosmoothened0.170
bynbrachyenteron0.168
gsbgooseberry0.160
senssenseless0.145
bnlbranchless0.140
htlheartless0.138
Abd-BAbdominal B0.136
ttvtout-velu0.136
SmoxSmad on X0.134
NNotch0.127
DadDaughters against dpp0.127
SerSerrate0.124
emcextra macrochaetae0.112
tkvthickveins0.111
hhhedgehog0.108
sogshort gastrulation0.107
stumpsCG31317 gene product from transcript CG31317-RC0.097
opaodd paired0.083
rapretina aberrant in pattern0.082
osaCG7467 gene product from transcript CG7467-RD0.080
ribribbon0.078
TlToll0.076
ash2absent, small, or homeotic discs 20.074
btdbuttonhead0.073
bibbig brain0.064
fzfrizzled0.063
kniknirps0.062
hbshibris0.057
Ras85DRas oncogene at 85D0.054
bowlbrother of odd with entrails limited0.053
phlpole hole0.052
rhorhomboid0.051
zfh1Zn finger homeodomain 10.051
cswcorkscrew0.049
slp2sloppy paired 20.048
oddodd skipped0.048
nkdnaked cuticle0.046
TrhTryptophan hydroxylase0.046
fasfaint sausage0.046
srpserpent0.044
gbbglass bottom boat0.044
CG14869CG14869 gene product from transcript CG14869-RB0.040
tsgtwisted gastrulation0.039
salmspalt major0.037
Wnt2Wnt oncogene analog 20.036
MedMedea0.033
GscGoosecoid0.033
retnretained0.032
atoatonal0.030
zfh2Zn finger homeodomain 20.029
B-H2BarH20.028
arrarrow0.028
Btk29ABtk family kinase at 29A0.028
HLH54FCG5005 gene product from transcript CG5005-RA0.028
DfdDeformed0.027
LanB2Laminin B20.027
NFATNFAT homolog0.025
tinctincar0.024
rnrotund0.024
HHairless0.023
lablabial0.022
mewmultiple edematous wings0.022
tlltailless0.022
lmdlame duck0.022
LanALaminin A0.021
pyrpyramus0.021
Wnt4Wnt oncogene analog 40.021
pntpointed0.021
ptrproximal to raf0.020
spispitz0.020
crbcrumbs0.020
Mef2Myocyte enhancer factor 20.019
slmbsupernumerary limbs0.019
ptcpatched0.019
rorough0.019
fs(1)hfemale sterile (1) homeotic0.019
kuzkuzbanian0.019
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Shhsonic hedgehog1.000
Pax2paired box gene 21.000
Fgfr2fibroblast growth factor receptor 21.000
Ctnnb1catenin (cadherin associated protein), beta 11.000
Fgf8fibroblast growth factor 81.000
Gli3GLI-Kruppel family member GLI31.000
Otx2orthodenticle homolog 2 (Drosophila)1.000
Bmp4bone morphogenetic protein 40.999
Pitx2paired-like homeodomain transcription factor 20.997
Vangl2vang-like 2 (van gogh, Drosophila)0.997
Hand1heart and neural crest derivatives expressed transcript 10.996
Nodalnodal0.996
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.995
Tbx1T-box 10.995
Foxc1forkhead box C10.989
Alx4aristaless-like homeobox 40.988
Pax3paired box gene 30.987
Hand2heart and neural crest derivatives expressed transcript 20.984
Dlx5distal-less homeobox 50.984
Sox2SRY-box containing gene 20.982
Fgfr1fibroblast growth factor receptor 10.979
Wnt3awingless-related MMTV integration site 3A0.977
Smad6MAD homolog 6 (Drosophila)0.973
Hoxa1homeobox A10.971
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.970
Hoxa11homeobox A110.963
Hoxd13homeobox D130.960
Hoxd11homeobox D110.948
Sox9SRY-box containing gene 90.933
Pax8paired box gene 80.923
Msx2homeobox, msh-like 20.922
Foxc2forkhead box C20.921
Smad4MAD homolog 4 (Drosophila)0.911
Pbx1pre B-cell leukemia transcription factor 10.910
Hmx3H6 homeobox 30.909
Tbx3T-box 30.906
Pou3f3POU domain, class 3, transcription factor 30.892
Chd7chromodomain helicase DNA binding protein 70.884
Eya1eyes absent 1 homolog (Drosophila)0.884
Lhx1LIM homeobox protein 10.874
Lmx1aLIM homeobox transcription factor 1 alpha0.871
Msx1homeobox, msh-like 10.856
Bmp7bone morphogenetic protein 70.855
Foxa2forkhead box A20.855
Isl1ISL1 transcription factor, LIM/homeodomain0.847
Rarbretinoic acid receptor, beta0.840
Hoxa13homeobox A130.834
Fgf10fibroblast growth factor 100.831
Gata4GATA binding protein 40.816
Prrx1paired related homeobox 10.804
Gbx2gastrulation brain homeobox 20.803
Rargretinoic acid receptor, gamma0.782
Dvl2dishevelled 2, dsh homolog (Drosophila)0.739
Gli2GLI-Kruppel family member GLI20.713
Jag1jagged 10.702
Efnb2ephrin B20.691
Nkx2-1NK2 homeobox 10.685
Zic3zinc finger protein of the cerebellum 30.677
Tgfb2transforming growth factor, beta 20.675
Tgfbr2transforming growth factor, beta receptor II0.669
Hes1hairy and enhancer of split 1 (Drosophila)0.651
Dkk1dickkopf homolog 1 (Xenopus laevis)0.649
Smad1MAD homolog 1 (Drosophila)0.648
Fgf3fibroblast growth factor 30.642
Apcadenomatosis polyposis coli0.639
Gdf3growth differentiation factor 30.633
Prrx2paired related homeobox 20.623
Pitx1paired-like homeodomain transcription factor 10.616
Gscgoosecoid homeobox0.613
Sfrp2secreted frizzled-related protein 20.605
Foxh1forkhead box H10.598
Tcfap2atranscription factor AP-2, alpha0.596
Wnt1wingless-related MMTV integration site 10.595
Otx1orthodenticle homolog 1 (Drosophila)0.587
En1engrailed 10.580
Foxf1aforkhead box F1a0.557
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.513
Gata6GATA binding protein 60.505
Ntf3neurotrophin 30.495
Hoxa2homeobox A20.490
Foxg1forkhead box G10.483
Smosmoothened homolog (Drosophila)0.476
Dvl3dishevelled 3, dsh homolog (Drosophila)0.471
Pax6paired box gene 60.449
Meis2Meis homeobox 20.436
Lhx3LIM homeobox protein 30.430
Chrdchordin0.430
Shesrc homology 2 domain-containing transforming protein E0.424
Sox11SRY-box containing gene 110.419
Bmpr1abone morphogenetic protein receptor, type 1A0.414
Ror2receptor tyrosine kinase-like orphan receptor 20.392
Tbx15T-box 150.390
Hoxa9homeobox A90.387
Gdf5growth differentiation factor 50.375
Acvr1activin A receptor, type 10.372
Wnt4wingless-related MMTV integration site 40.352
Alx3aristaless-like homeobox 30.349
Foxb1forkhead box B10.331
Meox2mesenchyme homeobox 20.330
Lef1lymphoid enhancer binding factor 10.326
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism