The network for 'negative regulation of microtubule depolymerization' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

negative regulation of microtubule depolymerization

Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule depolymerization; prevention of depolymerization of a microtubule can result from binding by 'capping' at the plus end (e.g. by interaction with another cellular protein of structure) or by exposing microtubules to a stabilizing drug such as taxol.

NameDescriptionProbabilityFunc Analog Organism
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.147
PSEN2presenilin 2 (Alzheimer disease 4)0.127
CDCA8cell division cycle associated 80.104
APCadenomatous polyposis coli0.077
ITGB4integrin, beta 40.064
BUB1budding uninhibited by benzimidazoles 1 homolog (yeast)0.057
RACGAP1Rac GTPase activating protein 10.055
EXOC1exocyst complex component 10.050
WASLWiskott-Aldrich syndrome-like0.045
CDK1cyclin-dependent kinase 10.042
GLIS2GLIS family zinc finger 20.033
ADRBK1adrenergic, beta, receptor kinase 10.031
KIF1Bkinesin family member 1B0.029
KIF20Akinesin family member 20A0.027
TUBG1tubulin, gamma 10.027
INCENPinner centromere protein antigens 135/155kDa0.026
KIF5Bkinesin family member 5B0.025
EXOC7exocyst complex component 70.023
KIF23kinesin family member 230.022
BIRC5baculoviral IAP repeat containing 50.021
CKAP5cytoskeleton associated protein 50.020
GPSM2G-protein signaling modulator 20.019
CENPJcentromere protein J0.019
TEX11testis expressed 110.018
CDK2cyclin-dependent kinase 20.017
CTNNA1catenin (cadherin-associated protein), alpha 1, 102kDa0.017
SUFUsuppressor of fused homolog (Drosophila)0.017
MARK2MAP/microtubule affinity-regulating kinase 20.017
SNX9sorting nexin 90.016
ATF7IPactivating transcription factor 7 interacting protein0.015
XPO1exportin 1 (CRM1 homolog, yeast)0.014
STRN3striatin, calmodulin binding protein 30.014
EXOC2exocyst complex component 20.014
DISC1disrupted in schizophrenia 10.013
CENPEcentromere protein E, 312kDa0.013
ANKRD17ankyrin repeat domain 170.012
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.012
CDKN3cyclin-dependent kinase inhibitor 30.012
AKAP9A kinase (PRKA) anchor protein (yotiao) 90.012
JUPjunction plakoglobin0.012
LBRlamin B receptor0.011
CCNA2cyclin A20.011
CCDC85Acoiled-coil domain containing 85A0.011
ZRANB1zinc finger, RAN-binding domain containing 10.010
ANKRD28ankyrin repeat domain 280.010
MOBKL1AMOB1, Mps One Binder kinase activator-like 1A (yeast)0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
exo84CG6095 gene product from transcript CG6095-RA0.879
Dhc64CDynein heavy chain 64C0.779
brubrunelleschi0.766
pblpebble0.761
DetDeterin0.745
diadiaphanous0.713
CG32038CG32038 gene product from transcript CG32038-RA0.698
sec8CG2095 gene product from transcript CG2095-RA0.687
Klp67AKinesin-like protein at 67A0.560
Spc25CG7242 gene product from transcript CG7242-RA0.427
aspabnormal spindle0.399
tefteflon0.368
nebnebbish0.312
flwflapwing0.223
vibvibrator0.219
scrascraps0.194
ncdnon-claret disjunctional0.185
aretarrest0.178
SseSeparase0.142
encencore0.130
htshu li tai shao0.122
cnncentrosomin0.121
stisticky0.110
ana3anastral spindle 30.109
poloCG12306 gene product from transcript CG12306-RA0.102
Poc1Proteome of centrioles 10.096
marsCG17064 gene product from transcript CG17064-RB0.089
austaustralin0.089
Grip75CG6176 gene product from transcript CG6176-RA0.075
fwsfour way stop0.069
Klp61FKinesin-like protein at 61F0.067
MrtfMyocardin-related transcription factor0.063
scnyscrawny0.060
rtGEFrho-type guanine exchange factor0.058
gwlgreatwall0.057
HphHIF prolyl hydroxylase0.052
PpcsPhosphopantothenoylcysteine synthetase0.050
spd-2spindle defective 20.049
Pak3CG14895 gene product from transcript CG14895-RA0.046
bondjames bond0.046
Spc105RSpc105-related0.044
pimpimples0.043
SMC2CG10212 gene product from transcript CG10212-RA0.043
nudECG8104 gene product from transcript CG8104-RB0.041
gammaTub37Cgamma-Tubulin at 37C0.039
mtgmind the gap0.039
CG2519CG2519 gene product from transcript CG2519-RB0.038
Cenp-CCG31258 gene product from transcript CG31258-RA0.037
CycB3Cyclin B30.037
Ndc80CG9938 gene product from transcript CG9938-RA0.036
Lis-1Lissencephaly-10.035
Unc-76CG3981 gene product from transcript CG3981-RB0.033
mei-P26CG12218 gene product from transcript CG12218-RA0.033
pavpavarotti0.032
larpLa related protein0.032
opa1-likeoptic atrophy 1-like0.032
flflfalafel0.030
sas-6spindle assembly abnormal 60.029
PTP-ERProtein tyrosine phosphatase-ERK/Enhancer of Ras10.029
mldmolting defective0.029
DAAMDishevelled Associated Activator of Morphogenesis0.028
fryfurry0.028
eglegalitarian0.028
synjsynaptojanin0.027
mei-38meiotic 380.027
CG14814CG14814 gene product from transcript CG14814-RA0.027
Grip71CG10346 gene product from transcript CG10346-RA0.027
Trc8CG2304 gene product from transcript CG2304-RB0.026
CG11329CG11329 gene product from transcript CG11329-RA0.025
alpha-Specalpha Spectrin0.025
enaenabled0.025
InvadolysinCG3953 gene product from transcript CG3953-RA0.025
NakNumb-associated kinase0.024
vasvasa0.024
rodrough deal0.024
cidcentromere identifier0.024
endoAendophilin A0.023
Psf1CG9187 gene product from transcript CG9187-RA0.023
APC4Anaphase Promoting Complex 40.023
zpgzero population growth0.023
aPKCatypical protein kinase C0.023
Tm1Tropomyosin 10.022
CG5491CG5491 gene product from transcript CG5491-RA0.022
CG4617CG4617 gene product from transcript CG4617-RA0.022
Cog7CG31040 gene product from transcript CG31040-RA0.022
slssallimus0.021
lkb1CG9374 gene product from transcript CG9374-RJ0.021
Grip128CG9201 gene product from transcript CG9201-RB0.021
tombtombola0.021
HtrA2CG8464 gene product from transcript CG8464-RA0.021
stwlstonewall0.020
ballballchen0.020
tudtudor0.020
fendforked end0.020
toctoucan0.019
Gef26CG9491 gene product from transcript CG9491-RB0.018
Rbcn-3BRabconnectin-3B0.018
Grip163CG5688 gene product from transcript CG5688-RA0.018
HipHopHP1-HOAP-interacting protein0.018
swshort wing0.018
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Prc1protein regulator of cytokinesis 10.959
Cdk1cyclin-dependent kinase 10.952
Ccnb1cyclin B10.876
Ccna2cyclin A20.729
Anlnanillin, actin binding protein0.720
Ckap2cytoskeleton associated protein 20.706
Cdc20cell division cycle 20 homolog (S. cerevisiae)0.647
Kif20akinesin family member 20A0.597
Birc5baculoviral IAP repeat-containing 50.578
Hmmrhyaluronan mediated motility receptor (RHAMM)0.565
Ccnb2cyclin B20.563
Dcxdoublecortin0.455
Dclk1doublecortin-like kinase 10.431
BrafBraf transforming gene0.423
Plk1polo-like kinase 1 (Drosophila)0.361
Kif4kinesin family member 40.360
Trim63tripartite motif-containing 630.356
Smad3MAD homolog 3 (Drosophila)0.353
Kif11kinesin family member 110.310
Cdkn3cyclin-dependent kinase inhibitor 30.294
Top2atopoisomerase (DNA) II alpha0.291
Racgap1Rac GTPase-activating protein 10.277
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.272
Kif23kinesin family member 230.242
Kif22kinesin family member 220.230
Kif2ckinesin family member 2C0.225
Itgb1integrin beta 1 (fibronectin receptor beta)0.192
Cdc25ccell division cycle 25 homolog C (S. pombe)0.190
Gtse1G two S phase expressed protein 10.185
Nr2e1nuclear receptor subfamily 2, group E, member 10.177
Mki67antigen identified by monoclonal antibody Ki 670.174
Nf1neurofibromatosis 10.169
Ctnnb1catenin (cadherin associated protein), beta 10.164
Bdnfbrain derived neurotrophic factor0.163
Dlgap5discs, large (Drosophila) homolog-associated protein 50.145
Trp63transformation related protein 630.137
Lmnalamin A0.129
Smc4structural maintenance of chromosomes 40.126
Fgfr2fibroblast growth factor receptor 20.111
Gsk3bglycogen synthase kinase 3 beta0.106
H2afxH2A histone family, member X0.097
Fam64afamily with sequence similarity 64, member A0.094
Egfrepidermal growth factor receptor0.093
Mxd3Max dimerization protein 30.093
Cdca8cell division cycle associated 80.088
Pax2paired box gene 20.086
Gata3GATA binding protein 30.083
Trim55tripartite motif-containing 550.082
Tbx10T-box 100.079
Tcf21transcription factor 210.072
Aspmasp (abnormal spindle)-like, microcephaly associated (Drosophila)0.071
Ube2cubiquitin-conjugating enzyme E2C0.070
Aurkaaurora kinase A0.068
Mad2l1MAD2 mitotic arrest deficient-like 1 (yeast)0.068
Trp53transformation related protein 530.066
Nkx2-1NK2 homeobox 10.066
Cenpacentromere protein A0.065
Smc2structural maintenance of chromosomes 20.064
Ccdc99coiled-coil domain containing 990.061
Cdca5cell division cycle associated 50.056
Asf1bASF1 anti-silencing function 1 homolog B (S. cerevisiae)0.056
Bcl2B-cell leukemia/lymphoma 20.056
Arandrogen receptor0.055
Cacna2d1calcium channel, voltage-dependent, alpha2/delta subunit 10.054
Tbx15T-box 150.052
Atcayataxia, cerebellar, Cayman type homolog (human)0.050
Pou3f4POU domain, class 3, transcription factor 40.050
Mstnmyostatin0.050
Otx2orthodenticle homolog 2 (Drosophila)0.048
Tacc3transforming, acidic coiled-coil containing protein 30.043
Nek2NIMA (never in mitosis gene a)-related expressed kinase 20.043
Pgrprogesterone receptor0.042
Bub1bbudding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)0.041
Fgfbp1fibroblast growth factor binding protein 10.041
Erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.040
Exoc3exocyst complex component 30.039
Ngfrnerve growth factor receptor (TNFR superfamily, member 16)0.039
Epas1endothelial PAS domain protein 10.036
Cks2CDC28 protein kinase regulatory subunit 20.035
Foxg1forkhead box G10.035
Clasp2CLIP associating protein 20.035
Sgcdsarcoglycan, delta (dystrophin-associated glycoprotein)0.034
Socs5suppressor of cytokine signaling 50.033
Kcnq2potassium voltage-gated channel, subfamily Q, member 20.033
Cenpfcentromere protein F0.031
Cep55centrosomal protein 550.031
Plaaphospholipase A2, activating protein0.030
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.029
D2Ertd750eDNA segment, Chr 2, ERATO Doi 750, expressed0.029
Gabra1gamma-aminobutyric acid (GABA) A receptor, subunit alpha 10.028
Fam83dfamily with sequence similarity 83, member D0.028
Idsiduronate 2-sulfatase0.028
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.028
Btbd3BTB (POZ) domain containing 30.027
Ntf3neurotrophin 30.027
C330027C09RikRIKEN cDNA C330027C09 gene0.027
Gabrb3gamma-aminobutyric acid (GABA) A receptor, subunit beta 30.027
Kcnma1potassium large conductance calcium-activated channel, subfamily M, alpha member 10.027
Thtyrosine hydroxylase0.027
TtkTtk protein kinase0.026
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Racgap1Rac GTPase-activating protein 10.424
Dlgap5discs, large (Drosophila) homolog-associated protein 50.195
Hmmrhyaluronan mediated motility receptor (RHAMM)0.070
Traf4af1TRAF4 associated factor 10.048
Pttg1pituitary tumor-transforming 10.047
Cdc20cell division cycle 20 homolog (S. cerevisiae)0.046
Prc1protein regulator of cytokinesis 10.032
Cdk1cyclin-dependent kinase 10.031
Plk1polo-like kinase 1 (Drosophila)0.030
Kif22kinesin family member 220.026
Myh7myosin, heavy chain 7, cardiac muscle, beta0.022
Fen1flap structure-specific endonuclease 10.022
Troaptrophinin associated protein0.021
Kif2ckinesin family member 2C0.021
Zw10ZW10, kinetochore associated, homolog (Drosophila)0.017
Spc25SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)0.016
Asf1bASF1 anti-silencing function 1 homolog B (S. cerevisiae)0.015
Nrxn1neurexin 10.015
Prim2primase, DNA, polypeptide 20.015
Kifc1kinesin family member C10.015
Ccnb2cyclin B20.015
Cks2CDC28 protein kinase regulatory subunit 20.015
Ccnb1cyclin B10.015
Slc2a3solute carrier family 2 (facilitated glucose transporter), member 30.015
Akt3v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)0.014
Nsg2neuron specific gene family member 20.014
Gng3guanine nucleotide binding protein (G protein), gamma 30.014
Bcl2l2Bcl2-like 20.014
Kif4kinesin family member 40.014
Aurkaaurora kinase A0.014
Rrm2ribonucleotide reductase M20.014
Uchl1ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)0.014
Prkcbprotein kinase C, beta0.013
Kif3ckinesin family member 3C0.013
Tk1thymidine kinase 1, soluble0.013
Cdca2cell division cycle associated 20.012
Olfm1olfactomedin 10.012
Socs5suppressor of cytokine signaling 50.012
Mcf2lMCF.2 cell line derived transforming sequence-like0.012
Eno2enolase 2, gamma, neuronal0.011
Fuca1fucosidase, alpha-L- 1, tissue0.011
Pygmphosphorylase, glycogen, muscle0.011
Trip13thyroid hormone receptor interactor 130.011
NsfN-ethylmaleimide-sensitive factor0.011
Abractive BCR-related gene0.010
Kcnma1potassium large conductance calcium-activated channel, subfamily M, alpha member 10.010
Spag5sperm associated antigen 50.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism