The network for 'regulation of intrinsic apoptotic signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of intrinsic apoptotic signaling pathway

Any process that modulates the frequency, rate or extent of intrinsic apoptotic signaling pathway.

NameDescriptionProbabilityFunc Analog Organism
BCL2L1BCL2-like 11.000
BCL2B-cell CLL/lymphoma 20.998
TP53tumor protein p530.998
BCL2L11BCL2-like 11 (apoptosis facilitator)0.990
MDM2Mdm2 p53 binding protein homolog (mouse)0.987
USP7ubiquitin specific peptidase 7 (herpes virus-associated)0.976
UBCubiquitin C0.976
BAXBCL2-associated X protein0.942
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.924
SFPQsplicing factor proline/glutamine-rich0.878
HDAC1histone deacetylase 10.867
MCL1myeloid cell leukemia sequence 1 (BCL2-related)0.866
TP53BP2tumor protein p53 binding protein, 20.845
NFE2L2nuclear factor (erythroid-derived 2)-like 20.793
CFTRcystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)0.786
PMLpromyelocytic leukemia0.777
BIDBH3 interacting domain death agonist0.774
SQSTM1sequestosome 10.754
S100A9S100 calcium binding protein A90.752
DAXXdeath-domain associated protein0.748
UBE3Aubiquitin protein ligase E3A0.722
S100A8S100 calcium binding protein A80.715
GUCY2Cguanylate cyclase 2C (heat stable enterotoxin receptor)0.669
S100A1S100 calcium binding protein A10.643
S100BS100 calcium binding protein B0.642
MDM4Mdm4 p53 binding protein homolog (mouse)0.641
RYBPRING1 and YY1 binding protein0.631
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)0.622
BMI1BMI1 polycomb ring finger oncogene0.607
S100A6S100 calcium binding protein A60.567
SLC9A3R1solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 10.552
MAFGv-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)0.546
S100A4S100 calcium binding protein A40.522
ESR1estrogen receptor 10.517
BADBCL2-associated agonist of cell death0.475
DERL1Der1-like domain family, member 10.472
BAK1BCL2-antagonist/killer 10.462
LASS2LAG1 homolog, ceramide synthase 20.445
SPRR2Asmall proline-rich protein 2A0.435
BIRC3baculoviral IAP repeat containing 30.414
XIAPX-linked inhibitor of apoptosis0.411
PTENphosphatase and tensin homolog0.406
HCKhemopoietic cell kinase0.399
UBQLN1ubiquilin 10.390
RELAv-rel reticuloendotheliosis viral oncogene homolog A (avian)0.389
ANXA2annexin A20.387
LCKlymphocyte-specific protein tyrosine kinase0.382
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.356
CASP8caspase 8, apoptosis-related cysteine peptidase0.335
TOP1topoisomerase (DNA) I0.332
SYVN1synovial apoptosis inhibitor 1, synoviolin0.330
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.310
SIN3ASIN3 homolog A, transcription regulator (yeast)0.308
MAPK8mitogen-activated protein kinase 80.299
S100A14S100 calcium binding protein A140.293
ZNF746zinc finger protein 7460.292
RNF11ring finger protein 110.284
DAZAP2DAZ associated protein 20.281
HSP90AA1heat shock protein 90kDa alpha (cytosolic), class A member 10.279
ITCHitchy E3 ubiquitin protein ligase homolog (mouse)0.279
SEPT2septin 20.272
WWOXWW domain containing oxidoreductase0.271
FKBP4FK506 binding protein 4, 59kDa0.269
JUNjun proto-oncogene0.267
HSP90B1heat shock protein 90kDa beta (Grp94), member 10.253
SYKspleen tyrosine kinase0.247
SMCR7LSmith-Magenis syndrome chromosome region, candidate 7-like0.246
BIKBCL2-interacting killer (apoptosis-inducing)0.244
IL8interleukin 80.235
FASFas (TNF receptor superfamily, member 6)0.230
ANXA1annexin A10.227
PPP1CCprotein phosphatase 1, catalytic subunit, gamma isozyme0.223
TNFAIP3tumor necrosis factor, alpha-induced protein 30.217
CASC5cancer susceptibility candidate 50.207
CANXcalnexin0.199
S100A11S100 calcium binding protein A110.194
BECN1beclin 1, autophagy related0.187
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.180
GSK3Bglycogen synthase kinase 3 beta0.178
RIPK2receptor-interacting serine-threonine kinase 20.168
UBE2Iubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)0.168
FIS1fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)0.166
HSPA5heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)0.160
ICAM1intercellular adhesion molecule 10.159
RHOAras homolog gene family, member A0.151
HTATSF1HIV-1 Tat specific factor 10.149
UBASH3Bubiquitin associated and SH3 domain containing B0.147
UBR3ubiquitin protein ligase E3 component n-recognin 3 (putative)0.147
MAFAv-maf musculoaponeurotic fibrosarcoma oncogene homolog A (avian)0.144
CENPEcentromere protein E, 312kDa0.144
GOPCgolgi-associated PDZ and coiled-coil motif containing0.141
SNW1SNW domain containing 10.139
EEDembryonic ectoderm development0.139
NCOR2nuclear receptor corepressor 20.139
DAD1defender against cell death 10.136
MAP2K7mitogen-activated protein kinase kinase 70.134
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.133
MSNmoesin0.129
SP1Sp1 transcription factor0.129
MYCv-myc myelocytomatosis viral oncogene homolog (avian)0.128
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
C14B1.8Protein C14B1.80.024
acly-2Protein ACLY-20.021
eak-7Protein EAK-70.017
mrpl-34Protein MRPL-340.017
apc-11Protein APC-110.017
C05C10.2Protein C05C10.20.017
lsm-3Protein LSM-30.017
gfl-1Protein GFL-10.016
M01A10.1Protein M01A10.10.016
spe-39Protein SPE-390.016
F56D1.2Protein F56D1.20.016
mrpl-23Protein MRPL-230.015
ZK1127.12Protein ZK1127.120.015
R06C7.2Protein R06C7.20.015
F40F11.3Protein F40F11.30.015
col-13Protein COL-130.015
F26H9.4Protein F26H9.40.015
F22G12.5Protein F22G12.50.014
spo-11Protein SPO-110.014
ZK930.1Protein ZK930.10.014
Y48G1C.9Protein Y48G1C.90.014
rpb-10Protein RPB-100.014
K11H3.4Protein K11H3.40.013
pqn-55Protein PQN-550.013
gut-2Protein GUT-20.013
C16C8.11Protein C16C8.110.013
unc-27Protein UNC-270.013
C24F3.2Protein C24F3.20.013
CELE_F25B4.5Protein F25B4.50.013
nlp-17Protein NLP-170.013
C14H10.2Protein C14H10.20.013
W06D11.3Protein W06D11.30.013
hda-6Protein HDA-60.013
CELE_T04B2.5Protein T04B2.50.013
T27F7.1Protein T27F7.10.013
hpd-1Protein HPD-10.013
CELE_F02H6.4Protein F02H6.40.013
F58A6.1Protein F58A6.10.013
T25E12.6Protein T25E12.60.012
gta-1Protein GTA-10.012
CELE_Y47G6A.19Protein Y47G6A.190.012
T01H8.2Protein T01H8.20.012
H14A12.3Protein H14A12.30.012
daf-22Protein DAF-220.012
haf-9Protein HAF-90.012
C14B1.9Protein C14B1.90.012
C06A8.3Protein C06A8.30.012
F48E8.6Protein F48E8.60.012
ttr-18Protein TTR-180.012
R10H10.3Protein R10H10.30.012
C07H6.2Protein C07H6.20.012
CELE_F43G6.7Protein F43G6.70.012
lin-49Protein LIN-490.012
mrpl-51Protein MRPL-510.012
bath-27Protein BATH-270.012
smg-7Protein SMG-70.012
bmy-1Protein BMY-10.012
F42A8.3Protein F42A8.30.012
T01G9.2Protein T01G9.20.012
ZK1058.5Protein ZK1058.50.012
CELE_JC8.5Protein JC8.50.012
K10C3.4Protein K10C3.40.012
pir-1Protein PIR-10.012
ras-2Protein RAS-20.012
CELE_F53F4.13Protein F53F4.130.012
mig-22Protein MIG-220.012
B0491.1Protein B0491.10.012
C33H5.8Protein C33H5.80.012
F40G9.2Protein F40G9.20.012
gst-6Protein GST-60.012
mdt-27Protein MDT-270.012
sod-2Protein SOD-20.012
T27A3.2Protein T27A3.20.011
CELE_F22E5.9Protein F22E5.90.011
gas-1Protein GAS-10.011
F28H6.4Protein F28H6.40.011
C14H10.1Protein C14H10.10.011
CELE_W07A8.2Protein W07A8.20.011
mrpl-28Protein MRPL-280.011
K09G1.1Protein K09G1.10.011
F49E7.2Protein F49E7.20.011
Y97E10AL.3Protein Y97E10AL.30.011
K06A5.1Protein K06A5.10.011
ttr-24Protein TTR-240.011
skr-3Protein SKR-30.011
col-182Protein COL-1820.011
F59A2.5Protein F59A2.50.011
F53B3.6Protein F53B3.60.011
ttr-31Protein TTR-310.011
T06D4.1Protein T06D4.10.011
col-133Protein COL-1330.011
sqt-2Protein SQT-20.011
pqn-22Protein PQN-220.011
msh-5Protein MSH-50.011
mpz-2Protein MPZ-20.011
C17E7.9Protein C17E7.90.011
C47D12.8Protein C47D12.80.011
emb-1Protein EMB-10.011
K11B4.2Protein K11B4.20.011
rsp-7Protein RSP-70.011
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
baxabcl2-associated X protein, a0.016
bcl2l1bcl2-like 10.014
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.999
Ptenphosphatase and tensin homolog0.983
Trp53transformation related protein 530.967
Tnftumor necrosis factor0.954
Lyz2lysozyme 20.926
Map3k7mitogen-activated protein kinase kinase kinase 70.914
Leprleptin receptor0.902
Ncoa3nuclear receptor coactivator 30.900
Tnfrsf1atumor necrosis factor receptor superfamily, member 1a0.818
Hdac2histone deacetylase 20.728
Nfe2l2nuclear factor, erythroid derived 2, like 20.709
Ighimmunoglobulin heavy chain complex0.672
Tgfb1transforming growth factor, beta 10.631
Mmp9matrix metallopeptidase 90.583
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.554
BaxBCL2-associated X protein0.547
Atp5a1ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 10.533
Mdm4transformed mouse 3T3 cell double minute 40.529
Atp5bATP synthase, H+ transporting mitochondrial F1 complex, beta subunit0.488
Ndufa9NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 90.475
Ikbkbinhibitor of kappaB kinase beta0.471
Stat3signal transducer and activator of transcription 30.469
Tnfaip3tumor necrosis factor, alpha-induced protein 30.458
Bcl2B-cell leukemia/lymphoma 20.456
Col1a1collagen, type I, alpha 10.455
Ren1renin 1 structural0.435
S100a9S100 calcium binding protein A9 (calgranulin B)0.430
S100a8S100 calcium binding protein A8 (calgranulin A)0.411
Ikbkginhibitor of kappaB kinase gamma0.404
Cdkn1bcyclin-dependent kinase inhibitor 1B0.404
Bak1BCL2-antagonist/killer 10.400
Crim1cysteine rich transmembrane BMP regulator 1 (chordin like)0.393
Agtr1aangiotensin II receptor, type 1a0.379
Cul3cullin 30.339
FasFas (TNF receptor superfamily member 6)0.325
Ppargc1aperoxisome proliferative activated receptor, gamma, coactivator 1 alpha0.321
Vhlvon Hippel-Lindau tumor suppressor0.319
Ywhaetyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide0.316
Sin3atranscriptional regulator, SIN3A (yeast)0.311
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.307
Sufusuppressor of fused homolog (Drosophila)0.285
Rpgrip1lRpgrip1-like0.270
Ppargperoxisome proliferator activated receptor gamma0.263
Timm17atranslocase of inner mitochondrial membrane 17a0.254
Rxraretinoid X receptor alpha0.251
Ppp2caprotein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform0.241
Ppp1ccprotein phosphatase 1, catalytic subunit, gamma isoform0.240
Ikzf1IKAROS family zinc finger 10.237
Hdac1histone deacetylase 10.235
Eif2c1eukaryotic translation initiation factor 2C, 10.234
Sfnstratifin0.229
Ncstnnicastrin0.228
Wt1Wilms tumor 1 homolog0.224
Lepleptin0.220
Kdm2blysine (K)-specific demethylase 2B0.215
Suz12suppressor of zeste 12 homolog (Drosophila)0.206
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.198
Nlrp3NLR family, pyrin domain containing 30.195
SkilSKI-like0.194
Casp8caspase 80.193
Mapk8mitogen-activated protein kinase 80.190
Cd79aCD79A antigen (immunoglobulin-associated alpha)0.189
Zfp362zinc finger protein 3620.188
TcraT-cell receptor alpha chain0.180
Cxcr4chemokine (C-X-C motif) receptor 40.175
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.174
Apoeapolipoprotein E0.167
Casp4caspase 4, apoptosis-related cysteine peptidase0.164
Plagl2pleiomorphic adenoma gene-like 20.163
Uqcrfs1ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 10.161
Zeb1zinc finger E-box binding homeobox 10.159
Usp9xubiquitin specific peptidase 9, X chromosome0.159
Relav-rel reticuloendotheliosis viral oncogene homolog A (avian)0.154
Cyldcylindromatosis (turban tumor syndrome)0.154
Nos3nitric oxide synthase 3, endothelial cell0.154
Ccr1chemokine (C-C motif) receptor 10.149
Ndufs2NADH dehydrogenase (ubiquinone) Fe-S protein 20.147
Tlr2toll-like receptor 20.147
Trp73transformation related protein 730.147
Suclg1succinate-CoA ligase, GDP-forming, alpha subunit0.147
H2-Eb1histocompatibility 2, class II antigen E beta0.144
Agtrapangiotensin II, type I receptor-associated protein0.143
Rnf19aring finger protein 19A0.137
Mta2metastasis-associated gene family, member 20.136
Agtangiotensinogen (serpin peptidase inhibitor, clade A, member 8)0.135
Setdb1SET domain, bifurcated 10.129
Bcl2l1BCL2-like 10.127
Traf6TNF receptor-associated factor 60.127
Sqstm1sequestosome 10.126
Ptprcprotein tyrosine phosphatase, receptor type, C0.125
Hnrnpa1heterogeneous nuclear ribonucleoprotein A10.125
Lrrk2leucine-rich repeat kinase 20.123
Lifleukemia inhibitory factor0.122
Egr2early growth response 20.120
Traf2TNF receptor-associated factor 20.115
Mdh2malate dehydrogenase 2, NAD (mitochondrial)0.111
Rbl1retinoblastoma-like 1 (p107)0.110
Cftrcystic fibrosis transmembrane conductance regulator homolog0.107
Park7Parkinson disease (autosomal recessive, early onset) 70.106
Timm23translocase of inner mitochondrial membrane 23 homolog (yeast)0.103
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism