The network for 'epidermis morphogenesis' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

epidermis morphogenesis

The process in which the anatomical structures of the epidermis are generated and organized. The epidermis is the outer epithelial layer of a plant or animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species.

NameDescriptionProbabilityFunc Analog Organism
CASKcalcium/calmodulin-dependent serine protein kinase (MAGUK family)0.999
TRIM29tripartite motif containing 290.999
KRT5keratin 50.998
KRT15keratin 150.998
TP63tumor protein p630.998
KLK10kallikrein-related peptidase 100.997
MDM2Mdm2 p53 binding protein homolog (mouse)0.997
KRT17keratin 170.996
DVL3dishevelled, dsh homolog 3 (Drosophila)0.996
PKP1plakophilin 1 (ectodermal dysplasia/skin fragility syndrome)0.986
KRT14keratin 140.983
LATS2LATS, large tumor suppressor, homolog 2 (Drosophila)0.981
KRT6Bkeratin 6B0.980
KRT19keratin 190.975
KLK7kallikrein-related peptidase 70.968
KRT6Ckeratin 6C0.961
DVL1dishevelled, dsh homolog 1 (Drosophila)0.928
FGF10fibroblast growth factor 100.922
KRT18keratin 180.920
TP53tumor protein p530.919
FGF1fibroblast growth factor 1 (acidic)0.915
KRT6Akeratin 6A0.911
SPRR1Asmall proline-rich protein 1A0.900
JAG1jagged 10.894
PARD6Gpar-6 partitioning defective 6 homolog gamma (C. elegans)0.886
KLK11kallikrein-related peptidase 110.878
LY6Dlymphocyte antigen 6 complex, locus D0.866
HIPK2homeodomain interacting protein kinase 20.862
KLK5kallikrein-related peptidase 50.836
PDZD11PDZ domain containing 110.833
EIF2C1eukaryotic translation initiation factor 2C, 10.771
PARD6Bpar-6 partitioning defective 6 homolog beta (C. elegans)0.768
NOTCH3notch 30.732
PRSS2protease, serine, 2 (trypsin 2)0.730
RAC1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)0.726
KRT13keratin 130.721
EP300E1A binding protein p3000.716
KRT16keratin 160.711
BCL2L1BCL2-like 10.710
KLK3kallikrein-related peptidase 30.705
DVL2dishevelled, dsh homolog 2 (Drosophila)0.704
KLK8kallikrein-related peptidase 80.698
SPRR1Bsmall proline-rich protein 1B0.686
PITX1paired-like homeodomain 10.626
CDKN2Acyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)0.626
AXIN1axin 10.605
LYPD3LY6/PLAUR domain containing 30.582
GJB5gap junction protein, beta 5, 31.1kDa0.581
DSG3desmoglein 30.580
GJB3gap junction protein, beta 3, 31kDa0.577
KRT1keratin 10.552
SULT2B1sulfotransferase family, cytosolic, 2B, member 10.539
KRT34keratin 340.529
KRT4keratin 40.527
SMARCD1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 10.520
KRT9keratin 90.505
HDAC1histone deacetylase 10.501
FGFR3fibroblast growth factor receptor 30.491
CHAC1ChaC, cation transport regulator homolog 1 (E. coli)0.487
PRKRAprotein kinase, interferon-inducible double stranded RNA dependent activator0.482
KRT75keratin 750.482
CSNK1Ecasein kinase 1, epsilon0.477
KLK6kallikrein-related peptidase 60.473
PKP3plakophilin 30.459
PRKCZprotein kinase C, zeta0.457
SPRR3small proline-rich protein 30.456
CLDN7claudin 70.453
LRRK2leucine-rich repeat kinase 20.431
C19orf50chromosome 19 open reading frame 500.427
KLK2kallikrein-related peptidase 20.414
TLE1transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)0.411
CITED2Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 20.411
EPHX3epoxide hydrolase 30.411
PARD6Apar-6 partitioning defective 6 homolog alpha (C. elegans)0.406
CDH3cadherin 3, type 1, P-cadherin (placental)0.403
SLURP1secreted LY6/PLAUR domain containing 10.402
CDC42cell division cycle 42 (GTP binding protein, 25kDa)0.393
KLK12kallikrein-related peptidase 120.380
TCF3transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)0.375
ALOX12Barachidonate 12-lipoxygenase, 12R type0.354
FGFR1fibroblast growth factor receptor 10.352
FGFBP1fibroblast growth factor binding protein 10.351
ARandrogen receptor0.332
PI3peptidase inhibitor 3, skin-derived0.329
SERPINB5serpin peptidase inhibitor, clade B (ovalbumin), member 50.316
CCDC33coiled-coil domain containing 330.314
KRT81keratin 810.308
S100A2S100 calcium binding protein A20.302
S100A14S100 calcium binding protein A140.294
KRT2keratin 20.293
C1orf116chromosome 1 open reading frame 1160.292
RBPJrecombination signal binding protein for immunoglobulin kappa J region0.291
ZBTB32zinc finger and BTB domain containing 320.286
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
CELE_T04H1.2Protein T04H1.20.190
dsh-2Protein DSH-20.166
bar-1Protein BAR-10.100
ula-1Protein ULA-10.086
unc-5Protein UNC-50.062
vab-23Protein VAB-230.043
cogc-2Protein COGC-20.040
clk-2Protein CLK-20.038
lin-36Protein LIN-360.034
egl-30Protein EGL-300.030
atg-18Protein ATG-180.028
F53F10.2Protein F53F10.20.027
R03E9.2Protein R03E9.20.025
Y54E5A.7Protein Y54E5A.70.024
lin-13Protein LIN-130.023
trim-9Protein TRIM-90.023
Y17G7B.8Protein Y17G7B.80.021
F09A5.4Protein F09A5.40.019
unc-95Protein UNC-950.018
lin-17Protein LIN-170.018
C43H6.4Protein C43H6.40.017
lam-3Protein LAM-30.017
F55F8.9Protein F55F8.90.015
lmn-1Protein LMN-10.015
rpc-1Protein RPC-10.014
pal-1Protein PAL-10.014
hbl-1Protein HBL-10.014
lev-1Protein LEV-10.014
C27C12.1Protein C27C12.10.014
pry-1Protein PRY-10.014
egl-36Protein EGL-360.014
ztf-15Protein ZTF-150.013
W02B8.1Protein W02B8.10.013
R07G3.7Protein R07G3.70.013
ten-1Protein TEN-10.013
egl-13Protein EGL-130.012
F53B3.5Protein F53B3.50.012
smp-1Protein SMP-10.012
gei-4Protein GEI-40.012
egl-44Protein EGL-440.012
sel-2Protein SEL-20.011
aqp-2Protein AQP-20.011
abl-1Protein ABL-10.010
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
prdm1aPR domain containing 1a, with ZNF domain0.419
lama5laminin, alpha 50.141
pbx4pre-B-cell leukemia transcription factor 40.080
cdh1cadherin 1, epithelial0.069
axin1axin 10.059
dlx3bdistal-less homeobox gene 3b0.058
lsrlipolysis stimulated lipoprotein receptor0.048
kal1aKallmann syndrome 1a sequence0.040
foxa1forkhead box A10.039
lamb1alaminin, beta 1a0.035
kal1bKallmann syndrome 1b sequence0.035
trim71tripartite motif-containing 710.035
wacaWW domain containing adaptor with coiled-coil a0.033
gata3GATA-binding protein 30.033
dag1dystroglycan 10.031
hhiphedgehog interacting protein0.030
epcamepithelial cell adhesion molecule0.029
robo3roundabout homolog 30.028
spint1aserine peptidase inhibitor, Kunitz type 1 a0.027
fzd7bfrizzled homolog 7b0.026
sox21aSRY-box containing gene 21a0.026
itga3bintegrin, alpha 3b0.026
pacsin3protein kinase C and casein kinase substrate in neurons 30.025
smad5MAD homolog 5 (Drosophila)0.025
lef1lymphocyte enhancer binding factor 10.024
vgll4lvestigial like 4 like0.022
lamc1laminin, gamma 10.022
krt4keratin 40.022
hand2heart and neural crest derivatives expressed transcript 20.022
prox1prospero-related homeobox gene 10.021
med12mediator of RNA polymerase II transcription, subunit 12 homolog0.019
dlx6adistal-less homeobox gene 6a0.019
robo1roundabout homolog 10.019
tbx1T-box 10.019
ovol1ovo-like 1 (Drosophila)0.018
nkx2.3NK2 transcription factor related 30.018
jag1bjagged 1b0.018
eya1eyes absent homolog 10.018
col14a1collagen, type XIV, alpha 10.017
kdm4blysine (K)-specific demethylase 4B0.017
atp6ap1ATPase, H+ transporting, lysosomal accessory protein 10.017
metmet proto-oncogene (hepatocyte growth factor receptor)0.017
arhgef7bRho guanine nucleotide exchange factor (GEF) 7b0.017
nr2f1anuclear receptor subfamily 2, group F, member 1a0.017
copb2coatomer protein complex, subunit beta 20.016
ripk4receptor-interacting serine-threonine kinase 40.016
irf6interferon regulatory factor 60.016
fgf3fibroblast growth factor 30.015
llgl2lethal giant larvae homolog 2 (Drosophila)0.015
inka1ainduced in neural crest by AP2, 1a0.015
furinafurin (paired basic amino acid cleaving enzyme) a0.015
ythdf1YTH domain family, member 10.015
sox2SRY-box containing gene 20.015
sox4aSRY-box containing gene 4a0.015
cxcr4achemokine (C-X-C motif) receptor 4a0.014
copacoatomer protein complex, subunit alpha0.014
foxi1forkhead box I10.014
gdf6agrowth differentiation factor 6a0.014
sumo1SMT3 suppressor of mif two 3 homolog 1 (yeast)0.014
cyp26b1cytochrome P450, family 26, subfamily b, polypeptide 10.014
dlx5adistal-less homeobox gene 5a0.014
fzd7afrizzled homolog 7a0.014
hoxc8ahomeo box C8a0.014
hoxb3ahomeo box B3a0.014
hmgn3high mobility group nucleosomal binding domain 30.014
cdk8cyclin-dependent kinase 80.014
jupjunction plakoglobin0.013
wif1wnt inhibitory factor 10.013
hoxd11ahomeo box D11a0.013
tmem161btransmembrane protein 161B0.013
trpv4transient receptor potential cation channel, subfamily V, member 40.013
shhasonic hedgehog a0.013
prkciprotein kinase C, iota0.013
rcn3reticulocalbin 3, EF-hand calcium binding domain0.013
hoxd10ahomeo box D10a0.013
arid4aAT rich interactive domain 4A (RBP1-like)0.013
gon4lgon-4-like (C.elegans)0.013
fgfrl1afibroblast growth factor receptor-like 1a0.012
ptgs1prostaglandin-endoperoxide synthase 10.012
pias4aprotein inhibitor of activated STAT, 4a0.012
hp1bp3heterochromatin protein 1, binding protein 30.012
dspadesmoplakin a0.012
brd2abromodomain-containing 2a0.012
zeb2azinc finger E-box binding homeobox 2a0.012
notch2notch homolog 20.012
pcdh10bprotocadherin 10b0.012
alox12arachidonate 12-lipoxygenase0.012
atp6v1baATPase, H+ transporting, lysosomal, V1 subunit B, member a0.012
hey1hairy/enhancer-of-split related with YRPW motif 10.012
fgf24fibroblast growth factor 240.012
LOC560606novel protein similar to human and mouse leishmanolysin-like (metallopeptidase M8 family) (LMLN)0.012
trpm7transient receptor potential cation channel, subfamily M, member 70.012
neo1neogenin 10.011
notch3notch homolog 30.011
rtf1Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)0.011
sepp1bselenoprotein P, plasma, 1b0.011
Loading network...
Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
Su(H)Suppressor of Hairless0.049
Rac1CG2248 gene product from transcript CG2248-RA0.025
stumpsCG31317 gene product from transcript CG31317-RC0.010
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Fgfr2fibroblast growth factor receptor 20.999
Foxc1forkhead box C10.998
Vangl2vang-like 2 (van gogh, Drosophila)0.993
Gli3GLI-Kruppel family member GLI30.992
Egfrepidermal growth factor receptor0.982
Msx2homeobox, msh-like 20.971
Pthlhparathyroid hormone-like peptide0.968
Ptenphosphatase and tensin homolog0.960
Sox9SRY-box containing gene 90.946
Foxn1forkhead box N10.910
Dvl2dishevelled 2, dsh homolog (Drosophila)0.896
Shhsonic hedgehog0.896
Tbx1T-box 10.883
Foxa2forkhead box A20.870
Ctnnb1catenin (cadherin associated protein), beta 10.858
Rargretinoic acid receptor, gamma0.824
Trp53transformation related protein 530.801
Hoxd13homeobox D130.796
Csf1colony stimulating factor 1 (macrophage)0.794
Psen1presenilin 10.767
Col1a1collagen, type I, alpha 10.753
Pax8paired box gene 80.739
Trp63transformation related protein 630.728
Notch1Notch gene homolog 1 (Drosophila)0.700
Dvl3dishevelled 3, dsh homolog (Drosophila)0.678
Bcl2l11BCL2-like 11 (apoptosis facilitator)0.656
Krt14keratin 140.655
Bmp4bone morphogenetic protein 40.652
Twist2twist homolog 2 (Drosophila)0.636
Krt8keratin 80.633
Krt35keratin 350.604
Krt17keratin 170.581
Krt19keratin 190.567
Gli2GLI-Kruppel family member GLI20.563
Prrx1paired related homeobox 10.550
Krt33bkeratin 33B0.535
Fgfr1fibroblast growth factor receptor 10.492
Pbx1pre B-cell leukemia transcription factor 10.462
Efnb2ephrin B20.459
Tgfatransforming growth factor alpha0.458
Etv4ets variant gene 4 (E1A enhancer binding protein, E1AF)0.451
Pkp1plakophilin 10.450
Vangl1vang-like 1 (van gogh, Drosophila)0.439
Pax3paired box gene 30.435
Pax2paired box gene 20.426
Krt71keratin 710.420
Bmpr1abone morphogenetic protein receptor, type 1A0.420
Loxlysyl oxidase0.406
Pitx1paired-like homeodomain transcription factor 10.395
Gata3GATA binding protein 30.394
Ptk7PTK7 protein tyrosine kinase 70.384
Rxraretinoid X receptor alpha0.380
Krt6akeratin 6A0.366
Ddx60DEAD (Asp-Glu-Ala-Asp) box polypeptide 600.353
Krt5keratin 50.352
Mmp14matrix metallopeptidase 14 (membrane-inserted)0.343
Dlx5distal-less homeobox 50.339
Jag1jagged 10.331
Ntf3neurotrophin 30.321
Dlx3distal-less homeobox 30.314
Ror2receptor tyrosine kinase-like orphan receptor 20.310
Nkx2-1NK2 homeobox 10.302
Pax6paired box gene 60.301
S100a14S100 calcium binding protein A140.300
Epha2Eph receptor A20.285
Eya1eyes absent 1 homolog (Drosophila)0.280
Hoxd11homeobox D110.280
Pitx2paired-like homeodomain transcription factor 20.278
Amhr2anti-Mullerian hormone type 2 receptor0.277
Tcf21transcription factor 210.275
Rarbretinoic acid receptor, beta0.262
Bcl2B-cell leukemia/lymphoma 20.257
Cyp26a1cytochrome P450, family 26, subfamily a, polypeptide 10.245
Rbpjrecombination signal binding protein for immunoglobulin kappa J region0.241
Pax9paired box gene 90.231
Psapl1prosaposin-like 10.231
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.223
Gscgoosecoid homeobox0.216
Foxe3forkhead box E30.216
Igdcc3immunoglobulin superfamily, DCC subclass, member 30.212
Mll1myeloid/lymphoid or mixed-lineage leukemia 10.206
Gata5GATA binding protein 50.204
Krt72-pskeratin 72, pseudogene0.203
Krt86keratin 860.202
Fgf10fibroblast growth factor 100.199
Ahraryl-hydrocarbon receptor0.195
Cldn3claudin 30.187
Padi3peptidyl arginine deiminase, type III0.183
Gdf11growth differentiation factor 110.183
Bnc1basonuclin 10.179
Krt2keratin 20.179
Rararetinoic acid receptor, alpha0.175
Ptpn11protein tyrosine phosphatase, non-receptor type 110.175
Hoxa1homeobox A10.173
Sprr1asmall proline-rich protein 1A0.172
Krt75keratin 750.169
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism