The network for 'regulation of intracellular estrogen receptor signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of intracellular estrogen receptor signaling pathway

Any process that modulates the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway.

NameDescriptionProbabilityFunc Analog Organism
NCOA1nuclear receptor coactivator 10.998
CREBBPCREB binding protein0.996
PAK1p21 protein (Cdc42/Rac)-activated kinase 10.996
ESR1estrogen receptor 10.992
NCOA3nuclear receptor coactivator 30.975
NCOA2nuclear receptor coactivator 20.952
ARHGEF7Rho guanine nucleotide exchange factor (GEF) 70.874
WDR5WD repeat domain 50.772
NCOA6nuclear receptor coactivator 60.671
CNOT6LCCR4-NOT transcription complex, subunit 6-like0.506
POU5F1POU class 5 homeobox 10.494
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.480
C16orf53chromosome 16 open reading frame 530.462
GRB2growth factor receptor-bound protein 20.423
CNOT6CCR4-NOT transcription complex, subunit 60.339
SLMAPsarcolemma associated protein0.332
DDX17DEAD (Asp-Glu-Ala-Asp) box polypeptide 170.277
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.246
RXRAretinoid X receptor, alpha0.230
EP300E1A binding protein p3000.206
SIKE1suppressor of IKBKE 10.163
DDX5DEAD (Asp-Glu-Ala-Asp) box polypeptide 50.137
ASH2Lash2 (absent, small, or homeotic)-like (Drosophila)0.130
STRNstriatin, calmodulin binding protein0.126
RBBP5retinoblastoma binding protein 50.115
FYNFYN oncogene related to SRC, FGR, YES0.107
CNOT1CCR4-NOT transcription complex, subunit 10.103
CNOT8CCR4-NOT transcription complex, subunit 80.099
CITED1Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 10.091
RARAretinoic acid receptor, alpha0.091
CNOT3CCR4-NOT transcription complex, subunit 30.082
BAIAP2BAI1-associated protein 20.082
SH3RF3SH3 domain containing ring finger 30.079
ESR2estrogen receptor 2 (ER beta)0.071
RHOUras homolog gene family, member U0.071
PAK2p21 protein (Cdc42/Rac)-activated kinase 20.057
FOXO1forkhead box O10.057
CTTNBP2NLCTTNBP2 N-terminal like0.056
FGFR1OP2FGFR1 oncogene partner 20.055
CEBPBCCAAT/enhancer binding protein (C/EBP), beta0.050
SORBS2sorbin and SH3 domain containing 20.046
SMARCC1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.039
STK24serine/threonine kinase 240.037
BCAR1breast cancer anti-estrogen resistance 10.033
STAT5Asignal transducer and activator of transcription 5A0.032
HNRNPA0heterogeneous nuclear ribonucleoprotein A00.032
CDK11Bcyclin-dependent kinase 11B0.032
CNOT2CCR4-NOT transcription complex, subunit 20.031
NCOR1nuclear receptor corepressor 10.031
SMARCD1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 10.030
GRIP1glutamate receptor interacting protein 10.028
SOX2SRY (sex determining region Y)-box 20.028
RBM4RNA binding motif protein 40.028
TSC22D1TSC22 domain family, member 10.027
ARHGEF6Rac/Cdc42 guanine nucleotide exchange factor (GEF) 60.026
SF1splicing factor 10.024
MED10mediator complex subunit 100.024
SMARCB1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 10.023
CRIPAKcysteine-rich PAK1 inhibitor0.022
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.022
CDK2cyclin-dependent kinase 20.021
CDK8cyclin-dependent kinase 80.020
ARID1AAT rich interactive domain 1A (SWI-like)0.020
CTDSP2CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 20.019
PRMT2protein arginine methyltransferase 20.017
AKAP13A kinase (PRKA) anchor protein 130.016
C10orf46chromosome 10 open reading frame 460.016
MED13mediator complex subunit 130.015
SMAD1SMAD family member 10.014
PARD6Bpar-6 partitioning defective 6 homolog beta (C. elegans)0.014
ERGv-ets erythroblastosis virus E26 oncogene homolog (avian)0.013
PPP5Cprotein phosphatase 5, catalytic subunit0.013
FAM40Afamily with sequence similarity 40, member A0.013
NCF2neutrophil cytosolic factor 20.012
CBLBCas-Br-M (murine) ecotropic retroviral transforming sequence b0.012
CNOT7CCR4-NOT transcription complex, subunit 70.012
CTTNcortactin0.012
GPIglucose-6-phosphate isomerase0.011
PAXIP1PAX interacting (with transcription-activation domain) protein 10.011
C14orf43chromosome 14 open reading frame 430.011
PARD6Gpar-6 partitioning defective 6 homolog gamma (C. elegans)0.010
KIF21Akinesin family member 21A0.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Esr1estrogen receptor 1 (alpha)0.534
Kiss1KiSS-1 metastasis-suppressor0.307
Nr5a1nuclear receptor subfamily 5, group A, member 10.195
Amhr2anti-Mullerian hormone type 2 receptor0.176
Ptprcprotein tyrosine phosphatase, receptor type, C0.133
Fshrfollicle stimulating hormone receptor0.074
Foxa2forkhead box A20.064
Khdrbs1KH domain containing, RNA binding, signal transduction associated 10.052
Cyp19a1cytochrome P450, family 19, subfamily a, polypeptide 10.051
Plcg2phospholipase C, gamma 20.050
Clockcircadian locomotor output cycles kaput0.046
Ptenphosphatase and tensin homolog0.043
Pax8paired box gene 80.042
WasWiskott-Aldrich syndrome homolog (human)0.041
Rac1RAS-related C3 botulinum substrate 10.036
Ghrgrowth hormone receptor0.036
Cdc42cell division cycle 42 homolog (S. cerevisiae)0.033
Pitx2paired-like homeodomain transcription factor 20.031
Cgaglycoprotein hormones, alpha subunit0.027
Gnrh1gonadotropin releasing hormone 10.026
Lhx3LIM homeobox protein 30.026
Lhcgrluteinizing hormone/choriogonadotropin receptor0.024
Ptpreprotein tyrosine phosphatase, receptor type, E0.024
Cd19CD19 antigen0.023
BC018507cDNA sequence BC0185070.023
Prlrprolactin receptor0.022
Arandrogen receptor0.022
Cdkn1bcyclin-dependent kinase inhibitor 1B0.021
Inhainhibin alpha0.021
Foxf2forkhead box F20.020
Pou2af1POU domain, class 2, associating factor 10.019
BlnkB-cell linker0.018
SpibSpi-B transcription factor (Spi-1/PU.1 related)0.018
Nr0b1nuclear receptor subfamily 0, group B, member 10.018
CblCasitas B-lineage lymphoma0.018
Cd22CD22 antigen0.017
Kiss1rKISS1 receptor0.016
Hnrnph1heterogeneous nuclear ribonucleoprotein H10.016
Cd247CD247 antigen0.015
Cd180CD180 antigen0.015
Ncoa6nuclear receptor coactivator 60.015
Bmpr1abone morphogenetic protein receptor, type 1A0.014
Gata4GATA binding protein 40.014
Foxn1forkhead box N10.014
Esyt3extended synaptotagmin-like protein 30.014
Duox2dual oxidase 20.014
Rac2RAS-related C3 botulinum substrate 20.014
Il2rbinterleukin 2 receptor, beta chain0.014
Cd8aCD8 antigen, alpha chain0.012
Myf5myogenic factor 50.012
Lcklymphocyte protein tyrosine kinase0.012
Prkceprotein kinase C, epsilon0.012
Tnfrsf13ctumor necrosis factor receptor superfamily, member 13c0.012
Zic3zinc finger protein of the cerebellum 30.011
Inhbainhibin beta-A0.011
Hdgfl1hepatoma derived growth factor-like 10.011
Ighimmunoglobulin heavy chain complex0.011
Cd79aCD79A antigen (immunoglobulin-associated alpha)0.010
OgtO-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)0.010
Gnrhrgonadotropin releasing hormone receptor0.010
Hcls1hematopoietic cell specific Lyn substrate 10.010
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Ntrk1neurotrophic tyrosine kinase, receptor, type 10.020
Akap14A kinase (PRKA) anchor protein 140.014
Tnrtenascin R0.014
Pfkfb26-phosphofructo-2-kinase/fructose-2,6-biphosphatase 20.013
Ascl1achaete-scute complex homolog 1 (Drosophila)0.013
Pou2f2POU class 2 homeobox 20.012
Kcnj13potassium inwardly-rectifying channel, subfamily J, member 130.012
Cacna1ccalcium channel, voltage-dependent, L type, alpha 1C subunit0.011
Ddr1discoidin domain receptor tyrosine kinase 10.011
Cacnb1calcium channel, voltage-dependent, beta 1 subunit0.011
Scn9asodium channel, voltage-gated, type IX, alpha0.011
Fgfr2fibroblast growth factor receptor 20.011
Ngfrnerve growth factor receptor (TNFR superfamily, member 16)0.010
Usp19ubiquitin specific peptidase 190.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism