The network for 'regulation of release of cytochrome c from mitochondria' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of release of cytochrome c from mitochondria

Any process that modulates the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation.

NameDescriptionProbabilityFunc Analog Organism
BCL2B-cell CLL/lymphoma 21.000
BCL2L1BCL2-like 11.000
BCL2L11BCL2-like 11 (apoptosis facilitator)1.000
BADBCL2-associated agonist of cell death1.000
CASP8caspase 8, apoptosis-related cysteine peptidase0.999
BAXBCL2-associated X protein0.996
BIDBH3 interacting domain death agonist0.977
BAK1BCL2-antagonist/killer 10.933
CFLARCASP8 and FADD-like apoptosis regulator0.919
TP53BP2tumor protein p53 binding protein, 20.879
BNIP3BCL2/adenovirus E1B 19kDa interacting protein 30.872
TNFRSF10Atumor necrosis factor receptor superfamily, member 10a0.785
SERPINE1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.773
CASP10caspase 10, apoptosis-related cysteine peptidase0.770
TNFRSF10Btumor necrosis factor receptor superfamily, member 10b0.758
FASFas (TNF receptor superfamily, member 6)0.754
FADDFas (TNFRSF6)-associated via death domain0.726
PMAIP1phorbol-12-myristate-13-acetate-induced protein 10.631
BBC3BCL2 binding component 30.369
BNIP3LBCL2/adenovirus E1B 19kDa interacting protein 3-like0.352
BIKBCL2-interacting killer (apoptosis-inducing)0.341
BECN1beclin 1, autophagy related0.321
PSMD7proteasome (prosome, macropain) 26S subunit, non-ATPase, 70.305
FKBP8FK506 binding protein 8, 38kDa0.294
VDAC2voltage-dependent anion channel 20.288
MCL1myeloid cell leukemia sequence 1 (BCL2-related)0.246
USP14ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)0.237
METmet proto-oncogene (hepatocyte growth factor receptor)0.229
NLRC4NLR family, CARD domain containing 40.159
ZNF746zinc finger protein 7460.157
ARRB1arrestin, beta 10.142
PSMD6proteasome (prosome, macropain) 26S subunit, non-ATPase, 60.140
FBXO7F-box protein 70.123
MAP1LC3Bmicrotubule-associated protein 1 light chain 3 beta0.119
MAPK8mitogen-activated protein kinase 80.112
SMCR7Smith-Magenis syndrome chromosome region, candidate 70.112
ZFYVE1zinc finger, FYVE domain containing 10.111
WWOXWW domain containing oxidoreductase0.108
KRT5keratin 50.101
GRPEL1GrpE-like 1, mitochondrial (E. coli)0.082
HUWE1HECT, UBA and WWE domain containing 10.076
PSMC6proteasome (prosome, macropain) 26S subunit, ATPase, 60.074
NR4A1nuclear receptor subfamily 4, group A, member 10.073
CABLES1Cdk5 and Abl enzyme substrate 10.065
PSEN2presenilin 2 (Alzheimer disease 4)0.058
H2AFXH2A histone family, member X0.058
APOHapolipoprotein H (beta-2-glycoprotein I)0.053
MDM4Mdm4 p53 binding protein homolog (mouse)0.051
PDPK13-phosphoinositide dependent protein kinase-10.051
PSMC2proteasome (prosome, macropain) 26S subunit, ATPase, 20.049
MEFVMediterranean fever0.049
BCL2L2BCL2-like 20.048
VDAC1voltage-dependent anion channel 10.042
PSMC1proteasome (prosome, macropain) 26S subunit, ATPase, 10.041
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.040
ACTBactin, beta0.040
PSMD11proteasome (prosome, macropain) 26S subunit, non-ATPase, 110.039
HRKharakiri, BCL2 interacting protein (contains only BH3 domain)0.038
PPP2CAprotein phosphatase 2, catalytic subunit, alpha isozyme0.037
PSMD2proteasome (prosome, macropain) 26S subunit, non-ATPase, 20.037
MDM2Mdm2 p53 binding protein homolog (mouse)0.035
MAPK1mitogen-activated protein kinase 10.034
AMBRA1autophagy/beclin-1 regulator 10.032
ZHX1zinc fingers and homeoboxes 10.032
TAGLN2transgelin 20.031
CLUclusterin0.031
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.031
SMCR7LSmith-Magenis syndrome chromosome region, candidate 7-like0.031
PSMC5proteasome (prosome, macropain) 26S subunit, ATPase, 50.031
TSPOtranslocator protein (18kDa)0.027
YPEL5yippee-like 5 (Drosophila)0.027
MAGEH1melanoma antigen family H, 10.027
AMTaminomethyltransferase0.027
SPNS1spinster homolog 1 (Drosophila)0.027
ORM1orosomucoid 10.027
RNF144Bring finger protein 144B0.027
C1orf93chromosome 1 open reading frame 930.026
TNFRSF1Atumor necrosis factor receptor superfamily, member 1A0.023
SQSTM1sequestosome 10.022
YAP1Yes-associated protein 10.022
TMEM11transmembrane protein 110.021
PSEN1presenilin 10.021
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.021
PPP1CAprotein phosphatase 1, catalytic subunit, alpha isozyme0.020
PSMD1proteasome (prosome, macropain) 26S subunit, non-ATPase, 10.019
PPHLN1periphilin 10.018
MAP2K4mitogen-activated protein kinase kinase 40.017
ARPC4actin related protein 2/3 complex, subunit 4, 20kDa0.017
C4orf14chromosome 4 open reading frame 140.017
TNFRSF12Atumor necrosis factor receptor superfamily, member 12A0.017
GBP2guanylate binding protein 2, interferon-inducible0.016
KRT6Ckeratin 6C0.016
MAP1LC3Amicrotubule-associated protein 1 light chain 3 alpha0.016
FLNAfilamin A, alpha0.016
PPM1Dprotein phosphatase, Mg2+/Mn2+ dependent, 1D0.016
PPP3R1protein phosphatase 3, regulatory subunit B, alpha0.015
VTNvitronectin0.015
LRRK2leucine-rich repeat kinase 20.015
FLNBfilamin B, beta0.015
BCAP31B-cell receptor-associated protein 310.015
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Bcl2B-cell leukemia/lymphoma 20.998
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.973
BaxBCL2-associated X protein0.690
Vhlvon Hippel-Lindau tumor suppressor0.541
Ikzf1IKAROS family zinc finger 10.487
Bak1BCL2-antagonist/killer 10.375
Ptenphosphatase and tensin homolog0.374
Mcl1myeloid cell leukemia sequence 10.300
Leprleptin receptor0.288
Igf1rinsulin-like growth factor I receptor0.279
Gbp5guanylate binding protein 50.245
Grb10growth factor receptor bound protein 100.244
Aim2absent in melanoma 20.235
Ldb3LIM domain binding 30.211
Casp1caspase 10.186
Insrinsulin receptor0.184
Ptpn22protein tyrosine phosphatase, non-receptor type 22 (lymphoid)0.183
Casp4caspase 4, apoptosis-related cysteine peptidase0.120
Ighimmunoglobulin heavy chain complex0.104
Lrrk2leucine-rich repeat kinase 20.103
Smn1survival motor neuron 10.098
Cd79aCD79A antigen (immunoglobulin-associated alpha)0.098
Rxraretinoid X receptor alpha0.083
Stim2stromal interaction molecule 20.072
Esr1estrogen receptor 1 (alpha)0.069
Tnfaip3tumor necrosis factor, alpha-induced protein 30.069
Mdm2transformed mouse 3T3 cell double minute 20.068
Becn1beclin 1, autophagy related0.067
Cd28CD28 antigen0.067
GnasGNAS (guanine nucleotide binding protein, alpha stimulating) complex locus0.065
Traf3ip2TRAF3 interacting protein 20.063
Kitkit oncogene0.061
Tnfrsf13btumor necrosis factor receptor superfamily, member 13b0.058
Ghrgrowth hormone receptor0.056
Opa1optic atrophy 1 homolog (human)0.056
Ppargperoxisome proliferator activated receptor gamma0.054
Egfrepidermal growth factor receptor0.053
Casp3caspase 30.051
Mfn2mitofusin 20.048
Igf2rinsulin-like growth factor 2 receptor0.048
Ptpn11protein tyrosine phosphatase, non-receptor type 110.047
FasFas (TNF receptor superfamily member 6)0.047
Lystlysosomal trafficking regulator0.046
Cdkn1ccyclin-dependent kinase inhibitor 1C (P57)0.045
Itgb1integrin beta 1 (fibronectin receptor beta)0.044
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.042
Bcl2l1BCL2-like 10.039
Bbc3BCL2 binding component 30.038
Mtormechanistic target of rapamycin (serine/threonine kinase)0.038
Nphs2nephrosis 2 homolog, podocin (human)0.037
Cd151CD151 antigen0.035
Commd6COMM domain containing 60.034
Ncoa3nuclear receptor coactivator 30.032
Ccdc58coiled-coil domain containing 580.032
Trp53transformation related protein 530.031
Col4a3collagen, type IV, alpha 30.031
Triap1TP53 regulated inhibitor of apoptosis 10.030
Nos3nitric oxide synthase 3, endothelial cell0.030
Tmem223transmembrane protein 2230.029
Fgfr2fibroblast growth factor receptor 20.029
Pard3par-3 (partitioning defective 3) homolog (C. elegans)0.028
Mmp2matrix metallopeptidase 20.027
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.027
Mapkap1mitogen-activated protein kinase associated protein 10.027
Psma4proteasome (prosome, macropain) subunit, alpha type 40.025
Smad3MAD homolog 3 (Drosophila)0.025
Sncaipsynuclein, alpha interacting protein (synphilin)0.024
Tpi1triosephosphate isomerase 10.023
Apoeapolipoprotein E0.023
Pompproteasome maturation protein0.022
Ins2insulin II0.020
Ifrd2interferon-related developmental regulator 20.020
Plcb1phospholipase C, beta 10.020
CebpaCCAAT/enhancer binding protein (C/EBP), alpha0.019
Tyro3TYRO3 protein tyrosine kinase 30.018
Gnaqguanine nucleotide binding protein, alpha q polypeptide0.018
WrnWerner syndrome homolog (human)0.018
BlnkB-cell linker0.018
AxlAXL receptor tyrosine kinase0.018
Prkceprotein kinase C, epsilon0.017
Nubp1nucleotide binding protein 10.016
Gphngephyrin0.016
Mapk8mitogen-activated protein kinase 80.016
Pxnpaxillin0.016
Nlrp3NLR family, pyrin domain containing 30.015
E2f1E2F transcription factor 10.015
Egln1EGL nine homolog 1 (C. elegans)0.015
Actn2actinin alpha 20.015
Crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.015
Thrbthyroid hormone receptor beta0.014
Ptk2PTK2 protein tyrosine kinase 20.014
Namptnicotinamide phosphoribosyltransferase0.014
Slc30a9solute carrier family 30 (zinc transporter), member 90.014
Marveld2MARVEL (membrane-associating) domain containing 20.014
Foxo1forkhead box O10.014
BtkBruton agammaglobulinemia tyrosine kinase0.014
Arpc4actin related protein 2/3 complex, subunit 40.014
Emg1EMG1 nucleolar protein homolog (S. cerevisiae)0.014
Atp6v1fATPase, H+ transporting, lysosomal V1 subunit F0.014
Col1a1collagen, type I, alpha 10.013
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism