The network for 'positive regulation of chromatin modification' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of chromatin modification

Any process that activates or increases the frequency, rate or extent of chromatin modification.

NameDescriptionProbabilityFunc Analog Organism
SIN3ASIN3 homolog A, transcription regulator (yeast)0.701
UHRF1ubiquitin-like with PHD and ring finger domains 10.645
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.620
DNMT3BDNA (cytosine-5-)-methyltransferase 3 beta0.595
CBX5chromobox homolog 50.590
ASH2Lash2 (absent, small, or homeotic)-like (Drosophila)0.562
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.549
HIST1H3Bhistone cluster 1, H3b0.521
LEO1Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.512
TP53tumor protein p530.507
NRIP1nuclear receptor interacting protein 10.466
CBX3chromobox homolog 30.444
DNMT1DNA (cytosine-5-)-methyltransferase 10.434
HDAC3histone deacetylase 30.422
WDR5WD repeat domain 50.398
MAPK1mitogen-activated protein kinase 10.380
CREBBPCREB binding protein0.369
SUZ12suppressor of zeste 12 homolog (Drosophila)0.361
MAPK14mitogen-activated protein kinase 140.344
NCOR1nuclear receptor corepressor 10.333
CHAF1Achromatin assembly factor 1, subunit A (p150)0.308
MAP3K7mitogen-activated protein kinase kinase kinase 70.304
LIN9lin-9 homolog (C. elegans)0.292
IRF2BP1interferon regulatory factor 2 binding protein 10.288
ZNF496zinc finger protein 4960.286
SMARCC1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.266
MLLmyeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)0.264
MED15mediator complex subunit 150.260
VEGFAvascular endothelial growth factor A0.243
RBBP5retinoblastoma binding protein 50.240
PARP1poly (ADP-ribose) polymerase 10.225
TGIF1TGFB-induced factor homeobox 10.223
RB1retinoblastoma 10.214
DNMT3ADNA (cytosine-5-)-methyltransferase 3 alpha0.201
DUSP1dual specificity phosphatase 10.197
VAC14Vac14 homolog (S. cerevisiae)0.175
EP300E1A binding protein p3000.170
NCOR2nuclear receptor corepressor 20.162
HDAC7histone deacetylase 70.137
TOP1topoisomerase (DNA) I0.118
MAPK3mitogen-activated protein kinase 30.113
NRP1neuropilin 10.110
TONSLtonsoku-like, DNA repair protein0.109
SUV39H1suppressor of variegation 3-9 homolog 1 (Drosophila)0.103
PIAS4protein inhibitor of activated STAT, 40.101
MBIPMAP3K12 binding inhibitory protein 10.093
GSK3Bglycogen synthase kinase 3 beta0.088
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.086
SMARCB1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 10.085
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.080
NBNnibrin0.079
MYCv-myc myelocytomatosis viral oncogene homolog (avian)0.077
HDAC1histone deacetylase 10.076
IKIK cytokine, down-regulator of HLA II0.076
EZH2enhancer of zeste homolog 2 (Drosophila)0.075
COASYCoA synthase0.072
ARRB2arrestin, beta 20.071
HDGFhepatoma-derived growth factor0.071
RXRAretinoid X receptor, alpha0.071
NCOA1nuclear receptor coactivator 10.070
RTF1Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.069
SUMO1SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)0.068
HCFC1host cell factor C1 (VP16-accessory protein)0.067
H2AFXH2A histone family, member X0.062
SUMO2SMT3 suppressor of mif two 3 homolog 2 (S. cerevisiae)0.061
CDCA4cell division cycle associated 40.061
PMLpromyelocytic leukemia0.060
HEXIM1hexamethylene bis-acetamide inducible 10.057
ENGendoglin0.056
PTPRJprotein tyrosine phosphatase, receptor type, J0.056
HIST2H3Chistone cluster 2, H3c0.056
HDAC5histone deacetylase 50.053
DHX30DEAH (Asp-Glu-Ala-His) box polypeptide 300.052
HIPK2homeodomain interacting protein kinase 20.051
MAPK10mitogen-activated protein kinase 100.051
HDAC9histone deacetylase 90.050
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.050
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.050
PGFplacental growth factor0.049
RICTORRPTOR independent companion of MTOR, complex 20.048
NCOA6nuclear receptor coactivator 60.048
CDAN1congenital dyserythropoietic anemia, type I0.047
MAP2K1mitogen-activated protein kinase kinase 10.047
DUSP3dual specificity phosphatase 30.046
OTUB1OTU domain, ubiquitin aldehyde binding 10.046
VAMP2vesicle-associated membrane protein 2 (synaptobrevin 2)0.045
CHAF1Bchromatin assembly factor 1, subunit B (p60)0.044
CTBP1C-terminal binding protein 10.043
NR2E3nuclear receptor subfamily 2, group E, member 30.042
PUM2pumilio homolog 2 (Drosophila)0.042
MYST3MYST histone acetyltransferase (monocytic leukemia) 30.041
TRIM28tripartite motif containing 280.041
CTBP2C-terminal binding protein 20.041
ARRB1arrestin, beta 10.040
SETDB1SET domain, bifurcated 10.040
LARP7La ribonucleoprotein domain family, member 70.040
PDGFRBplatelet-derived growth factor receptor, beta polypeptide0.040
CXXC1CXXC finger protein 10.039
JUBjub, ajuba homolog (Xenopus laevis)0.039
EEDembryonic ectoderm development0.038
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
mdt-1.2Protein MDT-1.20.012
uaf-1Protein UAF-10.011
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
cbx1achromobox homolog 1a (HP1 beta homolog Drosophila)0.399
ahctf1AT hook containing transcription factor 10.300
ube2iubiquitin-conjugating enzyme E2I0.298
pcnaproliferating cell nuclear antigen0.262
rif1RAP1 interacting factor homolog (yeast)0.246
apex1APEX nuclease (multifunctional DNA repair enzyme) 10.239
smad5MAD homolog 5 (Drosophila)0.201
usp1ubiquitin specific protease 10.199
mcm5MCM5 minichromosome maintenance deficient 5 (S. cerevisiae)0.193
tp53tumor protein p530.182
cstf1cleavage stimulation factor, 3' pre-RNA, subunit 10.179
twist1atwist1a0.165
tcea1transcription elongation factor A (SII), 10.159
naspnuclear autoantigenic sperm protein (histone-binding)0.130
kitakit receptor a0.121
cpsf2cleavage and polyadenylation specific factor 20.112
cx43.4connexin 43.40.109
hdac1histone deacetylase 10.099
dnmt3DNA (cytosine-5-)-methyltransferase 30.098
ilf3ainterleukin enhancer binding factor 3a0.096
cse1lchromosome segregation 1-like (S. cerevisiae)0.093
bub3BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast)0.093
cdc23CDC23 (cell division cycle 23, yeast, homolog)0.092
snai1asnail homolog 1a (Drosophila)0.089
sephs1selenophosphate synthetase 10.088
dnmt1DNA (cytosine-5-)-methyltransferase 10.086
hirip3HIRA interacting protein 30.083
ints8integrator complex subunit 80.082
lmnb1lamin B10.082
nphs1lnephrosis 1, congenital, Finnish type (nephrin)-like0.075
zgc:154063zgc:1540630.075
rbb4retinoblastoma binding protein 40.072
pola1polymerase (DNA directed), alpha 10.071
gins2GINS complex subunit 20.068
diexfdigestive organ expansion factor homolog0.068
cbx5chromobox homolog 5 (HP1 alpha homolog, Drosophila)0.067
rnaseh2aribonuclease H2, subunit A0.067
foxi2forkhead box I20.067
myst2MYST histone acetyltransferase 20.066
rargaretinoic acid receptor gamma a0.065
slc2a10solute carrier family 2 (facilitated glucose transporter), member 100.064
dnttdeoxynucleotidyltransferase, terminal0.061
zc3h13zinc finger CCCH-type containing 130.061
hnrnpa1heterogeneous nuclear ribonucleoprotein A10.060
msh2mutS homolog 2 (E. coli)0.059
rac1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.059
nup107nucleoporin 1070.058
casc3cancer susceptibility candidate 30.057
pold1polymerase (DNA directed), delta 1, catalytic subunit0.056
yes1v-yes-1 Yamaguchi sarcoma viral oncogene homolog 10.056
mcm7MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)0.056
whsc1Wolf-Hirschhorn syndrome candidate 10.053
ncapd2non-SMC condensin I complex, subunit D20.051
rpa1replication protein A10.051
rap1aRAP1A, member of RAS oncogene family0.051
pola2polymerase (DNA directed), alpha 20.051
wt1bwilms tumor 1b0.051
ptpraprotein tyrosine phosphatase, receptor type, A0.051
kpna4karyopherin alpha 4 (importin alpha 3)0.050
lmo4aLIM domain only 4a0.049
gon4lgon-4-like (C.elegans)0.049
zgc:110113zgc:1101130.048
dpf2lD4, zinc and double PHD fingers family 2, like0.047
wdr5WD repeat domain 50.047
mtmr8myotubularin related protein 80.047
ctnnb1catenin (cadherin-associated protein), beta 10.047
ppm1gprotein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform0.046
sfpqsplicing factor proline/glutamine rich (polypyrimidine tract binding protein associated)0.045
morc2MORC family CW-type zinc finger 20.045
rbm19RNA binding motif protein 190.045
hsp47heat shock protein 470.045
rhogcras homolog gene family, member Gc0.044
smc3structural maintenance of chromosomes 30.044
pbrm1lpolybromo 1, like0.044
si:dkey-7c22.1si:dkey-7c22.10.044
chek2CHK2 checkpoint homolog (S. pombe)0.043
si:dkeyp-35b8.5si:dkeyp-35b8.50.042
pppde1PPPDE peptidase domain containing 10.042
wlswntless homolog (Drosophila)0.042
plekha1pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 10.042
esco2establishment of cohesion 1 homolog 20.042
lppLIM domain containing preferred translocation partner in lipoma0.041
hdac4histone deacetylase 40.041
terttelomerase reverse transcriptase0.041
senp3aSUMO1/sentrin/SMT3 specific peptidase 3a0.040
snrpcsmall nuclear ribonucleoprotein polypeptide C0.040
mdm2transformed 3T3 cell double minute 2 homolog (mouse)0.040
sass6spindle assembly 6 homolog (C. elegans)0.040
gro1groucho 10.040
tmed2transmembrane emp24 domain trafficking protein 20.040
acvr1bactivin A receptor, type IB0.040
stilTAL1 (SCL) interrupting locus0.040
asf1bbASF1 anti-silencing function 1 homolog Bb0.039
bactin1bactin10.039
fen1flap structure-specific endonuclease 10.039
foxe3forkhead box E30.039
wtipWilms tumor 1 interacting protein0.039
mettl3methyltransferase like 30.039
mycl1av-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian) a0.039
kif23kinesin family member 230.038
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
DlDelta0.030
bazbazooka0.021
ChcClathrin heavy chain0.020
BicDBicaudal D0.018
ckcrinkled0.014
EcREcdysone receptor0.014
EphEph receptor tyrosine kinase0.014
escextra sexcombs0.013
CG7603CG7603 gene product from transcript CG7603-RA0.013
Pp2A-29BProtein phosphatase 2A at 29B0.013
mRpL33mitochondrial ribosomal protein L330.013
lsnlarsen0.013
l(3)01239lethal (3) 012390.012
CG11980CG11980 gene product from transcript CG11980-RB0.012
CG11076CG11076 gene product from transcript CG11076-RB0.012
flwflapwing0.012
CG3560CG3560 gene product from transcript CG3560-RA0.012
Arp66BActin-related protein 66B0.012
Cdc42CG12530 gene product from transcript CG12530-RA0.012
Rpb5CG11979 gene product from transcript CG11979-RA0.012
l(2)37Cglethal (2) 37Cg0.011
CG7338CG7338 gene product from transcript CG7338-RA0.011
AbiAbelson interacting protein0.011
l(2)03709lethal (2) 037090.011
numbCG3779 gene product from transcript CG3779-RB0.011
CkIIalphaCasein kinase II alpha subunit0.011
CG14210CG14210 gene product from transcript CG14210-RA0.011
CG9603CG9603 gene product from transcript CG9603-RA0.011
Tom20Translocase of outer membrane 200.011
CG14482CG14482 gene product from transcript CG14482-RA0.011
CG17776CG17776 gene product from transcript CG17776-RA0.011
mRpL49mitochondrial ribosomal protein L490.011
KlcKinesin light chain0.010
p120ctnAdherens junction protein p1200.010
levyCG17280 gene product from transcript CG17280-RA0.010
CG13364CG13364 gene product from transcript CG13364-RA0.010
CG5548CG5548 gene product from transcript CG5548-RA0.010
CG11583CG11583 gene product from transcript CG11583-RA0.010
CG9172CG9172 gene product from transcript CG9172-RA0.010
NHP2CG5258 gene product from transcript CG5258-RA0.010
rheaCG6831 gene product from transcript CG6831-RA0.010
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ezh2enhancer of zeste homolog 2 (Drosophila)0.998
Brca1breast cancer 10.947
Suz12suppressor of zeste 12 homolog (Drosophila)0.932
Jarid2jumonji, AT rich interactive domain 20.921
Trp53transformation related protein 530.824
Ptenphosphatase and tensin homolog0.820
Ncor1nuclear receptor co-repressor 10.795
Ppargperoxisome proliferator activated receptor gamma0.621
Lepleptin0.589
SkilSKI-like0.547
Dnmt3aDNA methyltransferase 3A0.520
JunJun oncogene0.461
Eedembryonic ectoderm development0.454
Trim24tripartite motif-containing 240.427
Arid1aAT rich interactive domain 1A (SWI-like)0.372
Egr1early growth response 10.369
Cav1caveolin 1, caveolae protein0.358
Rararetinoic acid receptor, alpha0.355
Trim28tripartite motif-containing 280.341
Kdm2blysine (K)-specific demethylase 2B0.320
Mdm4transformed mouse 3T3 cell double minute 40.304
Tnftumor necrosis factor0.299
Plin1perilipin 10.286
Rbbp4retinoblastoma binding protein 40.276
Setxsenataxin0.268
Kdm1alysine (K)-specific demethylase 1A0.264
Rxraretinoid X receptor alpha0.245
CrebbpCREB binding protein0.236
Hist1h3ghistone cluster 1, H3g0.222
Ptgs2prostaglandin-endoperoxide synthase 20.208
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.194
Nos1nitric oxide synthase 1, neuronal0.194
Pax3paired box gene 30.182
Pou5f1POU domain, class 5, transcription factor 10.181
Brd8bromodomain containing 80.181
Ep300E1A binding protein p3000.170
Mll1myeloid/lymphoid or mixed-lineage leukemia 10.164
Cdk1cyclin-dependent kinase 10.155
Sin3atranscriptional regulator, SIN3A (yeast)0.150
Col1a1collagen, type I, alpha 10.149
Parp1poly (ADP-ribose) polymerase family, member 10.147
Huwe1HECT, UBA and WWE domain containing 10.141
NanogNanog homeobox0.141
Mstnmyostatin0.141
Foxp1forkhead box P10.132
Leprleptin receptor0.129
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.127
Nr3c1nuclear receptor subfamily 3, group C, member 10.126
Zeb1zinc finger E-box binding homeobox 10.125
Gli2GLI-Kruppel family member GLI20.125
Hdac1histone deacetylase 10.124
FosFBJ osteosarcoma oncogene0.118
Kdm5alysine (K)-specific demethylase 5A0.117
Zfp292zinc finger protein 2920.103
Hdac7histone deacetylase 70.102
Pax7paired box gene 70.095
ArhgdiaRho GDP dissociation inhibitor (GDI) alpha0.093
Bod1lbiorientation of chromosomes in cell division 1-like0.093
Stk38serine/threonine kinase 380.092
Lrp1low density lipoprotein receptor-related protein 10.091
Btg2B-cell translocation gene 2, anti-proliferative0.087
Vdrvitamin D receptor0.087
Tgfb1transforming growth factor, beta 10.086
Rb1retinoblastoma 10.085
Cdkn1bcyclin-dependent kinase inhibitor 1B0.083
Lmnb1lamin B10.082
Ghrgrowth hormone receptor0.080
Ezh1enhancer of zeste homolog 1 (Drosophila)0.079
Sae1SUMO1 activating enzyme subunit 10.079
Atf3activating transcription factor 30.078
Ruvbl1RuvB-like protein 10.077
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.077
Ccnt2cyclin T20.075
Atmataxia telangiectasia mutated homolog (human)0.073
Srfserum response factor0.073
Gnai2guanine nucleotide binding protein (G protein), alpha inhibiting 20.071
Ylpm1YLP motif containing 10.070
Wfikkn2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 20.070
Thrathyroid hormone receptor alpha0.069
Ptf1apancreas specific transcription factor, 1a0.069
Rnf2ring finger protein 20.069
Runx1runt related transcription factor 10.067
Arandrogen receptor0.067
Clk1CDC-like kinase 10.067
Hellshelicase, lymphoid specific0.067
Pkd1polycystic kidney disease 1 homolog0.065
Fosl2fos-like antigen 20.065
Dmddystrophin, muscular dystrophy0.064
Smarca2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 20.062
Bub1bbudding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae)0.062
Arrb2arrestin, beta 20.062
Cd19CD19 antigen0.062
Trp63transformation related protein 630.061
Aebp2AE binding protein 20.061
Esr1estrogen receptor 1 (alpha)0.060
Brca2breast cancer 20.060
Arhgef1Rho guanine nucleotide exchange factor (GEF) 10.058
CtcfCCCTC-binding factor0.058
Ncoa1nuclear receptor coactivator 10.058
Smarcc1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.057
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
CLB3Clb3p0.231
RTF1Rtf1p0.124
TRA1Tra1p0.062
SPT16Spt16p0.056
NGG1Ngg1p0.051
LEO1Leo1p0.041
CTR9Ctr9p0.040
GCN5Gcn5p0.039
CLB1Clb1p0.039
SIC1Sic1p0.036
CKS1Cks1p0.035
STE5Ste5p0.033
SPT20Spt20p0.032
SPT8Spt8p0.028
STE4Ste4p0.027
TAF6Taf6p0.027
SWR1Swr1p0.026
HPR1Hpr1p0.023
CLB4Clb4p0.023
SAP190Sap190p0.021
TEC1Tec1p0.021
SWC3Swc3p0.021
HIR1Hir1p0.020
CDC6Cdc6p0.020
HDA2Hda2p0.020
CLB2Clb2p0.018
HHT1Hht1p0.017
MSG5Msg5p0.016
SPT7Spt7p0.016
CDC28Cdc28p0.016
CDC20Cdc20p0.016
TAF7Taf7p0.015
YNL155Whypothetical protein0.015
HHO1Hho1p0.015
RTT109Rtt109p0.014
CKA1Cka1p0.014
KSS1Kss1p0.013
BDF1Bdf1p0.013
SRD1Srd1p0.013
YLR264C-Ahypothetical protein0.013
HAT2Hat2p0.012
PDS1Pds1p0.012
YOL038C-Ahypothetical protein0.012
YLR162Whypothetical protein0.012
SET2Set2p0.012
LEU2Leu2p0.012
CAB3Cab3p0.012
PAF1Paf1p0.012
ARP10Arp10p0.012
OPT2Opt2p0.012
GZF3Gzf3p0.012
HXT3Hxt3p0.012
CRP1Crp1p0.012
ASF1Asf1p0.012
MER1Mer1p0.011
MF(ALPHA)2Mf(alpha)2p0.011
SPL2Spl2p0.011
CLN2Cln2p0.011
YAR068Whypothetical protein0.011
SGF73Sgf73p0.011
MDM20Mdm20p0.011
SWI3Swi3p0.010
YNL058Chypothetical protein0.010
NMT1Nmt1p0.010
TAF8Taf8p0.010
ATP6Atp6p0.010
BSC1Bsc1p0.010
YLR042Chypothetical protein0.010
PIN4Pin4p0.010
CBP1Cbp1p0.010
SGF29Sgf29p0.010
AUA1Aua1p0.010
SWC7Swc7p0.010
HHT2Hht2p0.010
YIL151Chypothetical protein0.010
CUP1-1Cup1-1p0.010
HOHop0.010