The network for 'double strand break repair via nonhomologous end joining' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

double strand break repair via nonhomologous end joining

The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends.

Homo sapiens
NameDescriptionProbabilityFunc Analog Organism
BRCA1breast cancer 1, early onset0.967
H2AFXH2A histone family, member X0.948
XRCC6X-ray repair complementing defective repair in Chinese hamster cells 60.945
PARP1poly (ADP-ribose) polymerase 10.941
PRKDCprotein kinase, DNA-activated, catalytic polypeptide0.929
XRCC4X-ray repair complementing defective repair in Chinese hamster cells 40.831
XRCC5X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)0.810
RPA1replication protein A1, 70kDa0.767
MDC1mediator of DNA-damage checkpoint 10.721
MSH6mutS homolog 6 (E. coli)0.640
BLMBloom syndrome, RecQ helicase-like0.492
NBNnibrin0.410
APLFaprataxin and PNKP like factor0.367
PSMC6proteasome (prosome, macropain) 26S subunit, ATPase, 60.310
FANCD2Fanconi anemia, complementation group D20.296
WRNWerner syndrome, RecQ helicase-like0.266
PCNAproliferating cell nuclear antigen0.235
PSMB4proteasome (prosome, macropain) subunit, beta type, 40.208
CDK2cyclin-dependent kinase 20.192
PSMD2proteasome (prosome, macropain) 26S subunit, non-ATPase, 20.131
RAD51RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)0.117
BRCA2breast cancer 2, early onset0.112
CHEK1CHK1 checkpoint homolog (S. pombe)0.110
BRIP1BRCA1 interacting protein C-terminal helicase 10.108
SMC1Astructural maintenance of chromosomes 1A0.094
CHAF1Achromatin assembly factor 1, subunit A (p150)0.087
RAD50RAD50 homolog (S. cerevisiae)0.078
XRCC1X-ray repair complementing defective repair in Chinese hamster cells 10.077
MRE11AMRE11 meiotic recombination 11 homolog A (S. cerevisiae)0.068
MSH2mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)0.053
POLA1polymerase (DNA directed), alpha 1, catalytic subunit0.050
TP53tumor protein p530.044
PSMD4proteasome (prosome, macropain) 26S subunit, non-ATPase, 40.043
APTXaprataxin0.038
PNKPpolynucleotide kinase 3'-phosphatase0.038
CSNK2A1casein kinase 2, alpha 1 polypeptide0.035
PSMB7proteasome (prosome, macropain) subunit, beta type, 70.030
PSMA6proteasome (prosome, macropain) subunit, alpha type, 60.026
PSMD1proteasome (prosome, macropain) 26S subunit, non-ATPase, 10.026
POLD3polymerase (DNA-directed), delta 3, accessory subunit0.026
ATMataxia telangiectasia mutated0.025
RBBP8retinoblastoma binding protein 80.025
PSMA3proteasome (prosome, macropain) subunit, alpha type, 30.025
RBM10RNA binding motif protein 100.025
MCM3minichromosome maintenance complex component 30.025
PSMD6proteasome (prosome, macropain) 26S subunit, non-ATPase, 60.024
TOP2Atopoisomerase (DNA) II alpha 170kDa0.024
ATRataxia telangiectasia and Rad3 related0.023
LIG4ligase IV, DNA, ATP-dependent0.022
PSMD13proteasome (prosome, macropain) 26S subunit, non-ATPase, 130.021
POMPproteasome maturation protein0.021
MLH1mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)0.019
ORC1origin recognition complex, subunit 10.019
PSMA1proteasome (prosome, macropain) subunit, alpha type, 10.017
RPA2replication protein A2, 32kDa0.017
PSMD7proteasome (prosome, macropain) 26S subunit, non-ATPase, 70.016
PSMB2proteasome (prosome, macropain) subunit, beta type, 20.016
PSMA2proteasome (prosome, macropain) subunit, alpha type, 20.016
FANCAFanconi anemia, complementation group A0.015
CHEK2CHK2 checkpoint homolog (S. pombe)0.015
PSMD11proteasome (prosome, macropain) 26S subunit, non-ATPase, 110.015
DHX30DEAH (Asp-Glu-Ala-His) box polypeptide 300.014
PSMC5proteasome (prosome, macropain) 26S subunit, ATPase, 50.014
TIMELESStimeless homolog (Drosophila)0.014
PSMC1proteasome (prosome, macropain) 26S subunit, ATPase, 10.014
RB1retinoblastoma 10.014
RAD21RAD21 homolog (S. pombe)0.014
PMS2PMS2 postmeiotic segregation increased 2 (S. cerevisiae)0.013
SSRP1structure specific recognition protein 10.012
POLA2polymerase (DNA directed), alpha 2 (70kD subunit)0.012
PSMA4proteasome (prosome, macropain) subunit, alpha type, 40.012
HNRNPABheterogeneous nuclear ribonucleoprotein A/B0.012
E2F1E2F transcription factor 10.011
DNMT1DNA (cytosine-5-)-methyltransferase 10.011
SUV39H1suppressor of variegation 3-9 homolog 1 (Drosophila)0.011
FANCGFanconi anemia, complementation group G0.011
PSMC2proteasome (prosome, macropain) 26S subunit, ATPase, 20.011
HMGA1high mobility group AT-hook 10.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
rrm1ribonucleotide reductase M1 polypeptide0.630
slbpstem-loop binding protein0.581
mybl2myeloblastosis oncogene-like 20.209
msh2mutS homolog 2 (E. coli)0.132
ipo9importin 90.116
hellshelicase, lymphoid-specific0.105
pola1polymerase (DNA directed), alpha 10.097
hat1histone acetyltransferase 10.093
mcm4MCM4 minichromosome maintenance deficient 4, mitotin (S. cerevisiae)0.092
wdhd1WD repeat and HMG-box DNA binding protein 10.090
mcm5MCM5 minichromosome maintenance deficient 5 (S. cerevisiae)0.087
LOC100537814kinetochore-associated protein 1-like0.085
dnmt1DNA (cytosine-5-)-methyltransferase 10.077
anp32bacidic (leucine-rich) nuclear phosphoprotein 32 family, member B0.075
naspnuclear autoantigenic sperm protein (histone-binding)0.061
rfc1replication factor C (activator 1) 10.060
ppm1gprotein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform0.058
fen1flap structure-specific endonuclease 10.057
mcmbpminichromosome maintenance complex binding protein0.048
prim1primase polypeptide 10.047
zgc:110113zgc:1101130.047
rbb4retinoblastoma binding protein 40.047
rpa1replication protein A10.045
pds5bPDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)0.038
ubr7ubiquitin protein ligase E3 component n-recognin 70.036
zgc:92648zgc:926480.036
dutdUTP pyrophosphatase0.034
rfc5replication factor C (activator 1) 50.033
rbb4lretinoblastoma binding protein 4, like0.032
pcnaproliferating cell nuclear antigen0.032
LOC563669cohesin subunit SA-3-like0.032
zgc:110540zgc:1105400.031
whsc1Wolf-Hirschhorn syndrome candidate 10.028
hirip3HIRA interacting protein 30.027
cdk2cyclin-dependent kinase 20.022
zgc:113210zgc:1132100.021
asf1bbASF1 anti-silencing function 1 homolog Bb0.021
acvr2aactivin receptor IIa0.020
orc6origin recognition complex, subunit 60.020
anp32aacidic (leucine-rich) nuclear phosphoprotein 32 family, member A0.018
mbd3bmethyl-CpG binding domain protein 3b0.018
usp1ubiquitin specific protease 10.018
sae1SUMO1 activating enzyme subunit 10.018
rpa3replication protein A30.017
ptpn11aprotein tyrosine phosphatase, non-receptor type 11, a0.016
si:ch1073-351m12.1si:ch1073-351m12.10.015
mcm7MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)0.015
msh6mutS homolog 6 (E. coli)0.014
ezh2enhancer of zeste homolog 2 (Drosophila)0.014
rrm2ribonucleotide reductase M2 polypeptide0.013
wnt8awingless-type MMTV integration site family, member 8a0.013
myst2MYST histone acetyltransferase 20.013
cpsf2cleavage and polyadenylation specific factor 20.013
ncapd2non-SMC condensin I complex, subunit D20.012
parp2poly (ADP-ribose) polymerase family, member 20.012
snrpasmall nuclear ribonucleoprotein polypeptide A0.011
ccne2cyclin E20.011
wu:fc85c01wu:fc85c010.011
pola2polymerase (DNA directed), alpha 20.011
zgc:113183zgc:1131830.010
zgc:100817zgc:1008170.010
elavl1ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)0.010
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
mus205mutagen-sensitive 2050.998
lokloki0.994
mus101mutagen-sensitive 1010.986
CG5524CG5524 gene product from transcript CG5524-RA0.985
DNApol-etaCG7143 gene product from transcript CG7143-RA0.977
Brca2Breast cancer 2, early onset homolog0.969
okrokra0.920
spn-Aspindle A0.895
Klp3AKinesin-like protein at 3A0.879
mus309mutagen-sensitive 3090.869
mus308mutagen-sensitive 3080.839
RPA2Replication protein A20.819
IrbpInverted repeat-binding protein0.788
mus301mutagen-sensitive 3010.716
Mcm3Minichromosome maintenance 30.622
Rev1CG12189 gene product from transcript CG12189-RA0.622
rad50CG6339 gene product from transcript CG6339-RD0.589
mus201mutagen-sensitive 2010.525
mei-9meiotic 90.394
spn-Bspindle B0.380
mus304mutagen-sensitive 3040.366
RecQ5homolog of RecQ0.309
Mcm7Minichromosome maintenance 70.286
mus312mutagen-sensitive 3120.239
RnrLRibonucleoside diphosphate reductase large subunit0.227
Lig4Ligase40.224
mei-41meiotic 410.179
CycJCyclin J0.169
RpA-70Replication Protein A 700.114
CDC45LCG3658 gene product from transcript CG3658-RA0.098
RfC4Replication factor C subunit 40.098
DNApol-deltaDNA-polymerase-delta0.096
CG13350CG13350 gene product from transcript CG13350-RA0.085
Ercc1CG10215 gene product from transcript CG10215-RA0.082
SsrpStructure specific recognition protein0.079
RecQ4CG7487 gene product from transcript CG7487-RA0.075
mus210mutagen-sensitive 2100.063
MCPH1Microcephalin0.058
CG5384CG5384 gene product from transcript CG5384-RA0.058
Smc5CG32438 gene product from transcript CG32438-RE0.057
spn-Espindle E0.053
Ku80CG18801 gene product from transcript CG18801-RA0.051
CG7376CG7376 gene product from transcript CG7376-RA0.050
hayhaywire0.034
CG5857CG5857 gene product from transcript CG5857-RA0.034
Ddx1Dead-box-10.031
feofascetto0.031
Orc4Origin recognition complex subunit 40.029
Mcm5Minichromosome maintenance 50.027
HiraCG12153 gene product from transcript CG12153-RA0.027
CG9576CG9576 gene product from transcript CG9576-RA0.025
nbsCG6754 gene product from transcript CG6754-RC0.024
CG7457CG7457 gene product from transcript CG7457-RA0.023
CG10722CG10722 gene product from transcript CG10722-RA0.023
CG2694CG2694 gene product from transcript CG2694-RA0.020
Mlh1CG11482 gene product from transcript CG11482-RA0.020
His2AvHistone H2A variant0.017
DNApol-alpha73DNA polymerase alpha 73kD0.015
CG6049CG6049 gene product from transcript CG6049-RC0.014
Chrac-14CG13399 gene product from transcript CG13399-RA0.013
AtuAnother transcription unit0.012
CG4680CG4680 gene product from transcript CG4680-RA0.012
armiarmitage0.011
WRNexoWRN exonuclease0.010
rumprumpelstiltskin0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Trp53transformation related protein 530.937
Atmataxia telangiectasia mutated homolog (human)0.917
Prim1DNA primase, p49 subunit0.866
Brca2breast cancer 20.726
Hdac1histone deacetylase 10.631
Mcm3minichromosome maintenance deficient 3 (S. cerevisiae)0.568
Rpa1replication protein A10.480
Prim2DNA primase, p58 subunit0.431
Suds3suppressor of defective silencing 3 homolog (S. cerevisiae)0.419
Nbnnibrin0.394
Cdt1chromatin licensing and DNA replication factor 10.328
Mlh1mutL homolog 1 (E. coli)0.312
Prkdcprotein kinase, DNA activated, catalytic polypeptide0.295
Cdc6cell division cycle 6 homolog (S. cerevisiae)0.277
Mcm4minichromosome maintenance deficient 4 homolog (S. cerevisiae)0.275
Msh2mutS homolog 2 (E. coli)0.273
Mcm7minichromosome maintenance deficient 7 (S. cerevisiae)0.249
Pold1polymerase (DNA directed), delta 1, catalytic subunit0.242
Brca1breast cancer 10.232
Ccne1cyclin E10.211
Tipintimeless interacting protein0.211
Hprthypoxanthine guanine phosphoribosyl transferase0.196
Pola2polymerase (DNA directed), alpha 20.194
Hdac6histone deacetylase 60.192
Ezh2enhancer of zeste homolog 2 (Drosophila)0.168
Dicer1Dicer1, Dcr-1 homolog (Drosophila)0.166
Dnajc9DnaJ (Hsp40) homolog, subfamily C, member 90.166
Cdk4cyclin-dependent kinase 40.143
Wdhd1WD repeat and HMG-box DNA binding protein 10.140
Dnmt1DNA methyltransferase (cytosine-5) 10.135
Ssrp1structure specific recognition protein 10.123
Mcm2minichromosome maintenance deficient 2 mitotin (S. cerevisiae)0.121
Parp2poly (ADP-ribose) polymerase family, member 20.114
Hellshelicase, lymphoid specific0.109
Timelesstimeless homolog (Drosophila)0.103
2700029M09RikRIKEN cDNA 2700029M09 gene0.097
Ighimmunoglobulin heavy chain complex0.093
Rad50RAD50 homolog (S. cerevisiae)0.081
Nup85nucleoporin 850.073
Mdm2transformed mouse 3T3 cell double minute 20.068
Pcnaproliferating cell nuclear antigen0.065
Lmnb1lamin B10.062
Hdac2histone deacetylase 20.058
Pole2polymerase (DNA directed), epsilon 2 (p59 subunit)0.057
Rnaseh2bribonuclease H2, subunit B0.054
Rfc2replication factor C (activator 1) 20.053
Cpsf3cleavage and polyadenylation specificity factor 30.051
Xrcc6X-ray repair complementing defective repair in Chinese hamster cells 60.051
Haus1HAUS augmin-like complex, subunit 10.051
Rfc1replication factor C (activator 1) 10.050
Gins1GINS complex subunit 1 (Psf1 homolog)0.047
Gmnngeminin0.046
Ccna2cyclin A20.045
Lrrc40leucine rich repeat containing 400.045
Pold3polymerase (DNA-directed), delta 3, accessory subunit0.043
Hspa14heat shock protein 140.042
Rfc5replication factor C (activator 1) 50.041
Mcm5minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)0.040
Hat1histone aminotransferase 10.040
BlmBloom syndrome, RecQ helicase-like0.039
H2afxH2A histone family, member X0.038
Ccz1CCZ1 vacuolar protein trafficking and biogenesis associated homolog (S. cerevisiae)0.036
Vrk1vaccinia related kinase 10.036
Atad5ATPase family, AAA domain containing 50.036
Nup88nucleoporin 880.036
Lig1ligase I, DNA, ATP-dependent0.035
MtbpMdm2, transformed 3T3 cell double minute p53 binding protein0.035
Th1lTH1-like homolog (Drosophila)0.033
Ppp1ccprotein phosphatase 1, catalytic subunit, gamma isoform0.033
Rfc4replication factor C (activator 1) 40.032
Smarcc1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.031
Tcfcp2l1transcription factor CP2-like 10.031
Chd1lchromodomain helicase DNA binding protein 1-like0.030
Rpa2replication protein A20.030
Polr2bpolymerase (RNA) II (DNA directed) polypeptide B0.029
Orc6origin recognition complex, subunit 60.028
Nup107nucleoporin 1070.026
TcrbT-cell receptor beta chain0.026
Xrcc5X-ray repair complementing defective repair in Chinese hamster cells 50.026
Pms2postmeiotic segregation increased 2 (S. cerevisiae)0.025
Nup93nucleoporin 930.025
Syce2synaptonemal complex central element protein 20.025
Ncapd3non-SMC condensin II complex, subunit D30.025
Mdm4transformed mouse 3T3 cell double minute 40.025
Parnpoly(A)-specific ribonuclease (deadenylation nuclease)0.025
TcrdT-cell receptor delta chain0.024
Naspnuclear autoantigenic sperm protein (histone-binding)0.023
Ncaphnon-SMC condensin I complex, subunit H0.023
Topbp1topoisomerase (DNA) II binding protein 10.023
Tada2atranscriptional adaptor 2A0.023
Cenpncentromere protein N0.023
Asf1bASF1 anti-silencing function 1 homolog B (S. cerevisiae)0.022
Larsleucyl-tRNA synthetase0.022
Rad51RAD51 homolog (S. cerevisiae)0.021
Dclre1cDNA cross-link repair 1C, PSO2 homolog (S. cerevisiae)0.021
Rrm1ribonucleotide reductase M10.021
Ttc27tetratricopeptide repeat domain 270.021
Mad2l1MAD2 mitotic arrest deficient-like 1 (yeast)0.020
Ckap5cytoskeleton associated protein 50.020
Creb1cAMP responsive element binding protein 10.019
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
RAD52Rad52p0.224
LEO1Leo1p0.205
TPD3Tpd3p0.176
XRS2Xrs2p0.165
PSY4Psy4p0.127
ASF1Asf1p0.123
POL30Pol30p0.086
RAD5Rad5p0.084
HHO1Hho1p0.080
RAD53Rad53p0.079
MRE11Mre11p0.076
EST1Est1p0.066
REV3Rev3p0.063
EAF7Eaf7p0.062
VPS71Vps71p0.060
RSC1Rsc1p0.056
EXO1Exo1p0.052
TOP1Top1p0.052
MMS1Mms1p0.051
VPS75Vps75p0.050
EST2Est2p0.047
RAD54Rad54p0.047
HHT2Hht2p0.047
PRI1Pri1p0.042
EPL1Epl1p0.042
RSC30Rsc30p0.041
RSC3Rsc3p0.040
GCN5Gcn5p0.040
TIP41Tip41p0.038
SAE2Sae2p0.038
MRC1Mrc1p0.038
RSC2Rsc2p0.037
RHO5Rho5p0.036
RAD1Rad1p0.034
POL2Pol2p0.034
HUL5Hul5p0.034
RSC4Rsc4p0.033
DDC1Ddc1p0.032
BDF1Bdf1p0.031
MLH3Mlh3p0.031
RAD59Rad59p0.030
EAF1Eaf1p0.030
NPR2Npr2p0.029
PSO2Pso2p0.029
CTF4Ctf4p0.028
PHO23Pho23p0.028
YDL156Whypothetical protein0.028
YLR257Whypothetical protein0.028
PDS5Pds5p0.027
ARE2Are2p0.027
DIA2Dia2p0.026
YLR422Whypothetical protein0.026
HAL5Hal5p0.026
ARG82Arg82p0.026
SWC4Swc4p0.026
SRS2Srs2p0.026
SWC7Swc7p0.025
MLH2Mlh2p0.025
ZEO1Zeo1p0.025
RAD9Rad9p0.025
CTK3Ctk3p0.024
TEL1Tel1p0.024
SEM1Sem1p0.024
TYE7Tye7p0.024
SIZ1Siz1p0.024
IML1Iml1p0.024
STE18Ste18p0.024
LIF1Lif1p0.023
ADI1Adi1p0.023
RTT109Rtt109p0.023
UBP2Ubp2p0.023
MMS22Mms22p0.023
RCO1Rco1p0.023
PRE2Pre2p0.023
TOF1Tof1p0.023
SRD1Srd1p0.023
HDA2Hda2p0.023
SMC6Smc6p0.023
MLP1Mlp1p0.023
BUR6Bur6p0.023
HST3Hst3p0.023
CRZ1Crz1p0.023
PDS1Pds1p0.022
YLR264C-Ahypothetical protein0.022
HST1Hst1p0.022
IXR1Ixr1p0.022
STH1Sth1p0.022
CUP1-1Cup1-1p0.022
UBP6Ubp6p0.022
OAF1Oaf1p0.022
RAD2Rad2p0.021
CRP1Crp1p0.021
SLX8Slx8p0.021
RNH201Rnh201p0.021
YNL144Chypothetical protein0.021
YOL038C-Ahypothetical protein0.021
YLR162Whypothetical protein0.021
UFD2Ufd2p0.021
LEU2Leu2p0.021
GPB2Gpb2p0.021