The network for 'rhodopsin mediated signaling pathway' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

rhodopsin mediated signaling pathway

The series of molecular signals generated as a consequence of excitation of rhodopsin by a photon and the events that convert the absorbed photons into a cellular response.

NameDescriptionProbabilityFunc Analog Organism
NCF1neutrophil cytosolic factor 10.943
CYBAcytochrome b-245, alpha polypeptide0.686
BLOC1S2biogenesis of lysosomal organelles complex-1, subunit 20.621
ITPR2inositol 1,4,5-trisphosphate receptor, type 20.546
ARRB1arrestin, beta 10.540
GUCY1B3guanylate cyclase 1, soluble, beta 30.392
MAGEB18melanoma antigen family B, 180.347
PRKCDprotein kinase C, delta0.267
TRIM9tripartite motif containing 90.194
PKD2polycystic kidney disease 2 (autosomal dominant)0.173
NUMBnumb homolog (Drosophila)0.164
HDAC6histone deacetylase 60.146
GIT1G protein-coupled receptor kinase interacting ArfGAP 10.141
NAGKN-acetylglucosamine kinase0.140
PRKCAprotein kinase C, alpha0.130
NCF2neutrophil cytosolic factor 20.111
NCF4neutrophil cytosolic factor 4, 40kDa0.108
PDE6Gphosphodiesterase 6G, cGMP-specific, rod, gamma0.090
ADRBK1adrenergic, beta, receptor kinase 10.087
ZBTB43zinc finger and BTB domain containing 430.061
KCNIP3Kv channel interacting protein 3, calsenilin0.060
FBP1fructose-1,6-bisphosphatase 10.058
PRKCBprotein kinase C, beta0.054
RICTORRPTOR independent companion of MTOR, complex 20.052
CEP70centrosomal protein 70kDa0.044
PTK2BPTK2B protein tyrosine kinase 2 beta0.041
RLIMring finger protein, LIM domain interacting0.037
ACTBactin, beta0.031
KHDRBS3KH domain containing, RNA binding, signal transduction associated 30.024
CA12carbonic anhydrase XII0.024
RPS6KA2ribosomal protein S6 kinase, 90kDa, polypeptide 20.024
RALBP1ralA binding protein 10.023
SDCBP2syndecan binding protein (syntenin) 20.023
LYNv-yes-1 Yamaguchi sarcoma viral related oncogene homolog0.022
CAV1caveolin 1, caveolae protein, 22kDa0.021
TRIM41tripartite motif containing 410.020
GNMTglycine N-methyltransferase0.020
BTKBruton agammaglobulinemia tyrosine kinase0.020
ENOX1ecto-NOX disulfide-thiol exchanger 10.018
CHMP7CHMP family, member 70.018
PAFAH1B2platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)0.018
FASLGFas ligand (TNF superfamily, member 6)0.017
NUDT18nudix (nucleoside diphosphate linked moiety X)-type motif 180.016
PRKCEprotein kinase C, epsilon0.016
PPT1palmitoyl-protein thioesterase 10.016
KLHDC5kelch domain containing 50.016
TUBB2Atubulin, beta 2A0.015
MAPK10mitogen-activated protein kinase 100.015
PASKPAS domain containing serine/threonine kinase0.015
GNASGNAS complex locus0.014
PRSS23protease, serine, 230.014
MAP3K5mitogen-activated protein kinase kinase kinase 50.014
TIFATRAF-interacting protein with forkhead-associated domain0.014
APIPAPAF1 interacting protein0.014
RASGRF1Ras protein-specific guanine nucleotide-releasing factor 10.014
ZBTB25zinc finger and BTB domain containing 250.014
KCTD17potassium channel tetramerisation domain containing 170.014
AGTR1angiotensin II receptor, type 10.013
SIRT2sirtuin 20.013
CRMP1collapsin response mediator protein 10.013
IMPDH1IMP (inosine 5'-monophosphate) dehydrogenase 10.013
PTPN21protein tyrosine phosphatase, non-receptor type 210.013
NT5C35'-nucleotidase, cytosolic III0.013
SAGS-antigen; retina and pineal gland (arrestin)0.013
FCHO1FCH domain only 10.012
ITPR1inositol 1,4,5-trisphosphate receptor, type 10.012
MEF2Cmyocyte enhancer factor 2C0.012
ADRBK2adrenergic, beta, receptor kinase 20.012
TRPC3transient receptor potential cation channel, subfamily C, member 30.012
FHL3four and a half LIM domains 30.012
IKBKGinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma0.012
EGFepidermal growth factor0.012
LDOC1leucine zipper, down-regulated in cancer 10.011
CARD11caspase recruitment domain family, member 110.011
LRMPlymphoid-restricted membrane protein0.011
INADLInaD-like (Drosophila)0.011
GRB10growth factor receptor-bound protein 100.011
PKN1protein kinase N10.011
ZBTB8Azinc finger and BTB domain containing 8A0.011
PRR5Lproline rich 5 like0.011
TSC22D4TSC22 domain family, member 40.010
MIIPmigration and invasion inhibitory protein0.010
NECAB2N-terminal EF-hand calcium binding protein 20.010
CDH1cadherin 1, type 1, E-cadherin (epithelial)0.010
SRCIN1SRC kinase signaling inhibitor 10.010
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
opn1sw1opsin 1 (cone pigments), short-wave-sensitive 10.933
gc3guanylyl cyclase 30.895
opn1lw1opsin 1 (cone pigments), long-wave-sensitive, 10.854
opn1sw2opsin 1 (cone pigments), short-wave-sensitive 20.840
opn4lopsin 4, like0.791
opn4aopsin 4a (melanopsin)0.576
gnat1guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 10.572
opn4x1opsin 4x10.505
gnat2guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 20.348
guca1cguanylate cyclase activator 1C0.316
gucy2fguanylate cyclase 2F, retinal0.314
scn1labsodium channel, voltage-gated, type I like, alpha b0.300
arr3aarrestin 3a, retinal (X-arrestin)0.259
opn1mw1opsin 1 (cone pigments), medium-wave-sensitive, 10.247
chatcholine acetyltransferase0.192
lin7alin-7 homolog A (C. elegans)0.186
rx1retinal homeobox gene 10.134
gc2guanylyl cyclase 20.114
aanat2arylalkylamine N-acetyltransferase0.092
rbp4lretinol binding protein 4, like0.087
arf1ADP-ribosylation factor 10.085
pi4kbphosphatidylinositol 4-kinase, catalytic, beta0.075
cadm2bcell adhesion molecule 2b0.071
crb3acrumbs homolog 3a0.067
grk7aG-protein-coupled receptor kinase 7a0.066
nbl1neuroblastoma, suppression of tumorigenicity 10.062
cacnb2bcalcium channel, voltage-dependent, beta 2b0.057
nfe2l1nuclear factor, erythroid derived 2,-like 10.056
irbpinterphotoreceptor retinoid-binding protein0.055
celsr3cadherin, EGF LAG seven-pass G-type receptor 30.055
guca1dguanylate cyclase activator 1d0.053
parapinopsinbparapinopsin b0.052
htr1aa5-hydroxytryptamine (serotonin) receptor 1A a0.052
gngt1guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 10.049
pde6hphosphodiesterase 6H, cGMP-specific, cone, gamma0.049
crxcone-rod homeobox0.047
rdh5retinol dehydrogenase 5 (11-cis/9-cis)0.046
rs1retinoschisis (X-linked, juvenile) 10.043
slc25a25asolute carrier family 25 (mitochondrial carrier; phosphate carrier), member 25a0.038
nrlneural retina leucine zipper0.033
vamp2vesicle-associated membrane protein 20.033
sagaS-antigen; retina and pineal gland (arrestin) a0.033
st3gal5lST3 beta-galactoside alpha-2,3-sialyltransferase 5, like0.032
hint2histidine triad nucleotide binding protein 20.032
calb2bcalbindin 2b, (calretinin)0.031
foxg1bforkhead box G1b0.030
mpp5bmembrane protein, palmitoylated 5b (MAGUK p55 subfamily member 5b)0.030
pdzd7aPDZ domain containing 7a0.030
slc1a2asolute carrier family 1 (glial high affinity glutamate transporter), member 2a0.030
pde6cphosphodiesterase 6C, cGMP-specific, cone, alpha prime0.030
sagbS-antigen; retina and pineal gland (arrestin) b0.030
grk1bG protein-coupled receptor kinase 1 b0.029
slc25a3asolute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3a0.029
slc2a11lsolute carrier family 2 (facilitated glucose transporter), member 11-like0.027
otx5orthodenticle homolog 50.027
opn3opsin 3 (encephalopsin, panopsin)0.026
th2tyrosine hydroxylase 20.025
kcnq1potassium voltage-gated channel, KQT-like subfamily, member 10.024
elnbelastin b0.024
slc6a4bsolute carrier family 6 (neurotransmitter transporter, serotonin), member 4B0.023
spg11spastic paraplegia 110.022
trpc5transient receptor potential cation channel, subfamily C, member 50.020
tmx3thioredoxin-related transmembrane protein 30.020
mc4rmelanocortin 4 receptor0.019
nr1d1nuclear receptor subfamily 1, group d, member 10.019
fbln5fibulin 50.019
arr3barrestin 3b, retinal (X-arrestin)0.019
htr1bd5-hydroxytryptamine (serotonin) receptor 1bd0.018
panx2pannexin 20.018
c21orf59lc21orf59 homolog (H. sapiens), like0.017
arl3l2ADP-ribosylation factor-like 3, like 20.017
atp1b2bATPase, Na+/K+ transporting, beta 2b polypeptide0.017
cx35connexin 350.017
gabra6agamma-aminobutyric acid (GABA) A receptor, alpha 6a0.017
opn1mw2opsin 1 (cone pigments), medium-wave-sensitive, 20.017
ulk2unc-51-like kinase 2 (C. elegans)0.017
lysmd3LysM, putative peptidoglycan-binding, domain containing 30.017
adra2cadrenergic, alpha-2C-, receptor0.017
LOC100331208probable pancreatic secretory proteinase inhibitor-like0.017
gnrhr3gonadotropin releasing hormone receptor 30.016
ckmt2creatine kinase, mitochondrial 2 (sarcomeric)0.016
pdzd7bPDZ domain containing 7b0.016
LOC799612prolactin 20.016
grin1aglutamate receptor, ionotropic, N-methyl D-aspartate 1a0.016
ift52intraflagellar transport protein 520.015
syt7bsynaptotagmin VIIb0.015
glra4bglycine receptor, alpha 4b0.015
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
trptransient receptor potential1.000
inaDinactivation no afterpotential D1.000
norpAno receptor potential A1.000
Galpha49BG protein alpha49B1.000
Arr2Arrestin 20.999
inaCinactivation no afterpotential C0.996
rdgCretinal degeneration C0.985
ninaCneither inactivation nor afterpotential C0.966
Rh3Rhodopsin 30.957
ninaEneither inactivation nor afterpotential E0.951
Rh5Rhodopsin 50.933
Rh6Rhodopsin 60.886
Gyc-89DbGuanylyl cyclase at 89Db0.868
rdgAretinal degeneration A0.747
ninaAneither inactivation nor afterpotential A0.721
inaF-DCG42563 gene product from transcript CG42563-RB0.706
Gyc-89DaGuanylyl cyclase at 89Da0.581
elavembryonic lethal abnormal vision0.568
Arr1Arrestin 10.515
rdgBretinal degeneration B0.497
G-oalpha47AG protein oalpha 47A0.479
Vha100-1CG1709 gene product from transcript CG1709-RF0.477
Gbeta76CG protein beta-subunit 76C0.452
CG14686CG14686 gene product from transcript CG14686-RA0.387
Ggamma1G protein gamma 10.368
CngCyclic-nucleotide-gated ion channel protein0.362
tadrtorn and diminished rhabdomeres0.323
14-3-3zetaCG17870 gene product from transcript CG17870-RB0.213
stopsslow termination of phototransduction0.151
Plc21CPhospholipase C at 21C0.115
HsfHeat shock factor0.087
Aac11CG6582 gene product from transcript CG6582-RA0.077
Tsp42EjTetraspanin 42Ej0.053
Ggamma30AG protein gamma30A0.052
dprdefective proboscis extension response0.051
CG4468CG4468 gene product from transcript CG4468-RA0.049
G-ialpha65AG protein alphai subunit 65A0.046
Snap25Synapse protein 250.045
CG8086CG8086 gene product from transcript CG8086-RF0.041
par-6CG5884 gene product from transcript CG5884-RA0.041
acj6abnormal chemosensory jump 60.040
CalxNa/Ca-exchange protein0.039
MYPT-75DCG6896 gene product from transcript CG6896-RA0.037
CG32627CG32627 gene product from transcript CG32627-RA0.036
santa-mariascavenger receptor acting in neural tissue and majority of rhodopsin is absent0.036
myoglianinCG1838 gene product from transcript CG1838-RD0.033
shakBshaking B0.032
CkIalphaCasein kinase Ialpha0.031
Gycalpha99BGuanylyl cyclase alpha-subunit at 99B0.030
ninaGCG6728 gene product from transcript CG6728-RA0.029
Applbeta amyloid protein precursor-like0.028
G-salpha60AG protein salpha 60A0.027
CG12026CG12026 gene product from transcript CG12026-RB0.027
CG15267CG15267 gene product from transcript CG15267-RA0.026
ppk28pickpocket 280.025
PknProtein kinase related to protein kinase N0.022
Gr43aGustatory receptor 43a0.022
ninaBneither inactivation nor afterpotential B0.020
inaEinactivation no afterpotential E0.019
Tak1TGF-beta activated kinase 10.018
Gr64bGustatory receptor 64b0.018
CG14591CG14591 gene product from transcript CG14591-RD0.017
Atg6Autophagy-specific gene 60.017
Gr33aGustatory receptor 33a0.017
bossbride of sevenless0.016
CG9813CG9813 gene product from transcript CG9813-RC0.016
Gr64eGustatory receptor 64e0.016
CG6983CG6983 gene product from transcript CG6983-RA0.016
Smg1CG32743 gene product from transcript CG32743-RA0.015
wtrwCG31284 gene product from transcript CG31284-RB0.015
PtpmegCG1228 gene product from transcript CG1228-RD0.014
Rh4Rhodopsin 40.014
CG11099CG11099 gene product from transcript CG11099-RA0.014
Or10aOdorant receptor 10a0.014
ppk19pickpocket 190.014
tamoCG4057 gene product from transcript CG4057-RA0.014
AceAcetylcholine esterase0.014
Vap-33-1CG5014 gene product from transcript CG5014-RB0.014
CG9279CG9279 gene product from transcript CG9279-RB0.013
Teh2tipE homolog 20.013
Gr59cGustatory receptor 59c0.013
gfAgiant fibre A0.013
king-tubbyking tubby0.013
CG17082CG17082 gene product from transcript CG17082-RD0.012
Gr64aGustatory receptor 64a0.012
CdsACDP diglyceride synthetase0.012
Gr64fGustatory receptor 64f0.012
PIP82CG11219 gene product from transcript CG11219-RA0.012
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Cacna1fcalcium channel, voltage-dependent, alpha 1F subunit0.990
Rp1retinitis pigmentosa 1 (human)0.989
Prph2peripherin 20.972
Plxnd1plexin D10.952
Crxcone-rod homeobox containing gene0.937
Gucy1b3guanylate cyclase 1, soluble, beta 30.927
Ldb3LIM domain binding 30.917
Pde6gphosphodiesterase 6G, cGMP-specific, rod, gamma0.822
Gnb3guanine nucleotide binding protein (G protein), beta 30.747
Rpe65retinal pigment epithelium 650.741
SeboxSEBOX homeobox0.740
Aipl1aryl hydrocarbon receptor-interacting protein-like 10.729
Opn1swopsin 1 (cone pigments), short-wave-sensitive (color blindness, tritan)0.698
Ptpn11protein tyrosine phosphatase, non-receptor type 110.698
Chrna6cholinergic receptor, nicotinic, alpha polypeptide 60.663
Cntn4contactin 40.657
Prkceprotein kinase C, epsilon0.646
Vsx2visual system homeobox 20.619
Rgrretinal G protein coupled receptor0.608
Pde6bphosphodiesterase 6B, cGMP, rod receptor, beta polypeptide0.598
Pou4f2POU domain, class 4, transcription factor 20.596
Rbp3retinol binding protein 3, interstitial0.543
Cnga1cyclic nucleotide gated channel alpha 10.530
Gabrr2gamma-aminobutyric acid (GABA) C receptor, subunit rho 20.530
Gucy2eguanylate cyclase 2e0.517
Cxadrcoxsackie virus and adenovirus receptor0.492
Tyrp1tyrosinase-related protein 10.491
Arr3arrestin 3, retinal0.491
Gnaqguanine nucleotide binding protein, alpha q polypeptide0.460
Homer1homer homolog 1 (Drosophila)0.457
Thrathyroid hormone receptor alpha0.431
Nrlneural retina leucine zipper gene0.425
Rs1retinoschisis (X-linked, juvenile) 1 (human)0.423
Crb1crumbs homolog 1 (Drosophila)0.412
Crxos1Crx opposite strand transcript 10.400
Nxnl1nucleoredoxin-like 10.395
Rrhretinal pigment epithelium derived rhodopsin homolog0.378
Rgs9regulator of G-protein signaling 90.376
Mipmajor intrinsic protein of eye lens fiber0.376
Cav1caveolin 1, caveolae protein0.376
Trpm1transient receptor potential cation channel, subfamily M, member 10.374
Slc24a1solute carrier family 24 (sodium/potassium/calcium exchanger), member 10.369
Cdh5cadherin 50.360
Itpr1inositol 1,4,5-trisphosphate receptor 10.354
Rasgrf2RAS protein-specific guanine nucleotide-releasing factor 20.348
Gnat1guanine nucleotide binding protein, alpha transducing 10.348
Gzmmgranzyme M (lymphocyte met-ase 1)0.344
CblCasitas B-lineage lymphoma0.341
Tnfrsf8tumor necrosis factor receptor superfamily, member 80.306
Flt1FMS-like tyrosine kinase 10.300
Pde6aphosphodiesterase 6A, cGMP-specific, rod, alpha0.293
Cplx4complexin 40.290
Gjd2gap junction protein, delta 20.277
Pcp2Purkinje cell protein 2 (L7)0.273
ND6NADH dehydrogenase subunit 60.267
Cabp5calcium binding protein 50.266
Six6sine oculis-related homeobox 6 homolog (Drosophila)0.261
Pde6hphosphodiesterase 6H, cGMP-specific, cone, gamma0.257
Dlg2discs, large homolog 2 (Drosophila)0.257
Vegfavascular endothelial growth factor A0.255
Crb2crumbs homolog 2 (Drosophila)0.251
Rdh10retinol dehydrogenase 10 (all-trans)0.245
Apbb2amyloid beta (A4) precursor protein-binding, family B, member 20.242
Ankrd33ankyrin repeat domain 330.241
Thrbthyroid hormone receptor beta0.238
Scn7asodium channel, voltage-gated, type VII, alpha0.235
Kcna4potassium voltage-gated channel, shaker-related subfamily, member 40.234
Pcdh15protocadherin 150.234
Lratlecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase)0.230
Guca1bguanylate cyclase activator 1B0.222
Grin1glutamate receptor, ionotropic, NMDA1 (zeta 1)0.221
Sagretinal S-antigen0.217
Insl5insulin-like 50.215
Cabp4calcium binding protein 40.207
Gabrg2gamma-aminobutyric acid (GABA) A receptor, subunit gamma 20.206
Clockcircadian locomotor output cycles kaput0.204
Ptk2PTK2 protein tyrosine kinase 20.199
Syt10synaptotagmin X0.196
Hmgcs13-hydroxy-3-methylglutaryl-Coenzyme A synthase 10.187
Gnat2guanine nucleotide binding protein, alpha transducing 20.186
Pvrl3poliovirus receptor-related 30.185
Cplx3complexin 30.183
Slc17a1solute carrier family 17 (sodium phosphate), member 10.180
Prkccprotein kinase C, gamma0.176
Mid2midline 20.173
Raxretina and anterior neural fold homeobox0.169
Dpf3D4, zinc and double PHD fingers, family 30.166
Grm8glutamate receptor, metabotropic 80.165
Edn2endothelin 20.160
Nmbrneuromedin B receptor0.154
Idi1isopentenyl-diphosphate delta isomerase0.153
Gabra1gamma-aminobutyric acid (GABA) A receptor, subunit alpha 10.149
Neurod4neurogenic differentiation 40.149
Mkl2MKL/myocardin-like 20.148
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Gucy1b3guanylate cyclase 1, soluble, beta 30.038
Ddx3xDEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked0.017
Mioxmyo-inositol oxygenase0.015
Grk1G protein-coupled receptor kinase 10.013
Pfkfb26-phosphofructo-2-kinase/fructose-2,6-biphosphatase 20.011
Wdr7WD repeat domain 70.011
Tgfb1transforming growth factor, beta 10.011
Kcnab2potassium voltage-gated channel, shaker-related subfamily, beta member 20.010
Rap1bRAP1B, member of RAS oncogene family0.010
Sept3septin 30.010
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism