The network for 'forebrain generation of neurons' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

forebrain generation of neurons

The process in which nerve cells are generated in the forebrain. This includes the production of neuroblasts from and their differentiation into neurons.

NameDescriptionProbabilityFunc Analog Organism
FGF1fibroblast growth factor 1 (acidic)0.999
VEGFAvascular endothelial growth factor A0.995
PDZD11PDZ domain containing 110.993
NEDD4neural precursor cell expressed, developmentally down-regulated 40.993
TAL1T-cell acute lymphocytic leukemia 10.980
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.973
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.952
TCF4transcription factor 40.948
ARRB1arrestin, beta 10.933
HNF4Ahepatocyte nuclear factor 4, alpha0.930
POU5F1POU class 5 homeobox 10.929
FGF2fibroblast growth factor 2 (basic)0.913
CITED2Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 20.911
LRP6low density lipoprotein receptor-related protein 60.909
FGF10fibroblast growth factor 100.907
RBFOX1RNA binding protein, fox-1 homolog (C. elegans) 10.907
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.905
WNT3Awingless-type MMTV integration site family, member 3A0.899
PPP1R9Bprotein phosphatase 1, regulatory (inhibitor) subunit 9B0.849
EGFRepidermal growth factor receptor0.842
AP2A1adaptor-related protein complex 2, alpha 1 subunit0.822
FZD1frizzled homolog 1 (Drosophila)0.802
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.795
ADORA2Aadenosine A2a receptor0.794
FGFR1fibroblast growth factor receptor 10.787
ANKS1Bankyrin repeat and sterile alpha motif domain containing 1B0.774
PAX8paired box 80.755
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.709
POU3F2POU class 3 homeobox 20.662
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.650
SHC1SHC (Src homology 2 domain containing) transforming protein 10.626
RUNX1runt-related transcription factor 10.625
CPEcarboxypeptidase E0.603
SH3BP4SH3-domain binding protein 40.594
HOXD12homeobox D120.587
ARID1AAT rich interactive domain 1A (SWI-like)0.553
PDX1pancreatic and duodenal homeobox 10.545
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.540
TP73tumor protein p730.524
TRIB3tribbles homolog 3 (Drosophila)0.522
FGFR2fibroblast growth factor receptor 20.516
FGF7fibroblast growth factor 70.514
TCEAL5transcription elongation factor A (SII)-like 50.512
ARHGEF12Rho guanine nucleotide exchange factor (GEF) 120.504
SH3RF3SH3 domain containing ring finger 30.478
PIK3R2phosphoinositide-3-kinase, regulatory subunit 2 (beta)0.465
HOXC8homeobox C80.446
NKX6-1NK6 homeobox 10.438
SOX11SRY (sex determining region Y)-box 110.435
FGFR3fibroblast growth factor receptor 30.430
SIX3SIX homeobox 30.422
FZD8frizzled homolog 8 (Drosophila)0.410
HES2hairy and enhancer of split 2 (Drosophila)0.376
CBFA2T3core-binding factor, runt domain, alpha subunit 2; translocated to, 30.373
FGF3fibroblast growth factor 30.368
FOSBFBJ murine osteosarcoma viral oncogene homolog B0.367
ROCK1Rho-associated, coiled-coil containing protein kinase 10.363
PLCG1phospholipase C, gamma 10.352
MPRIPmyosin phosphatase Rho interacting protein0.335
ARHGAP1Rho GTPase activating protein 10.331
CHN2chimerin (chimaerin) 20.330
FEZF2FEZ family zinc finger 20.307
SMAD7SMAD family member 70.305
NEDD4Lneural precursor cell expressed, developmentally down-regulated 4-like0.304
PGFplacental growth factor0.304
TROtrophinin0.299
SALL2sal-like 2 (Drosophila)0.297
RAXretina and anterior neural fold homeobox0.297
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.296
RUNX1T1runt-related transcription factor 1; translocated to, 1 (cyclin D-related)0.294
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.291
APCadenomatous polyposis coli0.286
POU3F3POU class 3 homeobox 30.283
ALX3ALX homeobox 30.280
SOX1SRY (sex determining region Y)-box 10.280
LHX2LIM homeobox 20.275
OLIG2oligodendrocyte lineage transcription factor 20.260
DKK1dickkopf homolog 1 (Xenopus laevis)0.260
LBX1ladybird homeobox 10.251
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.250
QKIquaking homolog, KH domain RNA binding (mouse)0.239
ACTL6Bactin-like 6B0.239
CACNA1Gcalcium channel, voltage-dependent, T type, alpha 1G subunit0.234
APBB2amyloid beta (A4) precursor protein-binding, family B, member 20.234
NOSTRINnitric oxide synthase trafficker0.232
ARID1BAT rich interactive domain 1B (SWI1-like)0.232
PRKRAprotein kinase, interferon-inducible double stranded RNA dependent activator0.229
NR5A2nuclear receptor subfamily 5, group A, member 20.228
DLG2discs, large homolog 2 (Drosophila)0.228
RAP1ARAP1A, member of RAS oncogene family0.225
HNF1BHNF1 homeobox B0.224
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.221
CADM4cell adhesion molecule 40.220
PBRM1polybromo 10.219
EIF2AK2eukaryotic translation initiation factor 2-alpha kinase 20.218
ARHGEF11Rho guanine nucleotide exchange factor (GEF) 110.213
NPAS1neuronal PAS domain protein 10.210
MSX1msh homeobox 10.209
SFRP5secreted frizzled-related protein 50.203
ATF4activating transcription factor 4 (tax-responsive enhancer element B67)0.202
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
dlx2adistal-less homeobox gene 2a0.965
tbx1T-box 10.964
dladeltaA0.960
lef1lymphocyte enhancer binding factor 10.944
ascl1aachaete-scute complex-like 1a (Drosophila)0.913
otx1borthodenticle homolog 1b0.906
eya1eyes absent homolog 10.896
dlx1adistal-less homeobox gene 1a0.882
lhx2bLIM homeobox 2b0.875
dlddeltaD0.847
foxp2forkhead box P20.843
pax6apaired box gene 6a0.835
neurog1neurogenin 10.813
fgf3fibroblast growth factor 30.776
otx2orthodenticle homolog 20.762
shhasonic hedgehog a0.758
robo3roundabout homolog 30.742
dbx1adeveloping brain homeobox 1a0.737
barhl2BarH-like 20.726
sim1asingle-minded homolog 1a (Drosophila)0.715
pitx3paired-like homeodomain transcription factor 30.678
sfrp1asecreted frizzled-related protein 1a0.670
lhx1aLIM homeobox 1a0.655
dlx5adistal-less homeobox gene 5a0.653
gli1GLI-Kruppel family member 10.650
dlx2bdistal-less homeobox gene 2b0.645
sox2SRY-box containing gene 20.615
wnt5bwingless-type MMTV integration site family, member 5b0.614
olig2oligodendrocyte lineage transcription factor 20.575
lhx5LIM homeobox 50.538
arxaristaless related homeobox0.499
otpborthopedia homolog b0.492
fezf2FEZ family zinc finger 20.468
her15.1hairy and enhancer of split-related 15.10.465
shhbsonic hedgehog b0.445
eomesaeomesodermin homolog a0.445
notch2notch homolog 20.402
rx3retinal homeobox gene 30.401
nkx2.1bNK2 homeobox 1b0.385
dlx6adistal-less homeobox gene 6a0.380
nkx2.1aNK2 homeobox 1a0.374
nkx2.2aNK2 transcription factor related 2a0.367
wnt3wingless-type MMTV integration site family, member 30.348
ephb4beph receptor B4b0.329
sox1aSRY-box containing gene 1a0.322
foxg1aforkhead box G1a0.317
nr2e1nuclear receptor subfamily 2, group E, member 10.284
dkk1bdickkopf 1b0.281
sox10SRY-box containing gene 100.277
six2asine oculis-related homeobox 2a0.228
fzd7bfrizzled homolog 7b0.227
foxn4forkhead box N40.224
emx3empty spiracles homeobox 30.219
fgfr3fibroblast growth factor receptor 30.209
fgf10afibroblast growth factor 10a0.208
notch1anotch homolog 1a0.207
wnt7bawingless-type MMTV integration site family, member 7Ba0.204
fgf19fibroblast growth factor 190.201
atoh1batonal homolog 1b0.198
zic1zic family member 1 (odd-paired homolog, Drosophila)0.193
pax6bpaired box gene 6b0.192
gbx2gastrulation brain homeo box 20.186
atoh1aatonal homolog 1a0.183
nrp2aneuropilin 2a0.182
jag2jagged 20.179
emx1empty spiracles homeobox 10.179
sox21bSRY-box containing gene 21 b0.176
flhfloating head0.175
hmgcrb3-hydroxy-3-methylglutaryl-Coenzyme A reductase b0.174
nxph1neurexophilin 10.173
foxd3forkhead box D30.171
elavl3ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C)0.166
vsx1visual system homeobox 1 homolog, chx10-like0.159
pou3f1POU class 3 homeobox 10.159
map2k4amitogen-activated protein kinase kinase 4a0.157
isl1islet10.155
dmbx1adiencephalon/mesencephalon homeobox 1a0.153
efnb2aephrin B2a0.149
oprd1bopioid receptor, delta 1b0.149
hoxd4ahomeo box D4a0.143
znf503zinc finger protein 5030.141
bonbonnie and clyde0.128
six3asine oculis homeobox homolog 3a0.126
tcf7l2transcription factor 7-like 2 (T-cell specific, HMG-box)0.122
fgfr4fibroblast growth factor receptor 40.120
wnt1wingless-type MMTV integration site family, member 10.115
gli2aGLI-Kruppel family member GLI2a0.113
bhlhe22basic helix-loop-helix family, member e220.112
osr2odd-skipped related 2 (Drosophila)0.112
sox3SRY-box containing gene 30.110
wnt8bwingless-type MMTV integration site family, member 8b0.107
dlx4bdistal-less homeobox gene 4b0.104
lmx1b.1LIM homeobox transcription factor 1, beta 10.102
six4bsine oculis homeobox homolog 4b0.102
wnt11rwingless-type MMTV integration site family, member 11, related0.100
metmet proto-oncogene (hepatocyte growth factor receptor)0.098
wnt9bwingless-type MMTV integration site family, member 9B0.097
ntn1bnetrin 1b0.097
zic3zic family member 3 heterotaxy 1 (odd-paired homolog, Drosophila)0.096
pcdh17protocadherin 170.096
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Shhsonic hedgehog1.000
Otx2orthodenticle homolog 2 (Drosophila)1.000
Fgfr2fibroblast growth factor receptor 21.000
Gli3GLI-Kruppel family member GLI31.000
Pax2paired box gene 21.000
Pax6paired box gene 61.000
Ctnnb1catenin (cadherin associated protein), beta 11.000
Msx1homeobox, msh-like 11.000
Pitx2paired-like homeodomain transcription factor 20.999
Sox9SRY-box containing gene 90.999
Emx1empty spiracles homolog 1 (Drosophila)0.999
Isl1ISL1 transcription factor, LIM/homeodomain0.999
Fgf8fibroblast growth factor 80.999
Pax3paired box gene 30.998
Hand1heart and neural crest derivatives expressed transcript 10.998
Lhx3LIM homeobox protein 30.998
Fgfr1fibroblast growth factor receptor 10.998
Tbx3T-box 30.997
Lef1lymphoid enhancer binding factor 10.996
Tcfap2atranscription factor AP-2, alpha0.996
Eya1eyes absent 1 homolog (Drosophila)0.996
Rargretinoic acid receptor, gamma0.995
Tbx1T-box 10.994
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.993
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.993
Fgf10fibroblast growth factor 100.992
Dlx5distal-less homeobox 50.992
Emx2empty spiracles homolog 2 (Drosophila)0.990
Hoxa1homeobox A10.989
Bmp4bone morphogenetic protein 40.988
Sox2SRY-box containing gene 20.986
Lhx1LIM homeobox protein 10.986
Prrx1paired related homeobox 10.985
Pitx1paired-like homeodomain transcription factor 10.985
Pax8paired box gene 80.982
Msx2homeobox, msh-like 20.982
Tgfb2transforming growth factor, beta 20.979
Nognoggin0.978
Dlx6distal-less homeobox 60.978
Hand2heart and neural crest derivatives expressed transcript 20.973
Gli2GLI-Kruppel family member GLI20.972
Foxg1forkhead box G10.967
Rarbretinoic acid receptor, beta0.967
Smosmoothened homolog (Drosophila)0.964
Gbx2gastrulation brain homeobox 20.961
Fgf3fibroblast growth factor 30.958
Vangl2vang-like 2 (van gogh, Drosophila)0.949
Hoxa2homeobox A20.949
Hoxa13homeobox A130.945
Pbx1pre B-cell leukemia transcription factor 10.945
Alx4aristaless-like homeobox 40.940
Insm1insulinoma-associated 10.938
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.928
Sall4sal-like 4 (Drosophila)0.925
Runx2runt related transcription factor 20.924
Rararetinoic acid receptor, alpha0.915
Sall3sal-like 3 (Drosophila)0.912
Drd2dopamine receptor D20.912
Chd7chromodomain helicase DNA binding protein 70.908
Chrdchordin0.905
Ascl1achaete-scute complex homolog 1 (Drosophila)0.895
Klklotho0.891
Pax9paired box gene 90.889
Dlx2distal-less homeobox 20.889
Nodalnodal0.886
Foxa2forkhead box A20.880
Ednraendothelin receptor type A0.876
Hes5hairy and enhancer of split 5 (Drosophila)0.875
Hoxd11homeobox D110.872
Wnt1wingless-related MMTV integration site 10.866
Foxc1forkhead box C10.859
Tlx3T-cell leukemia, homeobox 30.848
Lhx9LIM homeobox protein 90.841
Hoxb1homeobox B10.828
Rac1RAS-related C3 botulinum substrate 10.827
Sox11SRY-box containing gene 110.819
Pou5f1POU domain, class 5, transcription factor 10.818
Wnt3awingless-related MMTV integration site 3A0.816
Bdnfbrain derived neurotrophic factor0.815
Bmp7bone morphogenetic protein 70.814
Alx3aristaless-like homeobox 30.813
Adrb1adrenergic receptor, beta 10.813
Nr2e1nuclear receptor subfamily 2, group E, member 10.791
Prrx2paired related homeobox 20.784
Sox3SRY-box containing gene 30.783
Nkx1-2NK1 transcription factor related, locus 2 (Drosophila)0.783
Vax1ventral anterior homeobox containing gene 10.782
Gfra1glial cell line derived neurotrophic factor family receptor alpha 10.780
Hmx3H6 homeobox 30.773
Phox2bpaired-like homeobox 2b0.770
Retret proto-oncogene0.769
Six3sine oculis-related homeobox 3 homolog (Drosophila)0.767
Sim1single-minded homolog 1 (Drosophila)0.759
Neurod1neurogenic differentiation 10.758
Wnt7bwingless-related MMTV integration site 7B0.752
Myod1myogenic differentiation 10.752
Robo1roundabout homolog 1 (Drosophila)0.749
Pou4f2POU domain, class 4, transcription factor 20.748
Nkx2-2NK2 transcription factor related, locus 2 (Drosophila)0.738
Pou3f2POU domain, class 3, transcription factor 20.736
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Nr4a3nuclear receptor subfamily 4, group A, member 30.171
Glg1golgi apparatus protein 10.162
Pnliprp1pancreatic lipase-related protein 10.152
Dlgap3discs, large (Drosophila) homolog-associated protein 30.145
Erbb4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)0.111
Nlgn2neuroligin 20.111
Galr3galanin receptor 30.104
Unc5bunc-5 homolog B (C. elegans)0.088
Fgfr2fibroblast growth factor receptor 20.086
Cckbrcholecystokinin B receptor0.083
Foxi2forkhead box I20.083
B4galnt4beta-1,4-N-acetyl-galactosaminyl transferase 40.082
Ehfets homologous factor0.072
Mycsmyc-like oncogene, s-myc protein0.072
Sox17SRY (sex determining region Y)-box 170.064
Sdc3syndecan 30.057
Foxe3forkhead box E30.057
Lhx1LIM homeobox 10.054
Nkd1naked cuticle homolog 1 (Drosophila)0.048
Nfibnuclear factor I/B0.047
Sh2d3cSH2 domain containing 3C0.044
Arnt2aryl hydrocarbon receptor nuclear translocator 20.041
Ppypancreatic polypeptide0.040
Gata3GATA binding protein 30.038
Grm5glutamate receptor, metabotropic 50.038
Dlx5distal-less homeobox 50.038
Kcnip3Kv channel interacting protein 3, calsenilin0.038
Gdf11growth differentiation factor 110.037
Cyp2a3cytochrome P450, family 2, subfamily a, polypeptide 30.035
Arhgef7Rho guanine nucleotide exchange factor (GEF7)0.035
Nr4a1nuclear receptor subfamily 4, group A, member 10.032
Barhl2BarH-like homeobox 20.032
Cyp11b3cytochrome P450, family 11, subfamily b, polypeptide 30.031
Robo2roundabout homolog 2 (Drosophila)0.031
Kalrnkalirin, RhoGEF kinase0.030
Dchs1dachsous 1 (Drosophila)0.030
Nfianuclear factor I/A0.029
Hpcal4hippocalcin-like 40.029
Rftn2raftlin family member 20.028
Mpp2membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)0.026
Htr5b5-hydroxytryptamine (serotonin) receptor 5B0.024
Tpothyroid peroxidase0.024
Tceb3transcription elongation factor B (SIII), polypeptide 30.022
Bmp4bone morphogenetic protein 40.022
Arf6ADP-ribosylation factor 60.021
Adrb1adrenergic, beta-1-, receptor0.021
Htr1a5-hydroxytryptamine (serotonin) receptor 1A0.021
Scn5asodium channel, voltage-gated, type V, alpha subunit0.020
Camk1gcalcium/calmodulin-dependent protein kinase IG0.020
Ncanneurocan0.020
Chrm4cholinergic receptor, muscarinic 40.020
Dusp4dual specificity phosphatase 40.019
Ascl1achaete-scute complex homolog 1 (Drosophila)0.018
Foxc2forkhead box C20.018
Grm8glutamate receptor, metabotropic 80.017
UncxUNC homeobox0.017
Camkk2calcium/calmodulin-dependent protein kinase kinase 2, beta0.017
Rab3cRAB3C, member RAS oncogene family0.017
Pspnpersephin0.017
Camk2n2calcium/calmodulin-dependent protein kinase II inhibitor 20.017
Cmklr1chemokine-like receptor 10.017
Mgat5mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase0.016
Lrrc56leucine rich repeat containing 560.016
Scgb1a1secretoglobin, family 1A, member 1 (uteroglobin)0.016
Fgf22fibroblast growth factor 220.016
Pxdnperoxidasin homolog (Drosophila)0.016
Kcna3potassium voltage-gated channel, shaker-related subfamily, member 30.016
Gria4glutamate receptor, ionotrophic, AMPA 40.016
Homer3homer homolog 3 (Drosophila)0.015
Gcm1glial cells missing homolog 1 (Drosophila)0.015
Gpr182G protein-coupled receptor 1820.015
Acanaggrecan0.015
Cntfrciliary neurotrophic factor receptor0.015
Hdac1lhistone deacetylase 1-like0.014
RGD1563136similar to Cystatin-related protein 2 precursor (Prostatic 22 kDa glycoprotein P22K15)0.014
Zfp382zinc finger protein 3820.014
Gria1glutamate receptor, ionotropic, AMPA 10.014
Ugt8UDP glycosyltransferase 80.013
Pax8paired box 80.013
Fgfr3fibroblast growth factor receptor 30.013
Bmp6bone morphogenetic protein 60.013
Ucnurocortin0.013
Col9a1collagen, type IX, alpha 10.013
Hes3hairy and enhancer of split 3 (Drosophila)0.013
Hes5hairy and enhancer of split 5 (Drosophila)0.013
Grip1glutamate receptor interacting protein 10.013
Pcdhb12protocadherin beta 120.012
Hrh1histamine receptor H 10.012
Tmod2tropomodulin 20.012
Hoxc4homeo box C40.012
Zc3h7bzinc finger CCCH-type containing 7B0.012
Pip4k2bphosphatidylinositol-5-phosphate 4-kinase, type II, beta0.012
Epha7Eph receptor A70.012
Klk1c10l2kallikrein 1-related peptidase c10-like 20.012
Prss2protease, serine, 20.012
LOC64038sertolin0.011
Rai1retinoic acid induced 10.011
Gna11guanine nucleotide binding protein, alpha 110.011
Robo1roundabout homolog 1 (Drosophila)0.011
Arrb1arrestin, beta 10.011
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism