The network for 'interaction with host' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

interaction with host

An interaction between two organisms living together in more or less intimate association. The term host is used for the larger (macro) of the two members of a symbiosis; the various forms of symbiosis include parasitism, commensalism and mutualism.

NameDescriptionProbabilityFunc Analog Organism
SMURF2SMAD specific E3 ubiquitin protein ligase 20.997
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.995
BCL2B-cell CLL/lymphoma 20.993
SMAD3SMAD family member 30.974
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.959
RNF11ring finger protein 110.937
IFIT1interferon-induced protein with tetratricopeptide repeats 10.918
SMAD1SMAD family member 10.913
BCL2L1BCL2-like 10.863
TAP1transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)0.850
DDX58DEAD (Asp-Glu-Ala-Asp) box polypeptide 580.850
SMAD2SMAD family member 20.821
IFITM2interferon induced transmembrane protein 2 (1-8D)0.788
PVRL1poliovirus receptor-related 1 (herpesvirus entry mediator C)0.754
MED25mediator complex subunit 250.736
IFIT3interferon-induced protein with tetratricopeptide repeats 30.702
UBE2D4ubiquitin-conjugating enzyme E2D 4 (putative)0.702
SMAD5SMAD family member 50.693
FHL2four and a half LIM domains 20.681
BAXBCL2-associated X protein0.601
CCT8chaperonin containing TCP1, subunit 8 (theta)0.597
RRAGCRas-related GTP binding C0.596
TAPBPTAP binding protein (tapasin)0.584
IFIT5interferon-induced protein with tetratricopeptide repeats 50.544
ISG15ISG15 ubiquitin-like modifier0.529
SMAD4SMAD family member 40.455
RNF5ring finger protein 50.450
TAP2transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)0.440
AXLAXL receptor tyrosine kinase0.422
SMURF1SMAD specific E3 ubiquitin protein ligase 10.417
UBE2V1ubiquitin-conjugating enzyme E2 variant 10.392
RARAretinoic acid receptor, alpha0.392
TRIM39tripartite motif containing 390.364
ITGA5integrin, alpha 5 (fibronectin receptor, alpha polypeptide)0.359
BAK1BCL2-antagonist/killer 10.354
IFIT2interferon-induced protein with tetratricopeptide repeats 20.314
UBE2L6ubiquitin-conjugating enzyme E2L 60.294
PDIA3protein disulfide isomerase family A, member 30.273
TGFB1transforming growth factor, beta 10.266
IFITM3interferon induced transmembrane protein 3 (1-8U)0.242
DYNC1I2dynein, cytoplasmic 1, intermediate chain 20.226
RBCK1RanBP-type and C3HC4-type zinc finger containing 10.202
TGFBR1transforming growth factor, beta receptor 10.170
SMAD6SMAD family member 60.169
ZNFX1zinc finger, NFX1-type containing 10.168
MED15mediator complex subunit 150.168
SKILSKI-like oncogene0.160
TLN1talin 10.159
TGM2transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)0.155
FBXL15F-box and leucine-rich repeat protein 150.144
THBS1thrombospondin 10.144
PVRL3poliovirus receptor-related 30.140
PVRL4poliovirus receptor-related 40.139
DAXXdeath-domain associated protein0.130
ZFYVE9zinc finger, FYVE domain containing 90.129
INSRinsulin receptor0.127
TRIM21tripartite motif containing 210.123
CYLDcylindromatosis (turban tumor syndrome)0.121
SP110SP110 nuclear body protein0.119
TNFRSF12Atumor necrosis factor receptor superfamily, member 12A0.118
GCC1GRIP and coiled-coil domain containing 10.114
ITGB4integrin, beta 40.113
XIAPX-linked inhibitor of apoptosis0.110
IRF9interferon regulatory factor 90.107
CXXC5CXXC finger protein 50.104
TRIM43tripartite motif containing 430.104
EFCAB4BEF-hand calcium binding domain 4B0.101
TP53tumor protein p530.099
PTPN1protein tyrosine phosphatase, non-receptor type 10.095
ANKRD13Aankyrin repeat domain 13A0.091
HLA-Amajor histocompatibility complex, class I, A0.090
BCL2L11BCL2-like 11 (apoptosis facilitator)0.089
BADBCL2-associated agonist of cell death0.089
SPOPspeckle-type POZ protein0.088
PMAIP1phorbol-12-myristate-13-acetate-induced protein 10.087
SCNN1Bsodium channel, nonvoltage-gated 1, beta0.087
PPP2CBprotein phosphatase 2, catalytic subunit, beta isozyme0.086
IFITM1interferon induced transmembrane protein 1 (9-27)0.084
IGF1Rinsulin-like growth factor 1 receptor0.082
FN1fibronectin 10.077
CD63CD63 molecule0.076
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.074
RHOAras homolog gene family, member A0.073
PVRL2poliovirus receptor-related 2 (herpesvirus entry mediator B)0.073
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.071
FAM46Afamily with sequence similarity 46, member A0.068
MOV10Mov10, Moloney leukemia virus 10, homolog (mouse)0.068
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.067
ZNF263zinc finger protein 2630.065
DYNLL1dynein, light chain, LC8-type 10.065
VDAC1voltage-dependent anion channel 10.063
UBE2Uubiquitin-conjugating enzyme E2U (putative)0.061
TRIM5tripartite motif containing 50.060
RRAGDRas-related GTP binding D0.058
STAU1staufen, RNA binding protein, homolog 1 (Drosophila)0.057
PROX1prospero homeobox 10.057
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
itgb3bintegrin beta 3b0.292
mcl1amyeloid cell leukemia sequence 1a0.108
eif4a1aeukaryotic translation initiation factor 4A, isoform 1A0.103
ripk2receptor-interacting serine-threonine kinase 20.098
lamc1laminin, gamma 10.092
atp2b4ATPase, Ca++ transporting, plasma membrane 40.089
LOC566020Gig2-like protein DreO0.081
nr3c1nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)0.075
xbp1X-box binding protein 10.073
mxi1max interacting protein0.071
tcf7transcription factor 7 (T-cell specific, HMG-box)0.068
rspo1R-spondin homolog (Xenopus laevis)0.065
map2k4amitogen-activated protein kinase kinase 4a0.061
igf1rbinsulin-like growth factor 1b receptor0.058
mdm2transformed 3T3 cell double minute 2 homolog (mouse)0.058
mychmyelocytomatosis oncogene homolog0.058
cflarCASP8 and FADD-like apoptosis regulator0.057
ca8carbonic anhydrase VIII0.057
pkzprotein kinase containing Z-DNA binding domains0.056
tead3aTEA domain family member 3 a0.056
LOC567131calcitonin gene-related peptide type 1 receptor-like0.056
lass2LAG1 homolog, ceramide synthase 2 (S. cerevisiae)0.055
greb1growth regulation by estrogen in breast cancer 10.054
jag2jagged 20.051
shmt2serine hydroxymethyltransferase 2 (mitochondrial)0.051
ptpraprotein tyrosine phosphatase, receptor type, A0.051
mycamyelocytomatosis oncogene a0.049
rargbretinoic acid receptor, gamma b0.047
furinbfurin (paired basic amino acid cleaving enzyme) b0.047
alcamaactivated leukocyte cell adhesion molecule a0.047
ube2l3aubiquitin-conjugating enzyme E2L 3a0.046
bcl2l1bcl2-like 10.046
ef1aelongation factor 1-alpha0.046
tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.045
insrbinsulin receptor b0.045
yes1v-yes-1 Yamaguchi sarcoma viral oncogene homolog 10.044
tfe3atranscription factor binding to IGHM enhancer 3a0.044
eef2beukaryotic translation elongation factor 2b0.043
tp53bp2tumor protein p53 binding protein, 20.043
dusp1dual specificity phosphatase 10.042
slc2a11lsolute carrier family 2 (facilitated glucose transporter), member 11-like0.041
ifnphi1interferon phi 10.040
isg15ISG15 ubiquitin-like modifier0.040
robo4roundabout homolog 40.040
trim13tripartite motif-containing 130.039
lef1lymphocyte enhancer binding factor 10.039
cecr1acat eye syndrome chromosome region, candidate 1a0.039
vdravitamin D receptor a0.039
spry4sprouty (Drosophila) homolog 40.038
lama2laminin, alpha 20.037
ism1isthmin 10.036
baxabcl2-associated X protein, a0.036
stat1asignal transduction and activation of transcription 1a0.035
mycl1bv-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian) b0.034
gnb1aguanine nucleotide binding protein (G protein), beta polypeptide 1a0.034
arf5ADP-ribosylation factor 50.034
furinafurin (paired basic amino acid cleaving enzyme) a0.034
unc5bunc-5 homolog B (C. elegans)0.033
glulbglutamate-ammonia ligase (glutamine synthase) b0.033
tia1lcytotoxic granule-associated RNA binding protein 1, like0.032
casp8caspase 8, apoptosis-related cysteine peptidase0.032
bmf1Bcl2 modifying factor 10.032
sdf4stromal cell derived factor 40.030
cct2chaperonin containing TCP1, subunit 2 (beta)0.030
cyp3c1cytochrome P450, family 3, subfamily c, polypeptide 10.030
LOC100535549cytoplasmic polyadenylation element-binding protein 4-like0.030
jam3bjunctional adhesion molecule 3b0.029
stat3signal transduction and activation of transcription 30.029
junbljun B proto-oncogene, like0.029
prdm5PR domain containing 50.028
eprsglutamyl-prolyl-tRNA synthetase0.028
abcb3l1ATP-binding cassette, sub-family B (MDR/TAP), member 3 like 10.028
eif2ak2eukaryotic translation initiation factor 2-alpha kinase 20.028
kiss1KiSS-1 metastasis-suppressor0.027
cry3cryptochrome 30.027
sec61al2Sec61 alpha like 20.027
slc25a14solute carrier family 25 (mitochondrial carrier, brain), member 140.027
mknk2bMAP kinase-interacting serine/threonine kinase 2b0.026
LOC560602novel protein similar to vertebrate solute carrier family 2 (facilitated glucose transporter), member 6 (SLC2A6)0.026
irgq1immunity-related GTPase family, q10.026
rln3arelaxin 3a0.025
rnd1lRho family GTPase 1 like0.025
il17rdinterleukin 17 receptor D0.025
ldb1aLIM-domain binding factor 1a0.025
trim3atripartite motif-containing 3a0.025
bmp7bbone morphogenetic protein 7b0.025
slc2a10solute carrier family 2 (facilitated glucose transporter), member 100.025
mbtps1membrane-bound transcription factor protease, site 10.025
rxfp1relaxin/insulin-like family peptide receptor 10.025
sat1bspermidine/spermine N1-acetyl transferase 1b0.024
nos2anitric oxide synthase 2a, inducible0.024
vps4bvacuolar protein sorting 4b (yeast)0.024
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
TapbpTAP binding protein0.875
Trim30dtripartite motif-containing 30D0.472
Trim30atripartite motif-containing 30A0.460
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.395
Ifitm3interferon induced transmembrane protein 30.371
Ccr2chemokine (C-C motif) receptor 20.358
Traf3ip2TRAF3 interacting protein 20.210
Cd44CD44 antigen0.210
Irf9interferon regulatory factor 90.206
Irgm2immunity-related GTPase family M member 20.183
Irgm1immunity-related GTPase family M member 10.182
Stat1signal transducer and activator of transcription 10.180
Gbp7guanylate binding protein 70.178
Tgfb1transforming growth factor, beta 10.176
Il10interleukin 100.172
Kitkit oncogene0.172
Parp14poly (ADP-ribose) polymerase family, member 140.151
Tlr4toll-like receptor 40.145
Ifi44interferon-induced protein 440.143
Nos2nitric oxide synthase 2, inducible0.128
Trim21tripartite motif-containing 210.122
Ifih1interferon induced with helicase C domain 10.116
Trim12atripartite motif-containing 12A0.100
Spp1secreted phosphoprotein 10.096
Ddx60DEAD (Asp-Glu-Ala-Asp) box polypeptide 600.094
Myd88myeloid differentiation primary response gene 880.089
Ptprcprotein tyrosine phosphatase, receptor type, C0.086
Ifitm2interferon induced transmembrane protein 20.085
Bcl2B-cell leukemia/lymphoma 20.085
Oasl22'-5' oligoadenylate synthetase-like 20.085
Ptpn22protein tyrosine phosphatase, non-receptor type 22 (lymphoid)0.084
Usp18ubiquitin specific peptidase 180.083
Grb10growth factor receptor bound protein 100.079
Dtx3ldeltex 3-like (Drosophila)0.073
Icam1intercellular adhesion molecule 10.072
Tgfbr2transforming growth factor, beta receptor II0.072
Vdrvitamin D receptor0.071
Ifit3interferon-induced protein with tetratricopeptide repeats 30.068
Gbp3guanylate binding protein 30.067
Cct5chaperonin containing Tcp1, subunit 5 (epsilon)0.064
Foxp3forkhead box P30.064
Trim55tripartite motif-containing 550.062
Nos1nitric oxide synthase 1, neuronal0.060
Leprleptin receptor0.058
Tap1transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)0.058
Elavl1ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)0.056
Slfn4schlafen 40.055
Csf1colony stimulating factor 1 (macrophage)0.051
Isg15ISG15 ubiquitin-like modifier0.051
B2mbeta-2 microglobulin0.050
Rag1recombination activating gene 10.050
Gm12185predicted gene 121850.049
Cd19CD19 antigen0.049
S100a8S100 calcium binding protein A8 (calgranulin A)0.047
Uba7ubiquitin-like modifier activating enzyme 70.046
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.046
Ikzf1IKAROS family zinc finger 10.046
Parp10poly (ADP-ribose) polymerase family, member 100.045
Socs1suppressor of cytokine signaling 10.045
Fcgr2bFc receptor, IgG, low affinity IIb0.042
Rtp4receptor transporter protein 40.040
Eif2ak2eukaryotic translation initiation factor 2-alpha kinase 20.039
Psmb8proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)0.038
Tmem176atransmembrane protein 176A0.038
Ifnabinterferon alpha B0.037
Ighimmunoglobulin heavy chain complex0.035
Plauplasminogen activator, urokinase0.034
Rsad2radical S-adenosyl methionine domain containing 20.034
Nfe2l2nuclear factor, erythroid derived 2, like 20.032
Esr1estrogen receptor 1 (alpha)0.032
Pyhin1pyrin and HIN domain family, member 10.032
Vhlvon Hippel-Lindau tumor suppressor0.032
Ifi35interferon-induced protein 350.032
Stat3signal transducer and activator of transcription 30.031
Nfkb1nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p1050.031
Tor3atorsin family 3, member A0.031
Ppargperoxisome proliferator activated receptor gamma0.031
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.029
Il2interleukin 20.029
Ifnginterferon gamma0.029
LynYamaguchi sarcoma viral (v-yes-1) oncogene homolog0.029
Ifi47interferon gamma inducible protein 470.029
Ddx58DEAD (Asp-Glu-Ala-Asp) box polypeptide 580.028
Samhd1SAM domain and HD domain, 10.028
Il6stinterleukin 6 signal transducer0.028
Stx6syntaxin 60.028
Cd14CD14 antigen0.027
Tnfaip3tumor necrosis factor, alpha-induced protein 30.027
Ticam1toll-like receptor adaptor molecule 10.027
Acvr1activin A receptor, type 10.027
Herc6hect domain and RLD 60.026
Samd9lsterile alpha motif domain containing 9-like0.026
Lgals9lectin, galactose binding, soluble 90.026
Cdk9cyclin-dependent kinase 9 (CDC2-related kinase)0.025
Dmddystrophin, muscular dystrophy0.025
Ifit1interferon-induced protein with tetratricopeptide repeats 10.024
Iigp1interferon inducible GTPase 10.024
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.024
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism