The network for 'endothelial cell differentiation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

endothelial cell differentiation

The process in which a mesodermal, bone marrow or neural crest cell acquires specialized features of an endothelial cell, a thin flattened cell. A layer of such cells lines the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium.

NameDescriptionProbabilityFunc Analog Organism
CAV1caveolin 1, caveolae protein, 22kDa0.773
SMAD3SMAD family member 30.754
RARAretinoic acid receptor, alpha0.659
TGFB1transforming growth factor, beta 10.387
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.386
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.317
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.255
CD44CD44 molecule (Indian blood group)0.211
CAB39calcium binding protein 390.200
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.187
GAB1GRB2-associated binding protein 10.180
NCOA1nuclear receptor coactivator 10.166
SMAD2SMAD family member 20.159
SMURF2SMAD specific E3 ubiquitin protein ligase 20.153
SMAD7SMAD family member 70.149
NRP1neuropilin 10.145
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.143
FKBP1AFK506 binding protein 1A, 12kDa0.142
DTNAdystrobrevin, alpha0.139
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.133
PTPN13protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)0.114
NOTCH1notch 10.114
CNOT8CCR4-NOT transcription complex, subunit 80.110
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.104
PBX1pre-B-cell leukemia homeobox 10.099
PAX3paired box 30.097
RBPJrecombination signal binding protein for immunoglobulin kappa J region0.092
JAG1jagged 10.090
FLNAfilamin A, alpha0.088
EGFRepidermal growth factor receptor0.086
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.085
MED25mediator complex subunit 250.084
GAS6growth arrest-specific 60.078
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.078
POU3F2POU class 3 homeobox 20.073
CDH5cadherin 5, type 2 (vascular endothelium)0.072
TECPR1tectonin beta-propeller repeat containing 10.071
NEDD4Lneural precursor cell expressed, developmentally down-regulated 4-like0.071
PTCH1patched 10.071
SPOPspeckle-type POZ protein0.066
HNF4Ahepatocyte nuclear factor 4, alpha0.060
BMP2bone morphogenetic protein 20.058
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.058
POU5F1POU class 5 homeobox 10.053
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.047
BCRbreakpoint cluster region0.047
TJP1tight junction protein 1 (zona occludens 1)0.046
PLCG1phospholipase C, gamma 10.043
LATlinker for activation of T cells0.042
ERBB2IPerbb2 interacting protein0.042
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.041
RXRAretinoid X receptor, alpha0.041
FGFR1fibroblast growth factor receptor 10.040
GATA2GATA binding protein 20.039
PROX1prospero homeobox 10.039
GNB1guanine nucleotide binding protein (G protein), beta polypeptide 10.038
ABI1abl-interactor 10.036
CTNND1catenin (cadherin-associated protein), delta 10.034
PDCD10programmed cell death 100.033
CXCR5chemokine (C-X-C motif) receptor 50.031
ACVR1Bactivin A receptor, type IB0.030
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.030
RANBP9RAN binding protein 90.030
RAP1ARAP1A, member of RAS oncogene family0.029
TGFB3transforming growth factor, beta 30.029
TBC1D10ATBC1 domain family, member 10A0.029
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.029
EPS8epidermal growth factor receptor pathway substrate 80.028
GDF5growth differentiation factor 50.028
RAPGEF2Rap guanine nucleotide exchange factor (GEF) 20.028
FOXD3forkhead box D30.028
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.027
NOTCH3notch 30.026
PTENphosphatase and tensin homolog0.026
MAP4K1mitogen-activated protein kinase kinase kinase kinase 10.025
MEIS2Meis homeobox 20.023
NEDD4neural precursor cell expressed, developmentally down-regulated 40.022
GJA1gap junction protein, alpha 1, 43kDa0.022
DTNBdystrobrevin, beta0.022
THBS1thrombospondin 10.022
WWP2WW domain containing E3 ubiquitin protein ligase 20.021
ARHGEF40Rho guanine nucleotide exchange factor (GEF) 400.021
PTPRBprotein tyrosine phosphatase, receptor type, B0.021
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.021
VDRvitamin D (1,25- dihydroxyvitamin D3) receptor0.021
ID3inhibitor of DNA binding 3, dominant negative helix-loop-helix protein0.021
BMPR1Abone morphogenetic protein receptor, type IA0.020
KRT5keratin 50.020
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.020
PECAM1platelet/endothelial cell adhesion molecule0.020
MAML1mastermind-like 1 (Drosophila)0.019
IRAK2interleukin-1 receptor-associated kinase 20.019
CAV2caveolin 20.019
PICALMphosphatidylinositol binding clathrin assembly protein0.019
FAM46Afamily with sequence similarity 46, member A0.018
FYNFYN oncogene related to SRC, FGR, YES0.018
SKIv-ski sarcoma viral oncogene homolog (avian)0.018
ACTN4actinin, alpha 40.018
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
kdrlkinase insert domain receptor like0.926
wnt5bwingless-type MMTV integration site family, member 5b0.754
sox9aSRY-box containing gene 9a0.626
mibmind bomb0.575
etv2ets variant gene 20.551
sox19aSRY-box containing gene 19a0.425
hand2heart and neural crest derivatives expressed transcript 20.374
cldnbclaudin b0.309
nr2f2nuclear receptor subfamily 2, group F, member 20.297
cxcr4achemokine (C-X-C motif) receptor 4a0.243
pou3f2POU class 3 homeobox 20.238
mab21l2mab-21-like 20.200
ctsl1bcathepsin L, 1 b0.200
unc45aunc-45 homolog A (C. elegans)0.193
plcg1phospholipase C, gamma 10.193
sox11aSRY-box containing gene 11a0.187
rarabretinoic acid receptor, alpha b0.181
bhlhe22basic helix-loop-helix family, member e220.170
emx2empty spiracles homeobox 20.158
dll4delta-like 4 (Drosophila)0.158
jag2jagged 20.157
six4bsine oculis homeobox homolog 4b0.149
cxcl12bchemokine (C-X-C motif) ligand 12b (stromal cell-derived factor 1)0.144
lmx1b.1LIM homeobox transcription factor 1, beta 10.143
atoh1batonal homolog 1b0.133
sox9bSRY-box containing gene 9b0.131
fgfr2fibroblast growth factor receptor 20.128
tbx1T-box 10.122
arhgef7bRho guanine nucleotide exchange factor (GEF) 7b0.121
cyp3a65cytochrome P450, family 3, subfamily A, polypeptide 650.121
osr1odd-skipped related 1 (Drosophila)0.120
ela2lelastase 2 like0.118
fn1fibronectin 10.118
ptf1apancreas specific transcription factor, 1a0.115
gata4GATA-binding protein 40.109
cldn7bclaudin 7b0.108
plxnd1plexin D10.108
slc4a2asolute carrier family 4, anion exchanger, member 2a0.105
slc2a1asolute carrier family 2 (facilitated glucose transporter), member 1a0.097
her9hairy-related 90.094
snai1bsnail homolog 1b (Drosophila)0.093
hoxd13ahomeo box D13a0.091
foxc1aforkhead box C1a0.089
gata2aGATA-binding protein 2a0.087
tbx24T-box 240.085
tp63tumor protein p630.081
vcanaversican a0.081
nr2f1anuclear receptor subfamily 2, group F, member 1a0.076
slc2a13solute carrier family 2 (facilitated glucose transporter), member 130.076
tcf12transcription factor 120.073
flt4fms-related tyrosine kinase 40.072
wt1awilms tumor 1a0.072
edn1endothelin 10.070
atoh1aatonal homolog 1a0.070
hoxa13ahomeo box A13a0.068
sox1aSRY-box containing gene 1a0.068
irx5airoquois homeobox protein 5a0.067
ftr82finTRIM family, member 820.067
tmem88atransmembrane protein 88 a0.066
gata5GATA-binding protein 50.065
tie1endothelium-specific receptor tyrosine kinase 10.065
cldn1claudin 10.064
hs3st1l2heparan sulfate (glucosamine) 3-O-sulfotransferase 1-like 20.063
vcanbversican b0.063
traf4atnf receptor-associated factor 4a0.063
eya1eyes absent homolog 10.062
slc2a11bsolute carrier family 2 (facilitated glucose transporter), member 11b0.061
fli1afriend leukemia integration 1a0.060
metmet proto-oncogene (hepatocyte growth factor receptor)0.060
vhlvon Hippel-Lindau tumor suppressor0.058
ergv-ets erythroblastosis virus E26 oncogene like (avian)0.058
ptgs2aprostaglandin-endoperoxide synthase 2a0.058
rx2retinal homeobox gene 20.058
foxa1forkhead box A10.058
hoxb5ahomeo box B5a0.058
hnf1baHNF1 homeobox Ba0.057
ascl1aachaete-scute complex-like 1a (Drosophila)0.057
tp53tumor protein p530.056
clic4chloride intracellular channel 40.055
rxrgaretinoid x receptor, gamma a0.053
jag1bjagged 1b0.053
tbx2bT-box 2b0.050
aldocaaldolase C, fructose-bisphosphate, a0.050
nr2e1nuclear receptor subfamily 2, group E, member 10.050
cdh17cadherin 17, LI cadherin (liver-intestine)0.050
foxa3forkhead box A30.049
pcdh18aprotocadherin 18a0.049
clec14aC-type lectin domain family 14, member A0.048
ptgs1prostaglandin-endoperoxide synthase 10.047
ftr83finTRIM family, member 830.047
ccm2cerebral cavernous malformation 20.047
cldniclaudin i0.046
fzd5frizzled homolog 50.046
amotl2aangiomotin like 2a0.045
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Hand2heart and neural crest derivatives expressed transcript 20.995
Shhsonic hedgehog0.985
Fgf8fibroblast growth factor 80.978
Flt4FMS-like tyrosine kinase 40.977
Tgfbr2transforming growth factor, beta receptor II0.975
Pax3paired box gene 30.966
Six1sine oculis-related homeobox 1 homolog (Drosophila)0.956
Vegfavascular endothelial growth factor A0.953
Acvr1activin A receptor, type 10.953
Fgfr2fibroblast growth factor receptor 20.947
Fgfr1fibroblast growth factor receptor 10.924
Foxc2forkhead box C20.913
Meox2mesenchyme homeobox 20.896
Apcadenomatosis polyposis coli0.884
Gli3GLI-Kruppel family member GLI30.875
Isl1ISL1 transcription factor, LIM/homeodomain0.867
Id3inhibitor of DNA binding 30.855
Sox9SRY-box containing gene 90.851
Itgb1integrin beta 1 (fibronectin receptor beta)0.840
Foxc1forkhead box C10.824
Kdrkinase insert domain protein receptor0.823
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.818
Cdh5cadherin 50.816
Ror2receptor tyrosine kinase-like orphan receptor 20.812
Gata4GATA binding protein 40.784
Tbx2T-box 20.773
Smad4MAD homolog 4 (Drosophila)0.771
Hoxa5homeobox A50.762
Hand1heart and neural crest derivatives expressed transcript 10.753
Col4a2collagen, type IV, alpha 20.753
Smad6MAD homolog 6 (Drosophila)0.747
Ntf3neurotrophin 30.723
Hoxc4homeobox C40.712
Sox18SRY-box containing gene 180.707
Tgfb1transforming growth factor, beta 10.690
Hoxa9homeobox A90.670
Tcfap2atranscription factor AP-2, alpha0.668
Prrx1paired related homeobox 10.662
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.637
Shesrc homology 2 domain-containing transforming protein E0.618
Notch1Notch gene homolog 1 (Drosophila)0.616
Hoxb3homeobox B30.600
Prrx2paired related homeobox 20.593
Bmp4bone morphogenetic protein 40.583
Nos3nitric oxide synthase 3, endothelial cell0.574
Hoxc6homeobox C60.564
Pbx1pre B-cell leukemia transcription factor 10.562
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.548
Id1inhibitor of DNA binding 10.540
Bmp2bone morphogenetic protein 20.539
Smad7MAD homolog 7 (Drosophila)0.504
Kcnq1potassium voltage-gated channel, subfamily Q, member 10.488
Hey1hairy/enhancer-of-split related with YRPW motif 10.485
Ptch1patched homolog 10.479
Fgfr3fibroblast growth factor receptor 30.470
Hoxb5homeobox B50.468
Zic3zinc finger protein of the cerebellum 30.449
Hes1hairy and enhancer of split 1 (Drosophila)0.441
Hoxa3homeobox A30.433
Tgfb2transforming growth factor, beta 20.428
Smad3MAD homolog 3 (Drosophila)0.424
Hoxa10homeobox A100.417
Sox7SRY-box containing gene 70.400
Alx4aristaless-like homeobox 40.398
Col4a1collagen, type IV, alpha 10.385
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.378
Gfra1glial cell line derived neurotrophic factor family receptor alpha 10.376
Gli2GLI-Kruppel family member GLI20.372
Hoxd13homeobox D130.368
Hoxd9homeobox D90.363
Ctnnb1catenin (cadherin associated protein), beta 10.358
Hoxa1homeobox A10.355
Notch2Notch gene homolog 2 (Drosophila)0.352
Tcf4transcription factor 40.351
Ptprbprotein tyrosine phosphatase, receptor type, B0.347
Lhx1LIM homeobox protein 10.343
Flt1FMS-like tyrosine kinase 10.337
Hoxc9homeobox C90.336
Bmp7bone morphogenetic protein 70.333
Hif1ahypoxia inducible factor 1, alpha subunit0.331
Eya1eyes absent 1 homolog (Drosophila)0.317
Gdnfglial cell line derived neurotrophic factor0.313
Hoxc5homeobox C50.313
Csf1colony stimulating factor 1 (macrophage)0.312
Fzd1frizzled homolog 1 (Drosophila)0.307
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.304
Pcsk5proprotein convertase subtilisin/kexin type 50.301
Dkk1dickkopf homolog 1 (Xenopus laevis)0.299
Ptk2PTK2 protein tyrosine kinase 20.293
Hoxa13homeobox A130.291
Pou3f3POU domain, class 3, transcription factor 30.290
Wnt10bwingless related MMTV integration site 10b0.287
Kitlkit ligand0.278
Nf1neurofibromatosis 10.274
Hoxc8homeobox C80.268
Dll4delta-like 4 (Drosophila)0.264
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Tgfbr2transforming growth factor, beta receptor II0.440
Flt1FMS-related tyrosine kinase 10.180
Dag1dystroglycan 1 (dystrophin-associated glycoprotein 1)0.164
Adam10ADAM metallopeptidase domain 100.146
Itga6integrin, alpha 60.075
Itgb1integrin, beta 10.069
Litaflipopolysaccharide-induced TNF factor0.067
Arf6ADP-ribosylation factor 60.066
Tgfbr3transforming growth factor, beta receptor III0.062
Lims1LIM and senescent cell antigen-like domains 10.053
Itpr2inositol 1,4,5-triphosphate receptor, type 20.053
Id3inhibitor of DNA binding 30.049
Tpm4tropomyosin 40.044
Pdk4pyruvate dehydrogenase kinase, isozyme 40.041
Pecam1platelet/endothelial cell adhesion molecule 10.038
Hcrtr1hypocretin (orexin) receptor 10.035
Myh9myosin, heavy chain 9, non-muscle0.035
Slco2a1solute carrier organic anion transporter family, member 2a10.035
Fgfr2fibroblast growth factor receptor 20.035
Notch3Notch homolog 3 (Drosophila)0.034
Spock2sparc/osteonectin, cwcv and kazal-like domains proteoglycan 20.033
Calcrlcalcitonin receptor-like0.031
Sdcbpsyndecan binding protein0.030
Asmtacetylserotonin O-methyltransferase0.028
Twist2twist homolog 2 (Drosophila)0.026
Magi2membrane associated guanylate kinase, WW and PDZ domain containing 20.025
Tff2trefoil factor 20.024
Arpc5actin related protein 2/3 complex, subunit 50.024
Gnai3guanine nucleotide binding protein (G protein), alpha inhibiting 30.023
Cald1caldesmon 10.021
Fgf6fibroblast growth factor 60.021
Soat1sterol O-acyltransferase 10.021
Scn3asodium channel, voltage-gated, type III, alpha0.021
Col12a1collagen, type XII, alpha 10.020
Ppap2aphosphatidic acid phosphatase type 2A0.016
Slc12a1solute carrier family 12 (sodium/potassium/chloride transporters), member 10.016
Platplasminogen activator, tissue0.015
Pvrl4poliovirus receptor-related 40.015
Map4k2mitogen activated protein kinase kinase kinase kinase 20.015
Elf1E74-like factor 10.015
Nos3nitric oxide synthase 3, endothelial cell0.015
Igfbp5insulin-like growth factor binding protein 50.015
Foxs1forkhead box S10.015
Pctk2PCTAIRE protein kinase 20.015
Gulogulonolactone (L-) oxidase0.014
Mcammelanoma cell adhesion molecule0.014
Nek9NIMA (never in mitosis gene a)- related kinase 90.014
Cd38CD38 molecule0.014
Pcnaproliferating cell nuclear antigen0.013
Tln1talin 10.013
Sox7SRY (sex determining region Y)-box 70.013
Entpd1ectonucleoside triphosphate diphosphohydrolase 10.013
Mllt4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.012
Tgfbr1transforming growth factor, beta receptor 10.012
Myo1cmyosin IC0.012
Itpkbinositol 1,4,5-trisphosphate 3-kinase B0.012
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.012
Myo1emyosin IE0.012
Pak2p21 protein (Cdc42/Rac)-activated kinase 20.012
Cd44Cd44 molecule0.011
Adam9ADAM metallopeptidase domain 9 (meltrin gamma)0.011
Tgfatransforming growth factor alpha0.011
Lmnalamin A0.011
Arntaryl hydrocarbon receptor nuclear translocator0.011
Pdlim5PDZ and LIM domain 50.011
Xdhxanthine dehydrogenase0.011
Vcsa2variable coding sequence A20.011
Pde5aphosphodiesterase 5A, cGMP-specific0.011
Slc6a12solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 120.011
Slc30a1solute carrier family 30 (zinc transporter), member 10.011
Epas1endothelial PAS domain protein 10.011
Enpepglutamyl aminopeptidase0.011
Rrbp1ribosome binding protein 10.011
Cmtm6CKLF-like MARVEL transmembrane domain containing 60.010
Unc5bunc-5 homolog B (C. elegans)0.010
Cdh5cadherin 50.010
Rapgef3Rap guanine nucleotide exchange factor (GEF) 30.010
Stard8StAR-related lipid transfer (START) domain containing 80.010
Kcnj13potassium inwardly-rectifying channel, subfamily J, member 130.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism