The network for 'endoderm development' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

endoderm development

The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues.

NameDescriptionProbabilityFunc Analog Organism
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)1.000
COL1A1collagen, type I, alpha 10.995
SP1Sp1 transcription factor0.987
FHL2four and a half LIM domains 20.985
COL1A2collagen, type I, alpha 20.985
FGF1fibroblast growth factor 1 (acidic)0.953
PAX3paired box 30.915
FYNFYN oncogene related to SRC, FGR, YES0.912
LAMB1laminin, beta 10.905
COL6A1collagen, type VI, alpha 10.897
BMP2bone morphogenetic protein 20.897
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.875
POU3F2POU class 3 homeobox 20.859
SMAD2SMAD family member 20.851
PDIA3protein disulfide isomerase family A, member 30.810
COL4A1collagen, type IV, alpha 10.795
LAMC1laminin, gamma 1 (formerly LAMB2)0.789
COL4A2collagen, type IV, alpha 20.789
COL5A2collagen, type V, alpha 20.788
COL7A1collagen, type VII, alpha 10.767
COL3A1collagen, type III, alpha 10.763
DVL3dishevelled, dsh homolog 3 (Drosophila)0.748
ITGB4integrin, beta 40.728
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.696
COL6A2collagen, type VI, alpha 20.625
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.623
BMPR1Abone morphogenetic protein receptor, type IA0.582
NOTCH3notch 30.579
SPARCsecreted protein, acidic, cysteine-rich (osteonectin)0.556
FSTL1follistatin-like 10.552
SMAD7SMAD family member 70.545
ITGA3integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)0.483
ITGA2integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)0.471
LAMC2laminin, gamma 20.466
BMP7bone morphogenetic protein 70.449
ITGB2integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)0.425
SOX10SRY (sex determining region Y)-box 100.401
APCadenomatous polyposis coli0.348
FOXD3forkhead box D30.346
COL4A6collagen, type IV, alpha 60.339
SMAD4SMAD family member 40.320
POU5F1POU class 5 homeobox 10.316
DVL1dishevelled, dsh homolog 1 (Drosophila)0.309
CSNK1Ecasein kinase 1, epsilon0.303
CDH3cadherin 3, type 1, P-cadherin (placental)0.301
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.296
COL5A1collagen, type V, alpha 10.290
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.284
SOX2SRY (sex determining region Y)-box 20.268
FKBP1AFK506 binding protein 1A, 12kDa0.259
PXDNperoxidasin homolog (Drosophila)0.257
RTF1Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.251
BMPR1Bbone morphogenetic protein receptor, type IB0.249
COL6A3collagen, type VI, alpha 30.239
SMAD3SMAD family member 30.236
TNCtenascin C0.229
CD44CD44 molecule (Indian blood group)0.226
COL4A3collagen, type IV, alpha 3 (Goodpasture antigen)0.222
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.220
LTBP2latent transforming growth factor beta binding protein 20.219
NKX2-5NK2 transcription factor related, locus 5 (Drosophila)0.218
THBS1thrombospondin 10.211
DDR2discoidin domain receptor tyrosine kinase 20.208
RANBP9RAN binding protein 90.205
COL16A1collagen, type XVI, alpha 10.202
MMP1matrix metallopeptidase 1 (interstitial collagenase)0.198
FOXA2forkhead box A20.191
TGFB3transforming growth factor, beta 30.188
FBN1fibrillin 10.188
PAX8paired box 80.187
THBS2thrombospondin 20.178
COL18A1collagen, type XVIII, alpha 10.172
TGFB2transforming growth factor, beta 20.169
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.169
COL4A4collagen, type IV, alpha 40.164
WFIKKN1WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 10.162
LEO1Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.160
PCOLCEprocollagen C-endopeptidase enhancer0.153
WISP1WNT1 inducible signaling pathway protein 10.146
TIMP2TIMP metallopeptidase inhibitor 20.145
FLNBfilamin B, beta0.145
SOX11SRY (sex determining region Y)-box 110.140
COL2A1collagen, type II, alpha 10.133
LZTS2leucine zipper, putative tumor suppressor 20.131
MRC2mannose receptor, C type 20.130
HMGA1high mobility group AT-hook 10.130
ZNF512Bzinc finger protein 512B0.127
HSPG2heparan sulfate proteoglycan 20.126
POSTNperiostin, osteoblast specific factor0.120
MEOX2mesenchyme homeobox 20.118
GDF5growth differentiation factor 50.118
CTNND1catenin (cadherin-associated protein), delta 10.118
RBPJrecombination signal binding protein for immunoglobulin kappa J region0.115
GPKOWG patch domain and KOW motifs0.113
LAMB3laminin, beta 30.109
LAMA5laminin, alpha 50.107
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
pop-1Protein POP-10.332
mig-6Protein MIG-60.100
atg-7Protein ATG-70.098
hbl-1Protein HBL-10.088
epi-1Protein EPI-10.064
bar-1Protein BAR-10.052
egl-18Protein EGL-180.045
CELE_T04H1.2Protein T04H1.20.042
T28B4.1Protein T28B4.10.036
twk-18Protein TWK-180.035
mab-31Protein MAB-310.030
F11D5.1Protein F11D5.10.029
vab-3Protein VAB-30.029
lin-29Protein LIN-290.027
irx-1Protein IRX-10.026
elt-7Protein ELT-70.024
sox-2Protein SOX-20.024
ced-11Protein CED-110.023
unc-98Protein UNC-980.023
zhit-3Protein ZHIT-30.021
zoo-1Protein ZOO-10.021
dpl-1Protein DPL-10.020
lag-2Protein LAG-20.020
odd-2Protein ODD-20.020
mom-2Protein MOM-20.020
unc-62Protein UNC-620.020
atg-18Protein ATG-180.020
Y38C9A.1Protein Y38C9A.10.019
gei-17Protein GEI-170.019
vang-1Protein VANG-10.019
nid-1Protein NID-10.019
CELE_T05B11.1Protein T05B11.10.018
pha-4Protein PHA-40.018
trim-9Protein TRIM-90.018
Y53G8AM.8Protein Y53G8AM.80.018
egl-15Protein EGL-150.018
prx-12Protein PRX-120.018
hda-2Protein HDA-20.018
F37B12.1Protein F37B12.10.017
let-60Protein LET-600.017
hlh-1Protein HLH-10.017
lam-2Protein LAM-20.017
syd-2Protein SYD-20.017
unc-43Protein UNC-430.017
unc-130Protein UNC-1300.017
lin-1Protein LIN-10.016
nsy-4Protein NSY-40.016
ceh-34Protein CEH-340.016
sma-6Protein SMA-60.016
sma-10Protein SMA-100.016
pept-3Protein PEPT-30.016
cdf-1Protein CDF-10.016
dve-1Protein DVE-10.016
cog-1Protein COG-10.016
wrm-1Protein WRM-10.015
ttm-5Protein TTM-50.015
ccf-1Protein CCF-10.015
vps-16Protein VPS-160.015
CELE_F47G4.4Protein F47G4.40.014
ets-7Protein ETS-70.014
mps-2Protein MPS-20.014
eor-1Protein EOR-10.013
R04A9.3Protein R04A9.30.013
sec-8Protein SEC-80.013
pat-12Protein PAT-120.013
ref-2Protein REF-20.013
med-2Protein MED-20.013
ddr-2Protein DDR-20.013
CELE_C54C8.4Protein C54C8.40.013
sel-7Protein SEL-70.013
W04D2.4Protein W04D2.40.013
sdn-1Protein SDN-10.013
nac-2Protein NAC-20.013
haf-2Protein HAF-20.013
hrp-1Protein HRP-10.012
vab-2Protein VAB-20.012
gei-4Protein GEI-40.012
unc-42Protein UNC-420.012
rig-6Protein RIG-60.012
prkl-1Protein PRKL-10.012
CELE_F54D5.15Protein F54D5.150.012
daf-3Protein DAF-30.012
elt-6Protein ELT-60.012
fkh-2Protein FKH-20.012
lin-17Protein LIN-170.012
F07A11.4Protein F07A11.40.011
sem-2Protein SEM-20.011
flh-2Protein FLH-20.011
pxl-1Protein PXL-10.011
daf-11Protein DAF-110.011
nhr-67Protein NHR-670.011
swsn-6Protein SWSN-60.011
hlh-2Protein HLH-20.011
wrk-1Protein WRK-10.011
ncam-1Protein NCAM-10.011
sur-2Protein SUR-20.011
ketn-1Protein KETN-10.011
sfrp-1Protein SFRP-10.011
pry-1Protein PRY-10.011
CELE_T04B2.3Protein T04B2.30.011
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
flhfloating head0.967
fn1fibronectin 10.937
bmp4bone morphogenetic protein 40.930
osr1odd-skipped related 1 (Drosophila)0.890
her7hairy and enhancer of split related-70.865
emx3empty spiracles homeobox 30.812
oepone-eyed pinhead0.795
fgf17fibroblast growth factor 170.772
hnf1baHNF1 homeobox Ba0.741
fli1afriend leukemia integration 1a0.737
otx1borthodenticle homolog 1b0.725
spry4sprouty (Drosophila) homolog 40.712
cdh1cadherin 1, epithelial0.693
gata5GATA-binding protein 50.690
sox32SRY-box containing gene 320.663
tbx16T-box gene 160.629
gna12guanine nucleotide binding protein (G protein) alpha 120.588
smad1MAD homolog 1 (Drosophila)0.583
six4bsine oculis homeobox homolog 4b0.575
bmp2bbone morphogenetic protein 2b0.565
pax2apaired box gene 2a0.553
mespamesoderm posterior a0.543
foxh1forkhead box H10.543
eya1eyes absent homolog 10.537
frem2aFras1 related extracellular matrix protein 2a0.530
wnt2bbwingless-type MMTV integration site family, member 2Bb0.503
fgf3fibroblast growth factor 30.499
ctgfconnective tissue growth factor0.495
ventventral expressed homeobox0.493
eomesaeomesodermin homolog a0.485
her12hairy-related 120.470
mxtx2mix-type homeobox gene 20.456
vedventrally expressed dharma/bozozok antagonist0.450
fbln1fibulin 10.436
cxcr4achemokine (C-X-C motif) receptor 4a0.429
ascl1aachaete-scute complex-like 1a (Drosophila)0.428
rarabretinoic acid receptor, alpha b0.424
msgn1mesogenin 10.422
col8a1acollagen, type VIII, alpha 1a0.411
notch1anotch homolog 1a0.403
wnt11wingless-type MMTV integration site family, member 110.394
hhiphedgehog interacting protein0.393
nr2e1nuclear receptor subfamily 2, group E, member 10.390
cdx4caudal type homeo box transcription factor 40.389
foxn4forkhead box N40.388
mecomMDS1 and EVI1 complex locus0.386
otx1aorthodenticle homolog 1a0.383
gata3GATA-binding protein 30.369
pitx2paired-like homeodomain transcription factor 20.366
mmp2matrix metalloproteinase 20.363
rx3retinal homeobox gene 30.359
col2a1acollagen type II, alpha-1a0.345
inhbaainhibin, beta Aa0.329
wnt10awingless-type MMTV integration site family, member 10a0.318
tbx2aT-box gene 2a0.313
emx2empty spiracles homeobox 20.312
hmx4H6 family homeobox 40.307
wnt7bawingless-type MMTV integration site family, member 7Ba0.301
myf5myogenic factor 50.295
pax6bpaired box gene 6b0.293
her15.1hairy and enhancer of split-related 15.10.291
her1hairy-related 10.291
osr2odd-skipped related 2 (Drosophila)0.288
tp53tumor protein p530.282
snai1asnail homolog 1a (Drosophila)0.280
tbx6T-box gene 60.274
foxi1forkhead box I10.269
jag2jagged 20.265
col11a1bcollagen type XI alpha-1b and collagen, type XI, alpha 1b0.264
hand2heart and neural crest derivatives expressed transcript 20.264
foxd5forkhead box D50.263
bmp2abone morphogenetic protein 2a0.260
fgfr2fibroblast growth factor receptor 20.259
foxg1aforkhead box G1a0.253
runx1runt-related transcription factor 10.250
dact2dapper homolog 2, antagonist of beta-catenin (xenopus)0.250
cxcr4bchemokine (C-X-C motif), receptor 4b0.249
six3asine oculis homeobox homolog 3a0.247
hapln1ahyaluronan and proteoglycan link protein 1a0.247
tll1tolloid-like 10.246
wnt5bwingless-type MMTV integration site family, member 5b0.243
gdf6agrowth differentiation factor 6a0.242
lmx1b.1LIM homeobox transcription factor 1, beta 10.242
pcdh8protocadherin 80.240
tp63tumor protein p630.240
gna13bguanine nucleotide binding protein (G protein), alpha 13b0.240
sox10SRY-box containing gene 100.234
admpanti-dorsalizing morphogenic protein0.233
gli1GLI-Kruppel family member 10.230
dusp5dual specificity phosphatase 50.228
hey1hairy/enhancer-of-split related with YRPW motif 10.228
sox17SRY-box containing gene 170.224
pard6gbpar-6 partitioning defective 6 homolog gamma B (C. elegans)0.222
flt4fms-related tyrosine kinase 40.218
gbx2gastrulation brain homeo box 20.216
kdrlkinase insert domain receptor like0.215
foxi3aforkhead box I3a0.214
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
MadMothers against dpp0.673
HLHmdeltaE(spl) region transcript mdelta0.226
DadDaughters against dpp0.186
HLHm7E(spl) region transcript m70.182
cdicenter divider0.150
eyaeyes absent0.122
cicubitus interruptus0.113
HLHmbetaE(spl) region transcript mbeta0.102
CG4168CG4168 gene product from transcript CG4168-RA0.076
HLHm5E(spl) region transcript m50.067
LanALaminin A0.057
mewmultiple edematous wings0.049
malphaE(spl) region transcript malpha0.047
Sra-1specifically Rac1-associated protein 10.038
E(spl)Enhancer of split0.036
witwishful thinking0.036
BicDBicaudal D0.034
HLHmgammaE(spl) region transcript mgamma0.033
HLHm3E(spl) region transcript m30.030
Pi3K92ECG4141 gene product from transcript CG4141-RB0.029
m2E(spl) region transcript m20.028
EgfrEpidermal growth factor receptor0.027
opaodd paired0.017
Btk29ABtk family kinase at 29A0.016
oddodd skipped0.016
eastenhanced adult sensory threshold0.013
14-3-3zetaCG17870 gene product from transcript CG17870-RB0.012
numbCG3779 gene product from transcript CG3779-RB0.012
Fak56DFocal Adhesion Kinase0.011
zfh2Zn finger homeodomain 20.011
myoglianinCG1838 gene product from transcript CG1838-RD0.011
emcextra macrochaetae0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Pax2paired box gene 20.999
Shhsonic hedgehog0.999
Fgfr2fibroblast growth factor receptor 20.999
Lhx1LIM homeobox protein 10.999
Pitx2paired-like homeodomain transcription factor 20.996
Bmp4bone morphogenetic protein 40.992
Hand1heart and neural crest derivatives expressed transcript 10.991
Otx2orthodenticle homolog 2 (Drosophila)0.988
Gli3GLI-Kruppel family member GLI30.980
Gata4GATA binding protein 40.976
Fgf8fibroblast growth factor 80.972
Smad4MAD homolog 4 (Drosophila)0.963
Ctnnb1catenin (cadherin associated protein), beta 10.959
Nkx2-5NK2 transcription factor related, locus 5 (Drosophila)0.951
Vangl2vang-like 2 (van gogh, Drosophila)0.943
Foxh1forkhead box H10.938
Pax3paired box gene 30.937
Fgfr1fibroblast growth factor receptor 10.934
Smad3MAD homolog 3 (Drosophila)0.932
Tgfbr2transforming growth factor, beta receptor II0.927
Hes1hairy and enhancer of split 1 (Drosophila)0.920
Tbx3T-box 30.919
Zic3zinc finger protein of the cerebellum 30.904
Col2a1collagen, type II, alpha 10.897
Fgfr3fibroblast growth factor receptor 30.890
Sox9SRY-box containing gene 90.865
Lmx1aLIM homeobox transcription factor 1 alpha0.864
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.847
Acvr1activin A receptor, type 10.781
Hoxd13homeobox D130.772
Wnt6wingless-related MMTV integration site 60.722
Ptenphosphatase and tensin homolog0.713
Foxc2forkhead box C20.711
Igdcc3immunoglobulin superfamily, DCC subclass, member 30.696
Rargretinoic acid receptor, gamma0.688
Hspg2perlecan (heparan sulfate proteoglycan 2)0.683
Ror2receptor tyrosine kinase-like orphan receptor 20.678
Sox11SRY-box containing gene 110.675
Gli2GLI-Kruppel family member GLI20.668
Foxc1forkhead box C10.657
Alx4aristaless-like homeobox 40.639
Hand2heart and neural crest derivatives expressed transcript 20.626
Col1a1collagen, type I, alpha 10.622
Nr5a1nuclear receptor subfamily 5, group A, member 10.618
Hoxa13homeobox A130.580
Gata6GATA binding protein 60.579
Wnt3awingless-related MMTV integration site 3A0.576
Bmpr1abone morphogenetic protein receptor, type 1A0.575
Dvl3dishevelled 3, dsh homolog (Drosophila)0.574
Smosmoothened homolog (Drosophila)0.569
Map3k7mitogen-activated protein kinase kinase kinase 70.567
Pax8paired box gene 80.563
Psen1presenilin 10.540
Tbx1T-box 10.506
Onecut1one cut domain, family member 10.493
Notch3Notch gene homolog 3 (Drosophila)0.491
Pcsk5proprotein convertase subtilisin/kexin type 50.480
Emx2empty spiracles homolog 2 (Drosophila)0.474
Col3a1collagen, type III, alpha 10.474
Wt1Wilms tumor 1 homolog0.470
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.465
Snai1snail homolog 1 (Drosophila)0.463
Meox2mesenchyme homeobox 20.460
Pkd1polycystic kidney disease 1 homolog0.442
Shesrc homology 2 domain-containing transforming protein E0.438
Tcfap2atranscription factor AP-2, alpha0.431
Foxf1aforkhead box F1a0.415
Col11a1collagen, type XI, alpha 10.411
Dll4delta-like 4 (Drosophila)0.400
Jag1jagged 10.398
Tlx3T-cell leukemia, homeobox 30.396
Pou3f3POU domain, class 3, transcription factor 30.375
Retret proto-oncogene0.356
Sox17SRY-box containing gene 170.347
Lrp6low density lipoprotein receptor-related protein 60.344
Hoxd11homeobox D110.339
Gdf3growth differentiation factor 30.335
Gbx2gastrulation brain homeobox 20.333
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.331
Sox3SRY-box containing gene 30.326
En2engrailed 20.317
Rxraretinoid X receptor alpha0.315
Sox2SRY-box containing gene 20.311
Sall4sal-like 4 (Drosophila)0.299
Wnt4wingless-related MMTV integration site 40.294
Smad1MAD homolog 1 (Drosophila)0.294
Mmp9matrix metallopeptidase 90.293
Vangl1vang-like 1 (van gogh, Drosophila)0.290
Acvr2bactivin receptor IIB0.286
Matn3matrilin 30.285
Bmp7bone morphogenetic protein 70.279
Lhx9LIM homeobox protein 90.277
Hoxa1homeobox A10.276
Tgfbr1transforming growth factor, beta receptor I0.261
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism