The network for 'renal tubular secretion' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

renal tubular secretion

Secretion of substances from peritubular capillaries into the renal tubules to be incorporated subsequently into the urine. Substances that are secreted include organic anions, ammonia, potassium and drugs.

NameDescriptionProbabilityFunc Analog Organism
NCR2natural cytotoxicity triggering receptor 20.630
SLC28A1solute carrier family 28 (sodium-coupled nucleoside transporter), member 10.627
SLC34A1solute carrier family 34 (sodium phosphate), member 10.553
PRODH2proline dehydrogenase (oxidase) 20.464
SLC6A13solute carrier family 6 (neurotransmitter transporter, GABA), member 130.335
SLC12A3solute carrier family 12 (sodium/chloride transporters), member 30.289
CST9Lcystatin 9-like0.271
SLC22A8solute carrier family 22 (organic anion transporter), member 80.185
SLC17A1solute carrier family 17 (sodium phosphate), member 10.144
SLC13A3solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 30.133
CRYBB3crystallin, beta B30.106
PKLRpyruvate kinase, liver and RBC0.088
GLYATglycine-N-acyltransferase0.077
SLC6A12solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 120.068
MASP2mannan-binding lectin serine peptidase 20.063
AIREautoimmune regulator0.063
CRYAAcrystallin, alpha A0.063
SLC17A3solute carrier family 17 (sodium phosphate), member 30.060
C8Acomplement component 8, alpha polypeptide0.055
AGXTalanine-glyoxylate aminotransferase0.055
CCINcalicin0.051
SLC22A6solute carrier family 22 (organic anion transporter), member 60.050
TREHtrehalase (brush-border membrane glycoprotein)0.049
SHBGsex hormone-binding globulin0.048
RTP3receptor (chemosensory) transporter protein 30.047
GPTglutamic-pyruvate transaminase (alanine aminotransferase)0.046
CCL1chemokine (C-C motif) ligand 10.044
FTCDformiminotransferase cyclodeaminase0.044
RDH16retinol dehydrogenase 16 (all-trans)0.044
C8Bcomplement component 8, beta polypeptide0.044
DBHdopamine beta-hydroxylase (dopamine beta-monooxygenase)0.043
GBA3glucosidase, beta, acid 3 (cytosolic)0.041
SLC1A7solute carrier family 1 (glutamate transporter), member 70.040
FUT6fucosyltransferase 6 (alpha (1,3) fucosyltransferase)0.040
SLC22A7solute carrier family 22 (organic anion transporter), member 70.039
HPXhemopexin0.038
NR5A1nuclear receptor subfamily 5, group A, member 10.038
SERPINA10serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 100.037
UPB1ureidopropionase, beta0.035
C21orf62chromosome 21 open reading frame 620.035
GCGRglucagon receptor0.035
OR2F1olfactory receptor, family 2, subfamily F, member 10.035
CYP8B1cytochrome P450, family 8, subfamily B, polypeptide 10.035
FOXN1forkhead box N10.034
DPYSdihydropyrimidinase0.032
BAATbile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)0.031
HNF1BHNF1 homeobox B0.031
HNF4Ahepatocyte nuclear factor 4, alpha0.030
BTNL3butyrophilin-like 30.030
ALPIalkaline phosphatase, intestinal0.029
HPD4-hydroxyphenylpyruvate dioxygenase0.029
GPR31G protein-coupled receptor 310.029
PROZprotein Z, vitamin K-dependent plasma glycoprotein0.027
FCN2ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin)0.027
HABP2hyaluronan binding protein 20.026
FUT5fucosyltransferase 5 (alpha (1,3) fucosyltransferase)0.026
SYT11synaptotagmin XI0.025
DDCdopa decarboxylase (aromatic L-amino acid decarboxylase)0.025
CYP11B2cytochrome P450, family 11, subfamily B, polypeptide 20.025
DRD2dopamine receptor D20.025
XDHxanthine dehydrogenase0.024
KCNJ1potassium inwardly-rectifying channel, subfamily J, member 10.024
RHBGRh family, B glycoprotein (gene/pseudogene)0.024
ABCC2ATP-binding cassette, sub-family C (CFTR/MRP), member 20.024
LPAlipoprotein, Lp(a)0.024
TEX13Atestis expressed 13A0.023
SPATA21spermatogenesis associated 210.023
ESRRBestrogen-related receptor beta0.023
CYP1A2cytochrome P450, family 1, subfamily A, polypeptide 20.023
TM4SF5transmembrane 4 L six family member 50.022
HOXC8homeobox C80.022
BPIbactericidal/permeability-increasing protein0.022
CYP4A11cytochrome P450, family 4, subfamily A, polypeptide 110.022
VIL1villin 10.022
SLC6A2solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 20.022
XPNPEP2X-prolyl aminopeptidase (aminopeptidase P) 2, membrane-bound0.022
IFNA6interferon, alpha 60.022
C9complement component 90.022
CHRNDcholinergic receptor, nicotinic, delta0.022
RTDR1rhabdoid tumor deletion region gene 10.021
GUCA2Bguanylate cyclase activator 2B (uroguanylin)0.021
CLCNKBchloride channel Kb0.021
SLC13A2solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 20.021
GGTLC1gamma-glutamyltransferase light chain 10.021
PROCprotein C (inactivator of coagulation factors Va and VIIIa)0.021
LASS2LAG1 homolog, ceramide synthase 20.021
AFMafamin0.020
NR1I3nuclear receptor subfamily 1, group I, member 30.020
CYP4F11cytochrome P450, family 4, subfamily F, polypeptide 110.020
HAO2hydroxyacid oxidase 2 (long chain)0.020
CYP4F2cytochrome P450, family 4, subfamily F, polypeptide 20.020
FETUBfetuin B0.020
CPN2carboxypeptidase N, polypeptide 20.019
ABCB11ATP-binding cassette, sub-family B (MDR/TAP), member 110.019
G6PCglucose-6-phosphatase, catalytic subunit0.019
NAT8BN-acetyltransferase 8B (GCN5-related, putative, gene/pseudogene)0.019
FXYD2FXYD domain containing ion transport regulator 20.019
UNC93Aunc-93 homolog A (C. elegans)0.018
SLC22A2solute carrier family 22 (organic cation transporter), member 20.018
AQP7aquaporin 70.018
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Cyp2c54cytochrome P450, family 2, subfamily c, polypeptide 540.921
G6pcglucose-6-phosphatase, catalytic0.906
Cyp4a14cytochrome P450, family 4, subfamily a, polypeptide 140.892
Cyp2c38cytochrome P450, family 2, subfamily c, polypeptide 380.862
Keg1kidney expressed gene 10.840
Albalbumin0.839
Cyp3a11cytochrome P450, family 3, subfamily a, polypeptide 110.837
Akr1c6aldo-keto reductase family 1, member C60.777
Cyp2c29cytochrome P450, family 2, subfamily c, polypeptide 290.760
Ugt2b1UDP glucuronosyltransferase 2 family, polypeptide B10.755
Cps1carbamoyl-phosphate synthetase 10.741
Slc22a2solute carrier family 22 (organic cation transporter), member 20.674
Hsd3b2hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 20.674
Cyp2e1cytochrome P450, family 2, subfamily e, polypeptide 10.654
Pigrpolymeric immunoglobulin receptor0.649
Cyp2a12cytochrome P450, family 2, subfamily a, polypeptide 120.623
CrpC-reactive protein, pentraxin-related0.579
Cyp2c39cytochrome P450, family 2, subfamily c, polypeptide 390.538
Azgp1alpha-2-glycoprotein 1, zinc0.500
Cyp2b10cytochrome P450, family 2, subfamily b, polypeptide 100.482
Slc22a1solute carrier family 22 (organic cation transporter), member 10.479
Hpd4-hydroxyphenylpyruvic acid dioxygenase0.417
Cyp2b13cytochrome P450, family 2, subfamily b, polypeptide 130.401
Cml2camello-like 20.398
Cyp2c50cytochrome P450, family 2, subfamily c, polypeptide 500.397
Mup5major urinary protein 50.339
Cyp3a13cytochrome P450, family 3, subfamily a, polypeptide 130.326
Krtap6-1keratin associated protein 6-10.321
Cyp2b9cytochrome P450, family 2, subfamily b, polypeptide 90.300
Baatbile acid-Coenzyme A: amino acid N-acyltransferase0.286
Hgdhomogentisate 1, 2-dioxygenase0.278
Inmtindolethylamine N-methyltransferase0.274
Cyp2d9cytochrome P450, family 2, subfamily d, polypeptide 90.271
Cyp4b1cytochrome P450, family 4, subfamily b, polypeptide 10.266
Adh7alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide0.250
Upp2uridine phosphorylase 20.249
Nr1i3nuclear receptor subfamily 1, group I, member 30.249
Apohapolipoprotein H0.248
Cyp7a1cytochrome P450, family 7, subfamily a, polypeptide 10.238
Slc22a18solute carrier family 22 (organic cation transporter), member 180.236
Cyp2g1cytochrome P450, family 2, subfamily g, polypeptide 10.197
Slc17a1solute carrier family 17 (sodium phosphate), member 10.191
Timd2T-cell immunoglobulin and mucin domain containing 20.182
Serpina6serine (or cysteine) peptidase inhibitor, clade A, member 60.172
Cyp8b1cytochrome P450, family 8, subfamily b, polypeptide 10.172
Slc10a1solute carrier family 10 (sodium/bile acid cotransporter family), member 10.159
F9coagulation factor IX0.157
Otcornithine transcarbamylase0.145
Fmo3flavin containing monooxygenase 30.142
Cyp3a25cytochrome P450, family 3, subfamily a, polypeptide 250.140
Hamphepcidin antimicrobial peptide0.131
Pplperiplakin0.126
Ugt2a3UDP glucuronosyltransferase 2 family, polypeptide A30.124
Slc27a5solute carrier family 27 (fatty acid transporter), member 50.124
Aadacarylacetamide deacetylase (esterase)0.118
F13bcoagulation factor XIII, beta subunit0.110
C9complement component 90.109
Dmgdhdimethylglycine dehydrogenase precursor0.101
Hsd3b3hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 30.101
Akr1d1aldo-keto reductase family 1, member D10.100
Abcc2ATP-binding cassette, sub-family C (CFTR/MRP), member 20.099
Slc6a20bsolute carrier family 6 (neurotransmitter transporter), member 20B0.098
Pon1paraoxonase 10.092
Tattyrosine aminotransferase0.091
Sult1d1sulfotransferase family 1D, member 10.091
Pck1phosphoenolpyruvate carboxykinase 1, cytosolic0.088
Inhbcinhibin beta-C0.086
Pik3c2gphosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide0.084
Gsta2glutathione S-transferase, alpha 2 (Yc2)0.084
Slc17a3solute carrier family 17 (sodium phosphate), member 30.081
Ces1dcarboxylesterase 1D0.080
Fmo1flavin containing monooxygenase 10.075
Apoc4apolipoprotein C-IV0.075
Cyp2c70cytochrome P450, family 2, subfamily c, polypeptide 700.073
Cyp2j5cytochrome P450, family 2, subfamily j, polypeptide 50.071
Vnn3vanin 30.070
Bchebutyrylcholinesterase0.064
Ugt3a2UDP glycosyltransferases 3 family, polypeptide A20.063
Krt6bkeratin 6B0.063
Slc2a2solute carrier family 2 (facilitated glucose transporter), member 20.063
Tdo2tryptophan 2,3-dioxygenase0.062
Cfhr1complement factor H-related 10.062
Afmafamin0.061
Cyp4a31cytochrome P450, family 4, subfamily a, polypeptide 310.059
Dctdopachrome tautomerase0.059
Slco1b2solute carrier organic anion transporter family, member 1b20.056
Hchemolytic complement0.056
Krtap4-16keratin associated protein 4-160.054
Serpina1cserine (or cysteine) peptidase inhibitor, clade A, member 1C0.053
Acsm2acyl-CoA synthetase medium-chain family member 20.052
Cyp1a2cytochrome P450, family 1, subfamily a, polypeptide 20.051
Cyp4a12acytochrome P450, family 4, subfamily a, polypeptide 12a0.050
Hrghistidine-rich glycoprotein0.049
Krtap5-1keratin associated protein 5-10.048
Ces1gcarboxylesterase 1G0.048
BC089597cDNA sequence BC0895970.046
Lce1ilate cornified envelope 1I0.046
Olfr67olfactory receptor 670.045
Hoga14-hydroxy-2-oxoglutarate aldolase 10.044
Serpina3kserine (or cysteine) peptidase inhibitor, clade A, member 3K0.043
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism