The network for 'cell death' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

cell death

Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as \

NameDescriptionProbabilityFunc Analog Organism
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
hsp-1Protein HSP-10.895
lmn-1Protein LMN-10.878
icd-1Protein ICD-10.852
egl-18Protein EGL-180.846
ceh-20Protein CEH-200.754
pdfr-1Protein PDFR-10.737
H21P03.2Protein H21P03.20.710
mua-6Protein MUA-60.703
pdr-1Protein PDR-10.678
rpl-18Protein RPL-180.664
par-5Protein PAR-50.660
pbs-6Protein PBS-60.648
cam-1Protein CAM-10.642
prmt-1Protein PRMT-10.632
uba-1Protein UBA-10.630
kle-2Protein KLE-20.606
rps-2Protein RPS-20.606
egg-6Protein EGG-60.605
pas-6Protein PAS-60.596
sem-5Protein SEM-50.593
mig-5Protein MIG-50.590
rps-5Protein RPS-50.585
ceh-44Protein CEH-440.585
gex-3Protein GEX-30.578
vha-8Protein VHA-80.558
vab-3Protein VAB-30.557
his-68Protein HIS-680.550
imp-2Protein IMP-20.547
pac-1Protein PAC-10.543
C34E10.8Protein C34E10.80.541
jmjd-1.2Protein JMJD-1.20.541
C32D5.11Protein C32D5.110.539
pas-1Protein PAS-10.530
inx-8Protein INX-80.526
glp-1Protein GLP-10.523
nhr-2Protein NHR-20.519
lsm-5Protein LSM-50.518
rme-2Protein RME-20.510
nol-9Protein NOL-90.508
unc-60Protein UNC-600.506
dlc-1Protein DLC-10.502
nrde-2Protein NRDE-20.498
set-1Protein SET-10.497
cids-2Protein CIDS-20.494
cif-1Protein CIF-10.492
D2085.3Protein D2085.30.491
rps-0Protein RPS-00.490
rpl-16Protein RPL-160.482
emb-5Protein EMB-50.476
pmk-1Protein PMK-10.470
act-4Protein ACT-40.467
mec-2Protein MEC-20.461
nasp-2Protein NASP-20.461
zip-4Protein ZIP-40.461
skr-8Protein SKR-80.460
cct-1Protein CCT-10.450
crt-1Protein CRT-10.447
rad-23Protein RAD-230.447
rars-1Protein RARS-10.446
drp-1Protein DRP-10.445
rpn-3Protein RPN-30.440
dpy-23Protein DPY-230.440
rpl-12Protein RPL-120.440
mes-3Protein MES-30.439
act-5Protein ACT-50.438
him-1Protein HIM-10.438
clic-1Protein CLIC-10.437
unc-32Protein UNC-320.436
T19D12.4Protein T19D12.40.433
mat-3Protein MAT-30.432
mei-1Protein MEI-10.432
jtr-1Protein JTR-10.430
rpn-6.1Protein RPN-6.10.426
eat-6Protein EAT-60.423
let-23Protein LET-230.421
mut-16Protein MUT-160.418
snr-3Protein SNR-30.416
eef-1B.1Protein EEF-1B.10.415
tba-4Protein TBA-40.415
sax-7Protein SAX-70.412
mag-1Protein MAG-10.409
cra-1Protein CRA-10.407
tars-1Protein TARS-10.406
eef-1A.1Protein EEF-1A.10.405
plp-1Protein PLP-10.404
F39B2.1Protein F39B2.10.404
dnj-25Protein DNJ-250.402
rpt-2Protein RPT-20.401
gly-7Protein GLY-70.400
snr-4Protein SNR-40.399
rpl-11.1Protein RPL-11.10.399
pbs-5Protein PBS-50.399
exos-2Protein EXOS-20.398
rpl-13Protein RPL-130.397
eef-1GProtein EEF-1G0.393
ddl-1Protein DDL-10.393
klp-15Protein KLP-150.391
T27A3.1Protein T27A3.10.387
atn-1Protein ATN-10.387
let-70Protein LET-700.383
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
tp53tumor protein p530.961
pax2apaired box gene 2a0.816
cdh1cadherin 1, epithelial0.809
atp6v1baATPase, H+ transporting, lysosomal, V1 subunit B, member a0.776
tbx1T-box 10.741
tbx20T-box 200.730
pkd2polycystic kidney disease 20.726
kdrlkinase insert domain receptor like0.711
ntn1anetrin 1a0.656
wnt11rwingless-type MMTV integration site family, member 11, related0.562
bmp4bone morphogenetic protein 40.560
rpl18aribosomal protein L18a0.530
runx2brunt-related transcription factor 2b0.500
csnk1dacasein kinase 1, delta a0.498
gli1GLI-Kruppel family member 10.487
fgfr1afibroblast growth factor receptor 1a0.483
nrg2aneuregulin 2a0.481
runx1runt-related transcription factor 10.475
kif23kinesin family member 230.472
bbc3BCL2 binding component 30.464
wnt4awingless-type MMTV integration site family, member 4a0.452
fn1fibronectin 10.450
hspa5heat shock protein 50.446
rpsaribosomal protein SA0.440
cse1lchromosome segregation 1-like (S. cerevisiae)0.433
nrg1neuregulin 10.426
wnt1wingless-type MMTV integration site family, member 10.410
baxabcl2-associated X protein, a0.403
sox32SRY-box containing gene 320.387
fgf3fibroblast growth factor 30.384
cmybtranscription factor cmyb0.384
rpl19ribosomal protein L190.382
ptpraprotein tyrosine phosphatase, receptor type, A0.377
nrp2bneuropilin 2b0.370
ywhabltyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide like0.370
efnb2aephrin B2a0.363
rpl13ribosomal protein L130.362
wnt2bbwingless-type MMTV integration site family, member 2Bb0.361
spry4sprouty (Drosophila) homolog 40.357
cyp26c1cytochrome P450, family 26, subfamily C, polypeptide 10.354
gnb2l1guanine nucleotide binding protein (G protein), beta polypeptide 2-like 10.353
eif3deukaryotic translation initiation factor 3, subunit D0.345
bmp2bbone morphogenetic protein 2b0.338
fgf8afibroblast growth factor 8 a0.337
sox9aSRY-box containing gene 9a0.336
notch3notch homolog 30.333
lhx1aLIM homeobox 1a0.327
evx1even-skipped homeobox 10.322
pea3ETS-domain transcription factor pea30.319
atp6v1hATPase, H+ transporting, lysosomal, V1 subunit H0.318
tia1lcytotoxic granule-associated RNA binding protein 1, like0.309
thtyrosine hydroxylase0.308
cct7chaperonin containing TCP1, subunit 7 (eta)0.301
ctsl1acathepsin L, 1 a0.299
ca8carbonic anhydrase VIII0.297
tcp1t-complex polypeptide 10.295
zgc:92237zgc:922370.295
atp1a1ATPase, Na+/K+ transporting, alpha 1 polypeptide0.294
raraaretinoic acid receptor, alpha a0.294
pcnaproliferating cell nuclear antigen0.290
gpr126G protein-coupled receptor 1260.290
osr1odd-skipped related 1 (Drosophila)0.285
cebpbCCAAT/enhancer binding protein (C/EBP), beta0.278
itgb1bintegrin, beta 1b0.275
wnt8bwingless-type MMTV integration site family, member 8b0.270
otpaorthopedia homolog a0.270
alcambactivated leukocyte cell adhesion molecule b0.265
plxnb2aplexin b2a0.259
lhx2bLIM homeobox 2b0.254
nf1aneurofibromin 1a0.250
bdnfbrain-derived neurotrophic factor0.250
lcp1lymphocyte cytosolic plastin 10.248
cdc42cell division cycle 420.246
cct6achaperonin containing TCP1, subunit 6A (zeta 1)0.245
foxo3bforkhead box O3b0.245
kitakit receptor a0.245
wlswntless homolog (Drosophila)0.243
tgfb3transforming growth factor, beta 30.241
fauaFinkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed a0.238
ptpn11aprotein tyrosine phosphatase, non-receptor type 11, a0.235
etf1eukaryotic translation termination factor 10.235
egr1early growth response 10.234
mibmind bomb0.231
atp6v0caATPase, H+ transporting, lysosomal, V0 subunit c, a0.230
neo1neogenin 10.230
hand2heart and neural crest derivatives expressed transcript 20.229
bcl2l1bcl2-like 10.226
cnr1cannabinoid receptor 10.226
cnn2calponin 20.224
eif3haeukaryotic translation initiation factor 3, subunit H, a0.224
prpf8pre-mRNA processing factor 80.222
tp63tumor protein p630.222
ikzf1IKAROS family zinc finger 1 (Ikaros)0.221
tgif1TGFB-induced factor homeobox 10.220
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.219
ahcyl1S-adenosylhomocysteine hydrolase-like 10.218
mcm7MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)0.218
sox2SRY-box containing gene 20.217
pax7apaired box gene 7a0.216
ptproprotein tyrosine phosphatase, receptor type, O0.211
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
nejnejire0.999
Akt1CG4006 gene product from transcript CG4006-RA0.997
cicubitus interruptus0.996
slmbsupernumerary limbs0.992
Atg1Autophagy-specific gene 10.987
hephemipterous0.984
CG11347CG11347 gene product from transcript CG11347-RE0.957
Aos1CG12276 gene product from transcript CG12276-RA0.953
AtpalphaNa pump alpha subunit0.950
wgwingless0.940
Pi3K92ECG4141 gene product from transcript CG4141-RB0.939
saxsaxophone0.925
B52CG10851 gene product from transcript CG10851-RB0.920
dmdiminutive0.919
InRInsulin-like receptor0.919
rprreaper0.892
Dcp-1Death caspase-10.892
Dsp1Dorsal switch protein 10.890
pucpuckered0.882
S6kRPS6-p70-protein kinase0.879
Atg18Autophagy-specific gene 180.872
tsrtwinstar0.865
eIF-4aEukaryotic initiation factor 4a0.861
shnschnurri0.843
phlpole hole0.835
Trip1CG8882 gene product from transcript CG8882-RA0.822
tkvthickveins0.817
Itp-r83AInositol 1,4,5,-tris-phosphate receptor0.810
dncdunce0.804
agoarchipelago0.798
RASSF8CG5053 gene product from transcript CG5053-RA0.795
Rm62CG10279 gene product from transcript CG10279-RD0.788
alpha-Catalpha Catenin0.771
rapretina aberrant in pattern0.765
jarjaguar0.764
giggigas0.741
sosine oculis0.737
Nop60BNucleolar protein at 60B0.728
Sema-2aCG4700 gene product from transcript CG4700-RC0.721
kaykayak0.720
belbelle0.716
PakPAK-kinase0.711
Eip93FCG18389 gene product from transcript CG18389-RB0.709
Gyc76CGuanylyl cyclase at 76C0.707
Hel25EHelicase at 25E0.706
Sir2CG5216 gene product from transcript CG5216-RA0.698
kluklumpfuss0.696
kiskismet0.688
trntartan0.687
PtenCG5671 gene product from transcript CG5671-RB0.684
PvrPDGF- and VEGF-receptor related0.679
Stat92ESignal-transducer and activator of transcription protein at 92E0.672
poloCG12306 gene product from transcript CG12306-RA0.665
Eip74EFEcdysone-induced protein 74EF0.658
abd-Aabdominal A0.641
shishibire0.638
numbCG3779 gene product from transcript CG3779-RB0.636
RpL14Ribosomal protein L140.634
Pi3K21BCG2699 gene product from transcript CG2699-RA0.621
jingCG9397 gene product from transcript CG9397-RI0.618
drkdownstream of receptor kinase0.616
rutrutabaga0.614
SerSerrate0.612
drprdraper0.609
rlrolled0.600
Lis-1Lissencephaly-10.594
eIF-4EEukaryotic initiation factor 4E0.591
crolcrooked legs0.587
Sox14Sox box protein 140.587
KhcKinesin heavy chain0.584
IswiImitation SWI0.582
mrnmarionette0.581
Rpn2CG11888 gene product from transcript CG11888-RA0.580
ftz-f1ftz transcription factor 10.580
Ef2bElongation factor 2b0.575
Atg8aAutophagy-specific gene 8a0.570
Atg9Autophagy-specific gene 90.568
MadMothers against dpp0.559
egreiger0.558
msnmisshapen0.556
p53CG33336 gene product from transcript CG33336-RB0.550
putpunt0.546
TER94CG2331 gene product from transcript CG2331-RA0.543
hiwhighwire0.540
Top2Topoisomerase 20.538
skpACG16983 gene product from transcript CG16983-RD0.535
grogroucho0.534
CkIIalphaCasein kinase II alpha subunit0.533
MerMerlin0.522
MlfMyelodysplasia/myeloid leukemia factor0.521
ssspineless0.518
mus209mutagen-sensitive 2090.515
l(2)37Cclethal (2) 37Cc0.513
E(z)Enhancer of zeste0.513
cathDCG1548 gene product from transcript CG1548-RA0.511
foxoforkhead box, sub-group O0.511
RelRelish0.510
Su(H)Suppressor of Hairless0.506
lwrlesswright0.504
SoxNSoxNeuro0.498
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
SLT2Slt2p0.418
SSA1Ssa1p0.168
RPT6Rpt6p0.124
RPS6BRps6bp0.121
RPS3Rps3p0.109
RPL10Rpl10p0.099
RPG1Rpg1p0.086
CCT2Cct2p0.086
HHT1Hht1p0.081
TIF35Tif35p0.079
HYP2Hyp2p0.070
CDC55Cdc55p0.064
STI1Sti1p0.063
CMD1Cmd1p0.062
TEF4Tef4p0.061
BFR1Bfr1p0.060
HTB1Htb1p0.059
RPS7ARps7ap0.054
RPL19BRpl19bp0.053
MSN5Msn5p0.052
SBA1Sba1p0.051
RPS1ARps1ap0.051
ARB1Arb1p0.050
KAR2Kar2p0.049
EMW1Emw1p0.049
CCT3Cct3p0.046
PEP4Pep4p0.045
RPN12Rpn12p0.044
AQY2Aqy2p0.043
DSK2Dsk2p0.043
IDH2Idh2p0.042
PRT1Prt1p0.042
MSH3Msh3p0.039
RPL13ARpl13ap0.038
CCR4Ccr4p0.038
STE5Ste5p0.037
HMO1Hmo1p0.037
SSA3Ssa3p0.036
OYE2Oye2p0.036
BCK1Bck1p0.036
RPL3Rpl3p0.035
RPL5Rpl5p0.035
PIL1Pil1p0.034
BMH1Bmh1p0.034
SEC26Sec26p0.033
HSP82Hsp82p0.032
SOD2Sod2p0.032
SUR1Sur1p0.031
SCH9Sch9p0.031
RPS1BRps1bp0.031
CDC37Cdc37p0.030
LSP1Lsp1p0.030
PBS2Pbs2p0.030
YHR033Whypothetical protein0.029
YGL242Chypothetical protein0.029
TRA1Tra1p0.029
TIF5Tif5p0.029
LYS20Lys20p0.029
SGT2Sgt2p0.028
PRK1Prk1p0.028
LSM8Lsm8p0.028
RAD23Rad23p0.028
RPT1Rpt1p0.028
BMH2Bmh2p0.028
RTS1Rts1p0.027
SNO3Sno3p0.027
KSS1Kss1p0.027
HCR1Hcr1p0.027
MKT1Mkt1p0.027
MAD1Mad1p0.026
TOR1Tor1p0.026
ERP2Erp2p0.026
RPL25Rpl25p0.026
CKB1Ckb1p0.026
PET9Pet9p0.026
UFO1Ufo1p0.026
RPS11ARps11ap0.026
DNM1Dnm1p0.025
ALD6Ald6p0.025
MCK1Mck1p0.025
CDC20Cdc20p0.025
RPL32Rpl32p0.025
GET3Get3p0.024
GUT2Gut2p0.024
TPD3Tpd3p0.024
DCS2Dcs2p0.024
YPK2Ypk2p0.024
RPS5Rps5p0.024
MIS1Mis1p0.024
KSP1Ksp1p0.024
RPT3Rpt3p0.024
CCT6Cct6p0.024
ATG3Atg3p0.023
YOL098Chypothetical protein0.023
TEF1Tef1p0.023
MYO5Myo5p0.023
GAD1Gad1p0.023
RPL21ARpl21ap0.023
SHE3She3p0.023
MDV1Mdv1p0.023