The network for 'viral life cycle' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

viral life cycle

A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome.

NameDescriptionProbabilityFunc Analog Organism
THOC4THO complex 41.000
DDX58DEAD (Asp-Glu-Ala-Asp) box polypeptide 581.000
IFI44interferon-induced protein 441.000
THOC5THO complex 50.999
SP110SP110 nuclear body protein0.999
MX1myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)0.999
OAS12',5'-oligoadenylate synthetase 1, 40/46kDa0.999
OAS22'-5'-oligoadenylate synthetase 2, 69/71kDa0.999
ISG15ISG15 ubiquitin-like modifier0.998
IFIT3interferon-induced protein with tetratricopeptide repeats 30.998
IFI44Linterferon-induced protein 44-like0.997
SP1Sp1 transcription factor0.997
EIF2AK2eukaryotic translation initiation factor 2-alpha kinase 20.996
OASL2'-5'-oligoadenylate synthetase-like0.996
IFIT1interferon-induced protein with tetratricopeptide repeats 10.995
IFITM1interferon induced transmembrane protein 1 (9-27)0.994
DDX39BDEAD (Asp-Glu-Ala-Asp) box polypeptide 39B0.991
STAT1signal transducer and activator of transcription 1, 91kDa0.990
TAP1transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)0.982
IL8interleukin 80.981
MX2myxovirus (influenza virus) resistance 2 (mouse)0.980
SMARCA4SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 40.979
SP100SP100 nuclear antigen0.978
TP53tumor protein p530.977
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.977
CXCL10chemokine (C-X-C motif) ligand 100.971
DTX3Ldeltex 3-like (Drosophila)0.967
CXCL2chemokine (C-X-C motif) ligand 20.959
PLSCR1phospholipid scramblase 10.945
UBE2L6ubiquitin-conjugating enzyme E2L 60.942
IFI6interferon, alpha-inducible protein 60.936
CXCL1chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)0.933
MLLT4myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 40.933
IRF9interferon regulatory factor 90.920
THOC1THO complex 10.916
OAS32'-5'-oligoadenylate synthetase 3, 100kDa0.910
IFI27interferon, alpha-inducible protein 270.904
PVRL1poliovirus receptor-related 1 (herpesvirus entry mediator C)0.899
IRF7interferon regulatory factor 70.890
IFIT2interferon-induced protein with tetratricopeptide repeats 20.888
HDAC1histone deacetylase 10.875
NCBP1nuclear cap binding protein subunit 1, 80kDa0.875
IFI35interferon-induced protein 350.873
IFIH1interferon induced with helicase C domain 10.864
PARP12poly (ADP-ribose) polymerase family, member 120.861
FHL2four and a half LIM domains 20.851
BST2bone marrow stromal cell antigen 20.850
DDX60DEAD (Asp-Glu-Ala-Asp) box polypeptide 600.846
DICER1dicer 1, ribonuclease type III0.846
CXCL3chemokine (C-X-C motif) ligand 30.842
PTPN23protein tyrosine phosphatase, non-receptor type 230.824
CCL8chemokine (C-C motif) ligand 80.824
IL1Binterleukin 1, beta0.816
GABPAGA binding protein transcription factor, alpha subunit 60kDa0.814
PMLpromyelocytic leukemia0.809
XAF1XIAP associated factor 10.803
IFIT5interferon-induced protein with tetratricopeptide repeats 50.787
CCL2chemokine (C-C motif) ligand 20.787
TRIM21tripartite motif containing 210.780
IFI16interferon, gamma-inducible protein 160.776
RBCK1RanBP-type and C3HC4-type zinc finger containing 10.776
CXCL11chemokine (C-X-C motif) ligand 110.766
PRKRAprotein kinase, interferon-inducible double stranded RNA dependent activator0.732
ARID1BAT rich interactive domain 1B (SWI1-like)0.727
IL6interleukin 6 (interferon, beta 2)0.726
ARID1AAT rich interactive domain 1A (SWI-like)0.723
PSMB9proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)0.714
RSAD2radical S-adenosyl methionine domain containing 20.707
HERC5hect domain and RLD 50.689
NCOR1nuclear receptor corepressor 10.683
EP300E1A binding protein p3000.675
HIPK2homeodomain interacting protein kinase 20.671
UBE2D4ubiquitin-conjugating enzyme E2D 4 (putative)0.660
ATG12ATG12 autophagy related 12 homolog (S. cerevisiae)0.642
ADARadenosine deaminase, RNA-specific0.637
SUMO1SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae)0.618
CXCL9chemokine (C-X-C motif) ligand 90.614
TRIM41tripartite motif containing 410.606
CXCL5chemokine (C-X-C motif) ligand 50.603
DPP4dipeptidyl-peptidase 40.600
RELBv-rel reticuloendotheliosis viral oncogene homolog B0.600
CCL20chemokine (C-C motif) ligand 200.598
THOC2THO complex 20.596
HDGFhepatoma-derived growth factor0.589
PTGS2prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)0.588
ESR1estrogen receptor 10.565
VCAM1vascular cell adhesion molecule 10.561
PARP1poly (ADP-ribose) polymerase 10.558
UBE2Uubiquitin-conjugating enzyme E2U (putative)0.537
AXLAXL receptor tyrosine kinase0.517
GBP1guanylate binding protein 1, interferon-inducible0.507
CCR5chemokine (C-C motif) receptor 50.499
XRCC6X-ray repair complementing defective repair in Chinese hamster cells 60.492
IFITM3interferon induced transmembrane protein 3 (1-8U)0.492
SAMD9Lsterile alpha motif domain containing 9-like0.482
USP18ubiquitin specific peptidase 180.476
USP54ubiquitin specific peptidase 540.473
TRIM22tripartite motif containing 220.450
WWP2WW domain containing E3 ubiquitin protein ligase 20.449
SMAD4SMAD family member 40.447
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
vps24Charged multivesicular body protein 30.033
CG10103CG10103 gene product from transcript CG10103-RA0.020
Chmp1CG4108 gene product from transcript CG4108-RA0.017
CG6259CG6259 gene product from transcript CG6259-RA0.015
vps2CG14542 gene product from transcript CG14542-RA0.015
Atg18Autophagy-specific gene 180.014
Tsc1CG6147 gene product from transcript CG6147-RA0.012
e(y)3enhancer of yellow 30.012
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Irf9interferon regulatory factor 90.981
Oasl22'-5' oligoadenylate synthetase-like 20.974
Rsad2radical S-adenosyl methionine domain containing 20.966
Irf7interferon regulatory factor 70.962
Isg15ISG15 ubiquitin-like modifier0.959
Uba7ubiquitin-like modifier activating enzyme 70.909
Usp18ubiquitin specific peptidase 180.899
Ifit1interferon-induced protein with tetratricopeptide repeats 10.888
Stat1signal transducer and activator of transcription 10.887
Trim30atripartite motif-containing 30A0.882
Ddx60DEAD (Asp-Glu-Ala-Asp) box polypeptide 600.853
TapbpTAP binding protein0.821
Stat2signal transducer and activator of transcription 20.811
Parp14poly (ADP-ribose) polymerase family, member 140.807
Rtp4receptor transporter protein 40.770
Irgm1immunity-related GTPase family M member 10.769
Ifitm3interferon induced transmembrane protein 30.744
Ifih1interferon induced with helicase C domain 10.686
Irgm2immunity-related GTPase family M member 20.675
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.631
Gbp7guanylate binding protein 70.631
Ifi44interferon-induced protein 440.622
Tor3atorsin family 3, member A0.593
Psmb8proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7)0.591
Mndalmyeloid nuclear differentiation antigen like0.497
Ifit3interferon-induced protein with tetratricopeptide repeats 30.488
Ifi35interferon-induced protein 350.484
Trim25tripartite motif-containing 250.469
Atg12autophagy-related 12 (yeast)0.433
Mx2myxovirus (influenza virus) resistance 20.430
Trim30dtripartite motif-containing 30D0.422
Gbp3guanylate binding protein 30.407
Trim21tripartite motif-containing 210.396
BC006779cDNA sequence BC0067790.385
Igtpinterferon gamma induced GTPase0.374
Bst2bone marrow stromal cell antigen 20.356
BaxBCL2-associated X protein0.356
Zbp1Z-DNA binding protein 10.350
Parp9poly (ADP-ribose) polymerase family, member 90.347
Eif2ak2eukaryotic translation initiation factor 2-alpha kinase 20.307
Trim28tripartite motif-containing 280.307
Ddx58DEAD (Asp-Glu-Ala-Asp) box polypeptide 580.303
Tap2transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)0.299
Parp12poly (ADP-ribose) polymerase family, member 120.296
Oas22'-5' oligoadenylate synthetase 20.290
Oas32'-5' oligoadenylate synthetase 30.284
Arid1aAT rich interactive domain 1A (SWI-like)0.277
Trp53transformation related protein 530.268
Psmb9proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2)0.265
Lgals9lectin, galactose binding, soluble 90.255
Dtx3ldeltex 3-like (Drosophila)0.254
Dhx58DEXH (Asp-Glu-X-His) box polypeptide 580.250
Lgals3bplectin, galactoside-binding, soluble, 3 binding protein0.234
Irf1interferon regulatory factor 10.230
Oasl12'-5' oligoadenylate synthetase-like 10.218
Parp10poly (ADP-ribose) polymerase family, member 100.199
Samd9lsterile alpha motif domain containing 9-like0.181
Cdk4cyclin-dependent kinase 40.176
Ppp1ccprotein phosphatase 1, catalytic subunit, gamma isoform0.172
Cmpk2cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial0.172
Oas1a2'-5' oligoadenylate synthetase 1A0.166
Tap1transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)0.163
Herc6hect domain and RLD 60.147
Mx1myxovirus (influenza virus) resistance 10.144
Tcf7transcription factor 7, T-cell specific0.142
Oas1b2'-5' oligoadenylate synthetase 1B0.138
Prmt1protein arginine N-methyltransferase 10.132
Ube2l6ubiquitin-conjugating enzyme E2L 60.131
Hdac2histone deacetylase 20.130
DaxxFas death domain-associated protein0.127
NmiN-myc (and STAT) interactor0.125
Ifitm2interferon induced transmembrane protein 20.119
D14Ertd668eDNA segment, Chr 14, ERATO Doi 668, expressed0.118
Smarcc1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 10.115
Gbp2guanylate binding protein 20.115
Ifi47interferon gamma inducible protein 470.108
Traf3TNF receptor-associated factor 30.105
Xaf1XIAP associated factor 10.102
Cxcl10chemokine (C-X-C motif) ligand 100.101
Slfn4schlafen 40.100
Psme1proteasome (prosome, macropain) 28 subunit, alpha0.100
Bak1BCL2-antagonist/killer 10.097
Srrtserrate RNA effector molecule homolog (Arabidopsis)0.094
Srsf9serine/arginine-rich splicing factor 90.091
Pmaip1phorbol-12-myristate-13-acetate-induced protein 10.084
H2-K1histocompatibility 2, K1, K region0.083
Znfx1zinc finger, NFX1-type containing 10.083
Tmem106atransmembrane protein 106A0.082
Ifi203interferon activated gene 2030.081
Ppm1gprotein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform0.080
FosFBJ osteosarcoma oncogene0.079
Pmlpromyelocytic leukemia0.079
Bcl2B-cell leukemia/lymphoma 20.077
Eif2c1eukaryotic translation initiation factor 2C, 10.076
Ifi27l2ainterferon, alpha-inducible protein 27 like 2A0.074
Rbbp4retinoblastoma binding protein 40.071
Ifit2interferon-induced protein with tetratricopeptide repeats 20.064
Ewsr1Ewing sarcoma breakpoint region 10.062
Ddx39bDEAD (Asp-Glu-Ala-Asp) box polypeptide 39B0.062
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism