The network for 'regulation of intracellular steroid hormone receptor signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of intracellular steroid hormone receptor signaling pathway

Any process that modulates the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway.

NameDescriptionProbabilityFunc Analog Organism
ESR1estrogen receptor 11.000
CREBBPCREB binding protein0.997
NCOA1nuclear receptor coactivator 10.980
ARandrogen receptor0.963
HDAC1histone deacetylase 10.949
EP300E1A binding protein p3000.939
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.723
NCOA3nuclear receptor coactivator 30.714
NCOA2nuclear receptor coactivator 20.698
KAT2BK(lysine) acetyltransferase 2B0.644
SMAD3SMAD family member 30.555
RB1retinoblastoma 10.554
TRIM39tripartite motif containing 390.541
MTA1metastasis associated 10.493
QKIquaking homolog, KH domain RNA binding (mouse)0.472
C16orf53chromosome 16 open reading frame 530.455
POU5F1POU class 5 homeobox 10.412
ARID1AAT rich interactive domain 1A (SWI-like)0.396
RORARAR-related orphan receptor A0.383
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.380
DDX5DEAD (Asp-Glu-Ala-Asp) box polypeptide 50.361
NCOA6nuclear receptor coactivator 60.278
RXRAretinoid X receptor, alpha0.276
MDM2Mdm2 p53 binding protein homolog (mouse)0.275
ARHGEF7Rho guanine nucleotide exchange factor (GEF) 70.266
CNOT8CCR4-NOT transcription complex, subunit 80.251
HIPK2homeodomain interacting protein kinase 20.242
MED15mediator complex subunit 150.240
STRNstriatin, calmodulin binding protein0.216
SMAD9SMAD family member 90.214
NCOR1nuclear receptor corepressor 10.206
LDB1LIM domain binding 10.206
UBA1ubiquitin-like modifier activating enzyme 10.203
CNOT6LCCR4-NOT transcription complex, subunit 6-like0.190
HNRNPKheterogeneous nuclear ribonucleoprotein K0.188
MTA3metastasis associated 1 family, member 30.184
DDX17DEAD (Asp-Glu-Ala-Asp) box polypeptide 170.166
SP1Sp1 transcription factor0.164
MBD1methyl-CpG binding domain protein 10.157
RNF5ring finger protein 50.149
DAXXdeath-domain associated protein0.142
ESR2estrogen receptor 2 (ER beta)0.142
PMLpromyelocytic leukemia0.139
CLOCKclock homolog (mouse)0.135
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.133
SKILSKI-like oncogene0.131
UBE2D1ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)0.123
RNF126ring finger protein 1260.112
ARID1BAT rich interactive domain 1B (SWI1-like)0.111
RARAretinoic acid receptor, alpha0.111
FOXO1forkhead box O10.106
ARNTLaryl hydrocarbon receptor nuclear translocator-like0.093
SMAD4SMAD family member 40.089
CBLBCas-Br-M (murine) ecotropic retroviral transforming sequence b0.088
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.087
ZNF263zinc finger protein 2630.080
NFAT5nuclear factor of activated T-cells 5, tonicity-responsive0.077
MTA2metastasis associated 1 family, member 20.074
RNF111ring finger protein 1110.071
TSC22D1TSC22 domain family, member 10.070
NRIP1nuclear receptor interacting protein 10.070
MYO6myosin VI0.069
SUMO1SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)0.065
ARRB1arrestin, beta 10.062
CNOT3CCR4-NOT transcription complex, subunit 30.062
SMAD1SMAD family member 10.057
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.055
YY1YY1 transcription factor0.054
SKP1S-phase kinase-associated protein 10.054
PARP1poly (ADP-ribose) polymerase 10.053
BMPR1Bbone morphogenetic protein receptor, type IB0.052
CNOT4CCR4-NOT transcription complex, subunit 40.051
GRIP1glutamate receptor interacting protein 10.048
TRIM43tripartite motif containing 430.048
LDB2LIM domain binding 20.048
UBE2E2ubiquitin-conjugating enzyme E2E 2 (UBC4/5 homolog, yeast)0.045
KDM1Alysine (K)-specific demethylase 1A0.043
LMO4LIM domain only 40.043
PIAS1protein inhibitor of activated STAT, 10.043
PPP5Cprotein phosphatase 5, catalytic subunit0.040
FAM40Afamily with sequence similarity 40, member A0.037
SP3Sp3 transcription factor0.037
HEYLhairy/enhancer-of-split related with YRPW motif-like0.037
SIRT1sirtuin 10.036
HIPK1homeodomain interacting protein kinase 10.035
CSNK1Ecasein kinase 1, epsilon0.034
SMURF2SMAD specific E3 ubiquitin protein ligase 20.034
SMAD2SMAD family member 20.033
SEC24DSEC24 family, member D (S. cerevisiae)0.032
CNOT6CCR4-NOT transcription complex, subunit 60.031
RNF4ring finger protein 40.031
RNF11ring finger protein 110.031
STAU1staufen, RNA binding protein, homolog 1 (Drosophila)0.031
MAPRE2microtubule-associated protein, RP/EB family, member 20.030
CHD3chromodomain helicase DNA binding protein 30.030
TRIM5tripartite motif containing 50.030
CUEDC2CUE domain containing 20.030
SIAH1seven in absentia homolog 1 (Drosophila)0.030
TOPORStopoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase0.030
SOX2SRY (sex determining region Y)-box 20.029
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Arntlaryl hydrocarbon receptor nuclear translocator-like1.000
Per2period homolog 2 (Drosophila)1.000
Clockcircadian locomotor output cycles kaput1.000
Esr1estrogen receptor 1 (alpha)0.981
Sirt1sirtuin 1 (silent mating type information regulation 2, homolog) 1 (S. cerevisiae)0.910
Ptenphosphatase and tensin homolog0.876
Ghrgrowth hormone receptor0.865
Cry1cryptochrome 1 (photolyase-like)0.822
Rac1RAS-related C3 botulinum substrate 10.676
Leprleptin receptor0.667
Drd2dopamine receptor D20.639
Foxa2forkhead box A20.553
Ahraryl-hydrocarbon receptor0.535
Cry2cryptochrome 2 (photolyase-like)0.529
Ptpn11protein tyrosine phosphatase, non-receptor type 110.445
Esr2estrogen receptor 2 (beta)0.422
Thrbthyroid hormone receptor beta0.418
Pitx2paired-like homeodomain transcription factor 20.305
Fshrfollicle stimulating hormone receptor0.283
Pax8paired box gene 80.252
Cyp19a1cytochrome P450, family 19, subfamily a, polypeptide 10.246
Arandrogen receptor0.244
Kiss1KiSS-1 metastasis-suppressor0.234
Sall4sal-like 4 (Drosophila)0.216
Thrathyroid hormone receptor alpha0.210
Fgf10fibroblast growth factor 100.189
Egr2early growth response 20.186
Bglapbone gamma carboxyglutamate protein0.180
Egfrepidermal growth factor receptor0.178
Cd247CD247 antigen0.174
Cdkn1bcyclin-dependent kinase inhibitor 1B0.162
CblCasitas B-lineage lymphoma0.156
Cdc42cell division cycle 42 homolog (S. cerevisiae)0.149
Timp1tissue inhibitor of metalloproteinase 10.137
Retret proto-oncogene0.134
Arrb1arrestin, beta 10.125
Prlrprolactin receptor0.115
Esrrbestrogen related receptor, beta0.115
Fgfr2fibroblast growth factor receptor 20.114
Il2rginterleukin 2 receptor, gamma chain0.099
Adra1aadrenergic receptor, alpha 1a0.091
OgtO-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)0.086
Hand2heart and neural crest derivatives expressed transcript 20.083
Tcf21transcription factor 210.078
Cgaglycoprotein hormones, alpha subunit0.074
Kiss1rKISS1 receptor0.072
Csnk1ecasein kinase 1, epsilon0.072
Erbb3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.070
Lgals12lectin, galactose binding, soluble 120.070
Amhr2anti-Mullerian hormone type 2 receptor0.068
Phox2bpaired-like homeobox 2b0.066
Duox2dual oxidase 20.065
Sfrp2secreted frizzled-related protein 20.064
Csf1colony stimulating factor 1 (macrophage)0.064
Pik3caphosphatidylinositol 3-kinase, catalytic, alpha polypeptide0.061
Insrinsulin receptor0.061
Zic3zinc finger protein of the cerebellum 30.060
Chordc1cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 10.059
Ptk2PTK2 protein tyrosine kinase 20.058
Lhcgrluteinizing hormone/choriogonadotropin receptor0.057
Ctbp2C-terminal binding protein 20.054
Igf1insulin-like growth factor 10.053
Pgrprogesterone receptor0.051
Nr0b1nuclear receptor subfamily 0, group B, member 10.051
Ptpreprotein tyrosine phosphatase, receptor type, E0.050
Adam17a disintegrin and metallopeptidase domain 170.048
Ighmbp2immunoglobulin mu binding protein 20.048
TyrobpTYRO protein tyrosine kinase binding protein0.048
Cdkn1ccyclin-dependent kinase inhibitor 1C (P57)0.047
Rb1retinoblastoma 10.045
Tcfcp2l1transcription factor CP2-like 10.044
Irs2insulin receptor substrate 20.043
Fcer1gFc receptor, IgE, high affinity I, gamma polypeptide0.043
Nr3c1nuclear receptor subfamily 3, group C, member 10.040
Grb10growth factor receptor bound protein 100.040
Myf5myogenic factor 50.039
Nr5a1nuclear receptor subfamily 5, group A, member 10.039
Bdnfbrain derived neurotrophic factor0.038
Samm50sorting and assembly machinery component 50 homolog (S. cerevisiae)0.037
Pou4f2POU domain, class 4, transcription factor 20.036
Pthlhparathyroid hormone-like peptide0.034
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.034
Pik3r1phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)0.033
Ptprcprotein tyrosine phosphatase, receptor type, C0.033
Sim1single-minded homolog 1 (Drosophila)0.033
Polr2apolymerase (RNA) II (DNA directed) polypeptide A0.032
Ctnnb1catenin (cadherin associated protein), beta 10.032
Itgb1integrin beta 1 (fibronectin receptor beta)0.032
Tial1Tia1 cytotoxic granule-associated RNA binding protein-like 10.031
Gsx1GS homeobox 10.031
Ncoa6nuclear receptor coactivator 60.030
AxlAXL receptor tyrosine kinase0.030
Arid1aAT rich interactive domain 1A (SWI-like)0.030
Hif1ahypoxia inducible factor 1, alpha subunit0.029
Npas2neuronal PAS domain protein 20.029
Gfra1glial cell line derived neurotrophic factor family receptor alpha 10.028
BlnkB-cell linker0.028
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism