The network for 'tumor necrosis factor superfamily cytokine production' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

tumor necrosis factor superfamily cytokine production

The appearance of any member of the TNF superfamily due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.

NameDescriptionProbabilityFunc Analog Organism
TRAF1TNF receptor-associated factor 10.995
MYD88myeloid differentiation primary response gene (88)0.995
PTPN6protein tyrosine phosphatase, non-receptor type 60.989
SYKspleen tyrosine kinase0.987
C1QAcomplement component 1, q subcomponent, A chain0.986
IRAK2interleukin-1 receptor-associated kinase 20.983
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.934
TRADDTNFRSF1A-associated via death domain0.916
IRAK1interleukin-1 receptor-associated kinase 10.897
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.868
LILRB1leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 10.844
BIRC3baculoviral IAP repeat containing 30.822
IRAK3interleukin-1 receptor-associated kinase 30.773
PILRApaired immunoglobin-like type 2 receptor alpha0.744
TRAF6TNF receptor-associated factor 60.660
AXLAXL receptor tyrosine kinase0.619
LCKlymphocyte-specific protein tyrosine kinase0.598
RXRAretinoid X receptor, alpha0.596
ARFGEF1ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)0.567
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.564
TLR2toll-like receptor 20.544
IL12Binterleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)0.508
LILRB3leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 30.503
LILRA6leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 60.501
CXCL2chemokine (C-X-C motif) ligand 20.489
CCR1chemokine (C-C motif) receptor 10.458
MAPKAPK2mitogen-activated protein kinase-activated protein kinase 20.443
CXCL9chemokine (C-X-C motif) ligand 90.440
GAS6growth arrest-specific 60.430
MAPK14mitogen-activated protein kinase 140.428
CREBBPCREB binding protein0.405
PTAFRplatelet-activating factor receptor0.378
CCL5chemokine (C-C motif) ligand 50.372
RIPK2receptor-interacting serine-threonine kinase 20.371
ARFGEF2ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)0.364
IKBKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta0.337
CXCL3chemokine (C-X-C motif) ligand 30.324
BIRC2baculoviral IAP repeat containing 20.305
FCGR2AFc fragment of IgG, low affinity IIa, receptor (CD32)0.301
IL10RAinterleukin 10 receptor, alpha0.299
CCL4chemokine (C-C motif) ligand 40.272
TLR4toll-like receptor 40.261
FCN1ficolin (collagen/fibrinogen domain containing) 10.258
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.256
CSF2RBcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.248
IDEinsulin-degrading enzyme0.240
TNFtumor necrosis factor0.238
CCL8chemokine (C-C motif) ligand 80.235
BLNKB-cell linker0.224
CCL2chemokine (C-C motif) ligand 20.217
C1QCcomplement component 1, q subcomponent, C chain0.215
CEBPDCCAAT/enhancer binding protein (C/EBP), delta0.211
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.206
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.206
LILRA1leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 10.203
IL8interleukin 80.196
CASP1caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)0.193
LILRB2leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 20.190
FGRGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog0.190
EPORerythropoietin receptor0.187
LATlinker for activation of T cells0.184
CD163CD163 molecule0.184
CD48CD48 molecule0.184
LAIR1leukocyte-associated immunoglobulin-like receptor 10.171
SIGLEC7sialic acid binding Ig-like lectin 70.170
FCER1GFc fragment of IgE, high affinity I, receptor for; gamma polypeptide0.163
CD14CD14 molecule0.162
TNFRSF1Btumor necrosis factor receptor superfamily, member 1B0.160
CD33CD33 molecule0.159
RBCK1RanBP-type and C3HC4-type zinc finger containing 10.153
ITGA2Bintegrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)0.153
CCL20chemokine (C-C motif) ligand 200.147
INPP5Dinositol polyphosphate-5-phosphatase, 145kDa0.147
CCR5chemokine (C-C motif) receptor 50.142
TNFAIP2tumor necrosis factor, alpha-induced protein 20.140
CASP8caspase 8, apoptosis-related cysteine peptidase0.135
HSPB1heat shock 27kDa protein 10.135
TICAM2toll-like receptor adaptor molecule 20.133
HSF1heat shock transcription factor 10.131
IL23Ainterleukin 23, alpha subunit p190.125
SH3BP2SH3-domain binding protein 20.123
SPOPspeckle-type POZ protein0.122
TRAF5TNF receptor-associated factor 50.122
TFECtranscription factor EC0.119
NOD2nucleotide-binding oligomerization domain containing 20.111
TYMPthymidine phosphorylase0.109
APOEapolipoprotein E0.108
SOCS3suppressor of cytokine signaling 30.106
CD3ECD3e molecule, epsilon (CD3-TCR complex)0.105
MEFVMediterranean fever0.103
SETD8SET domain containing (lysine methyltransferase) 80.102
ZNF263zinc finger protein 2630.098
MARCOmacrophage receptor with collagenous structure0.094
MED15mediator complex subunit 150.094
TRIM39tripartite motif containing 390.093
CD86CD86 molecule0.088
CMKLR1chemokine-like receptor 10.087
C1QBcomplement component 1, q subcomponent, B chain0.085
MSR1macrophage scavenger receptor 10.085
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Lyz2lysozyme 20.989
Myd88myeloid differentiation primary response gene 880.988
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.977
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.923
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.902
Tlr4toll-like receptor 40.901
Gnrh1gonadotropin releasing hormone 10.870
Clec4nC-type lectin domain family 4, member n0.866
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.816
Traf6TNF receptor-associated factor 60.813
AxlAXL receptor tyrosine kinase0.796
Klrk1killer cell lectin-like receptor subfamily K, member 10.790
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.789
Map3k8mitogen-activated protein kinase kinase kinase 80.784
Clec4dC-type lectin domain family 4, member d0.761
Ascl1achaete-scute complex homolog 1 (Drosophila)0.702
Ccr1chemokine (C-C motif) receptor 10.669
FaslFas ligand (TNF superfamily, member 6)0.645
AF251705cDNA sequence AF2517050.614
Klrd1killer cell lectin-like receptor, subfamily D, member 10.606
BlkB lymphoid kinase0.568
Trim30dtripartite motif-containing 30D0.565
Gzmagranzyme A0.558
Cd44CD44 antigen0.558
Tnftumor necrosis factor0.557
Klrb1bkiller cell lectin-like receptor subfamily B member 1B0.536
Otx2orthodenticle homolog 2 (Drosophila)0.490
C3ar1complement component 3a receptor 10.482
FgrGardner-Rasheed feline sarcoma viral (Fgr) oncogene homolog0.478
Pik3caphosphatidylinositol 3-kinase, catalytic, alpha polypeptide0.469
Ccl4chemokine (C-C motif) ligand 40.462
FcrlaFc receptor-like A0.432
Gata4GATA binding protein 40.432
Itgaxintegrin alpha X0.427
Cd7CD7 antigen0.419
Ikzf1IKAROS family zinc finger 10.416
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.413
Chrnb2cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)0.393
Ncr1natural cytotoxicity triggering receptor 10.390
Adam19a disintegrin and metallopeptidase domain 19 (meltrin beta)0.390
Csf3rcolony stimulating factor 3 receptor (granulocyte)0.378
Map3k14mitogen-activated protein kinase kinase kinase 140.363
Klra9killer cell lectin-like receptor subfamily A, member 90.359
Clec4eC-type lectin domain family 4, member e0.346
Snai1snail homolog 1 (Drosophila)0.340
Cd300ldCD300 molecule-like family member d0.332
Socs1suppressor of cytokine signaling 10.299
Cd180CD180 antigen0.291
Cd40CD40 antigen0.287
Neurog2neurogenin 20.270
Ccr7chemokine (C-C motif) receptor 70.270
Cd209aCD209a antigen0.268
Cmklr1chemokine-like receptor 10.266
Il12binterleukin 12b0.264
Il7rinterleukin 7 receptor0.264
Hand2heart and neural crest derivatives expressed transcript 20.255
Ear2eosinophil-associated, ribonuclease A family, member 20.245
Ccl2chemokine (C-C motif) ligand 20.241
Neurod4neurogenic differentiation 40.231
F2rl2coagulation factor II (thrombin) receptor-like 20.230
Pax6paired box gene 60.226
Pik3ap1phosphoinositide-3-kinase adaptor protein 10.224
Tlr2toll-like receptor 20.218
Emx2empty spiracles homolog 2 (Drosophila)0.217
Il18rapinterleukin 18 receptor accessory protein0.217
Clec4b1C-type lectin domain family 4, member b10.217
Ticam1toll-like receptor adaptor molecule 10.214
Pyhin1pyrin and HIN domain family, member 10.213
Cxcl13chemokine (C-X-C motif) ligand 130.212
Chrna3cholinergic receptor, nicotinic, alpha polypeptide 30.209
Folr2folate receptor 2 (fetal)0.208
Il1rninterleukin 1 receptor antagonist0.207
Gpr132G protein-coupled receptor 1320.203
Gzmbgranzyme B0.199
Il18r1interleukin 18 receptor 10.197
Neurod1neurogenic differentiation 10.196
Cd84CD84 antigen0.196
Ccr5chemokine (C-C motif) receptor 50.195
Flt3FMS-like tyrosine kinase 30.195
Irf5interferon regulatory factor 50.194
En1engrailed 10.191
Socs3suppressor of cytokine signaling 30.190
Madcam1mucosal vascular addressin cell adhesion molecule 10.189
Ifnar1interferon (alpha and beta) receptor 10.188
Slamf8SLAM family member 80.187
Ikbkbinhibitor of kappaB kinase beta0.187
Nr5a1nuclear receptor subfamily 5, group A, member 10.186
Clec7aC-type lectin domain family 7, member a0.185
Ptgirprostaglandin I receptor (IP)0.182
Ms4a1membrane-spanning 4-domains, subfamily A, member 10.178
Ptprcprotein tyrosine phosphatase, receptor type, C0.176
Ctswcathepsin W0.172
Plaurplasminogen activator, urokinase receptor0.171
Msr1macrophage scavenger receptor 10.170
MecomMDS1 and EVI1 complex locus0.169
Tnip1TNFAIP3 interacting protein 10.168
Csf2rb2colony stimulating factor 2 receptor, beta 2, low-affinity (granulocyte-macrophage)0.167
Osr1odd-skipped related 1 (Drosophila)0.162
Runx1runt related transcription factor 10.160
Slc11a1solute carrier family 11 (proton-coupled divalent metal ion transporters), member 10.160
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Ccl7chemokine (C-C motif) ligand 70.550
Ccl2chemokine (C-C motif) ligand 20.419
Cd14CD14 molecule0.248
Il1binterleukin 1 beta0.218
Stat3signal transducer and activator of transcription 30.207
Cxcl1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.191
Icam1intercellular adhesion molecule 10.177
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.167
Litaflipopolysaccharide-induced TNF factor0.161
Cd44Cd44 molecule0.151
Igsf6immunoglobulin superfamily, member 60.148
Pla2g2aphospholipase A2, group IIA (platelets, synovial fluid)0.148
Cxcl10chemokine (C-X-C motif) ligand 100.126
Ccl3chemokine (C-C motif) ligand 30.113
Myd88myeloid differentiation primary response gene 880.099
Mmp12matrix metallopeptidase 120.098
Timp1TIMP metallopeptidase inhibitor 10.094
Cxcl2chemokine (C-X-C motif) ligand 20.084
