The network for 'small gtpase mediated signal transduction' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

small gtpase mediated signal transduction

Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals.

NameDescriptionProbabilityFunc Analog Organism
YWHAZtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide1.000
YWHAGtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide1.000
EGFRepidermal growth factor receptor1.000
CDC42cell division cycle 42 (GTP binding protein, 25kDa)1.000
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)1.000
YWHABtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide1.000
MDM2Mdm2 p53 binding protein homolog (mouse)1.000
SFNstratifin1.000
GRB2growth factor receptor-bound protein 21.000
RB1retinoblastoma 11.000
RAF1v-raf-1 murine leukemia viral oncogene homolog 11.000
MAPK14mitogen-activated protein kinase 141.000
CDKN1Acyclin-dependent kinase inhibitor 1A (p21, Cip1)1.000
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence1.000
RHOAras homolog gene family, member A0.999
SOS1son of sevenless homolog 1 (Drosophila)0.999
MAPK1mitogen-activated protein kinase 10.999
ARHGDIARho GDP dissociation inhibitor (GDI) alpha0.999
ABI1abl-interactor 10.999
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.999
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.999
ERBB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)0.999
RASSF5Ras association (RalGDS/AF-6) domain family member 50.998
PTK2PTK2 protein tyrosine kinase 20.998
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.998
ERBB2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.998
IGF1Rinsulin-like growth factor 1 receptor0.998
SRCv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)0.995
FGFR2fibroblast growth factor receptor 20.995
SH3KBP1SH3-domain kinase binding protein 10.994
PAK1p21 protein (Cdc42/Rac)-activated kinase 10.994
SMAD2SMAD family member 20.989
CCNE1cyclin E10.989
TSC2tuberous sclerosis 20.988
RICTORRPTOR independent companion of MTOR, complex 20.985
YWHAQtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide0.985
CDK2cyclin-dependent kinase 20.985
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.983
PAK2p21 protein (Cdc42/Rac)-activated kinase 20.982
BRAFv-raf murine sarcoma viral oncogene homolog B10.981
HRASv-Ha-ras Harvey rat sarcoma viral oncogene homolog0.980
CBLBCas-Br-M (murine) ecotropic retroviral transforming sequence b0.980
MAP2K1mitogen-activated protein kinase kinase 10.980
SH3BP2SH3-domain binding protein 20.979
RACGAP1Rac GTPase activating protein 10.979
ASAP1ArfGAP with SH3 domain, ankyrin repeat and PH domain 10.979
GSK3Bglycogen synthase kinase 3 beta0.977
BAIAP2BAI1-associated protein 20.976
IQGAP1IQ motif containing GTPase activating protein 10.976
DOCK1dedicator of cytokinesis 10.976
ESR1estrogen receptor 10.976
JAG1jagged 10.975
GIT1G protein-coupled receptor kinase interacting ArfGAP 10.975
STK4serine/threonine kinase 40.973
ITGB4integrin, beta 40.972
TNFAIP1tumor necrosis factor, alpha-induced protein 1 (endothelial)0.971
S100A6S100 calcium binding protein A60.967
STK3serine/threonine kinase 30.962
ARRB1arrestin, beta 10.962
NCK1NCK adaptor protein 10.960
PLCG1phospholipase C, gamma 10.960
MARK3MAP/microtubule affinity-regulating kinase 30.957
UBCubiquitin C0.953
ARHGAP1Rho GTPase activating protein 10.952
LATlinker for activation of T cells0.952
JUNjun proto-oncogene0.951
MPRIPmyosin phosphatase Rho interacting protein0.950
NCKAP1NCK-associated protein 10.949
MAPK3mitogen-activated protein kinase 30.948
YWHAHtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide0.939
DUSP1dual specificity phosphatase 10.935
S100A8S100 calcium binding protein A80.934
S100A11S100 calcium binding protein A110.924
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.924
PAFAH1B1platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)0.921
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.921
COL4A1collagen, type IV, alpha 10.920
RIN1Ras and Rab interactor 10.920
NCK2NCK adaptor protein 20.918
EIF4A3eukaryotic translation initiation factor 4A30.916
GABARAPL1GABA(A) receptor-associated protein like 10.914
GNB1guanine nucleotide binding protein (G protein), beta polypeptide 10.913
SH3RF1SH3 domain containing ring finger 10.911
S100BS100 calcium binding protein B0.910
CSNK2A1casein kinase 2, alpha 1 polypeptide0.907
KIF23kinesin family member 230.906
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.901
SRPK2SRSF protein kinase 20.899
VAV1vav 1 guanine nucleotide exchange factor0.898
CD28CD28 molecule0.895
ARHGEF11Rho guanine nucleotide exchange factor (GEF) 110.894
RAC2ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)0.893
FMNL1formin-like 10.890
SHC1SHC (Src homology 2 domain containing) transforming protein 10.886
WASF2WAS protein family, member 20.886
SORBS3sorbin and SH3 domain containing 30.884
CCND1cyclin D10.883
TAB1TGF-beta activated kinase 1/MAP3K7 binding protein 10.882
PRKCAprotein kinase C, alpha0.879
PKM2pyruvate kinase, muscle0.879
Loading network...
Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
egl-18Protein EGL-180.819
eor-1Protein EOR-10.476
sur-2Protein SUR-20.465
let-60Protein LET-600.414
smp-1Protein SMP-10.373
bet-2Protein BET-20.340
sem-5Protein SEM-50.271
unc-73Protein UNC-730.238
skn-1Protein SKN-10.227
hsr-9Protein HSR-90.220
etr-1Protein ETR-10.219
lin-25Protein LIN-250.211
cdf-1Protein CDF-10.205
eor-2Protein EOR-20.197
CELE_F47G4.4Protein F47G4.40.196
dab-1Protein DAB-10.193
C11E4.6Protein C11E4.60.173
klp-10Protein KLP-100.164
plc-1Protein PLC-10.158
mac-1Protein MAC-10.155
gld-1Protein GLD-10.146
pig-1Protein PIG-10.146
lin-45Protein LIN-450.141
lag-1Protein LAG-10.141
rpn-6.1Protein RPN-6.10.138
pxf-1Protein PXF-10.135
daf-19Protein DAF-190.124
sam-10Protein SAM-100.123
fzr-1Protein FZR-10.121
R90.1Protein R90.10.120
srgp-1Protein SRGP-10.120
symk-1Protein SYMK-10.119
goa-1Protein GOA-10.116
zfp-3Protein ZFP-30.115
let-607Protein LET-6070.114
F33H1.4Protein F33H1.40.113
unc-14Protein UNC-140.113
CELE_F14E5.2Protein F14E5.20.112
ubq-1Protein UBQ-10.108
T04F8.6Protein T04F8.60.108
cdt-1Protein CDT-10.106
num-1Protein NUM-10.105
lst-4Protein LST-40.104
snf-1Protein SNF-10.104
bed-1Protein BED-10.101
F22D3.2Protein F22D3.20.101
daf-3Protein DAF-30.100
sax-3Protein SAX-30.098
gop-1Protein GOP-10.097
pqe-1Protein PQE-10.095
ten-1Protein TEN-10.092
ehs-1Protein EHS-10.092
T23F11.1Protein T23F11.10.092
nra-3Protein NRA-30.092
K03H4.2Protein K03H4.20.091
tam-1Protein TAM-10.091
max-1Protein MAX-10.090
egl-27Protein EGL-270.090
pkn-1Protein PKN-10.090
sma-6Protein SMA-60.085
rig-6Protein RIG-60.085
unc-94Protein UNC-940.085
sym-4Protein SYM-40.084
sax-7Protein SAX-70.083
mom-5Protein MOM-50.082
CELE_C46H3.2Protein C46H3.20.082
cki-2Protein CKI-20.082
daf-1Protein DAF-10.082
rbc-1Protein RBC-10.082
rgs-7Protein RGS-70.078
atg-2Protein ATG-20.078
ztf-20Protein ZTF-200.078
ced-10Protein CED-100.078
B0432.8Protein B0432.80.077
tat-1Protein TAT-10.077
ykt-6Protein YKT-60.077
dpy-22Protein DPY-220.077
itr-1Protein ITR-10.076
pek-1Protein PEK-10.076
gfi-2Protein GFI-20.076
C46H11.2Protein C46H11.20.075
let-23Protein LET-230.075
git-1Protein GIT-10.074
epg-2Protein EPG-20.074
che-13Protein CHE-130.074
aha-1Protein AHA-10.074
cpf-2Protein CPF-20.073
CELE_T05E11.3Protein T05E11.30.072
fos-1Protein FOS-10.072
hmg-1.2Protein HMG-1.20.072
inx-1Protein INX-10.072
C18B12.4Protein C18B12.40.071
unc-71Protein UNC-710.071
zfp-1Protein ZFP-10.071
T14G11.1Protein T14G11.10.071
rme-4Protein RME-40.071
cgef-1Protein CGEF-10.071
sup-17Protein SUP-170.071
T19A5.1Protein T19A5.10.070
pak-1Protein PAK-10.070
Loading network...
Danio rerio
NameDescriptionProbabilityFunc Analog Organism
gna12guanine nucleotide binding protein (G protein) alpha 120.512
itgb1b.2integrin, beta 1b.20.449
itgb1bintegrin, beta 1b0.369
actn1actinin, alpha 10.367
gna13bguanine nucleotide binding protein (G protein), alpha 13b0.339
si:dkeyp-22b2.3si:dkeyp-22b2.30.311
tpm4tropomyosin 40.299
pafah1b1bplatelet-activating factor acetylhydrolase, isoform Ib, alpha subunit b0.289
prickle1aprickle-like 1 (Drosophila) a0.287
ywhaityrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, iota polypeptide0.282
cnn2calponin 20.229
ywhabltyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide like0.215
pvrl1bpoliovirus receptor-related 1b0.208
ywhaqbtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b0.207
sumo3aSMT3 suppressor of mif two 3 homolog 3a0.203
copebcore promoter element binding protein0.179
gna13aguanine nucleotide binding protein (G protein), alpha 13a0.172
yes1v-yes-1 Yamaguchi sarcoma viral oncogene homolog 10.167
gnao1aguanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, a0.166
ywhabbtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b0.156
nrg2aneuregulin 2a0.151
pafah1b1aplatelet-activating factor acetylhydrolase, isoform Ib, alpha subunit a0.141
cdkl1cyclin-dependent kinase-like 1 (CDC2-related kinase)0.140
chek1CHK1 checkpoint homolog (S. pombe)0.140
msnamoesin a0.133
hdac4histone deacetylase 40.129
zgc:100942zgc:1009420.125
zgc:101761zgc:1017610.123
krt4keratin 40.122
yap1Yes-associated protein 10.122
rhoabras homolog gene family, member Ab0.121
nf1aneurofibromin 1a0.120
pobpartial optokinetic response b0.113
unc5bunc-5 homolog B (C. elegans)0.108
sf3b1splicing factor 3b, subunit 10.106
zgc:123170zgc:1231700.106
appbamyloid beta (A4) precursor protein b0.105
rad21RAD21 homolog (S. pombe)0.103
fzd3afrizzled homolog 3a0.102
ywhae1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 10.097
arpc5bactin related protein 2/3 complex, subunit 5B0.097
pkd2polycystic kidney disease 20.097
sumo1SMT3 suppressor of mif two 3 homolog 1 (yeast)0.095
psen1presenilin 10.095
gnai2lguanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2, like0.094
LOC100535549cytoplasmic polyadenylation element-binding protein 4-like0.094
ube2v2ubiquitin-conjugating enzyme E2 variant 20.093
tmem2transmembrane protein 20.092
bactin1bactin10.092
znf711zinc finger protein 7110.090
gna11guanine nucleotide binding protein (G protein), alpha 11 (Gq class)0.090
cdc42cell division cycle 420.087
uba1ubiquitin-like modifier activating enzyme 10.086
anxa2aannexin A2a0.083
sox11bSRY-box containing gene 11b0.083
vcpvalosin containing protein0.083
pabpc1apoly A binding protein, cytoplasmic 1 a0.082
pycardPYD and CARD domain containing0.082
ptrfbpolymerase I and transcript release factor b0.081
gng3guanine nucleotide binding protein (G protein), gamma 30.080
sox4aSRY-box containing gene 4a0.079
mapk3mitogen-activated protein kinase 30.078
ap2a1adaptor-related protein complex 2, alpha 1 subunit0.077
mat2amethionine adenosyltransferase II, alpha0.077
mmd2progestin and adipoQ receptor 100.076
cd99l2CD99 antigen-like 20.074
arf2ADP-ribosylation factor 20.074
mfn2mitofusin 20.072
ppm1aaprotein phosphatase, Mg2+/Mn2+ dependent, 1Aa0.072
si:ch211-232m7.1si:ch211-232m7.10.071
ppp2r5eaprotein phosphatase 2, regulatory subunit B', epsilon isoform a0.070
rnps1RNA binding protein S1, serine-rich domain0.070
icnictacalcin0.070
esyt3extended synaptotagmin-like protein 30.070
anxa1aannexin A1a0.070
ptproprotein tyrosine phosphatase, receptor type, O0.069
col1a1acollagen, type I, alpha 1a0.069
fbn2bfibrillin 2b0.069
ehd1EH-domain containing 10.069
stmn1bstathmin 1b0.068
s100a10bS100 calcium binding protein A10b0.068
yrkYes-related kinase0.068
ctnnb1catenin (cadherin-associated protein), beta 10.067
celsr1bcadherin EGF LAG seven-pass G-type receptor 1b0.066
leo1Leo1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.066
ywhabatyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide a0.065
pard6gbpar-6 partitioning defective 6 homolog gamma B (C. elegans)0.065
dsc2ldesmocollin 2 like0.064
slc12a9solute carrier family 12 (potassium/chloride transporters), member 90.063
LOC569128hypothetical protein LOC5691280.062
ddx42DEAD (Asp-Glu-Ala-Asp) box polypeptide 420.062
spna2spectrin alpha 20.061
usp1ubiquitin specific protease 10.061
smc3structural maintenance of chromosomes 30.061
bnc2basonuclin 20.061
taldo1transaldolase 10.060
med12mediator of RNA polymerase II transcription, subunit 12 homolog0.060
si:ch211-272f3.4si:ch211-272f3.40.060
tbx1T-box 10.060
gsnagelsolin a0.060
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Rho1CG8416 gene product from transcript CG8416-RB0.981
Ras85DRas oncogene at 85D0.939
SosSon of sevenless0.920
AbiAbelson interacting protein0.819
Pi3K92ECG4141 gene product from transcript CG4141-RB0.779
bunbunched0.743
chicchickadee0.733
ShcSHC-adaptor protein0.712
JraJun-related antigen0.635
Dsor1Downstream of raf10.609
pucpuckered0.600
ttktramtrack0.600
putpunt0.594
Stat92ESignal-transducer and activator of transcription protein at 92E0.593
plexBplexin B0.567
flwflapwing0.525
Akt1CG4006 gene product from transcript CG4006-RA0.522
rlrolled0.499
Src64BSrc oncogene at 64B0.476
XNPCG4548 gene product from transcript CG4548-RA0.438
rokRho-kinase0.433
14-3-3epsilonCG31196 gene product from transcript CG31196-RA0.424
drkdownstream of receptor kinase0.423
gekgenghis khan0.418
tutlturtle0.403
maskmultiple ankyrin repeats single KH domain0.381
EphrinCG1862 gene product from transcript CG1862-RA0.362
msnmisshapen0.358
aopanterior open0.347
Mkp3Mitogen-activated protein kinase phosphatase 30.342
lealeak0.340
stysprouty0.337
trioCG18214 gene product from transcript CG18214-RA0.332
mbtmushroom bodies tiny0.322
p120ctnAdherens junction protein p1200.319
Rac1CG2248 gene product from transcript CG2248-RA0.318
synjsynaptojanin0.290
phlpole hole0.289
pntpointed0.285
Eip63EEcdysone-induced protein 63E0.275
saxsaxophone0.275
nwknervous wreck0.271
RhebCG1081 gene product from transcript CG1081-RA0.269
wtswarts0.262
inscinscuteable0.262
Sra-1specifically Rac1-associated protein 10.256
Cip4CG15015 gene product from transcript CG15015-RA0.255
Cdc42CG12530 gene product from transcript CG12530-RA0.250
CG5180CG5180 gene product from transcript CG5180-RB0.245
mrimrityu0.240
stgstring0.240
alpha-AdaptinCG4260 gene product from transcript CG4260-RA0.236
Pk61CProtein kinase 61C0.236
PknProtein kinase related to protein kinase N0.230
CG4751CG4751 gene product from transcript CG4751-RA0.230
MTF-1Metal response element-binding Transcription Factor-10.228
Taf1TBP-associated factor 10.225
edechinoid0.223
LnkCG17367 gene product from transcript CG17367-RC0.221
cswcorkscrew0.221
lqfliquid facets0.217
pod1CG4532 gene product from transcript CG4532-RF0.216
mopmyopic0.215
pydpolychaetoid0.214
Hnf4Hepatocyte nuclear factor 40.213
MadMothers against dpp0.211
SbfSET domain binding factor0.211
ApcAPC-like0.209
NNotch0.206
Rca1Regulator of cyclin A10.205
Bj1Bj1 protein0.204
S6kRPS6-p70-protein kinase0.202
WASpCG1520 gene product from transcript CG1520-RA0.199
Rap2lRas-associated protein 2-like0.196
sizschizo0.195
rawCG12437 gene product from transcript CG12437-RB0.193
shnschnurri0.192
roboroundabout0.192
bazbazooka0.192
p130CASCG1212 gene product from transcript CG1212-RA0.190
RalaRas-related protein0.189
Dcr-1Dicer-10.189
Arc-p34CG10954 gene product from transcript CG10954-RA0.185
CG7222CG7222 gene product from transcript CG7222-RA0.183
CG9797CG9797 gene product from transcript CG9797-RA0.180
ykiyorkie0.179
rapretina aberrant in pattern0.177
kaykayak0.173
Smg1CG32743 gene product from transcript CG32743-RA0.171
kuzkuzbanian0.164
CortactinCG3637 gene product from transcript CG3637-RA0.162
didumdilute class unconventional myosin0.162
simjsimjang0.161
mbcmyoblast city0.158
vavCG7893 gene product from transcript CG7893-RB0.155
lgslegless0.155
RhoGAP93BCG3421 gene product from transcript CG3421-RA0.155
CG15609CG15609 gene product from transcript CG15609-RE0.153
Lis-1Lissencephaly-10.152
AP-1sigmaCG5864 gene product from transcript CG5864-RA0.148
Loading network...
Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Grb2growth factor receptor bound protein 20.999
Ephb2Eph receptor B20.997
CblCasitas B-lineage lymphoma0.996
Ptpn11protein tyrosine phosphatase, non-receptor type 110.993
Itsn1intersectin 1 (SH3 domain protein 1A)0.992
Efnb2ephrin B20.992
Cdc42cell division cycle 42 homolog (S. cerevisiae)0.989
Ctnnb1catenin (cadherin associated protein), beta 10.988
Nf1neurofibromatosis 10.984
Leprleptin receptor0.983
Elnelastin0.962
Mapk3mitogen-activated protein kinase 30.958
SrcRous sarcoma oncogene0.957
Plcg1phospholipase C, gamma 10.955
Krasv-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog0.948
Nckap1lNCK associated protein 1 like0.947
Sema6asema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A0.945
Epha4Eph receptor A40.930
Inpp5dinositol polyphosphate-5-phosphatase D0.929
Apcadenomatosis polyposis coli0.928
Tnks1bp1tankyrase 1 binding protein 10.924
Ntrk2neurotrophic tyrosine kinase, receptor, type 20.923
Pafah1b1platelet-activating factor acetylhydrolase, isoform 1b, subunit 10.916
Pnpla2patatin-like phospholipase domain containing 20.914
Egfrepidermal growth factor receptor0.909
Pxnpaxillin0.900
Dnm1dynamin 10.898
Klk1b5kallikrein 1-related peptidase b50.898
Trp53transformation related protein 530.898
Col1a1collagen, type I, alpha 10.898
Ednrbendothelin receptor type B0.892
Git1G protein-coupled receptor kinase-interactor 10.882
BrafBraf transforming gene0.879
Sox10SRY-box containing gene 100.867
Arrb2arrestin, beta 20.864
Hmha1histocompatibility (minor) HA-10.863
Ntf3neurotrophin 30.853
2310014H01RikRIKEN cDNA 2310014H01 gene0.853
Fliiflightless I homolog (Drosophila)0.851
Cttncortactin0.848
Rac1RAS-related C3 botulinum substrate 10.848
Grin2bglutamate receptor, ionotropic, NMDA2B (epsilon 2)0.847
Raf1v-raf-leukemia viral oncogene 10.838
Dok1docking protein 10.836
Ccl2chemokine (C-C motif) ligand 20.832
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.831
Vav1vav 1 oncogene0.827
Vav2vav 2 oncogene0.814
Klf7Kruppel-like factor 7 (ubiquitous)0.809
S1pr1sphingosine-1-phosphate receptor 10.804
Dock1dedicator of cytokinesis 10.802
Plxna1plexin A10.796
Dok2docking protein 20.792
Selplgselectin, platelet (p-selectin) ligand0.788
RictorRPTOR independent companion of MTOR, complex 20.788
Trp63transformation related protein 630.779
Plxnd1plexin D10.778
Retret proto-oncogene0.778
Tgfb1transforming growth factor, beta 10.773
Prkceprotein kinase C, epsilon0.771
Fbn1fibrillin 10.763
Irs1insulin receptor substrate 10.762
Pik3caphosphatidylinositol 3-kinase, catalytic, alpha polypeptide0.758
Shc1src homology 2 domain-containing transforming protein C10.757
Itgb1integrin beta 1 (fibronectin receptor beta)0.757
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.756
Sh3bp1SH3-domain binding protein 10.751
Vaspvasodilator-stimulated phosphoprotein0.747
Adam19a disintegrin and metallopeptidase domain 19 (meltrin beta)0.745
Erbb2v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)0.745
P2rx7purinergic receptor P2X, ligand-gated ion channel, 70.743
Pik3r1phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)0.739
Gab1growth factor receptor bound protein 2-associated protein 10.735
Gnaqguanine nucleotide binding protein, alpha q polypeptide0.732
Axin1axin 10.732
Rasa1RAS p21 protein activator 10.730
Fmnl1formin-like 10.720
Itga3integrin alpha 30.717
Gfra2glial cell line derived neurotrophic factor family receptor alpha 20.715
Arhgef11Rho guanine nucleotide exchange factor (GEF) 110.715
Wnt7awingless-related MMTV integration site 7A0.711
Pdgfbplatelet derived growth factor, B polypeptide0.706
Ywhagtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide0.704
Lrrk2leucine-rich repeat kinase 20.702
Rgs12regulator of G-protein signaling 120.697
Cd2apCD2-associated protein0.695
Gab2growth factor receptor bound protein 2-associated protein 20.690
Drd2dopamine receptor D20.689
Jupjunction plakoglobin0.683
Shank3SH3/ankyrin domain gene 30.678
Dact1dapper homolog 1, antagonist of beta-catenin (xenopus)0.678
Rasgrp2RAS, guanyl releasing protein 20.677
Epb4.1l2erythrocyte protein band 4.1-like 20.676
Aceangiotensin I converting enzyme (peptidyl-dipeptidase A) 10.675
Mapk1mitogen-activated protein kinase 10.675
Plekho2pleckstrin homology domain containing, family O member 20.670
Laptm5lysosomal-associated protein transmembrane 50.668
Rasgrp1RAS guanyl releasing protein 10.667
Arhgef12Rho guanine nucleotide exchange factor (GEF) 120.667
Ccr2chemokine (C-C motif) receptor 20.667
Loading network...
Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Rap1bRAP1B, member of RAS oncogene family0.305
Ptafrplatelet-activating factor receptor0.222
Cacna1acalcium channel, voltage-dependent, P/Q type, alpha 1A subunit0.220
Rab7aRAB7A, member RAS oncogene family0.217
Ube2g1ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast)0.180
LOC100364212heterogeneous nuclear ribonucleoprotein K-like0.177
Tle4transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)0.174
Ppp2caprotein phosphatase 2, catalytic subunit, alpha isoform0.164
Jtbjumping translocation breakpoint0.145
Lgals3lectin, galactoside-binding, soluble, 30.136
Dbhdopamine beta-hydroxylase (dopamine beta-monooxygenase)0.135
Ywhaztyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide0.132
Arf6ADP-ribosylation factor 60.131
Dlg3discs, large homolog 3 (Drosophila)0.130
Ppp2cbprotein phosphatase 2, catalytic subunit, beta isoform0.124
Ppp3r1protein phosphatase 3, regulatory subunit B, alpha isoform0.119
Dag1dystroglycan 1 (dystrophin-associated glycoprotein 1)0.117
Anxa2annexin A20.114
Ppp1r12aprotein phosphatase 1, regulatory (inhibitor) subunit 12A0.114
Fkbp1aFK506 binding protein 1a0.110
Grin2bglutamate receptor, ionotropic, N-methyl D-aspartate 2B0.109
Kcnab1potassium voltage-gated channel, shaker-related subfamily, beta member 10.106
Utrnutrophin0.106
Rac1ras-related C3 botulinum toxin substrate 10.106
Kitv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog0.102
Dlg1discs, large homolog 1 (Drosophila)0.097
Cdh6cadherin 60.096
Golph3golgi phosphoprotein 3 (coat-protein)0.096
Exoc5exocyst complex component 50.093
Irs1insulin receptor substrate 10.092
Hk1hexokinase 10.091
Adora2aadenosine A2a receptor0.091
Slc23a2solute carrier family 23 (nucleobase transporters), member 20.090
Fam135afamily with sequence similarity 135, member A0.090
Litaflipopolysaccharide-induced TNF factor0.089
Mapk1mitogen activated protein kinase 10.089
Ccl2chemokine (C-C motif) ligand 20.087
Lynv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.086
Csnk1g3casein kinase 1, gamma 30.086
Mpripmyosin phosphatase Rho interacting protein0.086
LOC100360986mCG1035404-like0.086
Dock9dedicator of cytokinesis 90.086
S100a4S100 calcium-binding protein A40.085
Arf4ADP-ribosylation factor 40.084
Dnaja2DnaJ (Hsp40) homolog, subfamily A, member 20.084
Lcp2lymphocyte cytosolic protein 20.084
Eif5eukaryotic translation initiation factor 50.084
Ddx17DEAD (Asp-Glu-Ala-Asp) box polypeptide 170.084
Ubr5ubiquitin protein ligase E3 component n-recognin 50.083
Col1a1collagen, type I, alpha 10.083
Taok1TAO kinase 10.083
Cfpcomplement factor properdin0.081
Sirpasignal-regulatory protein alpha0.081
Lphn2latrophilin 20.080
Pfn1profilin 10.080
Lrrc15leucine rich repeat containing 150.080
Pde2aphosphodiesterase 2A, cGMP-stimulated0.079
P2ry6pyrimidinergic receptor P2Y, G-protein coupled, 60.079
Sfrp4secreted frizzled-related protein 40.078
S100a10S100 calcium binding protein A100.078
Dlgap1discs, large (Drosophila) homolog-associated protein 10.078
Eif4a2eukaryotic translation initiation factor 4A, isoform 20.078
Vimvimentin0.077
Olr416olfactory receptor 4160.077
Mapk9mitogen-activated protein kinase 90.077
Git1G protein-coupled receptor kinase interacting ArfGAP 10.076
Inpp5dinositol polyphosphate-5-phosphatase D0.076
Vamp3vesicle-associated membrane protein 30.075
Jak1Janus kinase 10.075
Syde1synapse defective 1, Rho GTPase, homolog 1 (C. elegans)0.075
Camk2acalcium/calmodulin-dependent protein kinase II alpha0.075
Ifitm3interferon induced transmembrane protein 30.075
Folh1folate hydrolase 10.074
Ppp2r1aprotein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform0.074
SnrkSNF related kinase0.074
Jak2Janus kinase 20.074
Cyb5r4cytochrome b5 reductase 40.073
Prkchprotein kinase C, eta0.073
Shank3SH3 and multiple ankyrin repeat domains 30.072
Mcpt2mast cell protease 20.072
Cap1CAP, adenylate cyclase-associated protein 1 (yeast)0.072
Ciitaclass II, major histocompatibility complex, transactivator0.072
Cnp2',3'-cyclic nucleotide 3' phosphodiesterase0.071
Sumo1SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)0.071
Rhoaras homolog gene family, member A0.071
Ppp1r13bprotein phosphatase 1, regulatory (inhibitor) subunit 13B0.071
Anxa1annexin A10.070
Slc1a3solute carrier family 1 (glial high affinity glutamate transporter), member 30.070
Csnk1ecasein kinase 1, epsilon0.070
Mgea5meningioma expressed antigen 5 (hyaluronidase)0.069
Cugbp2CUG triplet repeat, RNA binding protein 20.069
Ier5immediate early response 50.068
Fnbp1formin binding protein 10.068
Sox10SRY (sex determining region Y)-box 100.068
Gng7guanine nucleotide binding protein (G protein), gamma 70.068
Gnai3guanine nucleotide binding protein (G protein), alpha inhibiting 30.068
Gata2GATA binding protein 20.068
Myl12bmyosin, light chain 12B, regulatory0.068
Pak2p21 protein (Cdc42/Rac)-activated kinase 20.068
Gabrg1gamma-aminobutyric acid (GABA) A receptor, gamma 10.067
Loading network...
Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism
RHO1Rho1p0.941
ROM2Rom2p0.941
IRA1Ira1p0.454
PKC1Pkc1p0.450
RAS2Ras2p0.367
AKL1Akl1p0.343
GYL1Gyl1p0.330
BNI1Bni1p0.311
MKK1Mkk1p0.306
SEC3Sec3p0.285
YKR017Chypothetical protein0.277
GDI1Gdi1p0.272
KSS1Kss1p0.260
CDC50Cdc50p0.217
CDC25Cdc25p0.216
TPK2Tpk2p0.198
STE11Ste11p0.197
YIP3Yip3p0.191
REG1Reg1p0.175
SEC2Sec2p0.152
GPB2Gpb2p0.145
CDC42Cdc42p0.141
MYO3Myo3p0.133
YOL087Chypothetical protein0.133
VPS15Vps15p0.131
RIM15Rim15p0.130
SPA2Spa2p0.122
VPS27Vps27p0.119
FAR1Far1p0.119
FYV8Fyv8p0.118
BUD6Bud6p0.118
KOG1Kog1p0.118
RGD1Rgd1p0.105
UBR1Ubr1p0.099
SHE4She4p0.095
AVO1Avo1p0.086
PEP5Pep5p0.086
SSK2Ssk2p0.086
TRS65Trs65p0.085
SLT2Slt2p0.085
TCA17Tca17p0.081
KDX1Kdx1p0.079
GSH1Gsh1p0.078
CDC24Cdc24p0.076
MKS1Mks1p0.075
GEA2Gea2p0.074
INP53Inp53p0.074
SLG1Slg1p0.072
GIC2Gic2p0.072
APP1App1p0.072
RIM21Rim21p0.068
MSG5Msg5p0.067
BUD14Bud14p0.066
RHO3Rho3p0.065
AIM20Aim20p0.064
CDC12Cdc12p0.064
WSC4Wsc4p0.062
RTG3Rtg3p0.062
RDI1Rdi1p0.061
BET3Bet3p0.060
YPK1Ypk1p0.059
SAC7Sac7p0.059
SLM1Slm1p0.059
NUP192Nup192p0.058
EXO84Exo84p0.057
YPT53Ypt53p0.057
BEM3Bem3p0.056
SAC6Sac6p0.056
PTP2Ptp2p0.055
SAK1Sak1p0.054
SIA1Sia1p0.054
AFI1Afi1p0.054
STI1Sti1p0.054
SGE1Sge1p0.053
YLR049Chypothetical protein0.053
STE5Ste5p0.053
SKM1Skm1p0.053
BPT1Bpt1p0.053
TCO89Tco89p0.052
RFC1Rfc1p0.052
SCP1Scp1p0.051
VPS21Vps21p0.051
NHA1Nha1p0.050
YPL066Whypothetical protein0.050
STT4Stt4p0.049
FUS3Fus3p0.049
TRS31Trs31p0.048
YAP1801hypothetical protein0.048
CYR1Cyr1p0.048
ECM25Ecm25p0.047
PFK26Pfk26p0.047
APM2Apm2p0.046
UBA4Uba4p0.045
FAA2Faa2p0.045
YFR039Chypothetical protein0.044
DCD1Dcd1p0.044
TSC11Tsc11p0.044
CMK1Cmk1p0.043
RIM101Rim101p0.042
GPR1Gpr1p0.042