The network for 'positive regulation of rho gtpase activity' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of rho gtpase activity

Any process that activates or increases the activity of a GTPase of the Rho family.

NameDescriptionProbabilityFunc Analog Organism
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)1.000
CDC42cell division cycle 42 (GTP binding protein, 25kDa)1.000
PAK1p21 protein (Cdc42/Rac)-activated kinase 11.000
ARHGDIARho GDP dissociation inhibitor (GDI) alpha0.998
SH3KBP1SH3-domain kinase binding protein 10.969
PAK2p21 protein (Cdc42/Rac)-activated kinase 20.968
S100A6S100 calcium binding protein A60.949
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.949
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.946
S100A11S100 calcium binding protein A110.935
RHOAras homolog gene family, member A0.922
IGF1Rinsulin-like growth factor 1 receptor0.921
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide0.889
S100A8S100 calcium binding protein A80.874
BAIAP2BAI1-associated protein 20.871
ERBB2IPerbb2 interacting protein0.837
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.828
S100A4S100 calcium binding protein A40.818
NCF2neutrophil cytosolic factor 20.802
JUNjun proto-oncogene0.792
ABI1abl-interactor 10.774
S100A9S100 calcium binding protein A90.772
MDM2Mdm2 p53 binding protein homolog (mouse)0.772
S100BS100 calcium binding protein B0.765
NCKAP1NCK-associated protein 10.712
SOS1son of sevenless homolog 1 (Drosophila)0.683
YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.650
TRAF5TNF receptor-associated factor 50.637
ARHGEF11Rho guanine nucleotide exchange factor (GEF) 110.607
ARHGDIBRho GDP dissociation inhibitor (GDI) beta0.596
FOSFBJ murine osteosarcoma viral oncogene homolog0.578
DOCK1dedicator of cytokinesis 10.571
PTPRCprotein tyrosine phosphatase, receptor type, C0.543
PKN3protein kinase N30.531
PTK2PTK2 protein tyrosine kinase 20.518
S100A1S100 calcium binding protein A10.517
CCR5chemokine (C-C motif) receptor 50.514
TSC2tuberous sclerosis 20.507
GRB7growth factor receptor-bound protein 70.503
RASA1RAS p21 protein activator (GTPase activating protein) 10.500
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.478
SH3RF1SH3 domain containing ring finger 10.474
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.472
JUPjunction plakoglobin0.469
MAP3K11mitogen-activated protein kinase kinase kinase 110.456
LGALS1lectin, galactoside-binding, soluble, 10.428
RND1Rho family GTPase 10.426
RHOCras homolog gene family, member C0.424
SMAD2SMAD family member 20.417
ATF3activating transcription factor 30.399
RALBv-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)0.398
FMNL1formin-like 10.395
FLNBfilamin B, beta0.376
WASWiskott-Aldrich syndrome (eczema-thrombocytopenia)0.357
MARK3MAP/microtubule affinity-regulating kinase 30.349
ARHGAP1Rho GTPase activating protein 10.340
CCL19chemokine (C-C motif) ligand 190.331
EGFRepidermal growth factor receptor0.319
CNKSR2connector enhancer of kinase suppressor of Ras 20.290
BCAR1breast cancer anti-estrogen resistance 10.284
CCL4chemokine (C-C motif) ligand 40.277
NCK1NCK adaptor protein 10.270
TNFtumor necrosis factor0.268
ZMYND11zinc finger, MYND-type containing 110.267
RALAv-ral simian leukemia viral oncogene homolog A (ras related)0.266
RACGAP1Rac GTPase activating protein 10.246
CALM1calmodulin 1 (phosphorylase kinase, delta)0.245
RHOGras homolog gene family, member G (rho G)0.245
HCKhemopoietic cell kinase0.245
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.243
MYO9Bmyosin IXB0.240
ATP7AATPase, Cu++ transporting, alpha polypeptide0.239
SH3RF3SH3 domain containing ring finger 30.238
RASSF5Ras association (RalGDS/AF-6) domain family member 50.234
ANK1ankyrin 1, erythrocytic0.231
CCL2chemokine (C-C motif) ligand 20.229
KRT14keratin 140.222
PLXNB1plexin B10.214
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.213
PTPN13protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)0.208
PLXND1plexin D10.204
PAK4p21 protein (Cdc42/Rac)-activated kinase 40.193
DPP4dipeptidyl-peptidase 40.192
TMSB4Xthymosin beta 4, X-linked0.188
PAFAH1B1platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)0.185
SH3BGRL3SH3 domain binding glutamic acid-rich protein like 30.180
SORBS1sorbin and SH3 domain containing 10.177
APCadenomatous polyposis coli0.177
TRAF1TNF receptor-associated factor 10.177
PVRL2poliovirus receptor-related 2 (herpesvirus entry mediator B)0.175
ANXA2annexin A20.175
EMP3epithelial membrane protein 30.165
RALBP1ralA binding protein 10.163
PKP4plakophilin 40.155
FASLGFas ligand (TNF superfamily, member 6)0.149
CAPGcapping protein (actin filament), gelsolin-like0.148
MPRIPmyosin phosphatase Rho interacting protein0.145
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
plexBplexin B0.880
pod1CG4532 gene product from transcript CG4532-RF0.794
mbcmyoblast city0.777
Pi3K92ECG4141 gene product from transcript CG4141-RB0.746
SosSon of sevenless0.661
PknProtein kinase related to protein kinase N0.574
AbiAbelson interacting protein0.475
RhoGEF2CG9635 gene product from transcript CG9635-RF0.251
Mkp3Mitogen-activated protein kinase phosphatase 30.228
neuroliginCG13772 gene product from transcript CG13772-RA0.177
CG4853CG4853 gene product from transcript CG4853-RA0.176
UBL3CG9038 gene product from transcript CG9038-RC0.144
trioCG18214 gene product from transcript CG18214-RA0.143
Fak56DFocal Adhesion Kinase0.139
WnkCG7177 gene product from transcript CG7177-RA0.138
DAAMDishevelled Associated Activator of Morphogenesis0.135
RhoGAP68FCG6811 gene product from transcript CG6811-RA0.121
GrafCG8948 gene product from transcript CG8948-RB0.119
Wnt5Wnt oncogene analog 50.108
Myo31DFMyosin 31DF0.093
Vrp1Verprolin 10.092
CG6051CG6051 gene product from transcript CG6051-RB0.090
l(2)k16918lethal (2) k169180.087
bvesCG32513 gene product from transcript CG32513-RA0.086
Cip4CG15015 gene product from transcript CG15015-RA0.086
RhoGAP93BCG3421 gene product from transcript CG3421-RA0.086
CG32772CG32772 gene product from transcript CG32772-RC0.086
EphrinCG1862 gene product from transcript CG1862-RA0.082
alpha-Man-IIbCG4606 gene product from transcript CG4606-RA0.077
l(3)04053lethal (3) 040530.073
Drl-2Derailed 20.072
Itp-r83AInositol 1,4,5,-tris-phosphate receptor0.071
CG4751CG4751 gene product from transcript CG4751-RA0.070
CG2991CG2991 gene product from transcript CG2991-RA0.069
Ras85DRas oncogene at 85D0.069
Rho1CG8416 gene product from transcript CG8416-RB0.067
Fas3Fasciclin 30.055
CG15479CG15479 gene product from transcript CG15479-RA0.055
Rtnl1CG33113 gene product from transcript CG33113-RF0.055
Cad87ACG6977 gene product from transcript CG6977-RA0.053
vavCG7893 gene product from transcript CG7893-RB0.052
CG8155CG8155 gene product from transcript CG8155-RA0.050
JraJun-related antigen0.050
dosdaughter of sevenless0.048
Lsd-2Lipid storage droplet-20.048
Hr96Hormone receptor-like in 960.042
CG11033CG11033 gene product from transcript CG11033-RB0.039
RhoGAPp190CG32555 gene product from transcript CG32555-RB0.038
nwknervous wreck0.036
RepRab escort protein0.036
CG12734CG12734 gene product from transcript CG12734-RA0.036
CG15365CG15365 gene product from transcript CG15365-RA0.035
HrsHepatocyte growth factor regulated tyrosine kinase substrate0.035
SCARCG4636 gene product from transcript CG4636-RA0.035
Tre1trapped in endoderm-10.034
nerfin-1nervous fingers 10.034
ced-6CG11804 gene product from transcript CG11804-RC0.034
idaimaginal discs arrested0.033
taytay bridge0.033
CG1233CG1233 gene product from transcript CG1233-RB0.032
tankyraseCG4719 gene product from transcript CG4719-RA0.032
zorminCG33484 gene product from transcript CG33484-RC0.032
Pak3CG14895 gene product from transcript CG14895-RA0.031
CG6707CG6707 gene product from transcript CG6707-RA0.030
RalaRas-related protein0.030
myoglianinCG1838 gene product from transcript CG1838-RD0.029
spz5spatzle 50.028
drkdownstream of receptor kinase0.028
PezCG9493 gene product from transcript CG9493-RA0.027
CG7158CG7158 gene product from transcript CG7158-RA0.027
rawCG12437 gene product from transcript CG12437-RB0.026
cv-ccrossveinless c0.025
CG17233CG17233 gene product from transcript CG17233-RA0.024
SbfSET domain binding factor0.024
msd1mitotic spindle density 10.023
Tak1TGF-beta activated kinase 10.023
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Grb2growth factor receptor bound protein 20.998
Sema6asema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A0.988
Efnb2ephrin B20.981
Arhgef11Rho guanine nucleotide exchange factor (GEF) 110.952
Itsn1intersectin 1 (SH3 domain protein 1A)0.952
Pafah1b1platelet-activating factor acetylhydrolase, isoform 1b, subunit 10.944
Ephb2Eph receptor B20.937
Rac1RAS-related C3 botulinum substrate 10.934
Dlg4discs, large homolog 4 (Drosophila)0.934
Epha4Eph receptor A40.932
Ccl2chemokine (C-C motif) ligand 20.912
Nf1neurofibromatosis 10.904
CblCasitas B-lineage lymphoma0.833
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.803
Apcadenomatosis polyposis coli0.718
Vav1vav 1 oncogene0.705
Gfra2glial cell line derived neurotrophic factor family receptor alpha 20.703
Tgfatransforming growth factor alpha0.700
Erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.692
Shc1src homology 2 domain-containing transforming protein C10.670
Arrb2arrestin, beta 20.652
Leprleptin receptor0.636
Laptm5lysosomal-associated protein transmembrane 50.635
Plxna1plexin A10.626
Cd37CD37 antigen0.610
Prkcdprotein kinase C, delta0.580
Ctnnb1catenin (cadherin associated protein), beta 10.561
Cdc42cell division cycle 42 homolog (S. cerevisiae)0.556
Rassf5Ras association (RalGDS/AF-6) domain family member 50.555
Selplgselectin, platelet (p-selectin) ligand0.551
SrcRous sarcoma oncogene0.547
Hmha1histocompatibility (minor) HA-10.527
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.523
Nr3c1nuclear receptor subfamily 3, group C, member 10.517
Ptpn11protein tyrosine phosphatase, non-receptor type 110.456
Ptk2PTK2 protein tyrosine kinase 20.450
Itga3integrin alpha 30.424
Gfra1glial cell line derived neurotrophic factor family receptor alpha 10.417
Nrp1neuropilin 10.415
Magi1membrane associated guanylate kinase, WW and PDZ domain containing 10.371
Sh3bp1SH3-domain binding protein 10.371
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.367
Gab1growth factor receptor bound protein 2-associated protein 10.365
Elmo1engulfment and cell motility 1, ced-12 homolog (C. elegans)0.361
Ntf3neurotrophin 30.340
Numbnumb gene homolog (Drosophila)0.330
Arhgap21Rho GTPase activating protein 210.328
Pip4k2aphosphatidylinositol-5-phosphate 4-kinase, type II, alpha0.326
Asap1ArfGAP with SH# domain, ankyrin repeat and PH domain10.323
Kcnab2potassium voltage-gated channel, shaker-related subfamily, beta member 20.322
Bcrbreakpoint cluster region0.321
Nf2neurofibromatosis 20.320
Retret proto-oncogene0.311
Efna1ephrin A10.292
Git1G protein-coupled receptor kinase-interactor 10.289
BrafBraf transforming gene0.285
Ptpreprotein tyrosine phosphatase, receptor type, E0.274
Nrp2neuropilin 20.268
Prkcbprotein kinase C, beta0.255
Ptk2bPTK2 protein tyrosine kinase 2 beta0.244
Irf5interferon regulatory factor 50.240
Shhsonic hedgehog0.232
Myo1fmyosin IF0.232
Tbx2T-box 20.231
Fzd1frizzled homolog 1 (Drosophila)0.228
Pde1bphosphodiesterase 1B, Ca2+-calmodulin dependent0.226
Vav2vav 2 oncogene0.218
Apc2adenomatosis polyposis coli 20.216
Arrb1arrestin, beta 10.213
Dnm1dynamin 10.210
Vangl2vang-like 2 (van gogh, Drosophila)0.208
Sirpasignal-regulatory protein alpha0.204
Lama5laminin, alpha 50.201
Gab2growth factor receptor bound protein 2-associated protein 20.200
Pvrl1poliovirus receptor-related 10.194
Pak1p21 protein (Cdc42/Rac)-activated kinase 10.185
Ccl3chemokine (C-C motif) ligand 30.185
Hdac7histone deacetylase 70.183
Ptpn22protein tyrosine phosphatase, non-receptor type 22 (lymphoid)0.182
Flt1FMS-like tyrosine kinase 10.172
Gpsm3G-protein signalling modulator 3 (AGS3-like, C. elegans)0.170
Rasgrp2RAS, guanyl releasing protein 20.170
Shisa5shisa homolog 5 (Xenopus laevis)0.168
Sh3kbp1SH3-domain kinase binding protein 10.166
Prkceprotein kinase C, epsilon0.166
Cd3eCD3 antigen, epsilon polypeptide0.165
Lrp5low density lipoprotein receptor-related protein 50.163
Stk10serine/threonine kinase 100.161
Anxa2annexin A20.160
Lrrk2leucine-rich repeat kinase 20.160
Tcfcp2l1transcription factor CP2-like 10.155
Rargretinoic acid receptor, gamma0.155
Tjp1tight junction protein 10.154
Ednrbendothelin receptor type B0.154
Klf3Kruppel-like factor 3 (basic)0.153
C77080expressed sequence C770800.153
Fnbp1formin binding protein 10.153
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Dlg3discs, large homolog 3 (Drosophila)0.111
Ylpm1YLP motif containing 10.106
Kitv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog0.060
Stxbp5syntaxin binding protein 5 (tomosyn)0.045
Itpr2inositol 1,4,5-triphosphate receptor, type 20.035
Zmym4zinc finger, MYM-type 40.035
Mcf2lMCF.2 cell line derived transforming sequence-like0.035
Arhgef11Rho guanine nucleotide exchange factor (GEF) 110.034
Dock9dedicator of cytokinesis 90.030
Tjp1tight junction protein 10.025
Cap2CAP, adenylate cyclase-associated protein, 2 (yeast)0.025
Sptan1spectrin, alpha, non-erythrocytic 10.023
Cdc34cell division cycle 34 homolog (S. cerevisiae)0.023
Klf6Kruppel-like factor 60.023
Rasgrf2RAS protein-specific guanine nucleotide-releasing factor 20.022
Syn2synapsin II0.022
Stk10serine/threonine kinase 100.022
Plxnd1plexin D10.021
Pik3r3phosphoinositide-3-kinase, regulatory subunit 3 (gamma)0.019
Irf5interferon regulatory factor 50.019
Pld2phospholipase D20.018
TekTEK tyrosine kinase, endothelial0.018
Golgb1golgin B1, golgi integral membrane protein0.018
Sept10septin 100.017
Plcg1phospholipase C, gamma 10.017
Fgd2FYVE, RhoGEF and PH domain containing 20.016
Fgfr3fibroblast growth factor receptor 30.016
Bin2bridging integrator 20.015
Hmha1histocompatibility (minor) HA-10.015
Sh3gl2SH3-domain GRB2-like 20.014
Ldlrap1low density lipoprotein receptor adaptor protein 10.014
Tmprss2transmembrane protease, serine 20.014
Unc13bunc-13 homolog B (C. elegans)0.013
Rab15RAB15, member RAS oncogene family0.013
Pias3protein inhibitor of activated STAT, 30.013
Prkcdprotein kinase C, delta0.013
Atf3activating transcription factor 30.013
Dgkadiacylglycerol kinase, alpha0.012
Mllt4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.012
Dll4delta-like 4 (Drosophila)0.012
Pde2aphosphodiesterase 2A, cGMP-stimulated0.012
Kcnab1potassium voltage-gated channel, shaker-related subfamily, beta member 10.012
Ptprsprotein tyrosine phosphatase, receptor type, S0.012
Itpr1inositol 1,4,5-triphosphate receptor, type 10.012
Pak1p21 protein (Cdc42/Rac)-activated kinase 10.011
Map4k1mitogen activated protein kinase kinase kinase kinase 10.011
Rassf5Ras association (RalGDS/AF-6) domain family member 50.011
Zfp36zinc finger protein 360.011
Lcp2lymphocyte cytosolic protein 20.011
GraspGRP1 (general receptor for phosphoinositides 1)-associated scaffold protein0.010
Slc9a1solute carrier family 9 (sodium/hydrogen exchanger), member 10.010
Abi3ABI family, member 30.010
Pik3cdphosphoinositide-3-kinase, catalytic, delta polypeptide0.010
Cachd1cache domain containing 10.010
Kif13akinesin family member 13A0.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
YLR264C-Ahypothetical protein0.012
YOL038C-Ahypothetical protein0.011
YLR162Whypothetical protein0.010
YNL058Chypothetical protein0.010