The network for 'positive regulation of pathway restricted smad protein phosphorylation' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of pathway restricted smad protein phosphorylation

Any process that increases the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways.

NameDescriptionProbabilityFunc Analog Organism
TGFB1transforming growth factor, beta 11.000
TGFBR2transforming growth factor, beta receptor II (70/80kDa)1.000
ENGendoglin1.000
TGFB3transforming growth factor, beta 31.000
FSTL1follistatin-like 11.000
TGFBR1transforming growth factor, beta receptor 11.000
BMPR2bone morphogenetic protein receptor, type II (serine/threonine kinase)1.000
FKBP1AFK506 binding protein 1A, 12kDa0.999
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.996
BMPR1Bbone morphogenetic protein receptor, type IB0.996
SMAD7SMAD family member 70.993
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.982
NRP1neuropilin 10.979
BMPR1Abone morphogenetic protein receptor, type IA0.975
GDF5growth differentiation factor 50.971
WFIKKN1WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 10.956
BMP2bone morphogenetic protein 20.877
ACVR1activin A receptor, type I0.810
ZFYVE9zinc finger, FYVE domain containing 90.775
ACVR2Bactivin A receptor, type IIB0.651
BMP4bone morphogenetic protein 40.616
NOGnoggin0.573
SMURF2SMAD specific E3 ubiquitin protein ligase 20.527
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.463
ACVR1Bactivin A receptor, type IB0.450
PRKG1protein kinase, cGMP-dependent, type I0.436
SMAD2SMAD family member 20.255
SHC1SHC (Src homology 2 domain containing) transforming protein 10.232
RBFOX2RNA binding protein, fox-1 homolog (C. elegans) 20.162
FSTfollistatin0.158
SMAD6SMAD family member 60.155
GRB7growth factor receptor-bound protein 70.146
THBS1thrombospondin 10.130
RXRAretinoid X receptor, alpha0.127
DIP2ADIP2 disco-interacting protein 2 homolog A (Drosophila)0.125
MAPK8mitogen-activated protein kinase 80.123
TGFBR3transforming growth factor, beta receptor III0.116
RBFOX1RNA binding protein, fox-1 homolog (C. elegans) 10.115
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.111
RHOXF2Rhox homeobox family, member 20.094
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.094
TGFB2transforming growth factor, beta 20.089
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.087
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.070
SMAD1SMAD family member 10.069
APPamyloid beta (A4) precursor protein0.067
MYO6myosin VI0.060
COL2A1collagen, type II, alpha 10.056
QKIquaking homolog, KH domain RNA binding (mouse)0.053
FNDC3Bfibronectin type III domain containing 3B0.053
RBMS3RNA binding motif, single stranded interacting protein 30.045
BMP8Bbone morphogenetic protein 8b0.040
ZMYND11zinc finger, MYND-type containing 110.040
RAMP2receptor (G protein-coupled) activity modifying protein 20.039
SMAD5SMAD family member 50.039
SKIv-ski sarcoma viral oncogene homolog (avian)0.039
SMURF1SMAD specific E3 ubiquitin protein ligase 10.038
EYA2eyes absent homolog 2 (Drosophila)0.036
NRP2neuropilin 20.036
PDLIM4PDZ and LIM domain 40.034
HEYLhairy/enhancer-of-split related with YRPW motif-like0.033
SMAD3SMAD family member 30.032
NEDD4Lneural precursor cell expressed, developmentally down-regulated 4-like0.030
SOX7SRY (sex determining region Y)-box 70.030
LRP6low density lipoprotein receptor-related protein 60.027
ACVR2Aactivin A receptor, type IIA0.026
SKILSKI-like oncogene0.026
BMP7bone morphogenetic protein 70.024
LRP2low density lipoprotein receptor-related protein 20.024
RARAretinoic acid receptor, alpha0.024
GDF11growth differentiation factor 110.023
ATXN1ataxin 10.023
ACVRL1activin A receptor type II-like 10.023
ZC3H10zinc finger CCCH-type containing 100.021
TACC1transforming, acidic coiled-coil containing protein 10.021
CLUclusterin0.021
PITX1paired-like homeodomain 10.021
INHBBinhibin, beta B0.020
FOXC1forkhead box C10.020
PDGFCplatelet derived growth factor C0.019
FZD7frizzled homolog 7 (Drosophila)0.018
IGSF1immunoglobulin superfamily, member 10.018
FOXF1forkhead box F10.018
BMP3bone morphogenetic protein 30.018
WT1Wilms tumor 10.017
MMP9matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)0.017
MED25mediator complex subunit 250.016
PMEPA1prostate transmembrane protein, androgen induced 10.015
EFNB3ephrin-B30.015
FOXF2forkhead box F20.015
FN1fibronectin 10.015
FGF4fibroblast growth factor 40.015
USP15ubiquitin specific peptidase 150.014
PHF1PHD finger protein 10.014
TENC1tensin like C1 domain containing phosphatase (tensin 2)0.014
PTPN14protein tyrosine phosphatase, non-receptor type 140.014
BMP5bone morphogenetic protein 50.014
SOD3superoxide dismutase 3, extracellular0.014
WNT11wingless-type MMTV integration site family, member 110.014
HOXB9homeobox B90.013
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
MadMothers against dpp1.000
saxsaxophone0.999
tkvthickveins0.994
gbbglass bottom boat0.956
Ras85DRas oncogene at 85D0.931
dppdecapentaplegic0.865
EgfrEpidermal growth factor receptor0.827
DadDaughters against dpp0.775
Pi3K92ECG4141 gene product from transcript CG4141-RB0.730
Stat92ESignal-transducer and activator of transcription protein at 92E0.602
MedMedea0.546
putpunt0.502
ash2absent, small, or homeotic discs 20.491
TlToll0.488
sogshort gastrulation0.453
smosmoothened0.340
hhhedgehog0.263
comtcomatose0.160
Akt1CG4006 gene product from transcript CG4006-RA0.154
shnschnurri0.153
myoglianinCG1838 gene product from transcript CG1838-RD0.152
EcREcdysone receptor0.151
Atg1Autophagy-specific gene 10.128
InRInsulin-like receptor0.124
sdscalloped0.121
kaykayak0.113
ttvtout-velu0.112
slmbsupernumerary limbs0.110
cicubitus interruptus0.106
dallydivision abnormally delayed0.101
l(2)gllethal (2) giant larvae0.098
hthhomothorax0.093
dcodiscs overgrown0.090
eyaeyes absent0.089
tldtolloid0.084
mysmyospheroid0.083
hpohippo0.076
rhorhomboid0.070
cactcactus0.064
dmdiminutive0.062
bazbazooka0.061
Liprin-alphaCG11199 gene product from transcript CG11199-RB0.061
auxauxillin0.058
wunwunen0.054
crbcrumbs0.042
PtenCG5671 gene product from transcript CG5671-RB0.041
armarmadillo0.039
diadiaphanous0.038
fjfour-jointed0.037
Su(H)Suppressor of Hairless0.037
wgwingless0.037
enengrailed0.036
SaraSmad anchor for receptor activation0.033
Pk61CProtein kinase 61C0.030
Plc21CPhospholipase C at 21C0.029
cv-ccrossveinless c0.028
nosnanos0.027
Fak56DFocal Adhesion Kinase0.026
AGO1Argonaute-10.026
knknot0.026
srasarah0.025
cnkconnector enhancer of ksr0.024
sggshaggy0.024
Sin3ACG8815 gene product from transcript CG8815-RC0.024
phlpole hole0.023
PP2A-B'CG7913 gene product from transcript CG7913-RK0.022
stnAstoned A0.021
pntpointed0.021
sloslowpoke0.020
brkbrinker0.020
Smg1CG32743 gene product from transcript CG32743-RA0.020
exexpanded0.018
sydsunday driver0.018
cv-2crossveinless 20.018
porporcupine0.017
kek1kekkon-10.017
plepale0.016
par-1CG8201 gene product from transcript CG8201-RA0.016
Irk2Inwardly rectifying potassium channel 20.015
exuexuperantia0.015
caccacophony0.015
Gad1Glutamic acid decarboxylase 10.015
CG9139CG9139 gene product from transcript CG9139-RA0.015
dawdawdle0.015
bynbrachyenteron0.015
n-sybn-synaptobrevin0.014
stmAstambha A0.014
beta-Specbeta Spectrin0.014
ActbetaActivin-beta0.013
spispitz0.013
GluRIIAGlutamate receptor IIA0.013
CaMKIICalcium/calmodulin-dependent protein kinase II0.013
sqzsqueeze0.013
vvlventral veins lacking0.013
SnooSno oncogene0.013
spasspastin0.013
pumpumilio0.012
CG8709CG8709 gene product from transcript CG8709-RK0.012
highikaru genki0.012
Pde8Phosphodiesterase 80.012
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Smad4MAD homolog 4 (Drosophila)0.637
Apcadenomatosis polyposis coli0.352
Tgfbr2transforming growth factor, beta receptor II0.194
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.163
Bmp7bone morphogenetic protein 70.104
Bmpr1abone morphogenetic protein receptor, type 1A0.087
Smad1MAD homolog 1 (Drosophila)0.079
Bmp4bone morphogenetic protein 40.062
Tgfb2transforming growth factor, beta 20.056
Foxc1forkhead box C10.053
Smad3MAD homolog 3 (Drosophila)0.052
Erbb2ipErbb2 interacting protein0.052
Acvr1activin A receptor, type 10.042
Nodalnodal0.035
Bmpr2bone morphogenic protein receptor, type II (serine/threonine kinase)0.026
Axin1axin 10.021
Fgf8fibroblast growth factor 80.019
Acvrl1activin A receptor, type II-like 10.018
Gata4GATA binding protein 40.018
Foxc2forkhead box C20.016
Bmp2bone morphogenetic protein 20.015
Map3k7mitogen-activated protein kinase kinase kinase 70.013
Smosmoothened homolog (Drosophila)0.013
Fgfr3fibroblast growth factor receptor 30.012
Ror2receptor tyrosine kinase-like orphan receptor 20.012
Fstfollistatin0.011
Ptch1patched homolog 10.011
Engendoglin0.011
Prkg1protein kinase, cGMP-dependent, type I0.011
Hand2heart and neural crest derivatives expressed transcript 20.011
Sox9SRY-box containing gene 90.010
Tgfbr1transforming growth factor, beta receptor I0.010
Hand1heart and neural crest derivatives expressed transcript 10.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Smad7SMAD family member 70.021
Lamc1laminin, gamma 10.017
Fgfr1Fibroblast growth factor receptor 10.016
Tgfbr2transforming growth factor, beta receptor II0.014
Cald1caldesmon 10.013
Castcalpastatin0.012
Psen1presenilin 10.012
Lyve1lymphatic vessel endothelial hyaluronan receptor 10.012
Jak1Janus kinase 10.011
Adam10ADAM metallopeptidase domain 100.010
Prkchprotein kinase C, eta0.010
Col12a1collagen, type XII, alpha 10.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism