The network for 'engulfment of apoptotic cell' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

engulfment of apoptotic cell

The removal of the apoptotic cell by phagocytosis, by a neighboring cell or by a phagocyte.

NameDescriptionProbabilityFunc Analog Organism
MAPK8mitogen-activated protein kinase 80.982
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)0.966
SH3KBP1SH3-domain kinase binding protein 10.958
ACTR3ARP3 actin-related protein 3 homolog (yeast)0.923
ARPC5actin related protein 2/3 complex, subunit 5, 16kDa0.879
ARPC2actin related protein 2/3 complex, subunit 2, 34kDa0.875
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.872
FGF1fibroblast growth factor 1 (acidic)0.858
MAP2K4mitogen-activated protein kinase kinase 40.821
ATF2activating transcription factor 20.657
CASP8caspase 8, apoptosis-related cysteine peptidase0.645
FYNFYN oncogene related to SRC, FGR, YES0.638
FN1fibronectin 10.596
CBLCas-Br-M (murine) ecotropic retroviral transforming sequence0.564
MAPK8IP1mitogen-activated protein kinase 8 interacting protein 10.561
CFLARCASP8 and FADD-like apoptosis regulator0.525
CRADDCASP2 and RIPK1 domain containing adaptor with death domain0.485
CTGFconnective tissue growth factor0.470
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.463
ARPC3actin related protein 2/3 complex, subunit 3, 21kDa0.458
ABL1c-abl oncogene 1, non-receptor tyrosine kinase0.449
TNFRSF10Atumor necrosis factor receptor superfamily, member 10a0.447
ARPC1Bactin related protein 2/3 complex, subunit 1B, 41kDa0.444
CAP1CAP, adenylate cyclase-associated protein 1 (yeast)0.415
NXF1nuclear RNA export factor 10.409
SOS1son of sevenless homolog 1 (Drosophila)0.407
ADAM19ADAM metallopeptidase domain 190.382
JUNjun proto-oncogene0.377
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.358
DYNLT3dynein, light chain, Tctex-type 30.354
ACTR2ARP2 actin-related protein 2 homolog (yeast)0.348
XRCC5X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)0.339
CTNNB1catenin (cadherin-associated protein), beta 1, 88kDa0.325
PAFAH1B1platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)0.314
TNFRSF10Btumor necrosis factor receptor superfamily, member 10b0.285
ARHGDIBRho GDP dissociation inhibitor (GDI) beta0.283
NCKAP1NCK-associated protein 10.261
EGFRepidermal growth factor receptor0.256
ARRB1arrestin, beta 10.250
SMPD1sphingomyelin phosphodiesterase 1, acid lysosomal0.249
PXNpaxillin0.247
ARPC4actin related protein 2/3 complex, subunit 4, 20kDa0.246
RAPGEF1Rap guanine nucleotide exchange factor (GEF) 10.244
ASAP1ArfGAP with SH3 domain, ankyrin repeat and PH domain 10.242
CRKLv-crk sarcoma virus CT10 oncogene homolog (avian)-like0.230
CASP10caspase 10, apoptosis-related cysteine peptidase0.230
ABI1abl-interactor 10.197
BCORBCL6 corepressor0.188
IQGAP1IQ motif containing GTPase activating protein 10.185
TCF4transcription factor 40.164
FADDFas (TNFRSF6)-associated via death domain0.161
FGF2fibroblast growth factor 2 (basic)0.158
RIPK1receptor (TNFRSF)-interacting serine-threonine kinase 10.154
RIN1Ras and Rab interactor 10.152
SPRR2Asmall proline-rich protein 2A0.150
DNM1dynamin 10.144
S100A10S100 calcium binding protein A100.144
CORO1Ccoronin, actin binding protein, 1C0.143
CBLBCas-Br-M (murine) ecotropic retroviral transforming sequence b0.142
MAP3K1mitogen-activated protein kinase kinase kinase 10.139
PIK3R1phosphoinositide-3-kinase, regulatory subunit 1 (alpha)0.138
PDCD6programmed cell death 60.135
NAV1neuron navigator 10.133
ANXA1annexin A10.131
KIF5Bkinesin family member 5B0.131
SS18synovial sarcoma translocation, chromosome 180.129
VCLvinculin0.128
WASLWiskott-Aldrich syndrome-like0.128
ANXA5annexin A50.122
HSPG2heparan sulfate proteoglycan 20.119
NME3non-metastatic cells 3, protein expressed in0.116
GOLGA2golgin A20.111
RHOAras homolog gene family, member A0.111
POLA1polymerase (DNA directed), alpha 1, catalytic subunit0.101
DAB2disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)0.100
MYL12Bmyosin, light chain 12B, regulatory0.100
SNX9sorting nexin 90.100
PRKACBprotein kinase, cAMP-dependent, catalytic, beta0.092
NDEL1nudE nuclear distribution gene E homolog (A. nidulans)-like 10.090
SOS2son of sevenless homolog 2 (Drosophila)0.089
CBFBcore-binding factor, beta subunit0.087
WASF1WAS protein family, member 10.087
NCK1NCK adaptor protein 10.085
ARFGEF1ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)0.085
FBXW11F-box and WD repeat domain containing 110.085
ORC1origin recognition complex, subunit 10.083
SUPT16Hsuppressor of Ty 16 homolog (S. cerevisiae)0.082
ADAM9ADAM metallopeptidase domain 90.080
MMP2matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)0.080
MSNmoesin0.079
GLOD4glyoxalase domain containing 40.079
PACSIN2protein kinase C and casein kinase substrate in neurons 20.078
TGM2transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase)0.078
ITGAVintegrin, alpha V (vitronectin receptor, alpha polypeptide, antigen CD51)0.074
XPO7exportin 70.073
PICALMphosphatidylinositol binding clathrin assembly protein0.073
ITGB3integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)0.073
RAB14RAB14, member RAS oncogene family0.073
FGFR1fibroblast growth factor receptor 10.072
EPS8epidermal growth factor receptor pathway substrate 80.069
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
gei-18Protein GEI-180.260
mig-2Protein MIG-20.117
rab-5Protein RAB-50.113
sem-5Protein SEM-50.107
pat-2Protein PAT-20.086
T19A5.3Protein T19A5.30.084
hpo-22Protein HPO-220.074
ina-1Protein INA-10.073
ptr-11Protein PTR-110.070
F59A3.4Protein F59A3.40.068
mam-3Protein MAM-30.067
CELE_Y39B6A.1Protein Y39B6A.10.067
npp-7Protein NPP-70.061
cka-1Protein CKA-10.061
ubc-20Protein UBC-200.061
epg-8Protein EPG-80.060
sptl-3Protein SPTL-30.059
oac-46Protein OAC-460.059
F13B12.1Protein F13B12.10.059
C33A11.1Protein C33A11.10.057
cdc-42Protein CDC-420.057
pat-3Protein PAT-30.055
praf-3Protein PRAF-30.055
mex-1Protein MEX-10.054
K10C8.3Protein K10C8.30.054
lat-1Protein LAT-10.052
acl-14Protein ACL-140.052
ung-1Protein UNG-10.051
acy-3Protein ACY-30.051
CELE_C12D8.1Protein C12D8.10.049
pry-1Protein PRY-10.049
ced-10Protein CED-100.049
erp-1Protein ERP-10.048
let-60Protein LET-600.048
hpo-28Protein HPO-280.047
mdt-19Protein MDT-190.047
sar-1Protein SAR-10.047
dyn-1Protein DYN-10.046
aph-2Protein APH-20.046
swd-2.2Protein SWD-2.20.046
CELE_Y37A1B.17Protein Y37A1B.170.045
F44B9.5Protein F44B9.50.045
R02F11.1Protein R02F11.10.045
ttr-6Protein TTR-60.045
R10E11.6Protein R10E11.60.045
chc-1Protein CHC-10.044
Y25C1A.5Protein Y25C1A.50.044
vms-1Protein VMS-10.044
Y106G6A.1Protein Y106G6A.10.043
ZC247.2Protein ZC247.20.043
F57B10.8Protein F57B10.80.042
rgl-1Protein RGL-10.042
sas-4Protein SAS-40.041
msh-6Protein MSH-60.041
CELE_C29F7.3Protein C29F7.30.041
unc-73Protein UNC-730.041
plc-3Protein PLC-30.041
C49H3.6Protein C49H3.60.040
F16F9.4Protein F16F9.40.040
mig-1Protein MIG-10.040
F10G8.6Protein F10G8.60.040
dpf-7Protein DPF-70.040
rsp-2Protein RSP-20.040
cki-1Protein CKI-10.040
CELE_Y69H2.3Protein Y69H2.30.040
K10D3.4Protein K10D3.40.039
R74.8Protein R74.80.039
ehbp-1Protein EHBP-10.039
Y55F3AM.3Protein Y55F3AM.30.038
rab-10Protein RAB-100.038
snap-1Protein SNAP-10.038
rnf-121Protein RNF-1210.037
ced-6Protein CED-60.037
bus-18Protein BUS-180.037
slo-1Protein SLO-10.037
dcn-1Protein DCN-10.037
acs-20Protein ACS-200.037
F13D12.3Protein F13D12.30.037
D2085.5Protein D2085.50.037
T27E9.2Protein T27E9.20.037
abu-13Protein ABU-130.036
unc-43Protein UNC-430.036
ets-6Protein ETS-60.036
unc-6Protein UNC-60.036
vav-1Protein VAV-10.036
cyk-3Protein CYK-30.036
mup-4Protein MUP-40.036
B0336.3Protein B0336.30.036
Y43F4B.10Protein Y43F4B.100.036
ttx-1Protein TTX-10.036
CELE_Y64G10A.7Protein Y64G10A.70.036
T24B8.3Protein T24B8.30.035
cex-1Protein CEX-10.035
C13C4.5Protein C13C4.50.035
pcaf-1Protein PCAF-10.035
scpl-2Protein SCPL-20.035
pbs-2Protein PBS-20.035
pxf-1Protein PXF-10.035
nhx-9Protein NHX-90.035
pcf-11Protein PCF-110.035
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Rab5Rab-protein 50.156
Cdc42CG12530 gene product from transcript CG12530-RA0.113
Arp66BActin-related protein 66B0.108
mbcmyoblast city0.102
enaenabled0.068
PvrPDGF- and VEGF-receptor related0.065
Rho1CG8416 gene product from transcript CG8416-RB0.065
chicchickadee0.052
HemHEM-protein0.045
Lis-1Lissencephaly-10.040
Eb1CG3265 gene product from transcript CG3265-RF0.037
gekgenghis khan0.031
cnocanoe0.029
mopmyopic0.025
Rac2CG8556 gene product from transcript CG8556-RA0.025
HrsHepatocyte growth factor regulated tyrosine kinase substrate0.023
RelRelish0.023
bskbasket0.023
Arc-p34CG10954 gene product from transcript CG10954-RA0.021
MoeMoesin0.020
Vrp1Verprolin 10.019
BG4CG12297 gene product from transcript CG12297-RA0.016
kstkarst0.016
ChcClathrin heavy chain0.015
SmoxSmad on X0.014
Rab11Rab-protein 110.014
stcshuttle craft0.013
Arf51FADP ribosylation factor 51F0.013
Rab6Rab-protein 60.013
DlicDynein light intermediate chain0.012
rheaCG6831 gene product from transcript CG6831-RA0.012
mtsmicrotubule star0.012
Rac1CG2248 gene product from transcript CG2248-RA0.012
rokRho-kinase0.012
imdimmune deficiency0.012
RalaRas-related protein0.012
Vps16AVacuolar protein sorting 16A0.011
WASpCG1520 gene product from transcript CG1520-RA0.011
Arf79FADP ribosylation factor 79F0.011
kelkelch0.011
fngfringe0.010
CG16718CG16718 gene product from transcript CG16718-RA0.010
bnlbranchless0.010
S6kRPS6-p70-protein kinase0.010
Dcr-2Dicer-20.010
mewmultiple edematous wings0.010
G-oalpha47AG protein oalpha 47A0.010
zipzipper0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Ctnnb1catenin (cadherin associated protein), beta 11.000
Map3k14mitogen-activated protein kinase kinase kinase 140.979
Ptenphosphatase and tensin homolog0.974
Bmpr1abone morphogenetic protein receptor, type 1A0.882
Cdc42cell division cycle 42 homolog (S. cerevisiae)0.875
Dysfdysferlin0.871
Rac1RAS-related C3 botulinum substrate 10.856
Itgb1integrin beta 1 (fibronectin receptor beta)0.814
Mapk8ip3mitogen-activated protein kinase 8 interacting protein 30.795
Gbp5guanylate binding protein 50.769
Smad3MAD homolog 3 (Drosophila)0.745
Tnfsf14tumor necrosis factor (ligand) superfamily, member 140.705
Engendoglin0.696
Casp4caspase 4, apoptosis-related cysteine peptidase0.682
Hif1ahypoxia inducible factor 1, alpha subunit0.678
Ltblymphotoxin B0.671
Pak1p21 protein (Cdc42/Rac)-activated kinase 10.671
Efnb2ephrin B20.645
Axin1axin 10.629
Apcadenomatosis polyposis coli0.601
Smad4MAD homolog 4 (Drosophila)0.581
Casp1caspase 10.569
Tnfrsf1btumor necrosis factor receptor superfamily, member 1b0.541
Msnmoesin0.518
Sox9SRY-box containing gene 90.501
Mapk14mitogen-activated protein kinase 140.489
Vclvinculin0.485
Ptk2PTK2 protein tyrosine kinase 20.472
Tmem38btransmembrane protein 38B0.470
Shhsonic hedgehog0.448
Fstl1follistatin-like 10.432
S100a11S100 calcium binding protein A11 (calgizzarin)0.400
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.397
Cxcr4chemokine (C-X-C motif) receptor 40.395
Il1binterleukin 1 beta0.370
Itgb3integrin beta 30.359
Tnftumor necrosis factor0.354
Apoeapolipoprotein E0.353
Add1adducin 1 (alpha)0.346
Rdh8retinol dehydrogenase 80.337
Ric8resistance to inhibitors of cholinesterase 8 homolog (C. elegans)0.320
Ltalymphotoxin A0.318
Anxa1annexin A10.314
Lgals3lectin, galactose binding, soluble 30.303
Becn1beclin 1, autophagy related0.302
Npc1Niemann Pick type C10.298
Thbs2thrombospondin 20.297
Nf2neurofibromatosis 20.286
Csf1colony stimulating factor 1 (macrophage)0.283
Lrp6low density lipoprotein receptor-related protein 60.280
Mapk9mitogen-activated protein kinase 90.275
Toxthymocyte selection-associated high mobility group box0.273
Osmroncostatin M receptor0.271
Il7interleukin 70.271
Pacsin1protein kinase C and casein kinase substrate in neurons 10.268
Klc2kinesin light chain 20.261
Il6stinterleukin 6 signal transducer0.261
Pik3cdphosphatidylinositol 3-kinase catalytic delta polypeptide0.261
S100a6S100 calcium binding protein A6 (calcyclin)0.260
Cycscytochrome c, somatic0.258
Ikbkbinhibitor of kappaB kinase beta0.258
Lrp1low density lipoprotein receptor-related protein 10.251
Hspg2perlecan (heparan sulfate proteoglycan 2)0.251
Tpm4tropomyosin 40.249
Cstbcystatin B0.247
Nfkb2nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, p49/p1000.242
Alox5aparachidonate 5-lipoxygenase activating protein0.229
ArhgdibRho, GDP dissociation inhibitor (GDI) beta0.223
Lyz2lysozyme 20.218
Nid1nidogen 10.215
Rbl2retinoblastoma-like 20.215
Trp53transformation related protein 530.214
Prkacaprotein kinase, cAMP dependent, catalytic, alpha0.211
Klf5Kruppel-like factor 50.209
Dlg4discs, large homolog 4 (Drosophila)0.208
Nde1nuclear distribution gene E homolog 1 (A nidulans)0.204
Atf2activating transcription factor 20.204
Cdkn1acyclin-dependent kinase inhibitor 1A (P21)0.202
Anxa2annexin A20.193
Bsnbassoon0.193
Cxcr5chemokine (C-X-C motif) receptor 50.192
Grb2growth factor receptor bound protein 20.189
Lgals1lectin, galactose binding, soluble 10.189
Aplp2amyloid beta (A4) precursor-like protein 20.189
Il18interleukin 180.188
S100a10S100 calcium binding protein A10 (calpactin)0.188
Mcm2minichromosome maintenance deficient 2 mitotin (S. cerevisiae)0.187
Orai1ORAI calcium release-activated calcium modulator 10.187
Wdr1WD repeat domain 10.186
Abcg1ATP-binding cassette, sub-family G (WHITE), member 10.183
Pxnpaxillin0.182
Gsk3bglycogen synthase kinase 3 beta0.181
Rhoaras homolog gene family, member A0.181
Efna1ephrin A10.172
Arhgap1Rho GTPase activating protein 10.172
Pik3cbphosphatidylinositol 3-kinase, catalytic, beta polypeptide0.171
CebpaCCAAT/enhancer binding protein (C/EBP), alpha0.170
Anxa5annexin A50.170
Fgfr1fibroblast growth factor receptor 10.168
Bmp1bone morphogenetic protein 10.168
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism