The network for 'forebrain neuron differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

forebrain neuron differentiation

The process in which a relatively unspecialized cell acquires specialized features of a neuron that will reside in the forebrain.

NameDescriptionProbabilityFunc Analog Organism
CDC42cell division cycle 42 (GTP binding protein, 25kDa)1.000
FGF1fibroblast growth factor 1 (acidic)0.992
NEDD4neural precursor cell expressed, developmentally down-regulated 40.902
EIF2C2eukaryotic translation initiation factor 2C, 20.873
ARID1AAT rich interactive domain 1A (SWI-like)0.866
TAL1T-cell acute lymphocytic leukemia 10.857
VEGFAvascular endothelial growth factor A0.806
FGF10fibroblast growth factor 100.736
ADORA2Aadenosine A2a receptor0.685
POU5F1POU class 5 homeobox 10.683
SMARCD1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 10.649
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.629
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.606
FOXD3forkhead box D30.574
CITED2Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 20.561
FGF7fibroblast growth factor 70.535
TCF4transcription factor 40.516
RUNX1runt-related transcription factor 10.483
HNF4Ahepatocyte nuclear factor 4, alpha0.478
FGF2fibroblast growth factor 2 (basic)0.477
PPP1R9Bprotein phosphatase 1, regulatory (inhibitor) subunit 9B0.477
TCEAL5transcription elongation factor A (SII)-like 50.447
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.404
FGFR2fibroblast growth factor receptor 20.398
PAX8paired box 80.395
TRIB3tribbles homolog 3 (Drosophila)0.383
SH3RF3SH3 domain containing ring finger 30.380
PDX1pancreatic and duodenal homeobox 10.368
CPEcarboxypeptidase E0.365
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.341
ANKS1Bankyrin repeat and sterile alpha motif domain containing 1B0.296
PBRM1polybromo 10.291
POU3F2POU class 3 homeobox 20.281
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.265
FGF3fibroblast growth factor 30.246
ARRB1arrestin, beta 10.221
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.207
SLC6A3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.206
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.194
ARID1BAT rich interactive domain 1B (SWI1-like)0.192
TP63tumor protein p630.190
EIF2C1eukaryotic translation initiation factor 2C, 10.183
LBX1ladybird homeobox 10.183
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.180
HES1hairy and enhancer of split 1, (Drosophila)0.180
TP73tumor protein p730.177
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.174
TNRC6Btrinucleotide repeat containing 6B0.174
NKX6-1NK6 homeobox 10.167
PIK3R2phosphoinositide-3-kinase, regulatory subunit 2 (beta)0.166
FGFR1fibroblast growth factor receptor 10.160
HOXC8homeobox C80.159
SOX11SRY (sex determining region Y)-box 110.159
NR4A3nuclear receptor subfamily 4, group A, member 30.156
PGFplacental growth factor0.156
SIX3SIX homeobox 30.152
FOSBFBJ murine osteosarcoma viral oncogene homolog B0.151
PLCG1phospholipase C, gamma 10.149
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.143
FRS2fibroblast growth factor receptor substrate 20.142
SOX1SRY (sex determining region Y)-box 10.142
TNRC6Atrinucleotide repeat containing 6A0.142
FGFR3fibroblast growth factor receptor 30.140
SHC1SHC (Src homology 2 domain containing) transforming protein 10.139
SMARCB1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 10.138
CBFA2T3core-binding factor, runt domain, alpha subunit 2; translocated to, 30.137
FEZF2FEZ family zinc finger 20.137
NR4A1nuclear receptor subfamily 4, group A, member 10.134
KCTD1potassium channel tetramerisation domain containing 10.133
SMARCA2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 20.131
DLG2discs, large homolog 2 (Drosophila)0.130
SH3BP4SH3-domain binding protein 40.128
CHN2chimerin (chimaerin) 20.125
SMAD7SMAD family member 70.123
SOX2SRY (sex determining region Y)-box 20.122
PRKRAprotein kinase, interferon-inducible double stranded RNA dependent activator0.122
RDH11retinol dehydrogenase 11 (all-trans/9-cis/11-cis)0.118
RAXretina and anterior neural fold homeobox0.115
ALX3ALX homeobox 30.113
KCNA1potassium voltage-gated channel, shaker-related subfamily, member 1 (episodic ataxia with myokymia)0.111
EIF2AK2eukaryotic translation initiation factor 2-alpha kinase 20.106
TLE1transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)0.105
HOXD12homeobox D120.105
FZD1frizzled homolog 1 (Drosophila)0.103
HES2hairy and enhancer of split 2 (Drosophila)0.102
MSX1msh homeobox 10.099
CTBP2C-terminal binding protein 20.098
GBX2gastrulation brain homeobox 20.097
SMARCC1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.097
NTRK1neurotrophic tyrosine kinase, receptor, type 10.095
POU3F3POU class 3 homeobox 30.093
PAX6paired box 60.093
NR5A2nuclear receptor subfamily 5, group A, member 20.092
SALL2sal-like 2 (Drosophila)0.091
CARM1coactivator-associated arginine methyltransferase 10.090
TNRC6Ctrinucleotide repeat containing 6C0.090
LHX2LIM homeobox 20.089
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.089
HNF1BHNF1 homeobox B0.088
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
lhx2bLIM homeobox 2b0.935
dlx2adistal-less homeobox gene 2a0.802
tbx1T-box 10.746
lef1lymphocyte enhancer binding factor 10.707
wnt1wingless-type MMTV integration site family, member 10.608
barhl2BarH-like 20.597
wnt8bwingless-type MMTV integration site family, member 8b0.554
gli1GLI-Kruppel family member 10.552
lhx5LIM homeobox 50.531
foxp2forkhead box P20.522
dbx1adeveloping brain homeobox 1a0.499
lmx1b.1LIM homeobox transcription factor 1, beta 10.482
pitx3paired-like homeodomain transcription factor 30.444
otx2orthodenticle homolog 20.418
eya1eyes absent homolog 10.418
fgf3fibroblast growth factor 30.401
otpborthopedia homolog b0.399
sfrp1asecreted frizzled-related protein 1a0.362
fezf2FEZ family zinc finger 20.343
rx3retinal homeobox gene 30.342
otx1borthodenticle homolog 1b0.336
nr2e1nuclear receptor subfamily 2, group E, member 10.322
oprd1bopioid receptor, delta 1b0.307
sim1asingle-minded homolog 1a (Drosophila)0.297
arxaristaless related homeobox0.281
shhasonic hedgehog a0.276
zic1zic family member 1 (odd-paired homolog, Drosophila)0.274
ephb4beph receptor B4b0.264
notch2notch homolog 20.258
wnt2bbwingless-type MMTV integration site family, member 2Bb0.256
wnt7bawingless-type MMTV integration site family, member 7Ba0.253
dlx1adistal-less homeobox gene 1a0.252
notch1anotch homolog 1a0.250
robo3roundabout homolog 30.231
gbx2gastrulation brain homeo box 20.220
lratblecithin retinol acyltransferase b (phosphatidylcholine--retinol O-acyltransferase b)0.219
wnt3wingless-type MMTV integration site family, member 30.217
olig2oligodendrocyte lineage transcription factor 20.212
pax6apaired box gene 6a0.211
gli2aGLI-Kruppel family member GLI2a0.209
ascl1aachaete-scute complex-like 1a (Drosophila)0.204
fgfr3fibroblast growth factor receptor 30.198
wnt3awingless-type MMTV integration site family, member 3A0.188
wnt4awingless-type MMTV integration site family, member 4a0.183
metmet proto-oncogene (hepatocyte growth factor receptor)0.178
nrp2bneuropilin 2b0.166
nkx2.1aNK2 homeobox 1a0.163
foxg1aforkhead box G1a0.159
six2asine oculis-related homeobox 2a0.152
myf5myogenic factor 50.152
lhx1aLIM homeobox 1a0.142
zic3zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila)0.142
sema3aasemaphorin 3aa0.139
mibmind bomb0.135
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.133
smad1MAD homolog 1 (Drosophila)0.131
eomesaeomesodermin homolog a0.129
sox1aSRY-box containing gene 1a0.122
pcdh10bprotocadherin 10b0.121
atoh1batonal homolog 1b0.119
restRE1-silencing transcription factor0.107
nkx2.1bNK2 homeobox 1b0.101
dlx2bdistal-less homeobox gene 2b0.096
ndr2nodal-related 20.095
sox2SRY-box containing gene 20.090
hmx4H6 family homeobox 40.089
dlx6adistal-less homeobox gene 6a0.088
hmgcrb3-hydroxy-3-methylglutaryl-Coenzyme A reductase b0.086
robo2roundabout homolog 20.086
elavl3ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)0.085
jag2jagged 20.084
ephb3aeph receptor B3a0.083
notch3notch homolog 30.082
fgfr4fibroblast growth factor receptor 40.082
foxc1aforkhead box C1a0.082
cdh2cadherin 2, neuronal0.078
wnt5bwingless-type MMTV integration site family, member 5b0.076
pou3f1POU class 3 homeobox 10.076
six3asine oculis homeobox homolog 3a0.075
gro1groucho 10.074
eng2aengrailed 2a0.073
sox21bSRY-box containing gene 21 b0.073
cdkn1ccyclin-dependent kinase inhibitor 1C (p57, Kip2)0.072
shhbsonic hedgehog b0.069
sst1.1somatostatin 1, tandem duplicate 10.069
spry2sprouty homolog 20.068
wnt2wingless-type MMTV integration site family member 20.068
epha4aeph receptor A4a0.067
tal1T-cell acute lymphocytic leukemia 10.067
nkx2.2aNK2 transcription factor related 2a0.066
znf503zinc finger protein 5030.065
spry4sprouty (Drosophila) homolog 40.065
fgfr2fibroblast growth factor receptor 20.064
bocbrother of CDO0.064
fzd7afrizzled homolog 7a0.063
med12mediator of RNA polymerase II transcription, subunit 12 homolog0.063
wif1wnt inhibitory factor 10.062
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Otx2orthodenticle homolog 2 (Drosophila)1.000
Fgfr2fibroblast growth factor receptor 21.000
Shhsonic hedgehog1.000
Gli3GLI-Kruppel family member GLI31.000
Isl1ISL1 transcription factor, LIM/homeodomain1.000
Fgf8fibroblast growth factor 81.000
Pax2paired box gene 21.000
Pitx2paired-like homeodomain transcription factor 21.000
Hand1heart and neural crest derivatives expressed transcript 11.000
Pax3paired box gene 30.999
Sox9SRY-box containing gene 90.999
Msx1homeobox, msh-like 10.999
Dlx5distal-less homeobox 50.999
Emx1empty spiracles homolog 1 (Drosophila)0.998
Tcfap2atranscription factor AP-2, alpha0.998
Hand2heart and neural crest derivatives expressed transcript 20.998
Pax6paired box gene 60.997
Rargretinoic acid receptor, gamma0.997
Sox2SRY-box containing gene 20.996
Eya1eyes absent 1 homolog (Drosophila)0.996
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.995
Tbx3T-box 30.995
Gli2GLI-Kruppel family member GLI20.994
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.994
Foxg1forkhead box G10.993
Fgf3fibroblast growth factor 30.993
Foxc1forkhead box C10.993
Pax8paired box gene 80.989
Lhx3LIM homeobox protein 30.989
Sall3sal-like 3 (Drosophila)0.987
Emx2empty spiracles homolog 2 (Drosophila)0.987
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.986
Fgfr1fibroblast growth factor receptor 10.986
Dlx6distal-less homeobox 60.984
Gata4GATA binding protein 40.984
Sall4sal-like 4 (Drosophila)0.983
Pitx1paired-like homeodomain transcription factor 10.983
Hoxa1homeobox A10.982
Tgfb2transforming growth factor, beta 20.977
Lhx1LIM homeobox protein 10.975
Msx2homeobox, msh-like 20.974
Prrx1paired related homeobox 10.973
Alx4aristaless-like homeobox 40.968
Bmp4bone morphogenetic protein 40.965
Smosmoothened homolog (Drosophila)0.964
Wnt1wingless-related MMTV integration site 10.963
Hoxa2homeobox A20.961
Igdcc3immunoglobulin superfamily, DCC subclass, member 30.957
Rarbretinoic acid receptor, beta0.952
Fgf10fibroblast growth factor 100.951
Tlx3T-cell leukemia, homeobox 30.940
Foxc2forkhead box C20.939
Pax9paired box gene 90.939
Tbx1T-box 10.932
Phox2bpaired-like homeobox 2b0.927
Ednraendothelin receptor type A0.927
Ascl1achaete-scute complex homolog 1 (Drosophila)0.925
Jag1jagged 10.924
Ctnnb1catenin (cadherin associated protein), beta 10.920
Chd7chromodomain helicase DNA binding protein 70.916
Hoxd3homeobox D30.900
Six3sine oculis-related homeobox 3 homolog (Drosophila)0.898
Gscgoosecoid homeobox0.882
Rararetinoic acid receptor, alpha0.881
Retret proto-oncogene0.867
Aldh1a2aldehyde dehydrogenase family 1, subfamily A20.865
Rxraretinoid X receptor alpha0.863
Foxa2forkhead box A20.861
Gbx2gastrulation brain homeobox 20.852
Ptpn11protein tyrosine phosphatase, non-receptor type 110.851
Lmx1aLIM homeobox transcription factor 1 alpha0.841
Dlx1distal-less homeobox 10.841
Hes5hairy and enhancer of split 5 (Drosophila)0.830
Adrb1adrenergic receptor, beta 10.828
Drd2dopamine receptor D20.827
Sim1single-minded homolog 1 (Drosophila)0.825
Lhx5LIM homeobox protein 50.822
UncxUNC homeobox0.820
Otx1orthodenticle homolog 1 (Drosophila)0.814
Sox1SRY-box containing gene 10.806
Dlx2distal-less homeobox 20.806
Hoxb1homeobox B10.806
Alx3aristaless-like homeobox 30.799
Pou5f1POU domain, class 5, transcription factor 10.795
Hmx3H6 homeobox 30.790
Nkx2-1NK2 homeobox 10.787
Hoxd13homeobox D130.773
Sox3SRY-box containing gene 30.762
Bdnfbrain derived neurotrophic factor0.758
En1engrailed 10.755
Gdnfglial cell line derived neurotrophic factor0.752
Hes1hairy and enhancer of split 1 (Drosophila)0.748
Lmx1bLIM homeobox transcription factor 1 beta0.740
Lhx9LIM homeobox protein 90.739
Dccdeleted in colorectal carcinoma0.727
Pou3f2POU domain, class 3, transcription factor 20.721
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Dlgap3discs, large (Drosophila) homolog-associated protein 30.222
Hoxb7homeo box B70.095
Gdf11growth differentiation factor 110.061
Unc5bunc-5 homolog B (C. elegans)0.059
Sox17SRY (sex determining region Y)-box 170.042
Arhgef7Rho guanine nucleotide exchange factor (GEF7)0.035
Ppypancreatic polypeptide0.032
Hand2heart and neural crest derivatives expressed 20.031
Nr4a1nuclear receptor subfamily 4, group A, member 10.031
Barhl2BarH-like homeobox 20.030
Galr3galanin receptor 30.030
Foxi2forkhead box I20.028
Gata3GATA binding protein 30.026
Hes3hairy and enhancer of split 3 (Drosophila)0.026
Prss2protease, serine, 20.025
Hpcal4hippocalcin-like 40.024
Mycsmyc-like oncogene, s-myc protein0.024
Nfibnuclear factor I/B0.023
Kalrnkalirin, RhoGEF kinase0.022
Adarb2adenosine deaminase, RNA-specific, B20.022
Lhx1LIM homeobox 10.021
Nek9NIMA (never in mitosis gene a)- related kinase 90.021
Grm5glutamate receptor, metabotropic 50.021
Rftn2raftlin family member 20.020
Pax8paired box 80.020
Hrh1histamine receptor H 10.019
Fgfr2fibroblast growth factor receptor 20.019
Gata6GATA binding protein 60.019
Ehfets homologous factor0.018
Nfianuclear factor I/A0.018
Sdc3syndecan 30.017
Grm8glutamate receptor, metabotropic 80.017
Nlgn2neuroligin 20.016
Bmp6bone morphogenetic protein 60.016
Cyp2a3cytochrome P450, family 2, subfamily a, polypeptide 30.015
Pnliprp1pancreatic lipase-related protein 10.015
Ugt8UDP glycosyltransferase 80.015
Glg1golgi apparatus protein 10.015
Hoxc4homeo box C40.015
Sgp158proline-rich glycoprotein (sgp158)0.015
Mgat5mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase0.014
Socs3suppressor of cytokine signaling 30.014
Ascl1achaete-scute complex homolog 1 (Drosophila)0.013
Smad7SMAD family member 70.013
Adrb1adrenergic, beta-1-, receptor0.013
Arhgef11Rho guanine nucleotide exchange factor (GEF) 110.013
Tgfbr2transforming growth factor, beta receptor II0.013
RGD1563136similar to Cystatin-related protein 2 precursor (Prostatic 22 kDa glycoprotein P22K15)0.013
Gcm1glial cells missing homolog 1 (Drosophila)0.012
Grin2dglutamate receptor, ionotropic, N-methyl D-aspartate 2D0.012
Dccdeleted in colorectal carcinoma0.012
Cntfrciliary neurotrophic factor receptor0.012
Foxe3forkhead box E30.012
Slc28a1solute carrier family 28 (sodium-coupled nucleoside transporter), member 10.011
Gria4glutamate receptor, ionotrophic, AMPA 40.011
Scarf2scavenger receptor class F, member 20.011
Myo1cmyosin IC0.011
Ahraryl hydrocarbon receptor0.011
Syn3synapsin III0.011
Itpkbinositol 1,4,5-trisphosphate 3-kinase B0.011
Dchs1dachsous 1 (Drosophila)0.010
Chrm4cholinergic receptor, muscarinic 40.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism