The network for 'regulation of behavior' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of behavior

Any process that modulates the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli.

NameDescriptionProbabilityFunc Analog Organism
CAV1caveolin 1, caveolae protein, 22kDa0.999
JAG1jagged 10.987
EGFRepidermal growth factor receptor0.982
FGFR1fibroblast growth factor receptor 10.980
PTPN1protein tyrosine phosphatase, non-receptor type 10.979
CXCL9chemokine (C-X-C motif) ligand 90.966
CCR5chemokine (C-C motif) receptor 50.964
PDIA3protein disulfide isomerase family A, member 30.959
GNAI2guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 20.959
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.958
S100BS100 calcium binding protein B0.957
CEACAM1carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)0.955
VEGFAvascular endothelial growth factor A0.928
ARandrogen receptor0.922
CEACAM6carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)0.920
CCL3chemokine (C-C motif) ligand 30.894
TEKTEK tyrosine kinase, endothelial0.893
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.878
PAG1phosphoprotein associated with glycosphingolipid microdomains 10.874
CXCL10chemokine (C-X-C motif) ligand 100.873
SNAP23synaptosomal-associated protein, 23kDa0.846
CXCL2chemokine (C-X-C motif) ligand 20.811
SNAP25synaptosomal-associated protein, 25kDa0.781
IL8interleukin 80.781
CCL5chemokine (C-C motif) ligand 50.777
ESR1estrogen receptor 10.766
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.752
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.750
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.738
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)0.732
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.717
CREBBPCREB binding protein0.714
NOTCH1notch 10.713
NRP1neuropilin 10.707
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.696
ARRB1arrestin, beta 10.675
AXLAXL receptor tyrosine kinase0.662
NCF1neutrophil cytosolic factor 10.652
ABCA1ATP-binding cassette, sub-family A (ABC1), member 10.650
DPP4dipeptidyl-peptidase 40.610
CCL8chemokine (C-C motif) ligand 80.596
DHX30DEAH (Asp-Glu-Ala-His) box polypeptide 300.591
PLCG1phospholipase C, gamma 10.590
ADORA2Aadenosine A2a receptor0.584
CCL2chemokine (C-C motif) ligand 20.583
FGFR2fibroblast growth factor receptor 20.575
CXCL3chemokine (C-X-C motif) ligand 30.559
IGF1Rinsulin-like growth factor 1 receptor0.558
CCL19chemokine (C-C motif) ligand 190.556
FGAfibrinogen alpha chain0.549
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.533
HLA-DRAmajor histocompatibility complex, class II, DR alpha0.522
PLAURplasminogen activator, urokinase receptor0.522
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.510
S100A16S100 calcium binding protein A160.504
CCL4chemokine (C-C motif) ligand 40.477
ARHGDIBRho GDP dissociation inhibitor (GDI) beta0.474
CTNND1catenin (cadherin-associated protein), delta 10.462
IFNGinterferon, gamma0.433
MPDZmultiple PDZ domain protein0.432
TGM2transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)0.430
NTRK2neurotrophic tyrosine kinase, receptor, type 20.429
CCL7chemokine (C-C motif) ligand 70.426
PPP2R5Dprotein phosphatase 2, regulatory subunit B', delta0.419
S100A14S100 calcium binding protein A140.409
IL2RBinterleukin 2 receptor, beta0.406
MAPK14mitogen-activated protein kinase 140.405
NEDD4neural precursor cell expressed, developmentally down-regulated 40.400
CCR2chemokine (C-C motif) receptor 20.379
MDM2Mdm2 p53 binding protein homolog (mouse)0.378
YWHAEtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.371
PDIA4protein disulfide isomerase family A, member 40.371
IL6interleukin 6 (interferon, beta 2)0.355
CXCL11chemokine (C-X-C motif) ligand 110.346
CCL20chemokine (C-C motif) ligand 200.335
NAPAN-ethylmaleimide-sensitive factor attachment protein, alpha0.334
CEACAM5carcinoembryonic antigen-related cell adhesion molecule 50.331
MAD2L2MAD2 mitotic arrest deficient-like 2 (yeast)0.318
PTENphosphatase and tensin homolog0.318
IL10interleukin 100.314
ABI2abl-interactor 20.312
DLG4discs, large homolog 4 (Drosophila)0.306
P4HBprolyl 4-hydroxylase, beta polypeptide0.305
IL12Binterleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)0.303
CCL13chemokine (C-C motif) ligand 130.292
CCL22chemokine (C-C motif) ligand 220.290
MAP3K5mitogen-activated protein kinase kinase kinase 50.287
BMI1BMI1 polycomb ring finger oncogene0.284
INSRinsulin receptor0.282
CCR7chemokine (C-C motif) receptor 70.275
CCR1chemokine (C-C motif) receptor 10.269
PLATplasminogen activator, tissue0.265
GAS6growth arrest-specific 60.256
JAM2junctional adhesion molecule 20.251
HSPB8heat shock 22kDa protein 80.245
TLR2toll-like receptor 20.240
IRS1insulin receptor substrate 10.240
EP300E1A binding protein p3000.238
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
unc-9Protein UNC-90.702
math-4Protein MATH-40.341
vav-1Protein VAV-10.308
goa-1Protein GOA-10.303
sng-1Protein SNG-10.261
vab-3Protein VAB-30.234
daf-1Protein DAF-10.234
nlg-1Protein NLG-10.206
cam-1Protein CAM-10.203
lev-8Protein LEV-80.202
egl-8Protein EGL-80.197
unc-29Protein UNC-290.192
unc-36Protein UNC-360.184
egl-15Protein EGL-150.171
pdfr-1Protein PDFR-10.161
cyp-35C1Protein CYP-35C10.153
ldb-1Protein LDB-10.150
mig-2Protein MIG-20.138
daf-11Protein DAF-110.133
cat-1Protein CAT-10.129
ifd-1Protein IFD-10.129
T19B10.8Protein T19B10.80.128
unc-38Protein UNC-380.126
vha-5Protein VHA-50.118
daf-5Protein DAF-50.118
unc-7Protein UNC-70.117
cyp-35A3Protein CYP-35A30.115
aakg-5Protein AAKG-50.114
gar-3Protein GAR-30.110
F11A10.5Protein F11A10.50.106
madd-4Protein MADD-40.105
rig-4Protein RIG-40.104
F56C9.10Protein F56C9.100.102
perm-5Protein PERM-50.101
C18A11.3Protein C18A11.30.100
acr-16Protein ACR-160.100
dnj-27Protein DNJ-270.093
cca-1Protein CCA-10.092
glp-1Protein GLP-10.092
K01A2.9Protein K01A2.90.091
madf-2Protein MADF-20.090
rig-6Protein RIG-60.089
daf-4Protein DAF-40.089
sdz-28Protein SDZ-280.087
inx-4Protein INX-40.086
dpy-23Protein DPY-230.086
eat-16Protein EAT-160.085
glr-5Protein GLR-50.085
unc-79Protein UNC-790.084
ZC247.2Protein ZC247.20.084
mec-2Protein MEC-20.084
mod-1Protein MOD-10.082
plc-1Protein PLC-10.082
nlp-3Protein NLP-30.079
plc-3Protein PLC-30.078
ant-1.1Protein ANT-1.10.078
trp-1Protein TRP-10.078
K10B3.6Protein K10B3.60.077
pat-10Protein PAT-100.077
ida-1Protein IDA-10.076
cka-2Protein CKA-20.076
C54D10.5Protein C54D10.50.076
lin-66Protein LIN-660.075
F26E4.3Protein F26E4.30.075
C03H5.6Protein C03H5.60.075
bar-1Protein BAR-10.075
ser-2Protein SER-20.074
ggr-1Protein GGR-10.073
unc-40Protein UNC-400.072
Y102A11A.2Protein Y102A11A.20.072
K09E9.1Protein K09E9.10.071
rib-2Protein RIB-20.071
eat-4Protein EAT-40.071
rgs-2Protein RGS-20.071
C06E4.2Protein C06E4.20.070
F14F11.2Protein F14F11.20.070
cyp-35A2Protein CYP-35A20.069
C25F9.4Protein C25F9.40.069
mlk-1Protein MLK-10.069
M03F8.6Protein M03F8.60.069
arl-3Protein ARL-30.069
egl-36Protein EGL-360.069
arrd-25Protein ARRD-250.069
faah-1Protein FAAH-10.069
gap-2Protein GAP-20.068
T22F3.3Protein T22F3.30.068
zig-1Protein ZIG-10.068
acr-2Protein ACR-20.068
CELE_F25E5.1Protein F25E5.10.067
tag-303Protein TAG-3030.067
atg-2Protein ATG-20.067
unc-104Protein UNC-1040.067
egl-30Protein EGL-300.066
let-23Protein LET-230.066
C32C4.3Protein C32C4.30.066
unc-73Protein UNC-730.065
C33H5.18Protein C33H5.180.065
ipp-5Protein IPP-50.065
R04E5.2Protein R04E5.20.065
igdb-2Protein IGDB-20.065
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
tbx1T-box 10.571
chrna1cholinergic receptor, nicotinic, alpha polypeptide 10.353
bmp2abone morphogenetic protein 2a0.322
ptch1patched 10.252
efnb2aephrin B2a0.238
vmhcventricular myosin heavy chain0.227
wnt8bwingless-type MMTV integration site family, member 8b0.221
cdh23cadherin-like 230.209
hlxb9lahomeo box HB9 like a0.191
myf5myogenic factor 50.186
hs6st1bheparan sulfate 6-O-sulfotransferase 1b0.184
esr1estrogen receptor 10.178
nrp1aneuropilin 1a0.173
dab1adisabled homolog 1a (Drosophila)0.157
lmx1b.1LIM homeobox transcription factor 1, beta 10.156
tbx2aT-box gene 2a0.144
otx5orthodenticle homolog 50.143
wnt4awingless-type MMTV integration site family, member 4a0.137
itga5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.124
sox4bSRY-box containing gene 4b0.099
wnt10awingless-type MMTV integration site family, member 10a0.099
dbhdopamine beta hydroxylase0.093
spry4sprouty (Drosophila) homolog 40.091
flot1flotillin 10.088
cx39.9connexin 39.90.086
wnt3wingless-type MMTV integration site family, member 30.085
wnt1wingless-type MMTV integration site family, member 10.084
unc45bunc-45 homolog B (C. elegans)0.084
pomcaproopiomelanocortin a0.081
nrp2bneuropilin 2b0.080
rxrgbretinoid X receptor, gamma b0.076
tll1tolloid-like 10.075
fgfr1afibroblast growth factor receptor 1a0.073
frem3Fras1 related extracellular matrix 30.073
pld1aphospholipase D1a0.072
lhx3LIM homeobox 30.072
tp53bp2tumor protein p53 binding protein, 20.072
mc4rmelanocortin 4 receptor0.071
thtyrosine hydroxylase0.071
wnt3awingless-type MMTV integration site family, member 3A0.070
gdnfglial cell derived neurotrophic factor0.070
dlg2discs, large (Drosophila) homolog 20.069
wnt10bwingless-type MMTV integration site family, member 10b0.068
jam2ajunctional adhesion molecule 2a0.068
bmp4bone morphogenetic protein 40.068
tie1endothelium-specific receptor tyrosine kinase 10.067
gc2guanylyl cyclase 20.066
hsp90a.1heat shock protein 90-alpha 10.066
lama2laminin, alpha 20.065
mylz3myosin, light polypeptide 3, skeletal muscle0.064
xirp2axin actin-binding repeat containing 2a0.063
atp2a1ATPase, Ca++ transporting, cardiac muscle, fast twitch 10.062
bmp2bbone morphogenetic protein 2b0.062
gnb1aguanine nucleotide binding protein (G protein), beta polypeptide 1a0.061
cxcl12achemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1)0.060
dmrt3adoublesex and mab-3 related transcription factor 3a0.058
has3hyaluronan synthase 30.056
kdrkinase insert domain receptor (a type III receptor tyrosine kinase)0.055
smyd1bSET and MYND domain containing 1b0.055
sulf1sulfatase 10.051
eif2c4eukaryotic translation initiation factor 2C, 40.050
ogg18-oxoguanine DNA glycosylase0.050
gadd45bbgrowth arrest and DNA-damage-inducible, beta b0.049
igf1insulin-like growth factor 10.049
ankrd6ankyrin repeat domain 60.048
pbx1apre-B-cell leukemia transcription factor 1a0.046
myo7aamyosin VIIAa0.046
myhz2myosin, heavy polypeptide 2, fast muscle specific0.046
ucn3lurocortin 3, like0.046
pomt2protein-O-mannosyltransferase 20.046
cebp1CCAAT/enhancer binding protein (C/EBP) 10.045
angpt1angiopoietin 10.045
vegfcvascular endothelial growth factor c0.045
rapsnreceptor-associated protein of the synapse, 43kD0.044
hand2heart and neural crest derivatives expressed transcript 20.044
atmataxia telangiectasia mutated0.043
fgf8bfibroblast growth factor 8 b0.043
nr6a1anuclear receptor subfamily 6, group A, member 1a0.042
fgf17fibroblast growth factor 170.042
npas2neuronal PAS domain protein 20.041
rdh10aretinol dehydrogenase 10a0.041
esrraestrogen-related receptor alpha0.041
procprotein C (inactivator of coagulation factors Va and VIIIa)0.041
fgf20afibroblast growth factor 20a0.041
insrainsulin receptor a0.041
nadl1.1neural adhesion molecule L1.10.040
ptprsaprotein tyrosine phosphatase, receptor type, s, a0.040
crabp1bcellular retinoic acid binding protein 1b0.040
chrna7cholinergic receptor, nicotinic, alpha polypeptide 70.040
amotl2aangiomotin like 2a0.039
wnt7bawingless-type MMTV integration site family, member 7Ba0.038
postnperiostin, osteoblast specific factor0.038
slit1aslit homolog 1a (Drosophila)0.038
wnt2bbwingless-type MMTV integration site family, member 2Bb0.038
mybpc2bmyosin binding protein C, fast type b0.037
ttnatitin a0.037
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Fmr1CG6203 gene product from transcript CG6203-RC0.997
Gyc76CGuanylyl cyclase at 76C0.928
elavembryonic lethal abnormal vision0.906
TbhTyramine beta hydroxylase0.880
Sema-1aCG18405 gene product from transcript CG18405-RD0.853
CaMKIICalcium/calmodulin-dependent protein kinase II0.831
Ptp69DProtein tyrosine phosphatase 69D0.828
Fas2Fasciclin 20.818
PdfPigment-dispersing factor0.808
Ilp5Insulin-like peptide 50.774
CG42629CG42629 gene product from transcript CG42629-RB0.700
G-oalpha47AG protein oalpha 47A0.660
CG32810CG32810 gene product from transcript CG32810-RB0.588
robo3CG5423 gene product from transcript CG5423-RA0.577
unc-5CG8166 gene product from transcript CG8166-RA0.573
RdlResistant to dieldrin0.488
TrpA1Transient receptor potential A10.488
unc-13CG2999 gene product from transcript CG2999-RA0.483
EcREcdysone receptor0.457
drkdownstream of receptor kinase0.448
neuroliginCG13772 gene product from transcript CG13772-RA0.437
CG34400CG34400 gene product from transcript CG34400-RD0.426
norpAno receptor potential A0.421
Octbeta2RCG33976 gene product from transcript CG33976-RA0.417
slmbsupernumerary limbs0.416
jebjelly belly0.384
eagether a go-go0.372
CG4822CG4822 gene product from transcript CG4822-RB0.365
Wnt5Wnt oncogene analog 50.365
Nmdar2NMDA receptor 20.354
stnBstoned B0.345
AP-2CG7807 gene product from transcript CG7807-RB0.319
EphEph receptor tyrosine kinase0.317
Or22aOdorant receptor 22a0.309
Gr28bGustatory receptor 28b0.294
nanarrow abdomen0.294
Ork1Open rectifier K[+] channel 10.294
plexAplexin A0.291
sNPFshort neuropeptide F precursor0.284
ppk11pickpocket 110.278
Atg1Autophagy-specific gene 10.273
Pka-C1cAMP-dependent protein kinase 10.269
DatDopamine N acetyltransferase0.263
plexBplexin B0.260
eyseyes shut0.258
OambOctopamine receptor in mushroom bodies0.253
PoxnPox neuro0.247
Hr51Hormone receptor 510.242
IhI[[h]] channel0.240
dnr1defense repressor 10.235
InRInsulin-like receptor0.233
CG14869CG14869 gene product from transcript CG14869-RB0.228
trioCG18214 gene product from transcript CG18214-RA0.218
Gr32aGustatory receptor 32a0.217
CHOp24CG3564 gene product from transcript CG3564-RA0.215
ShawShaker cognate w0.213
Nmdar1NMDA receptor 10.209
Sema-2aCG4700 gene product from transcript CG4700-RC0.207
AdarAdenosine deaminase acting on RNA0.201
Ilp2Insulin-like peptide 20.193
gogogolden goal0.190
unc-104CG8566 gene product from transcript CG8566-RB0.181
ewgerect wing0.176
Spn77BaSerpin 77Ba0.173
SasSialic acid phosphate synthase0.172
Nf1Neurofibromin 10.169
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Il8rbinterleukin 8 receptor, beta0.860
Ptafrplatelet-activating factor receptor0.746
Chrna7cholinergic receptor, nicotinic, alpha 70.596
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.576
Adora2aadenosine A2a receptor0.525
Fgfr2fibroblast growth factor receptor 20.513
Ccl2chemokine (C-C motif) ligand 20.484
Ppyr1pancreatic polypeptide receptor 10.477
Slc6a3solute carrier family 6 (neurotransmitter transporter, dopamine), member 30.477
Bcl2B-cell CLL/lymphoma 20.470
Fgf2fibroblast growth factor 20.460
RGD1564327similar to integrin alpha 80.442
Il1binterleukin 1 beta0.428
Mmp12matrix metallopeptidase 120.419
Edn1endothelin 10.408
Cxcl10chemokine (C-X-C motif) ligand 100.395
Itgb7integrin, beta 70.392
P4hbprolyl 4-hydroxylase, beta polypeptide0.388
Sec61a1Sec61 alpha 1 subunit (S. cerevisiae)0.383
Slco2b1solute carrier organic anion transporter family, member 2b10.379
Insrrinsulin receptor-related receptor0.351
Vdrvitamin D (1,25- dihydroxyvitamin D3) receptor0.351
Cyp21a1cytochrome P450, family 21, subfamily a, polypeptide 10.350
Trib1tribbles homolog 1 (Drosophila)0.344
Il2rginterleukin 2 receptor, gamma0.338
Cxcl2chemokine (C-X-C motif) ligand 20.332
RT1-BbRT1 class II, locus Bb0.331
Il4interleukin 40.304
Dlgap1discs, large (Drosophila) homolog-associated protein 10.300
Lin7clin-7 homolog C (C. elegans)0.297
Ednraendothelin receptor type A0.294
Neurod2neurogenic differentiation 20.285
Il12binterleukin 12B0.277
Metmet proto-oncogene0.272
Tacr1tachykinin receptor 10.252
Kcnmb1potassium large conductance calcium-activated channel, subfamily M, beta member 10.252
Smgbneonatal submandibular gland protein B0.250
Naaladl1N-acetylated alpha-linked acidic dipeptidase-like 10.248
Afap1actin filament associated protein 10.248
Aplnrapelin receptor0.246
Calcrlcalcitonin receptor-like0.244
Adrb1adrenergic, beta-1-, receptor0.242
Grk1G protein-coupled receptor kinase 10.241
Cd14CD14 molecule0.240
N5DNA binding protein N50.239
Fgf7fibroblast growth factor 70.239
Prkcgprotein kinase C, gamma0.231
Atp7bATPase, Cu++ transporting, beta polypeptide0.231
Htr3a5-hydroxytryptamine (serotonin) receptor 3a0.227
Grm6glutamate receptor, metabotropic 60.227
Iappislet amyloid polypeptide0.225
Ccr5chemokine (C-C motif) receptor 50.222
Hoxa2homeo box A20.220
Avparginine vasopressin0.217
Qpctglutaminyl-peptide cyclotransferase0.217
Aqp5aquaporin 50.213
Socs3suppressor of cytokine signaling 30.213
Krt34keratin 340.209
Arandrogen receptor0.207
Ndst1N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 10.206
Fam65afamily with sequence similarity 65, member A0.205
Tnfsf4tumor necrosis factor (ligand) superfamily, member 40.205
Muskmuscle, skeletal, receptor tyrosine kinase0.199
Htr1d5-hydroxytryptamine (serotonin) receptor 1D0.198
Hrh2histamine receptor H 20.197
Myo1bmyosin Ib0.195
Mmp3matrix metallopeptidase 30.192
P2ry4pyrimidinergic receptor P2Y, G-protein coupled, 40.189
Slc12a1solute carrier family 12 (sodium/potassium/chloride transporters), member 10.187
Serpinb2serpin peptidase inhibitor, clade B (ovalbumin), member 20.178
Vipr2vasoactive intestinal peptide receptor 20.177
Kcnab2potassium voltage-gated channel, shaker-related subfamily, beta member 20.176
Glp1rglucagon-like peptide 1 receptor0.173
Casp3caspase 30.172
Mfrpmembrane frizzled-related protein0.167
Cgaglycoprotein hormones, alpha polypeptide0.163
Fosl1fos-like antigen 10.158
Myl7myosin, light chain 7, regulatory0.156
Shank1SH3 and multiple ankyrin repeat domains 10.153
Cmtm2aCKLF-like MARVEL transmembrane domain containing 2A0.151
Htr5b5-hydroxytryptamine (serotonin) receptor 5B0.150
Itgadintegrin, alpha D0.150
Kcng2potassium voltage-gated channel, subfamily G, member 20.150
Ccl4chemokine (C-C motif) ligand 40.148
Tnni2troponin I type 2 (skeletal, fast)0.148
Reg3gregenerating islet-derived 3 gamma0.146
Cd53Cd53 molecule0.142
Ncr1natural cytotoxicity triggering receptor 10.142
Il6interleukin 60.139
Sellselectin L0.137
Gpr6G protein-coupled receptor 60.133
F2rl1coagulation factor II (thrombin) receptor-like 10.132
Nfianuclear factor I/A0.131
Olr1082olfactory receptor 10820.128
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism