The network for 'dna catabolic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

dna catabolic process

The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one.

NameDescriptionProbabilityFunc Analog Organism
SLX4SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae)0.998
MSH2mutS homolog 2, colon cancer, nonpolyposis type 1 (E. coli)0.998
BRCA1breast cancer 1, early onset0.991
XRCC6X-ray repair complementing defective repair in Chinese hamster cells 60.945
CHEK1CHK1 checkpoint homolog (S. pombe)0.931
EME1essential meiotic endonuclease 1 homolog 1 (S. pombe)0.916
TP53tumor protein p530.893
XRCC5X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)0.880
MUS81MUS81 endonuclease homolog (S. cerevisiae)0.878
BAK1BCL2-antagonist/killer 10.793
H2AFXH2A histone family, member X0.780
BCL2L1BCL2-like 10.748
RAD51RAD51 homolog (RecA homolog, E. coli) (S. cerevisiae)0.738
DFFADNA fragmentation factor, 45kDa, alpha polypeptide0.725
CASP9caspase 9, apoptosis-related cysteine peptidase0.713
SLX1BSLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)0.713
RAD50RAD50 homolog (S. cerevisiae)0.697
BCL2B-cell CLL/lymphoma 20.674
PMS2PMS2 postmeiotic segregation increased 2 (S. cerevisiae)0.637
MSH6mutS homolog 6 (E. coli)0.604
EXOSC3exosome component 30.577
E2F1E2F transcription factor 10.512
BLMBloom syndrome, RecQ helicase-like0.497
NBNnibrin0.432
PARP1poly (ADP-ribose) polymerase 10.416
DFFBDNA fragmentation factor, 40kDa, beta polypeptide (caspase-activated DNase)0.414
GNLYgranulysin0.400
MRE11AMRE11 meiotic recombination 11 homolog A (S. cerevisiae)0.354
BAXBCL2-associated X protein0.353
C20orf94chromosome 20 open reading frame 940.339
WRNWerner syndrome, RecQ helicase-like0.332
VDAC1voltage-dependent anion channel 10.293
MCL1myeloid cell leukemia sequence 1 (BCL2-related)0.282
CHEK2CHK2 checkpoint homolog (S. pombe)0.271
MLH1mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)0.242
EXOSC10exosome component 100.241
POU5F1POU class 5 homeobox 10.213
DIS3DIS3 mitotic control homolog (S. cerevisiae)0.201
XIAPX-linked inhibitor of apoptosis0.198
XRCC1X-ray repair complementing defective repair in Chinese hamster cells 10.196
BRCA2breast cancer 2, early onset0.151
FANCD2Fanconi anemia, complementation group D20.149
C19orf39chromosome 19 open reading frame 390.149
UBE2V1ubiquitin-conjugating enzyme E2 variant 10.145
RAD1RAD1 homolog (S. pombe)0.144
MDM2Mdm2 p53 binding protein homolog (mouse)0.139
PCNAproliferating cell nuclear antigen0.139
CCT2chaperonin containing TCP1, subunit 2 (beta)0.138
HSPA8heat shock 70kDa protein 80.137
EXO1exonuclease 10.135
XRCC4X-ray repair complementing defective repair in Chinese hamster cells 40.128
ATMataxia telangiectasia mutated0.126
PRKDCprotein kinase, DNA-activated, catalytic polypeptide0.114
XPCxeroderma pigmentosum, complementation group C0.112
MDC1mediator of DNA-damage checkpoint 10.112
PRMT6protein arginine methyltransferase 60.111
RAD52RAD52 homolog (S. cerevisiae)0.104
RPA1replication protein A1, 70kDa0.101
CDK2cyclin-dependent kinase 20.100
BCL2L11BCL2-like 11 (apoptosis facilitator)0.095
EXOSC7exosome component 70.094
ERCC4excision repair cross-complementing rodent repair deficiency, complementation group 40.077
PRF1perforin 1 (pore forming protein)0.076
TERF2IPtelomeric repeat binding factor 2, interacting protein0.075
RAD18RAD18 homolog (S. cerevisiae)0.074
MCM10minichromosome maintenance complex component 100.074
TELO2TEL2, telomere maintenance 2, homolog (S. cerevisiae)0.073
EIF2C1eukaryotic translation initiation factor 2C, 10.071
PHBprohibitin0.070
HUWE1HECT, UBA and WWE domain containing 10.069
ERCC1excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)0.069
C4orf14chromosome 4 open reading frame 140.067
RNR2l-rRNA0.065
MSH3mutS homolog 3 (E. coli)0.064
CCNE1cyclin E10.064
EXOSC4exosome component 40.056
PRKRAprotein kinase, interferon-inducible double stranded RNA dependent activator0.056
PARP2poly (ADP-ribose) polymerase 20.056
RCC1regulator of chromosome condensation 10.055
TARBP2TAR (HIV-1) RNA binding protein 20.053
NUDT1nudix (nucleoside diphosphate linked moiety X)-type motif 10.052
BRIP1BRCA1 interacting protein C-terminal helicase 10.050
NCLnucleolin0.049
EXOSC8exosome component 80.049
CLSPNclaspin0.048
EXOSC5exosome component 50.048
MOCS3molybdenum cofactor synthesis 30.048
MYCNv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.048
CASP3caspase 3, apoptosis-related cysteine peptidase0.047
PNKPpolynucleotide kinase 3'-phosphatase0.047
EP300E1A binding protein p3000.045
NME2non-metastatic cells 2, protein (NM23B) expressed in0.045
POLQpolymerase (DNA directed), theta0.045
POLD3polymerase (DNA-directed), delta 3, accessory subunit0.044
RECQL4RecQ protein-like 40.043
SOX2SRY (sex determining region Y)-box 20.043
TOMM22translocase of outer mitochondrial membrane 22 homolog (yeast)0.043
HSPA1Bheat shock 70kDa protein 1B0.043
RBL1retinoblastoma-like 1 (p107)0.042
FEN1flap structure-specific endonuclease 10.041
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
mcm5MCM5 minichromosome maintenance deficient 5 (S. cerevisiae)0.863
pcnaproliferating cell nuclear antigen0.789
prim1primase polypeptide 10.393
rrm1ribonucleotide reductase M1 polypeptide0.267
setdb1aSET domain, bifurcated 1a0.256
zgc:103564zgc:1035640.219
bactin1bactin10.201
brip1BRCA1 interacting protein C-terminal helicase 10.199
ccnd1cyclin D10.174
tymsthymidylate synthase0.168
si:ch211-1n9.7si:ch211-1n9.70.160
zgc:101661zgc:1016610.159
msh2mutS homolog 2 (E. coli)0.157
npatnuclear protein, ataxia-telangiectasia locus0.148
slbpstem-loop binding protein0.140
mcm4MCM4 minichromosome maintenance deficient 4, mitotin (S. cerevisiae)0.140
dutdUTP pyrophosphatase0.128
mybl2myeloblastosis oncogene-like 20.126
hnrnpa1heterogeneous nuclear ribonucleoprotein A10.120
palb2partner and localizer of BRCA20.120
mycamyelocytomatosis oncogene a0.118
rac1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.111
srmspermidine synthase0.089
zgc:77165zgc:771650.084
dhfrdihydrofolate reductase0.084
pola2polymerase (DNA directed), alpha 20.079
aldh1a2aldehyde dehydrogenase 1 family, member A20.078
chek2CHK2 checkpoint homolog (S. pombe)0.078
rpa1replication protein A10.076
ncapd2non-SMC condensin I complex, subunit D20.075
prmt1protein arginine methyltransferase 10.072
hnrnpa0heterogeneous nuclear ribonucleoprotein A00.072
ptger4aprostaglandin E receptor 4 (subtype EP4) a0.071
ppm1gprotein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform0.070
lrrc42leucine rich repeat containing 420.069
zgc:92661zgc:926610.064
ncapgnon-SMC condensin I complex, subunit G0.062
ipo9importin 90.061
ywhae1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 10.058
wdhd1WD repeat and HMG-box DNA binding protein 10.058
ccng1cyclin G10.057
cdc7cell division cycle 7 homolog (S. cerevisiae)0.057
zgc:110113zgc:1101130.056
mus81MUS81 endonuclease homolog (yeast)0.056
racgap1Rac GTPase-activating protein 10.056
zff9zinc finger protein 90.055
kif14kinesin family member 140.054
fen1flap structure-specific endonuclease 10.053
efna2ephrin A20.052
zgc:92648zgc:926480.052
zgc:56197zgc:561970.052
LOC560606novel protein similar to human and mouse leishmanolysin-like (metallopeptidase M8 family) (LMLN)0.048
cdc45CDC45 cell division cycle 45 homolog (S. cerevisiae)0.048
hellshelicase, lymphoid-specific0.048
dnmt1DNA (cytosine-5-)-methyltransferase 10.047
chtf18CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae)0.047
arpc5aactin related protein 2/3 complex, subunit 5A0.044
tp53tumor protein p530.043
setd8aSET domain containing (lysine methyltransferase) 8a0.043
bcl2l1bcl2-like 10.043
hgfahepatocyte growth factor a0.042
arid4aAT rich interactive domain 4A (RBP1-like)0.042
pomgnt1protein O-linked mannose beta1,2-N-acetylglucosaminyltransferase0.041
pole3polymerase (DNA directed), epsilon 3 (p17 subunit)0.041
gins1GINS complex subunit 1 (Psf1 homolog)0.040
eif4eeukaryotic translation initiation factor 4e0.040
ncaphnon-SMC condensin I complex, subunit H0.040
cep70centrosomal protein 700.039
zgc:152930zgc:1529300.038
anapc5anaphase promoting complex subunit 50.038
si:ch211-254d18.3si:ch211-254d18.30.038
rad51crad51 homolog C (S. cerevisiae)0.037
aldh7a1aldehyde dehydrogenase 7 family, member A10.037
ilf2interleukin enhancer binding factor 20.037
wdr76WD repeat domain 760.037
zgc:112425zgc:1124250.036
arf2ADP-ribosylation factor 20.036
zgc:110540zgc:1105400.036
nipblbnovel protein similar to vertebrate Nipped-B homolog and nipped-b homolog b (Drosophila)0.035
fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.035
ssbSjogren syndrome antigen B (autoantigen La)0.035
arntl2aryl hydrocarbon receptor nuclear translocator-like 20.035
hsp90b1heat shock protein 90, beta (grp94), member 10.035
anp32bacidic (leucine-rich) nuclear phosphoprotein 32 family, member B0.034
ankrd49ankyrin repeat domain 490.034
setbSET translocation (myeloid leukemia-associated) B0.033
rnasenribonuclease type III, nuclear0.033
zgc:154089zgc:1540890.033
ddx20DEAD (Asp-Glu-Ala-Asp) box polypeptide 200.032
esco2establishment of cohesion 1 homolog 20.030
apex1APEX nuclease (multifunctional DNA repair enzyme) 10.030
sephs1selenophosphate synthetase 10.030
tgfb3transforming growth factor, beta 30.029
cdk2cyclin-dependent kinase 20.029
fabp7afatty acid binding protein 7, brain, a0.029
tuba1tubulin, alpha 10.029
zgc:100817zgc:1008170.029
rfc4replication factor C (activator 1) 40.029
ck2bcasein kinase 2 beta0.029
rad51l1RAD51-like 1 (S. cerevisiae)0.029
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
mus301mutagen-sensitive 3010.144
spn-Bspindle B0.132
mei-9meiotic 90.101
Smc5CG32438 gene product from transcript CG32438-RE0.077
mus205mutagen-sensitive 2050.067
Brca2Breast cancer 2, early onset homolog0.046
spn-Espindle E0.044
Mcm5Minichromosome maintenance 50.035
mus304mutagen-sensitive 3040.034
CG4973CG4973 gene product from transcript CG4973-RA0.033
lokloki0.029
nbsCG6754 gene product from transcript CG6754-RC0.029
mus101mutagen-sensitive 1010.027
stepsteppke0.023
spn-Aspindle A0.021
Eb1CG3265 gene product from transcript CG3265-RF0.021
p53CG33336 gene product from transcript CG33336-RB0.019
Patr-1Protein associated with topo II related - 10.019
Dcp-1Death caspase-10.018
CG9752CG9752 gene product from transcript CG9752-RA0.017
Cks30ACyclin-dependent kinase subunit 30A0.017
ranshiCG9793 gene product from transcript CG9793-RA0.017
CG11164CG11164 gene product from transcript CG11164-RA0.016
MAGECG10059 gene product from transcript CG10059-RA0.015
Df31Decondensation factor 310.015
NcNedd2-like caspase0.013
RhoGAP92BCG4755 gene product from transcript CG4755-RA0.013
cavcaravaggio0.013
mus201mutagen-sensitive 2010.013
CG5524CG5524 gene product from transcript CG5524-RA0.012
tefutelomere fusion0.012
Mcm7Minichromosome maintenance 70.011
okrokra0.011
CG9247CG9247 gene product from transcript CG9247-RA0.011
AGO3Argonaute 30.011
Klp3AKinesin-like protein at 3A0.011
orboo18 RNA-binding protein0.010
CG5602CG5602 gene product from transcript CG5602-RA0.010
CG10638CG10638 gene product from transcript CG10638-RA0.010
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Rb1retinoblastoma 10.773
Brca1breast cancer 10.763
Brca2breast cancer 20.534
DffbDNA fragmentation factor, beta subunit0.499
Cdk4cyclin-dependent kinase 40.385
Trp53transformation related protein 530.360
Ppp1ccprotein phosphatase 1, catalytic subunit, gamma isoform0.330
Prkdcprotein kinase, DNA activated, catalytic polypeptide0.267
Nbnnibrin0.197
Casp1caspase 10.166
Ccne1cyclin E10.164
Casp4caspase 4, apoptosis-related cysteine peptidase0.150
Cdkn1bcyclin-dependent kinase inhibitor 1B0.116
Hellshelicase, lymphoid specific0.112
Gbp5guanylate binding protein 50.104
Hspd1heat shock protein 1 (chaperonin)0.083
Ccnd1cyclin D10.076
Hdac1histone deacetylase 10.075
Il18interleukin 180.072
Wdhd1WD repeat and HMG-box DNA binding protein 10.071
Cdc6cell division cycle 6 homolog (S. cerevisiae)0.070
Map3k7mitogen-activated protein kinase kinase kinase 70.069
Atmataxia telangiectasia mutated homolog (human)0.066
Terf1telomeric repeat binding factor 10.064
PycardPYD and CARD domain containing0.063
Ppp1caprotein phosphatase 1, catalytic subunit, alpha isoform0.063
Rfc3replication factor C (activator 1) 30.062
Orc1origin recognition complex, subunit 10.060
Rbl1retinoblastoma-like 1 (p107)0.055
Pms2postmeiotic segregation increased 2 (S. cerevisiae)0.053
Atrataxia telangiectasia and Rad3 related0.053
Ighimmunoglobulin heavy chain complex0.048
Mis18bp1MIS18 binding protein 10.046
Ezh2enhancer of zeste homolog 2 (Drosophila)0.046
Dtldenticleless homolog (Drosophila)0.044
Tlr4toll-like receptor 40.043
Nphp4nephronophthisis 4 (juvenile) homolog (human)0.043
Mdm2transformed mouse 3T3 cell double minute 20.042
Casp3caspase 30.040
Kiss1KiSS-1 metastasis-suppressor0.039
Tgfbr2transforming growth factor, beta receptor II0.039
Dicer1Dicer1, Dcr-1 homolog (Drosophila)0.039
Naspnuclear autoantigenic sperm protein (histone-binding)0.039
Plk4polo-like kinase 4 (Drosophila)0.037
Cdk2cyclin-dependent kinase 20.037
Plin1perilipin 10.037
Pole2polymerase (DNA directed), epsilon 2 (p59 subunit)0.036
Mcm4minichromosome maintenance deficient 4 homolog (S. cerevisiae)0.036
Lrpprcleucine-rich PPR-motif containing0.035
Ndufab1NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 10.035
Bub1budding uninhibited by benzimidazoles 1 homolog (S. cerevisiae)0.035
Apcadenomatosis polyposis coli0.033
Droshadrosha, ribonuclease type III0.033
Mlh1mutL homolog 1 (E. coli)0.032
Chek2CHK2 checkpoint homolog (S. pombe)0.032
Cdca7lcell division cycle associated 7 like0.032
Il1binterleukin 1 beta0.032
Parp2poly (ADP-ribose) polymerase family, member 20.031
Lig4ligase IV, DNA, ATP-dependent0.030
Bak1BCL2-antagonist/killer 10.029
Stk11serine/threonine kinase 110.029
WrnWerner syndrome homolog (human)0.029
Xpaxeroderma pigmentosum, complementation group A0.028
FaddFas (TNFRSF6)-associated via death domain0.027
Pola1polymerase (DNA directed), alpha 10.027
Suz12suppressor of zeste 12 homolog (Drosophila)0.027
Tfamtranscription factor A, mitochondrial0.026
Cycscytochrome c, somatic0.026
Trip13thyroid hormone receptor interactor 130.026
Mcm7minichromosome maintenance deficient 7 (S. cerevisiae)0.025
Fen1flap structure specific endonuclease 10.025
Kif11kinesin family member 110.024
Cenpkcentromere protein K0.024
Srsf9serine/arginine-rich splicing factor 90.024
Ccna2cyclin A20.024
Prkab1protein kinase, AMP-activated, beta 1 non-catalytic subunit0.023
Ccnb1cyclin B10.023
Mdm4transformed mouse 3T3 cell double minute 40.023
Timm8a1translocase of inner mitochondrial membrane 8 homolog a1 (yeast)0.023
Dhfrdihydrofolate reductase0.023
Ranbp1RAN binding protein 10.022
Smc2structural maintenance of chromosomes 20.022
Ikbkbinhibitor of kappaB kinase beta0.022
E2f1E2F transcription factor 10.021
Hist1h1ahistone cluster 1, H1a0.021
Gmnngeminin0.021
Ndufaf4NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 40.021
Ints9integrator complex subunit 90.020
Rttnrotatin0.020
Chek1checkpoint kinase 1 homolog (S. pombe)0.020
Dsn1DSN1, MIND kinetochore complex component, homolog (S. cerevisiae)0.020
Impdh2inosine 5'-phosphate dehydrogenase 20.020
Cdc7cell division cycle 7 (S. cerevisiae)0.020
Mybl2myeloblastosis oncogene-like 20.020
Ikbkginhibitor of kappaB kinase gamma0.020
Prim1DNA primase, p49 subunit0.019
Cox5acytochrome c oxidase, subunit Va0.019
Nlrp3NLR family, pyrin domain containing 30.019
Mcm10minichromosome maintenance deficient 10 (S. cerevisiae)0.019
Ccdc99coiled-coil domain containing 990.019
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
RAD1Rad1p0.804
XRS2Xrs2p0.602
RAD10Rad10p0.486
RAD59Rad59p0.436
MSH2Msh2p0.417
RAD14Rad14p0.216
ASF1Asf1p0.191
RAD18Rad18p0.180
MLH1Mlh1p0.174
RAD52Rad52p0.167
TEL1Tel1p0.129
RFA1Rfa1p0.129
RAD53Rad53p0.109
RFA3Rfa3p0.108
MRC1Mrc1p0.107
MSH3Msh3p0.101
POL32Pol32p0.091
EXO1Exo1p0.089
RAD2Rad2p0.088
MEC1Mec1p0.082
RAD5Rad5p0.075
ULP1Ulp1p0.065
MMS1Mms1p0.064
DNA2Dna2p0.063
SAW1Saw1p0.063
HDA2Hda2p0.062
MSH6Msh6p0.062
REV3Rev3p0.059
SLX4Slx4p0.054
PMS1Pms1p0.054
SEN1Sen1p0.049
MGS1Mgs1p0.049
SAE2Sae2p0.047
TIM44Tim44p0.047
THO2Tho2p0.044
SIR3Sir3p0.042
NTG1Ntg1p0.042
RPS5Rps5p0.041
TOP1Top1p0.041
RMI1Rmi1p0.038
RAD16Rad16p0.037
PIF1Pif1p0.035
MUS81Mus81p0.035
JHD2Jhd2p0.034
RAD26Rad26p0.033
CAK1Cak1p0.032
MDJ1Mdj1p0.032
YLR264C-Ahypothetical protein0.032
SGS1Sgs1p0.032
APN2Apn2p0.032
RAD7Rad7p0.031
MPH1Mph1p0.031
SIS2Sis2p0.031
RLF2Rlf2p0.031
YBL044Whypothetical protein0.030
ADI1Adi1p0.030
APN1Apn1p0.030
DUN1Dun1p0.030
RAD17Rad17p0.029
SRD1Srd1p0.029
NTA1Nta1p0.029
URA6Ura6p0.029
SMC6Smc6p0.028
YLR419Whypothetical protein0.028
PSO2Pso2p0.028
ALT2Alt2p0.027
LEU2Leu2p0.027
YLR162Whypothetical protein0.027
RPL7BRpl7bp0.026
YOL038C-Ahypothetical protein0.026
YPL068Chypothetical protein0.026
HOHop0.025
YAR068Whypothetical protein0.025
DOT1Dot1p0.025
PET309Pet309p0.025
GYL1Gyl1p0.025
YIR035Chypothetical protein0.025
POM34Pom34p0.025
URA3Ura3p0.024
ARG8Arg8p0.024
LIF1Lif1p0.024
CUP1-1Cup1-1p0.024
UGO1Ugo1p0.024
MER1Mer1p0.024
RAD24Rad24p0.023
YLR363W-Ahypothetical protein0.023
SHU1Shu1p0.023
SUT2Sut2p0.023
MMS4Mms4p0.023
CLN2Cln2p0.023
YPL260Whypothetical protein0.023
REV1Rev1p0.022
PTP3Ptp3p0.022
KTI12Kti12p0.022
SOM1Som1p0.022
THP2Thp2p0.022
POL31Pol31p0.022
HST3Hst3p0.021
ATP6Atp6p0.021
YBR013Chypothetical protein0.021