Lgals3lectin, galactoside-binding, soluble, 30.083
S100a6S100 calcium binding protein A60.081
Klrd1killer cell lectin-like receptor, subfamily D, member 10.060
Ccr2chemokine (C-C motif) receptor 20.051
Ifi204interferon activated gene 2040.049
Ccl4chemokine (C-C motif) ligand 40.048
Ier3immediate early response 30.048
Olr1oxidized low density lipoprotein (lectin-like) receptor 10.045
C5ar1complement component 5a receptor 10.044
Il6interleukin 60.042
Rab32RAB32, member RAS oncogene family0.040
Il1r2interleukin 1 receptor, type II0.039
Hmox1heme oxygenase (decycling) 10.039
Ltbrlymphotoxin beta receptor (TNFR superfamily, member 3)0.038
Tlr2toll-like receptor 20.037
Itgamintegrin, alpha M0.035
Rgs1regulator of G-protein signaling 10.033
Xdhxanthine dehydrogenase0.031
St8sia4ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 40.031
Junbjun B proto-oncogene0.030
CebpbCCAAT/enhancer binding protein (C/EBP), beta0.030
Il2rginterleukin 2 receptor, gamma0.029
Cdk4cyclin-dependent kinase 40.026
Il8rbinterleukin 8 receptor, beta0.026
Selpselectin P0.025
Plscr1phospholipid scramblase 10.025
Cd247Cd247 molecule0.025
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.024
Cd68Cd68 molecule0.023
Cfdcomplement factor D (adipsin)0.023
Gzmkgranzyme K0.023
Xcl1chemokine (C motif) ligand 10.023
LOC685020similar to paired immunoglobin-like type 2 receptor alpha0.022
Tbc1d2bTBC1 domain family, member 2B0.022
Serpina3nserine (or cysteine) peptidase inhibitor, clade A, member 3N0.021
Bcl3B-cell CLL/lymphoma 30.021
Il4interleukin 40.021
Il1ainterleukin 1 alpha0.021
Slpisecretory leukocyte peptidase inhibitor0.020
Hpgdshematopoietic prostaglandin D synthase0.020
Sellselectin L0.020
Zfp36l1zinc finger protein 36, C3H type-like 10.020
Tspan4tetraspanin 40.020
Ncf4neutrophil cytosolic factor 40.019
Adora2aadenosine A2a receptor0.019
Samsn1SAM domain, SH3 domain and nuclear localization signals, 10.019
Socs3suppressor of cytokine signaling 30.019
Ece1endothelin converting enzyme 10.018
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.018
Vamp8vesicle-associated membrane protein 80.018
Rhojras homolog gene family, member J0.018
Mmp3matrix metallopeptidase 30.017
Fosl1fos-like antigen 10.017
Cxcl3chemokine (C-X-C motif) ligand 30.016
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.016
Efna5ephrin A50.016
Igsf7immunoglobulin superfamily, member 70.016
Map3k8mitogen-activated protein kinase kinase kinase 80.016
Il2rbinterleukin 2 receptor, beta0.015
Csf1colony stimulating factor 1 (macrophage)0.015
Lcn2lipocalin 20.015
CebpdCCAAT/enhancer binding protein (C/EBP), delta0.014
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.014
Adrb2adrenergic, beta-2-, receptor, surface0.014
Atf3activating transcription factor 30.014
Ch25hcholesterol 25-hydroxylase0.013
Cd40CD40 molecule, TNF receptor superfamily member 50.013
Lilrb4leukocyte immunoglobulin-like receptor, subfamily B, member 40.013
Plauplasminogen activator, urokinase0.013
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.012
C1dC1D nuclear receptor co-repressor0.012
Cd8aCD8a molecule0.011
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.011
Ifitm3interferon induced transmembrane protein 30.011
Folr2folate receptor 2 (fetal)0.011
Mrc1mannose receptor, C type 10.011
Gzmbgranzyme B0.011
Ube2d2ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast)0.011
Nmur2neuromedin U receptor 20.010
Bcl2a1dB-cell leukemia/lymphoma 2 related protein A1d0.010
Ncr1natural cytotoxicity triggering receptor 10.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism