The network for 'positive regulation of reactive oxygen species biosynthetic process' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

positive regulation of reactive oxygen species biosynthetic process

Any process that activates or increases the frequency, rate or extent of reactive oxygen species biosynthetic process.

NameDescriptionProbabilityFunc Analog Organism
EGFRepidermal growth factor receptor0.999
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.883
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.841
IL8interleukin 80.679
IL1R1interleukin 1 receptor, type I0.667
GOPCgolgi-associated PDZ and coiled-coil motif containing0.631
IGF1Rinsulin-like growth factor 1 receptor0.553
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.538
TICAM2toll-like receptor adaptor molecule 20.515
NFKBIAnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.504
TNFAIP3tumor necrosis factor, alpha-induced protein 30.460
PPARGC1Aperoxisome proliferator-activated receptor gamma, coactivator 1 alpha0.415
PTPN1protein tyrosine phosphatase, non-receptor type 10.344
FOSFBJ murine osteosarcoma viral oncogene homolog0.325
ZFP36zinc finger protein 36, C3H type, homolog (mouse)0.321
NOXA1NADPH oxidase activator 10.314
TNFRSF1Btumor necrosis factor receptor superfamily, member 1B0.279
PPP5Cprotein phosphatase 5, catalytic subunit0.258
CAV1caveolin 1, caveolae protein, 22kDa0.249
TNIP1TNFAIP3 interacting protein 10.242
STAT5Asignal transducer and activator of transcription 5A0.234
KLF4Kruppel-like factor 4 (gut)0.218
STAT3signal transducer and activator of transcription 3 (acute-phase response factor)0.214
MPDZmultiple PDZ domain protein0.213
NTRK1neurotrophic tyrosine kinase, receptor, type 10.196
MALT1mucosa associated lymphoid tissue lymphoma translocation gene 10.186
PICK1protein interacting with PRKCA 10.181
PKD1polycystic kidney disease 1 (autosomal dominant)0.167
MAP2K4mitogen-activated protein kinase kinase 40.167
INSRinsulin receptor0.167
ALDOBaldolase B, fructose-bisphosphate0.149
RIPK2receptor-interacting serine-threonine kinase 20.148
NFKB1nuclear factor of kappa light polypeptide gene enhancer in B-cells 10.146
NFKBIEnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon0.141
ESR1estrogen receptor 10.141
TNIP2TNFAIP3 interacting protein 20.140
TRPC1transient receptor potential cation channel, subfamily C, member 10.134
EPORerythropoietin receptor0.131
HNF4Ahepatocyte nuclear factor 4, alpha0.129
SOCS1suppressor of cytokine signaling 10.125
MLPHmelanophilin0.119
BCL3B-cell CLL/lymphoma 30.113
RELBv-rel reticuloendotheliosis viral oncogene homolog B0.113
MEF2Amyocyte enhancer factor 2A0.112
NCF1neutrophil cytosolic factor 10.111
MYLK2myosin light chain kinase 20.111
TRADDTNFRSF1A-associated via death domain0.110
SOCS3suppressor of cytokine signaling 30.108
GHRgrowth hormone receptor0.107
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.103
PTPRZ1protein tyrosine phosphatase, receptor-type, Z polypeptide 10.101
IRS1insulin receptor substrate 10.100
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.095
PARD6Apar-6 partitioning defective 6 homolog alpha (C. elegans)0.094
TNFRSF1Atumor necrosis factor receptor superfamily, member 1A0.094
YAP1Yes-associated protein 10.094
MAPTmicrotubule-associated protein tau0.093
TIRAPtoll-interleukin 1 receptor (TIR) domain containing adaptor protein0.092
IL1RAPinterleukin 1 receptor accessory protein0.092
SSTR2somatostatin receptor 20.091
NFKBIZnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta0.091
PARD6Bpar-6 partitioning defective 6 homolog beta (C. elegans)0.088
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.082
NR0B2nuclear receptor subfamily 0, group B, member 20.082
CFLARCASP8 and FADD-like apoptosis regulator0.081
LATlinker for activation of T cells0.080
SOD1superoxide dismutase 1, soluble0.078
XPO7exportin 70.077
PPARGperoxisome proliferator-activated receptor gamma0.073
CSF2RBcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.072
IL1RNinterleukin 1 receptor antagonist0.072
ANKS1Bankyrin repeat and sterile alpha motif domain containing 1B0.071
CTBP1C-terminal binding protein 10.069
NFKB2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)0.068
SRSF5serine/arginine-rich splicing factor 50.066
PSMD4proteasome (prosome, macropain) 26S subunit, non-ATPase, 40.066
APPamyloid beta (A4) precursor protein0.066
CCL14chemokine (C-C motif) ligand 140.064
MEF2Cmyocyte enhancer factor 2C0.062
IL1Binterleukin 1, beta0.061
IL1R2interleukin 1 receptor, type II0.061
GAB2GRB2-associated binding protein 20.061
SH3RF1SH3 domain containing ring finger 10.060
KLF6Kruppel-like factor 60.060
SLC4A1solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group)0.059
DLG2discs, large homolog 2 (Drosophila)0.059
SSTR3somatostatin receptor 30.058
BADBCL2-associated agonist of cell death0.057
LY96lymphocyte antigen 960.057
ARandrogen receptor0.057
MIF4GDMIF4G domain containing0.057
RNF19Bring finger protein 19B0.057
BCAR1breast cancer anti-estrogen resistance 10.057
PRKCZprotein kinase C, zeta0.056
PIK3R2phosphoinositide-3-kinase, regulatory subunit 2 (beta)0.056
SYTL4synaptotagmin-like 40.056
JUNjun proto-oncogene0.054
STAT5Bsignal transducer and activator of transcription 5B0.051
SHANK1SH3 and multiple ankyrin repeat domains 10.051
GRB10growth factor receptor-bound protein 100.050
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Pi3K92ECG4141 gene product from transcript CG4141-RB0.083
spispitz0.053
InRInsulin-like receptor0.039
hephemipterous0.021
EcREcdysone receptor0.019
foxoforkhead box, sub-group O0.016
kaykayak0.014
chicoCG5686 gene product from transcript CG5686-RB0.013
S6kRPS6-p70-protein kinase0.012
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Tnftumor necrosis factor0.998
Ccr2chemokine (C-C motif) receptor 20.993
Tlr4toll-like receptor 40.993
Myd88myeloid differentiation primary response gene 880.986
Nos2nitric oxide synthase 2, inducible0.977
Il10interleukin 100.962
B2mbeta-2 microglobulin0.951
Klra9killer cell lectin-like receptor subfamily A, member 90.921
H2-D1histocompatibility 2, D region locus 10.892
Rag1recombination activating gene 10.877
Ptenphosphatase and tensin homolog0.864
Il6interleukin 60.855
H2-K1histocompatibility 2, K1, K region0.850
Relbavian reticuloendotheliosis viral (v-rel) oncogene related B0.809
Ifnginterferon gamma0.802
Lyz2lysozyme 20.750
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.748
Mef2dmyocyte enhancer factor 2D0.727
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.722
Vdrvitamin D receptor0.696
Il1ainterleukin 1 alpha0.666
Klrk1killer cell lectin-like receptor subfamily K, member 10.589
H2-Q7histocompatibility 2, Q region locus 70.576
Leprleptin receptor0.554
Akt1thymoma viral proto-oncogene 10.553
Ncr1natural cytotoxicity triggering receptor 10.540
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.531
Nos3nitric oxide synthase 3, endothelial cell0.525
Il2rginterleukin 2 receptor, gamma chain0.506
Mmp9matrix metallopeptidase 90.487
Stat3signal transducer and activator of transcription 30.457
FasFas (TNF receptor superfamily member 6)0.444
Cd19CD19 antigen0.443
Map3k14mitogen-activated protein kinase kinase kinase 140.442
Esr1estrogen receptor 1 (alpha)0.428
Lystlysosomal trafficking regulator0.425
Stat1signal transducer and activator of transcription 10.423
Prf1perforin 1 (pore forming protein)0.421
Cd44CD44 antigen0.407
Socs1suppressor of cytokine signaling 10.389
TcraT-cell receptor alpha chain0.387
Ccl2chemokine (C-C motif) ligand 20.385
Ren1renin 1 structural0.375
Hspa8heat shock protein 80.356
Tgfb1transforming growth factor, beta 10.340
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.330
Klrd1killer cell lectin-like receptor, subfamily D, member 10.319
Il6stinterleukin 6 signal transducer0.319
Hsp90ab1heat shock protein 90 alpha (cytosolic), class B member 10.305
Tnfsf11tumor necrosis factor (ligand) superfamily, member 110.289
Spp1secreted phosphoprotein 10.282
Ostm1osteopetrosis associated transmembrane protein 10.280
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.279
Lair1leukocyte-associated Ig-like receptor 10.278
Klrc1killer cell lectin-like receptor subfamily C, member 10.278
Nfkbianuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha0.277
Klra5killer cell lectin-like receptor, subfamily A, member 50.255
Sytl5synaptotagmin-like 50.246
Cpceruloplasmin0.244
Ptprcprotein tyrosine phosphatase, receptor type, C0.239
Gzmbgranzyme B0.234
Slc40a1solute carrier family 40 (iron-regulated transporter), member 10.228
Ptgs2prostaglandin-endoperoxide synthase 20.225
Il7rinterleukin 7 receptor0.216
Trp53transformation related protein 530.213
CblbCasitas B-lineage lymphoma b0.212
Col1a1collagen, type I, alpha 10.206
Hsp90aa1heat shock protein 90, alpha (cytosolic), class A member 10.203
Stx11syntaxin 110.201
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.198
Agtr1aangiotensin II receptor, type 1a0.195
Mapk14mitogen-activated protein kinase 140.191
FaslFas ligand (TNF superfamily, member 6)0.191
Invsinversin0.191
Clec4eC-type lectin domain family 4, member e0.188
Klra7killer cell lectin-like receptor, subfamily A, member 70.187
Crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.187
Slc12a1solute carrier family 12, member 10.186
Smad3MAD homolog 3 (Drosophila)0.184
Nfkbienuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon0.184
H2-Q6histocompatibility 2, Q region locus 60.180
Adamts1a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 10.170
Zbtb37zinc finger and BTB domain containing 370.167
Clec4nC-type lectin domain family 4, member n0.164
Klra6killer cell lectin-like receptor, subfamily A, member 60.162
Cd14CD14 antigen0.153
Flt3FMS-like tyrosine kinase 30.151
Pyhin1pyrin and HIN domain family, member 10.151
Clec4a2C-type lectin domain family 4, member a20.151
Tnfsf14tumor necrosis factor (ligand) superfamily, member 140.150
F9coagulation factor IX0.149
Apoeapolipoprotein E0.149
Vhlvon Hippel-Lindau tumor suppressor0.147
Emr4EGF-like module containing, mucin-like, hormone receptor-like sequence 40.147
Pkd1polycystic kidney disease 1 homolog0.144
Ltalymphotoxin A0.143
Gzmagranzyme A0.136
Adora3adenosine A3 receptor0.133
FcrlaFc receptor-like A0.132
Chordc1cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 10.127
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
LOC100359522LRRGT00191-like0.149
LOC100364265ribosomal protein L19-like0.135
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.035
Serpina3kserine (or cysteine) peptidase inhibitor, clade A, member 3K0.031
Hspa5heat shock protein 50.031
Olr1oxidized low density lipoprotein (lectin-like) receptor 10.030
Slc2a3solute carrier family 2 (facilitated glucose transporter), member 30.028
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.028
Eef2eukaryotic translation elongation factor 20.027
Htr2b5-hydroxytryptamine (serotonin) receptor 2B0.026
Albalbumin0.025
Irf1interferon regulatory factor 10.025
Ccl2chemokine (C-C motif) ligand 20.025
Procprotein C0.025
Ptpn12protein tyrosine phosphatase, non-receptor type 120.024
Dnaja1DnaJ (Hsp40) homolog, subfamily A, member 10.024
Dmgdhdimethylglycine dehydrogenase0.024
Cxcl10chemokine (C-X-C motif) ligand 100.023
Ptgs2prostaglandin-endoperoxide synthase 20.023
C3complement component 30.023
Gna12guanine nucleotide binding protein (G protein) alpha 120.023
Atp1a1ATPase, Na+/K+ transporting, alpha 1 polypeptide0.023
Sykspleen tyrosine kinase0.023
Prkacbprotein kinase, cAMP dependent, catalytic, beta0.022
Mbl1mannose-binding lectin (protein A) 10.022
Acsm5acyl-CoA synthetase medium-chain family member 50.022
Grm8glutamate receptor, metabotropic 80.022
Gpamglycerol-3-phosphate acyltransferase, mitochondrial0.022
Fgafibrinogen alpha chain0.022
Il18interleukin 180.022
Syt4synaptotagmin IV0.021
Ccl3chemokine (C-C motif) ligand 30.021
Slco2a1solute carrier organic anion transporter family, member 2a10.021
Aqp9aquaporin 90.021
A1i3alpha-1-inhibitor III0.021
Ccr2chemokine (C-C motif) receptor 20.021
Dccdeleted in colorectal carcinoma0.021
Cxcl2chemokine (C-X-C motif) ligand 20.021
Cyp3a2cytochrome P450, family 3, subfamily a, polypeptide 20.020
Klrg1killer cell lectin-like receptor subfamily G, member 10.020
Prkcdprotein kinase C, delta0.020
Selpselectin P0.020
Litaflipopolysaccharide-induced TNF factor0.020
Tmigd1transmembrane and immunoglobulin domain containing 10.020
RGD1564599RGD15645990.020
Odf3bouter dense fiber of sperm tails 3B0.020
Il1rninterleukin 1 receptor antagonist0.020
Stat6signal transducer and activator of transcription 60.019
Mmp12matrix metallopeptidase 120.019
Ceacam11carcinoembryonic antigen-related cell adhesion molecule 110.019
Mca32mast cell antigen 320.019
Apoa5apolipoprotein A-V0.019
Agtr1aangiotensin II receptor, type 1a0.019
Slc5a5solute carrier family 5 (sodium iodide symporter), member 50.019
Jak1Janus kinase 10.019
Gckrglucokinase (hexokinase 4) regulator0.019
JunJun oncogene0.019
Gifgastric intrinsic factor0.019
Smad2SMAD family member 20.019
Hsph1heat shock 105/110 protein 10.018
Admadrenomedullin0.018
C8bcomplement component 8, beta polypeptide0.018
Zfp36l1zinc finger protein 36, C3H type-like 10.018
Edn1endothelin 10.018
Tnftumor necrosis factor (TNF superfamily, member 2)0.018
Arf6ADP-ribosylation factor 60.018
LOC100361261rCG23560-like0.018
Csf2rbcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)0.018
Tff3trefoil factor 3, intestinal0.018
Cpb1carboxypeptidase B1 (tissue)0.018
Cyp2c22cytochrome P450, family 2, subfamily c, polypeptide 220.018
Cd2Cd2 molecule0.018
Map2k4mitogen activated protein kinase kinase 40.018
Serpina4serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 40.018
Serpine1serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 10.018
Cxcl1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.018
Pyypeptide YY (mapped)0.018
Rararetinoic acid receptor, alpha0.018
Phkg1phosphorylase kinase, gamma 10.017
Hckhemopoietic cell kinase0.017
Arhgap1Rho GTPase activating protein 10.017
Spp2secreted phosphoprotein 20.017
Spink3serine peptidase inhibitor, Kazal type 30.017
Ptprcprotein tyrosine phosphatase, receptor type, C0.017
Hspa8heat shock protein 80.017
Cd83CD83 molecule0.017
Lgr4leucine-rich repeat-containing G protein-coupled receptor 40.017
Cops7aCOP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis)0.017
Il1binterleukin 1 beta0.017
Il17reinterleukin 17 receptor E0.017
Arl5cADP-ribosylation factor-like 5C0.017
Gria2glutamate receptor, ionotropic, AMPA 20.017
Stat3signal transducer and activator of transcription 30.017
Arl5aADP-ribosylation factor-like 5A0.017
Gulogulonolactone (L-) oxidase0.017
Abcc6ATP-binding cassette, subfamily C (CFTR/MRP), member 60.017
LOC286992peptide HP (rs14)0.017
RGD1359529similar to chromosome 1 open reading frame 630.017
Adam10ADAM metallopeptidase domain 100.017
Adam5a disintegrin and metallopeptidase domain 50.017
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism