The network for 'viral genome replication' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

viral genome replication

Any process involved directly in viral genome replication, including viral nucleotide metabolism.

Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
IFIT3interferon-induced protein with tetratricopeptide repeats 30.994
OAS12',5'-oligoadenylate synthetase 1, 40/46kDa0.978
IFIT1interferon-induced protein with tetratricopeptide repeats 10.974
IFI44interferon-induced protein 440.957
IFITM1interferon induced transmembrane protein 1 (9-27)0.953
MX1myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)0.945
DDX58DEAD (Asp-Glu-Ala-Asp) box polypeptide 580.935
SP110SP110 nuclear body protein0.912
OAS22'-5'-oligoadenylate synthetase 2, 69/71kDa0.910
EIF2AK2eukaryotic translation initiation factor 2-alpha kinase 20.909
IFI44Linterferon-induced protein 44-like0.881
IFIH1interferon induced with helicase C domain 10.846
STAT1signal transducer and activator of transcription 1, 91kDa0.818
IRF9interferon regulatory factor 90.817
PLSCR1phospholipid scramblase 10.807
IFI6interferon, alpha-inducible protein 60.758
CXCL10chemokine (C-X-C motif) ligand 100.747
OASL2'-5'-oligoadenylate synthetase-like0.746
IFITM3interferon induced transmembrane protein 3 (1-8U)0.724
CXCL3chemokine (C-X-C motif) ligand 30.717
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.695
IL8interleukin 80.694
IFIT2interferon-induced protein with tetratricopeptide repeats 20.674
SP100SP100 nuclear antigen0.620
DICER1dicer 1, ribonuclease type III0.592
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.576
ATG12ATG12 autophagy related 12 homolog (S. cerevisiae)0.556
ISG15ISG15 ubiquitin-like modifier0.555
CCR5chemokine (C-C motif) receptor 50.517
DTX3Ldeltex 3-like (Drosophila)0.514
CXCL2chemokine (C-X-C motif) ligand 20.503
XAF1XIAP associated factor 10.496
CCL8chemokine (C-C motif) ligand 80.452
PRKRAprotein kinase, interferon-inducible double stranded RNA dependent activator0.449
HERC5hect domain and RLD 50.418
MX2myxovirus (influenza virus) resistance 2 (mouse)0.401
CXCL11chemokine (C-X-C motif) ligand 110.311
CMPK2cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial0.302
CCL2chemokine (C-C motif) ligand 20.294
IL6interleukin 6 (interferon, beta 2)0.290
IFITM2interferon induced transmembrane protein 2 (1-8D)0.259
IFIT5interferon-induced protein with tetratricopeptide repeats 50.256
DHX9DEAH (Asp-Glu-Ala-His) box polypeptide 90.251
OAS32'-5'-oligoadenylate synthetase 3, 100kDa0.247
UBE2L6ubiquitin-conjugating enzyme E2L 60.246
SAMD9sterile alpha motif domain containing 90.241
CCL4chemokine (C-C motif) ligand 40.234
PARP9poly (ADP-ribose) polymerase family, member 90.231
IFI35interferon-induced protein 350.229
IFI27interferon, alpha-inducible protein 270.219
CXCL5chemokine (C-X-C motif) ligand 50.216
CXCL9chemokine (C-X-C motif) ligand 90.207
SAMD9Lsterile alpha motif domain containing 9-like0.202
IDEinsulin-degrading enzyme0.182
IL1Binterleukin 1, beta0.179
BST2bone marrow stromal cell antigen 20.176
CCL20chemokine (C-C motif) ligand 200.167
HNF4Ahepatocyte nuclear factor 4, alpha0.154
DPP4dipeptidyl-peptidase 40.142
DDX60DEAD (Asp-Glu-Ala-Asp) box polypeptide 600.138
IRF7interferon regulatory factor 70.137
BCL2L1BCL2-like 10.134
PRPF4PRP4 pre-mRNA processing factor 4 homolog (yeast)0.130
PARP14poly (ADP-ribose) polymerase family, member 140.130
CXCL6chemokine (C-X-C motif) ligand 6 (granulocyte chemotactic protein 2)0.129
CARM1coactivator-associated arginine methyltransferase 10.121
CHERPcalcium homeostasis endoplasmic reticulum protein0.118
AXLAXL receptor tyrosine kinase0.114
RSAD2radical S-adenosyl methionine domain containing 20.108
THOC4THO complex 40.106
TARBP2TAR (HIV-1) RNA binding protein 20.101
BAG2BCL2-associated athanogene 20.098
NAMPTnicotinamide phosphoribosyltransferase0.085
CCL5chemokine (C-C motif) ligand 50.083
SRPK1SRSF protein kinase 10.082
CCL18chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)0.081
SMARCC1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.081
USP18ubiquitin specific peptidase 180.080
XRCC5X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)0.077
CCL7chemokine (C-C motif) ligand 70.070
IFI16interferon, gamma-inducible protein 160.066
APOL1apolipoprotein L, 10.065
MMP12matrix metallopeptidase 12 (macrophage elastase)0.064
CXCL13chemokine (C-X-C motif) ligand 130.061
TRIM14tripartite motif containing 140.060
EIF2C2eukaryotic translation initiation factor 2C, 20.057
BCL2A1BCL2-related protein A10.055
CCR1chemokine (C-C motif) receptor 10.055
PDPK13-phosphoinositide dependent protein kinase-10.054
PI3peptidase inhibitor 3, skin-derived0.050
SIGLEC1sialic acid binding Ig-like lectin 1, sialoadhesin0.050
CCL13chemokine (C-C motif) ligand 130.049
OSBPL9oxysterol binding protein-like 90.048
EPSTI1epithelial stromal interaction 1 (breast)0.047
GBP1guanylate binding protein 1, interferon-inducible0.046
IL10interleukin 100.046
TP53tumor protein p530.045
LAP3leucine aminopeptidase 30.044
NMIN-myc (and STAT) interactor0.043
PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)0.042
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
DlDelta0.013
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Irf7interferon regulatory factor 70.975
Rsad2radical S-adenosyl methionine domain containing 20.933
Ddx60DEAD (Asp-Glu-Ala-Asp) box polypeptide 600.919
Dhx58DEXH (Asp-Glu-X-His) box polypeptide 580.873
BaxBCL2-associated X protein0.766
Usp18ubiquitin specific peptidase 180.751
Uba7ubiquitin-like modifier activating enzyme 70.691
Trim30atripartite motif-containing 30A0.686
Gbp7guanylate binding protein 70.682
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.644
Rtp4receptor transporter protein 40.599
Oasl12'-5' oligoadenylate synthetase-like 10.565
Irf9interferon regulatory factor 90.564
Isg15ISG15 ubiquitin-like modifier0.547
Oasl22'-5' oligoadenylate synthetase-like 20.538
Mx1myxovirus (influenza virus) resistance 10.534
Tor3atorsin family 3, member A0.496
Oas22'-5' oligoadenylate synthetase 20.476
Oas1a2'-5' oligoadenylate synthetase 1A0.433
Trim30dtripartite motif-containing 30D0.388
Ifi44interferon-induced protein 440.383
Zbp1Z-DNA binding protein 10.362
Ifit3interferon-induced protein with tetratricopeptide repeats 30.344
Parp14poly (ADP-ribose) polymerase family, member 140.321
Atg12autophagy-related 12 (yeast)0.295
Oas32'-5' oligoadenylate synthetase 30.263
Ifit1interferon-induced protein with tetratricopeptide repeats 10.248
Oas1b2'-5' oligoadenylate synthetase 1B0.234
Ddx58DEAD (Asp-Glu-Ala-Asp) box polypeptide 580.232
Ube2l6ubiquitin-conjugating enzyme E2L 60.225
Stat2signal transducer and activator of transcription 20.211
Slfn4schlafen 40.210
Lgals3bplectin, galactoside-binding, soluble, 3 binding protein0.178
Cmpk2cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial0.147
BC006779cDNA sequence BC0067790.143
Pmaip1phorbol-12-myristate-13-acetate-induced protein 10.124
Trim21tripartite motif-containing 210.118
Trim12atripartite motif-containing 12A0.114
Mndalmyeloid nuclear differentiation antigen like0.108
Ifi35interferon-induced protein 350.099
Lgals9lectin, galactose binding, soluble 90.096
Tmem106atransmembrane protein 106A0.092
Mx2myxovirus (influenza virus) resistance 20.092
Epsti1epithelial stromal interaction 1 (breast)0.089
Bak1BCL2-antagonist/killer 10.086
Irgm1immunity-related GTPase family M member 10.080
Xaf1XIAP associated factor 10.071
Bcl2B-cell leukemia/lymphoma 20.071
Herc6hect domain and RLD 60.069
Stat1signal transducer and activator of transcription 10.066
D14Ertd668eDNA segment, Chr 14, ERATO Doi 668, expressed0.066
Sp100nuclear antigen Sp1000.062
Trim25tripartite motif-containing 250.060
Eef1a1eukaryotic translation elongation factor 1 alpha 10.049
Bst2bone marrow stromal cell antigen 20.047
Plac8placenta-specific 80.046
Dtx3ldeltex 3-like (Drosophila)0.046
TapbpTAP binding protein0.045
Ly6alymphocyte antigen 6 complex, locus A0.044
Trim34atripartite motif-containing 34A0.044
Ifi203interferon activated gene 2030.042
Pmlpromyelocytic leukemia0.042
Parp10poly (ADP-ribose) polymerase family, member 100.040
Eif2ak2eukaryotic translation initiation factor 2-alpha kinase 20.039
Slfn2schlafen 20.038
Parp9poly (ADP-ribose) polymerase family, member 90.036
Psmb8proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)0.036
Samd9lsterile alpha motif domain containing 9-like0.034
H2-T24histocompatibility 2, T region locus 240.034
Safbscaffold attachment factor B0.031
Batf2basic leucine zipper transcription factor, ATF-like 20.031
Pyhin1pyrin and HIN domain family, member 10.030
Traf3TNF receptor-associated factor 30.029
Apol9aapolipoprotein L 9a0.028
Irgm2immunity-related GTPase family M member 20.027
ND6NADH dehydrogenase subunit 60.026
Cxcl10chemokine (C-X-C motif) ligand 100.025
Gm12185predicted gene 121850.025
Zc3hav1zinc finger CCCH type, antiviral 10.024
Polr2dpolymerase (RNA) II (DNA directed) polypeptide D0.023
Parp12poly (ADP-ribose) polymerase family, member 120.022
Lcn2lipocalin 20.021
Tmem176atransmembrane protein 176A0.021
Tmem176btransmembrane protein 176B0.021
Ifih1interferon induced with helicase C domain 10.020
Slfn8schlafen 80.020
Unc93b1unc-93 homolog B1 (C. elegans)0.020
Fcgr4Fc receptor, IgG, low affinity IV0.020
Tnpo3transportin 30.020
Mlklmixed lineage kinase domain-like0.019
Tcirg1T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A30.019
Ncoa5nuclear receptor coactivator 50.019
Saa3serum amyloid A 30.019
Mndamyeloid cell nuclear differentiation antigen0.019
Samhd1SAM domain and HD domain, 10.019
Gsdmdgasdermin D0.019
Tnfsf10tumor necrosis factor (ligand) superfamily, member 100.018
Trim5tripartite motif-containing 50.018
Oas1c2'-5' oligoadenylate synthetase 1C0.017
Psmb9proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)0.017
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Usp18ubiquitin specific peptidase 180.325
Irf7interferon regulatory factor 70.240
Ifit3interferon-induced protein with tetratricopeptide repeats 30.166
Ifitm1interferon induced transmembrane protein 10.108
Ifitm2interferon induced transmembrane protein 20.087
Cxcl10chemokine (C-X-C motif) ligand 100.082
Oas1a2'-5' oligoadenylate synthetase 1A0.079
Lgals3bplectin, galactoside-binding, soluble, 3 binding protein0.055
Ifitm3interferon induced transmembrane protein 30.055
Oasl2'-5'-oligoadenylate synthetase-like0.048
S100a11S100 calcium binding protein A11 (calizzarin)0.045
Timp1TIMP metallopeptidase inhibitor 10.038
C1scomplement component 1, s subcomponent0.036
Mgpmatrix Gla protein0.035
Serping1serine (or cysteine) peptidase inhibitor, clade G, member 10.035
Isg15ISG15 ubiquitin-like modifier0.031
Klrd1killer cell lectin-like receptor, subfamily D, member 10.030
Fkbp3FK506 binding protein 30.030
Slfn3schlafen 30.027
Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 10.025
Calm2calmodulin 20.025
RT1-S3RT1 class Ib, locus S30.024
Nkg7natural killer cell group 7 sequence0.022
Dynll1dynein light chain LC8-type 10.020
Cfbcomplement factor B0.020
Hnrnpa2b1heterogeneous nuclear ribonucleoprotein A2/B10.020
Sp110SP110 nuclear body protein0.019
C1rcomplement component 1, r subcomponent0.017
Akr1a1aldo-keto reductase family 1, member A1 (aldehyde reductase)0.017
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.017
C1dC1D nuclear receptor co-repressor0.016
Il2rbinterleukin 2 receptor, beta0.016
Thoc1THO complex 10.016
Foxk2forkhead box K20.016
Sub1SUB1 homolog (S. cerevisiae)0.016
Txn1thioredoxin 10.015
Cxcl9chemokine (C-X-C motif) ligand 90.014
Zbp1Z-DNA binding protein 10.014
Sec62SEC62 homolog (S. cerevisiae)0.014
Pla1aphospholipase A1 member A0.014
Ywhaqtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.014
Pcnxl3pecanex-like 3 (Drosophila)0.014
Serinc1serine incorporator 10.013
Xdhxanthine dehydrogenase0.013
Eif4heukaryotic translation initiation factor 4H0.013
Mx1myxovirus (influenza virus) resistance 10.013
H3f3bH3 histone, family 3B0.013
Fam195bfamily with sequence similarity 195, member B0.012
Bcl2a1dB-cell leukemia/lymphoma 2 related protein A1d0.012
Kcnj13potassium inwardly-rectifying channel, subfamily J, member 130.012
Sp140SP140 nuclear body protein0.012
Srgnserglycin0.012
Gbp2guanylate binding protein 20.012
Kcnj15potassium inwardly-rectifying channel, subfamily J, member 150.011
Gzmmgranzyme M (lymphocyte met-ase 1)0.011
Nfixnuclear factor I/X (CCAAT-binding transcription factor)0.011
Isg20interferon stimulated exonuclease gene 200.011
LOC100364500RT1 class I, locus CE11-like0.011
Cxcl1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.011
Fcgr3aFc fragment of IgG, low affinity IIIa, receptor0.011
S100a6S100 calcium binding protein A60.011
Slc25a5solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 50.011
Casp12caspase 120.011
Cxcr3chemokine (C-X-C motif) receptor 30.011
Rbm39RNA binding motif protein 390.011
Oas1b2-5 oligoadenylate synthetase 1B0.010
Cxcl13chemokine (C-X-C motif) ligand 130.010
Napsanapsin A aspartic peptidase0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism