The network for 'double strand break repair' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

double strand break repair

The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.

NameDescriptionProbabilityFunc Analog Organism
BRCA1breast cancer 1, early onset1.000
RAD51RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)1.000
H2AFXH2A histone family, member X1.000
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 41.000
PRKDCprotein kinase, DNA-activated, catalytic polypeptide1.000
RPA1replication protein A1, 70kDa1.000
BLMBloom syndrome, RecQ helicase-like1.000
MSH2mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)1.000
NBNnibrin1.000
MDC1mediator of DNA-damage checkpoint 11.000
MRE11AMRE11 meiotic recombination 11 homolog A (S. cerevisiae)0.999
RAD18RAD18 homolog (S. cerevisiae)0.999
PARP1poly (ADP-ribose) polymerase 10.999
MSH6mutS homolog 6 (E. coli)0.998
PCNAproliferating cell nuclear antigen0.998
BRCA2breast cancer 2, early onset0.996
CHEK1CHK1 checkpoint homolog (S. pombe)0.996
C19orf39chromosome 19 open reading frame 390.995
TP53tumor protein p530.994
CHEK2CHK2 checkpoint homolog (S. pombe)0.993
RAD51CRAD51 homolog C (S. cerevisiae)0.993
POLA1polymerase (DNA directed), alpha 1, catalytic subunit0.991
FANCD2Fanconi anemia, complementation group D20.991
XRCC5X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)0.986
WRNWerner syndrome, RecQ helicase-like0.986
HDAC1histone deacetylase 10.984
MCM2minichromosome maintenance complex component 20.981
RAD51L3RAD51-like 3 (S. cerevisiae)0.980
RAD50RAD50 homolog (S. cerevisiae)0.980
SMC1Astructural maintenance of chromosomes 1A0.980
XRCC4X-ray repair complementing defective repair in Chinese hamster cells 40.979
BRCC3BRCA1/BRCA2-containing complex, subunit 30.978
RAD21RAD21 homolog (S. pombe)0.970
GINS2GINS complex subunit 2 (Psf2 homolog)0.970
RAD1RAD1 homolog (S. pombe)0.967
SMARCC1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.947
CDK2cyclin-dependent kinase 20.946
MCM3minichromosome maintenance complex component 30.934
FAM175Afamily with sequence similarity 175, member A0.923
E2F1E2F transcription factor 10.919
RPA2replication protein A2, 32kDa0.918
SMC3structural maintenance of chromosomes 30.913
MMS22LMMS22-like, DNA repair protein0.910
ASF1BASF1 anti-silencing function 1 homolog B (S. cerevisiae)0.897
SMC6structural maintenance of chromosomes 60.888
MCM6minichromosome maintenance complex component 60.885
PLK1polo-like kinase 10.882
MCM5minichromosome maintenance complex component 50.878
INO80INO80 homolog (S. cerevisiae)0.873
MCM4minichromosome maintenance complex component 40.869
APLFaprataxin and PNKP like factor0.849
ATMataxia telangiectasia mutated0.846
ACTL6Aactin-like 6A0.834
CCNE1cyclin E10.832
XRCC1X-ray repair complementing defective repair in Chinese hamster cells 10.821
XRCC3X-ray repair complementing defective repair in Chinese hamster cells 30.820
GINS4GINS complex subunit 4 (Sld5 homolog)0.803
DTLdenticleless homolog (Drosophila)0.798
MCM7minichromosome maintenance complex component 70.797
RB1retinoblastoma 10.773
DTX3Ldeltex 3-like (Drosophila)0.765
POLE2polymerase (DNA directed), epsilon 2 (p59 subunit)0.756
RPA3replication protein A3, 14kDa0.721
SLX4SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)0.706
APTXaprataxin0.689
CHD4chromodomain helicase DNA binding protein 40.679
UBE2Nubiquitin-conjugating enzyme E2N (UBC13 homolog, yeast)0.660
BRIP1BRCA1 interacting protein C-terminal helicase 10.641
POLD1polymerase (DNA directed), delta 1, catalytic subunit 125kDa0.630
SMARCD1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 10.623
MDM2Mdm2 p53 binding protein homolog (mouse)0.618
RAD52RAD52 homolog (S. cerevisiae)0.614
BREbrain and reproductive organ-expressed (TNFRSF1A modulator)0.602
CHAF1Achromatin assembly factor 1, subunit A (p150)0.598
FEN1flap structure-specific endonuclease 10.597
PALB2partner and localizer of BRCA20.595
ORC1origin recognition complex, subunit 10.568
LRP1low density lipoprotein receptor-related protein 10.565
MSH3mutS homolog 3 (E. coli)0.560
ATRataxia telangiectasia and Rad3 related0.556
RAD54LRAD54-like (S. cerevisiae)0.550
WAPALwings apart-like homolog (Drosophila)0.550
EXO1exonuclease 10.539
SP1Sp1 transcription factor0.525
TNFSF14tumor necrosis factor (ligand) superfamily, member 140.521
INO80EINO80 complex subunit E0.518
MRFAP1Morf4 family associated protein 10.516
PARP9poly (ADP-ribose) polymerase family, member 90.515
EME1essential meiotic endonuclease 1 homolog 1 (S. pombe)0.510
MUS81MUS81 endonuclease homolog (S. cerevisiae)0.497
XRCC6X-ray repair complementing defective repair in Chinese hamster cells 60.483
RNF11ring finger protein 110.480
SUPT16Hsuppressor of Ty 16 homolog (S. cerevisiae)0.473
TERF2telomeric repeat binding factor 20.460
SMEK1SMEK homolog 1, suppressor of mek1 (Dictyostelium)0.460
CDC45cell division cycle 45 homolog (S. cerevisiae)0.456
RAD51AP1RAD51 associated protein 10.454
RECQL4RecQ protein-like 40.448
POLA2polymerase (DNA directed), alpha 2 (70kD subunit)0.443
TONSLtonsoku-like, DNA repair protein0.424
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
knl-1Protein KNL-10.103
smc-5Protein SMC-50.060
F54E12.2Protein F54E12.20.043
gon-4Protein GON-40.042
zyg-9Protein ZYG-90.032
glh-4Protein GLH-40.027
coh-3Protein COH-30.027
M01A10.1Protein M01A10.10.023
msh-6Protein MSH-60.022
pas-1Protein PAS-10.021
ndc-80Protein NDC-800.021
mcm-6Protein MCM-60.020
Y47D3A.29Protein Y47D3A.290.020
mes-4Protein MES-40.020
icp-1Protein ICP-10.018
acly-2Protein ACLY-20.018
T19A5.1Protein T19A5.10.016
wago-9Protein WAGO-90.016
gei-14Protein GEI-140.015
drh-3Protein DRH-30.015
klc-1Protein KLC-10.015
nmy-2Protein NMY-20.014
orc-5Protein ORC-50.014
pme-3Protein PME-30.013
polq-1Protein POLQ-10.013
npl-4.2Protein NPL-4.20.012
F52B5.3Protein F52B5.30.012
nra-1Protein NRA-10.012
bath-19Protein BATH-190.012
rpa-1Protein RPA-10.012
ima-2Protein IMA-20.011
chk-1Protein CHK-10.011
met-2Protein MET-20.011
C27A12.7Protein C27A12.70.011
spd-2Protein SPD-20.010
F10C2.4Protein F10C2.40.010
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
pola2polymerase (DNA directed), alpha 20.852
fen1flap structure-specific endonuclease 10.810
chtf18CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)0.648
naspnuclear autoantigenic sperm protein (histone-binding)0.598
wdhd1WD repeat and HMG-box DNA binding protein 10.555
hirip3HIRA interacting protein 30.462
pcnaproliferating cell nuclear antigen0.457
mybl2myeloblastosis oncogene-like 20.377
zgc:92139zgc:921390.356
palb2partner and localizer of BRCA20.343
hellshelicase, lymphoid-specific0.337
gins2GINS complex subunit 20.316
rbb4retinoblastoma binding protein 40.307
dnmt1DNA (cytosine-5-)-methyltransferase 10.280
pold1polymerase (DNA directed), delta 1, catalytic subunit0.267
pola1polymerase (DNA directed), alpha 10.237
zgc:92648zgc:926480.229
hat1histone acetyltransferase 10.228
slbpstem-loop binding protein0.225
cdc45CDC45 cell division cycle 45 homolog (S. cerevisiae)0.221
zgc:154089zgc:1540890.216
mus81MUS81 endonuclease homolog (yeast)0.200
suv39h1bsuppressor of variegation 3-9 homolog 1b0.198
zgc:55943zgc:559430.192
prim1primase polypeptide 10.189
smc2structural maintenance of chromosomes 20.189
lrrc42leucine rich repeat containing 420.188
dutdUTP pyrophosphatase0.180
sass6spindle assembly 6 homolog (C. elegans)0.180
zgc:92661zgc:926610.162
atad5aATPase family, AAA domain containing 5a0.147
esco2establishment of cohesion 1 homolog 20.146
mcm4MCM4 minichromosome maintenance deficient 4, mitotin (S. cerevisiae)0.145
cdc7cell division cycle 7 homolog (S. cerevisiae)0.136
rpa1replication protein A10.131
zgc:56197zgc:561970.125
ncapd2non-SMC condensin I complex, subunit D20.122
pds5bPDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)0.120
cuedc2CUE domain containing 20.119
cdk2cyclin-dependent kinase 20.119
zgc:174506zgc:1745060.108
nipblbnovel protein similar to vertebrate Nipped-B homolog and nipped-b homolog b (Drosophila)0.107
msh2mutS homolog 2 (E. coli)0.107
trip13thyroid hormone receptor interactor 130.106
chaf1bchromatin assembly factor 1, subunit B0.106
dnmt5DNA (cytosine-5-)-methyltransferase 50.103
rfc4replication factor C (activator 1) 40.102
traipTRAF-interacting protein0.102
zgc:73100zgc:731000.101
wdr76WD repeat domain 760.096
maf1MAF1 homolog (S. cerevisiae)0.094
spc24SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae)0.092
si:ch211-218c6.5si:ch211-218c6.50.091
ddx39bDEAD (Asp-Glu-Ala-Asp) box polypeptide 39b0.091
neil3nei endonuclease VIII-like 3 (E. coli)0.090
paxip1PAX interacting (with transcription-activation domain) protein 10.089
si:ch211-215h6.2si:ch211-215h6.20.085
pspc1paraspeckle component 10.084
si:dkeyp-35b8.5si:dkeyp-35b8.50.084
hnrnpa0heterogeneous nuclear ribonucleoprotein A00.083
pole2polymerase (DNA directed), epsilon 20.082
LOC100333229PCNA-associated factor-like0.080
rap1aRAP1A, member of RAS oncogene family0.077
ck2bcasein kinase 2 beta0.076
usp5ubiquitin specific protease 50.076
rfc5replication factor C (activator 1) 50.075
si:ch211-239j15.4si:ch211-239j15.40.074
ppp2cbprotein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform0.071
lppr3blipid phosphate phosphatase-related protein type 3b0.069
dhfrdihydrofolate reductase0.069
ssrp1astructure specific recognition protein 1a0.068
orc6origin recognition complex, subunit 60.068
zgc:110540zgc:1105400.067
rpa2replication protein A20.066
orc1origin recognition complex, subunit 10.066
cbx1achromobox homolog 1a (HP1 beta homolog Drosophila)0.065
usf1upstream transcription factor 10.064
im:6898523im:68985230.064
hnrnpul1heterogeneous nuclear ribonucleoprotein U-like 10.064
eif3jaeukaryotic translation initiation factor 3, subunit Ja0.064
tymsthymidylate synthase0.064
calm3bcalmodulin 3b (phosphorylase kinase, delta)0.064
nuf2NUF2, NDC80 kinetochore complex component, homolog0.063
hmgb2bhigh-mobility group box 2b0.062
cse1lchromosome segregation 1-like (S. cerevisiae)0.060
rnaseh2aribonuclease H2, subunit A0.060
syap1synapse associated protein 10.059
pdcd8programmed cell death 8 (apoptosis-inducing factor)0.058
morf4l1mortality factor 4 like 10.057
unguracil-DNA glycosylase0.056
zgc:101661zgc:1016610.055
zgc:103440zgc:1034400.053
zgc:92172zgc:921720.051
smc4structural maintenance of chromosomes 40.050
rad51crad51 homolog C (S. cerevisiae)0.050
brca2breast cancer 2, early onset0.049
lztfl1leucine zipper transcription factor-like 10.048
hdac1histone deacetylase 10.048
tial1TIA1 cytotoxic granule-associated RNA binding protein-like 10.047
zgc:113143zgc:1131430.047
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
mus205mutagen-sensitive 2050.999
okrokra0.998
lokloki0.996
DNApol-etaCG7143 gene product from transcript CG7143-RA0.992
IrbpInverted repeat-binding protein0.987
Mcm2Minichromosome maintenance 20.984
mus308mutagen-sensitive 3080.975
RpA-70Replication Protein A 700.964
mei-9meiotic 90.960
tefutelomere fusion0.952
mus101mutagen-sensitive 1010.948
p53CG33336 gene product from transcript CG33336-RB0.944
spn-Aspindle A0.938
Brca2Breast cancer 2, early onset homolog0.937
CG5524CG5524 gene product from transcript CG5524-RA0.937
rad50CG6339 gene product from transcript CG6339-RD0.936
mus301mutagen-sensitive 3010.889
hayhaywire0.888
mus201mutagen-sensitive 2010.856
mus210mutagen-sensitive 2100.856
RfC4Replication factor C subunit 40.789
mre11meiotic recombination 110.775
RecQ5homolog of RecQ0.743
Rev1CG12189 gene product from transcript CG12189-RA0.741
mus309mutagen-sensitive 3090.727
Cks30ACyclin-dependent kinase subunit 30A0.727
Mcm3Minichromosome maintenance 30.673
mus304mutagen-sensitive 3040.652
spn-Bspindle B0.635
mei-41meiotic 410.618
RecQ4CG7487 gene product from transcript CG7487-RA0.601
Mcm6Minichromosome maintenance 60.562
Ercc1CG10215 gene product from transcript CG10215-RA0.501
E(z)Enhancer of zeste0.484
RnrLRibonucleoside diphosphate reductase large subunit0.476
CG13350CG13350 gene product from transcript CG13350-RA0.423
CDC45LCG3658 gene product from transcript CG3658-RA0.392
Mcm5Minichromosome maintenance 50.391
CG8142CG8142 gene product from transcript CG8142-RA0.385
CG9576CG9576 gene product from transcript CG9576-RA0.327
cutletCG33122 gene product from transcript CG33122-RA0.323
RfC3Replication factor C subunit 30.293
CSN4COP9 complex homolog subunit 40.288
CG16908CG16908 gene product from transcript CG16908-RA0.281
CG2694CG2694 gene product from transcript CG2694-RA0.269
Smc5CG32438 gene product from transcript CG32438-RE0.263
CG5857CG5857 gene product from transcript CG5857-RA0.260
Mcm7Minichromosome maintenance 70.249
raspCG11495 gene product from transcript CG11495-RA0.216
spn-Espindle E0.203
CycHCyclin H0.186
nbsCG6754 gene product from transcript CG6754-RC0.179
WRNexoWRN exonuclease0.155
Lig4Ligase40.148
mus312mutagen-sensitive 3120.143
CG8247CG8247 gene product from transcript CG8247-RB0.128
piepineapple eye0.128
defldeflated0.120
mit(1)15mitotic 150.120
RPA2Replication protein A20.112
CG2982CG2982 gene product from transcript CG2982-RB0.105
CG5745CG5745 gene product from transcript CG5745-RA0.105
pashapartner of drosha0.097
MAGECG10059 gene product from transcript CG10059-RA0.095
Mlh1CG11482 gene product from transcript CG11482-RA0.092
Su(var)2-HP2CG12864 gene product from transcript CG12864-RB0.090
CG7099CG7099 gene product from transcript CG7099-RA0.088
Gnf1Germ line transcription factor 10.086
ShcSHC-adaptor protein0.084
ash2absent, small, or homeotic discs 20.082
Caf1Chromatin assembly factor 1 subunit0.081
Nup75Nucleoporin 750.078
cmetCENP-meta0.076
CG12391CG12391 gene product from transcript CG12391-RA0.073
wdnwings down0.072
CG13349CG13349 gene product from transcript CG13349-RA0.071
Mcm10Sensitized chromosome inheritance modifier 190.067
DNApol-alpha50DNA polymerase alpha 50kD0.066
Top2Topoisomerase 20.065
Uba1Ubiquitin activating enzyme 10.065
DNApol-alpha73DNA polymerase alpha 73kD0.063
stwlstonewall0.063
pngpan gu0.062
Pms2CG8169 gene product from transcript CG8169-RA0.062
mofmales absent on the first0.062
idaimaginal discs arrested0.061
Caf1-105CG12892 gene product from transcript CG12892-RA0.060
CkaConnector of kinase to AP-10.060
CG8963CG8963 gene product from transcript CG8963-RB0.054
Rpn3Regulatory particle non-ATPase 30.054
fs(2)ltoPP43female sterile (2) ltoPP430.054
l(2)dtllethal-(2)-denticleless0.053
CG9772CG9772 gene product from transcript CG9772-RB0.052
AGO3Argonaute 30.052
DNApol-deltaDNA-polymerase-delta0.051
D12CG13400 gene product from transcript CG13400-RA0.050
scnyscrawny0.050
hanghangover0.049
Rpn1CG7762 gene product from transcript CG7762-RA0.049
desat1CG5887 gene product from transcript CG5887-RA0.048
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Brca1breast cancer 10.999
Brca2breast cancer 20.999
Trp53transformation related protein 530.998
Pou5f1POU domain, class 5, transcription factor 10.994
Cdt1chromatin licensing and DNA replication factor 10.987
Mcm3minichromosome maintenance deficient 3 (S. cerevisiae)0.980
Prkdcprotein kinase, DNA activated, catalytic polypeptide0.958
Hellshelicase, lymphoid specific0.944
Atmataxia telangiectasia mutated homolog (human)0.939
Mcm2minichromosome maintenance deficient 2 mitotin (S. cerevisiae)0.916
Cdc6cell division cycle 6 homolog (S. cerevisiae)0.855
Orc1origin recognition complex, subunit 10.852
Rad51RAD51 homolog (S. cerevisiae)0.844
Pola1polymerase (DNA directed), alpha 10.840
Prim1DNA primase, p49 subunit0.839
Wdhd1WD repeat and HMG-box DNA binding protein 10.826
Smc2structural maintenance of chromosomes 20.813
Smc3structural maintenace of chromosomes 30.729
Gmnngeminin0.702
E2f1E2F transcription factor 10.701
Mlh1mutL homolog 1 (E. coli)0.693
Timelesstimeless homolog (Drosophila)0.691
Rttnrotatin0.691
Mybl2myeloblastosis oncogene-like 20.683
Pcnaproliferating cell nuclear antigen0.673
Hdac1histone deacetylase 10.671
Mdm4transformed mouse 3T3 cell double minute 40.659
Sgol1shugoshin-like 1 (S. pombe)0.657
Nbnnibrin0.634
Chek1checkpoint kinase 1 homolog (S. pombe)0.599
Sin3atranscriptional regulator, SIN3A (yeast)0.569
Mcm4minichromosome maintenance deficient 4 homolog (S. cerevisiae)0.567
Smc1astructural maintenance of chromosomes 1A0.541
Mecp2methyl CpG binding protein 20.539
Terf1telomeric repeat binding factor 10.529
Mcm5minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)0.502
Pold1polymerase (DNA directed), delta 1, catalytic subunit0.497
Mcm7minichromosome maintenance deficient 7 (S. cerevisiae)0.458
Bub1budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae)0.455
TtkTtk protein kinase0.411
Rfc2replication factor C (activator 1) 20.408
Lrr1leucine rich repeat protein 10.402
Tipintimeless interacting protein0.401
Hdac2histone deacetylase 20.400
Cdca5cell division cycle associated 50.393
Mre11ameiotic recombination 11 homolog A (S. cerevisiae)0.392
Pold3polymerase (DNA-directed), delta 3, accessory subunit0.390
Smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.388
Mms22lMMS22-like, DNA repair protein0.369
Ccne1cyclin E10.369
Rrm1ribonucleotide reductase M10.360
Rfc1replication factor C (activator 1) 10.357
2700029M09RikRIKEN cDNA 2700029M09 gene0.347
Ccnfcyclin F0.346
Smarcc1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.342
Atrxalpha thalassemia/mental retardation syndrome X-linked homolog (human)0.337
Haus6HAUS augmin-like complex, subunit 60.332
Fancd2Fanconi anemia, complementation group D20.331
Cenpncentromere protein N0.314
Cdca7cell division cycle associated 70.305
Ezh2enhancer of zeste homolog 2 (Drosophila)0.297
Nek2NIMA (never in mitosis gene a)-related expressed kinase 20.291
Polepolymerase (DNA directed), epsilon0.290
Rbl1retinoblastoma-like 1 (p107)0.278
Ncapd3non-SMC condensin II complex, subunit D30.263
Msh2mutS homolog 2 (E. coli)0.262
Lig1ligase I, DNA, ATP-dependent0.257
Rfc4replication factor C (activator 1) 40.251
Rfc3replication factor C (activator 1) 30.241
Mcm8minichromosome maintenance deficient 8 (S. cerevisiae)0.238
Kntc1kinetochore associated 10.237
Arid1bAT rich interactive domain 1B (SWI-like)0.235
Dkc1dyskeratosis congenita 1, dyskerin homolog (human)0.226
Mcm6minichromosome maintenance deficient 6 (MIS5 homolog, S. pombe) (S. cerevisiae)0.225
Dtldenticleless homolog (Drosophila)0.215
Kif4kinesin family member 40.205
StilScl/Tal1 interrupting locus0.201
Pole2polymerase (DNA directed), epsilon 2 (p59 subunit)0.199
Creb1cAMP responsive element binding protein 10.194
Rad50RAD50 homolog (S. cerevisiae)0.192
E2f8E2F transcription factor 80.188
Mis18bp1MIS18 binding protein 10.188
Dicer1Dicer1, Dcr-1 homolog (Drosophila)0.179
Pola2polymerase (DNA directed), alpha 20.178
Ccdc99coiled-coil domain containing 990.176
Gins1GINS complex subunit 1 (Psf1 homolog)0.175
Polhpolymerase (DNA directed), eta (RAD 30 related)0.175
Hdac6histone deacetylase 60.174
Hat1histone aminotransferase 10.174
Dhfrdihydrofolate reductase0.169
Xrcc5X-ray repair complementing defective repair in Chinese hamster cells 50.167
Cbx5chromobox homolog 5 (Drosophila HP1a)0.164
Exo1exonuclease 10.159
Pms2postmeiotic segregation increased 2 (S. cerevisiae)0.157
BlmBloom syndrome, RecQ helicase-like0.155
Plk4polo-like kinase 4 (Drosophila)0.153
Topbp1topoisomerase (DNA) II binding protein 10.152
Nup85nucleoporin 850.151
Melkmaternal embryonic leucine zipper kinase0.150
Cdca7lcell division cycle associated 7 like0.148
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Psmd2proteasome (prosome, macropain) 26S subunit, non-ATPase, 20.616
Nsfl1cNSFL1 (p97) cofactor (p47)0.606
Top2atopoisomerase (DNA) II alpha0.386
Tcfe2atranscription factor E2a0.234
Spc25SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)0.167
LOC100364212heterogeneous nuclear ribonucleoprotein K-like0.154
Ccne1cyclin E10.150
Melkmaternal embryonic leucine zipper kinase0.143
Vcpvalosin-containing protein0.140
Dscc1defective in sister chromatid cohesion 1 homolog (S. cerevisiae)0.127
Ppp1cbprotein phosphatase 1, catalytic subunit, beta isoform0.120
Gtf2e2general transcription factor IIE, polypeptide 2, beta0.118
Zc3h15zinc finger CCCH-type containing 150.117
Rad23bRAD23 homolog B (S. cerevisiae)0.099
Chd4chromodomain helicase DNA binding protein 40.099
Smc3structural maintenance of chromosomes 30.098
Tymsthymidylate synthetase0.096
Timelesstimeless homolog (Drosophila)0.095
Psmd11proteasome (prosome, macropain) 26S subunit, non-ATPase, 110.094
Psmd1proteasome (prosome, macropain) 26S subunit, non-ATPase, 10.077
Bub1bbudding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)0.076
Psmc5proteasome (prosome, macropain) 26S subunit, ATPase, 50.076
Kifc1kinesin family member C10.075
Mcm6minichromosome maintenance complex component 60.074
Wdfy3WD repeat and FYVE domain containing 30.073
Ccnb1cyclin B10.073
Ufd1lubiquitin fusion degradation 1 like (yeast)0.071
Psmc6proteasome (prosome, macropain) 26S subunit, ATPase, 60.070
Rfc4replication factor C (activator 1) 40.070
Hist1h1ahistone cluster 1, H1a0.069
Psmc2proteasome (prosome, macropain) 26S subunit, ATPase 20.068
Ect2epithelial cell transforming sequence 2 oncogene0.068
Asf1bASF1 anti-silencing function 1 homolog B (S. cerevisiae)0.065
Prim1DNA primase, p49 subunit0.063
Cenpicentromere protein I0.062
Ppp5cprotein phosphatase 5, catalytic subunit0.061
Nudcd2NudC domain containing 20.059
Cand1cullin-associated and neddylation-dissociated 10.057
Gins4GINS complex subunit 4 (Sld5 homolog)0.055
Psmd7proteasome (prosome, macropain) 26S subunit, non-ATPase, 70.055
Mcm5minichromosome maintenance complex component 50.054
Exoc7exocyst complex component 70.054
Cct8chaperonin containing Tcp1, subunit 8 (theta)0.054
Stip1stress-induced phosphoprotein 10.052
Ns5atp9NS5A (hepatitis C virus) transactivated protein 90.051
Nploc4nuclear protein localization 4 homolog (S. cerevisiae)0.048
Pfdn2prefoldin subunit 20.047
Nrd1nardilysin 10.046
Ubtfupstream binding transcription factor, RNA polymerase I0.046
Chek1CHK1 checkpoint homolog (S. pombe)0.045
Psmc1proteasome (prosome, macropain) 26S subunit, ATPase, 10.044
Cenpkcentromere protein K0.043
Cadcarbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase0.043
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.039
Plk4polo-like kinase 4 (Drosophila)0.039
Ddx50DEAD (Asp-Glu-Ala-Asp) box polypeptide 500.039
Psmd4proteasome (prosome, macropain) 26S subunit, non-ATPase, 40.038
Strapserine/threonine kinase receptor associated protein0.038
Csde1cold shock domain containing E1, RNA binding0.038
Fkbp3FK506 binding protein 30.038
Gartphosphoribosylglycinamide formyltransferase0.037
Marsmethionine-tRNA synthetase0.037
Rbm25RNA binding motif protein 250.036
Ube2tubiquitin-conjugating enzyme E2T (putative)0.036
Arhgap11aRho GTPase activating protein 11A0.035
Fam195bfamily with sequence similarity 195, member B0.035
Smarca4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.034
Depdc1DEP domain containing 10.034
Ccdc97coiled-coil domain containing 970.034
Aqraquarius homolog (mouse)0.033
Safbscaffold attachment factor B0.033
Dtx3deltex homolog 3 (Drosophila)0.033
Lbrlamin B receptor0.033
Rpa2replication protein A20.032
TfptTCF3 (E2A) fusion partner0.032
Aurkbaurora kinase B0.032
Ppp2r2aprotein phosphatase 2 (formerly 2A), regulatory subunit B, alpha isoform0.032
Psmd3proteasome (prosome, macropain) 26S subunit, non-ATPase, 30.032
Smarcb1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 10.031
Dnajc21DnaJ (Hsp40) homolog, subfamily C, member 210.031
Psmd12proteasome (prosome, macropain) 26S subunit, non-ATPase, 120.031
Dhfrdihydrofolate reductase0.030
Psmd6proteasome (prosome, macropain) 26S subunit, non-ATPase, 60.030
Psmc3proteasome (prosome, macropain) 26S subunit, ATPase 30.030
Kif4kinesin family member 40.030
Sf3b2splicing factor 3b, subunit 20.030
Ppm1aprotein phosphatase 1A, magnesium dependent, alpha isoform0.029
Prim2primase, DNA, polypeptide 20.029
RGD1304693similar to CG14803-PA0.029
Wrap53WD repeat containing, antisense to TP530.029
Mtr5-methyltetrahydrofolate-homocysteine methyltransferase0.028
Ccna2cyclin A20.028
Narsasparaginyl-tRNA synthetase0.028
Cdc45lCDC45 cell division cycle 45-like (S. cerevisiae)0.028
Narg1NMDA receptor regulated 10.027
Rbm18RNA binding motif protein 180.027
Mcm2minichromosome maintenance complex component 20.027
Ezh2enhancer of zeste homolog 2 (Drosophila)0.026
Usp47ubiquitin specific peptidase 470.026
Bard1BRCA1 associated RING domain 10.026
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
RAD53Rad53p0.999
CTF4Ctf4p0.995
RAD52Rad52p0.992
RAD9Rad9p0.991
RFA1Rfa1p0.983
SLD5Sld5p0.980
SMC6Smc6p0.972
SRS2Srs2p0.969
MCM5Mcm5p0.969
RAD54Rad54p0.965
MRC1Mrc1p0.964
XRS2Xrs2p0.957
MCM4Mcm4p0.949
CDC45Cdc45p0.948
POL30Pol30p0.938
RDH54Rdh54p0.937
RTT107Rtt107p0.931
RAD50Rad50p0.926
TOF1Tof1p0.926
ELG1Elg1p0.910
SLX4Slx4p0.903
SIR2Sir2p0.887
MRE11Mre11p0.886
POL3Pol3p0.886
MCM6Mcm6p0.882
MSH6Msh6p0.877
LIF1Lif1p0.875
DDC1Ddc1p0.861
MCM3Mcm3p0.842
POL2Pol2p0.842
RAD1Rad1p0.839
MCM2Mcm2p0.825
RSC1Rsc1p0.815
RAD5Rad5p0.812
SHU1Shu1p0.808
MMS1Mms1p0.793
PSF1Psf1p0.791
MCM7Mcm7p0.786
SMC3Smc3p0.784
MSH2Msh2p0.778
ASF1Asf1p0.777
POL12Pol12p0.772
RAD24Rad24p0.752
SLX8Slx8p0.750
TOP1Top1p0.745
TEL1Tel1p0.734
ARP4Arp4p0.727
POL1Pol1p0.722
INO80Ino80p0.715
SGS1Sgs1p0.714
PSY3Psy3p0.709
MEC1Mec1p0.691
DPB11Dpb11p0.662
CSM3Csm3p0.659
DBF4Dbf4p0.643
ARP9Arp9p0.630
MCM10Mcm10p0.628
MMS21Mms21p0.621
RSC2Rsc2p0.620
IES3Ies3p0.609
RAD18Rad18p0.603
RAD27Rad27p0.588
DNL4Dnl4p0.582
SCC2Scc2p0.570
DMC1Dmc1p0.558
PPH21Pph21p0.557
SLD2Sld2p0.552
RSC8Rsc8p0.551
RAD10Rad10p0.546
POB3Pob3p0.538
PSF2Psf2p0.530
YAF9Yaf9p0.527
EST2Est2p0.509
SHU2Shu2p0.505
REV7Rev7p0.491
RAD59Rad59p0.475
IES1Ies1p0.470
NPL6Npl6p0.466
CSM2Csm2p0.461
NUP120Nup120p0.438
PSF3Psf3p0.433
HHF1Hhf1p0.410
MMS22Mms22p0.395
EPL1Epl1p0.387
NUP85Nup85p0.368
PSY4Psy4p0.367
DCC1Dcc1p0.360
FUN30Fun30p0.336
POL31Pol31p0.335
EST1Est1p0.331
SLX5Slx5p0.327
SAE2Sae2p0.323
MUS81Mus81p0.316
MEC3Mec3p0.312
HST3Hst3p0.298
RFA2Rfa2p0.292
TPD3Tpd3p0.284
RMI1Rmi1p0.282
PPH3Pph3p0.281
STH1Sth1p0.280