The network for 'regulation of axon guidance' in your query organism is displayed on the left, if relationships are supported by the integrated data. Moving any of the genes in that network will simultaneously update the homologs in the networks displayed to the right (if they exist). Additionally, hovering over any nodes will highlight the identified functionally similar homologs in the other networks. Last, the bar above the networks allows you to remove/add additional organisms. Simily drag and drop the organism names in the desired order.

Multiple Organisms

regulation of axon guidance

Any process that modulates the frequency, rate or extent of axon guidance.

NameDescriptionProbabilityFunc Analog Organism
DHX30DEAH (Asp-Glu-Ala-His) box polypeptide 301.000
VEGFAvascular endothelial growth factor A1.000
KDRkinase insert domain receptor (a type III receptor tyrosine kinase)1.000
NRP1neuropilin 11.000
FGFR1fibroblast growth factor receptor 10.999
FGFR2fibroblast growth factor receptor 20.998
RING1ring finger protein 10.995
PLCG1phospholipase C, gamma 10.991
IKBKAPinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein0.987
PGFplacental growth factor0.984
CBX8chromobox homolog 80.981
ELP2elongation protein 2 homolog (S. cerevisiae)0.979
RNF2ring finger protein 20.978
FLT1fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)0.977
CBX6chromobox homolog 60.931
TGFBR2transforming growth factor, beta receptor II (70/80kDa)0.914
PDGFRAplatelet-derived growth factor receptor, alpha polypeptide0.907
PCGF2polycomb group ring finger 20.897
ELP4elongation protein 4 homolog (S. cerevisiae)0.897
MYBBP1AMYB binding protein (P160) 1a0.881
PPP2R5Dprotein phosphatase 2, regulatory subunit B', delta0.878
PRKG1protein kinase, cGMP-dependent, type I0.866
USP11ubiquitin specific peptidase 110.782
PLXND1plexin D10.773
CBX7chromobox homolog 70.767
CDK9cyclin-dependent kinase 90.737
JAG2jagged 20.702
AGTPBP1ATP/GTP binding protein 10.688
CAV1caveolin 1, caveolae protein, 22kDa0.658
FGFR3fibroblast growth factor receptor 30.622
FZD1frizzled homolog 1 (Drosophila)0.620
CACNA1Acalcium channel, voltage-dependent, P/Q type, alpha 1A subunit0.608
SEMA6Dsema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D0.600
ZNF512Bzinc finger protein 512B0.598
MAGI2membrane associated guanylate kinase, WW and PDZ domain containing 20.583
CPEcarboxypeptidase E0.577
MAPK8mitogen-activated protein kinase 80.568
FGF7fibroblast growth factor 70.562
PCGF1polycomb group ring finger 10.554
FGF1fibroblast growth factor 1 (acidic)0.545
SORBS1sorbin and SH3 domain containing 10.529
PDGFBplatelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)0.525
FGF10fibroblast growth factor 100.435
ATXN7ataxin 70.425
LTBP4latent transforming growth factor beta binding protein 40.423
SIN3ASIN3 homolog A, transcription regulator (yeast)0.415
AGRNagrin0.409
BMPR1Abone morphogenetic protein receptor, type IA0.395
RBBP7retinoblastoma binding protein 70.384
ACVR1activin A receptor, type I0.382
PLXNB2plexin B20.357
ATN1atrophin 10.345
DPP4dipeptidyl-peptidase 40.312
RUNX1T1runt-related transcription factor 1; translocated to, 1 (cyclin D-related)0.310
DMPKdystrophia myotonica-protein kinase0.301
PTPRCprotein tyrosine phosphatase, receptor type, C0.291
LRP6low density lipoprotein receptor-related protein 60.290
SEMA6Asema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A0.283
CBX4chromobox homolog 40.257
PTPRDprotein tyrosine phosphatase, receptor type, D0.256
CDH5cadherin 5, type 2 (vascular endothelium)0.254
TCF4transcription factor 40.247
BMI1BMI1 polycomb ring finger oncogene0.247
TGFB3transforming growth factor, beta 30.244
PDIA3protein disulfide isomerase family A, member 30.235
DCCdeleted in colorectal carcinoma0.230
SHC2SHC (Src homology 2 domain containing) transforming protein 20.204
MAPK8IP2mitogen-activated protein kinase 8 interacting protein 20.198
SLIT2slit homolog 2 (Drosophila)0.195
SORBS2sorbin and SH3 domain containing 20.174
NTRK2neurotrophic tyrosine kinase, receptor, type 20.172
CDH11cadherin 11, type 2, OB-cadherin (osteoblast)0.169
RBL1retinoblastoma-like 1 (p107)0.161
MBIPMAP3K12 binding inhibitory protein 10.158
FRS2fibroblast growth factor receptor substrate 20.153
NEDD4neural precursor cell expressed, developmentally down-regulated 40.149
STC2stanniocalcin 20.147
SLC6A8solute carrier family 6 (neurotransmitter transporter, creatine), member 80.144
PTPRSprotein tyrosine phosphatase, receptor type, S0.142
RBBP4retinoblastoma binding protein 40.138
BCAMbasal cell adhesion molecule (Lutheran blood group)0.138
RDH11retinol dehydrogenase 11 (all-trans/9-cis/11-cis)0.136
FGF2fibroblast growth factor 2 (basic)0.135
CHRDchordin0.132
ITGB1integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)0.130
RBMS3RNA binding motif, single stranded interacting protein 30.127
PTNpleiotrophin0.126
FZD8frizzled homolog 8 (Drosophila)0.125
CAV2caveolin 20.123
STC1stanniocalcin 10.122
PLXNB1plexin B10.115
CSNK2A2casein kinase 2, alpha prime polypeptide0.108
BMP4bone morphogenetic protein 40.107
GFI1Bgrowth factor independent 1B transcription repressor0.104
TGFB2transforming growth factor, beta 20.099
HSPG2heparan sulfate proteoglycan 20.098
FLNBfilamin B, beta0.097
SEMA5Asema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A0.094
CELSR2cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)0.093
LPHN1latrophilin 10.088
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Caenorhabditis elegans
NameDescriptionProbabilityFunc Analog Organism
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Danio rerio
NameDescriptionProbabilityFunc Analog Organism
robo3roundabout homolog 30.945
bmp2abone morphogenetic protein 2a0.917
robo1roundabout homolog 10.912
lhx2bLIM homeobox 2b0.870
lef1lymphocyte enhancer binding factor 10.826
wnt4awingless-type MMTV integration site family, member 4a0.815
tbx1T-box 10.786
wnt8bwingless-type MMTV integration site family, member 8b0.714
sim1asingle-minded homolog 1a (Drosophila)0.582
otx5orthodenticle homolog 50.557
wnt1wingless-type MMTV integration site family, member 10.543
slit3slit (Drosophila) homolog 30.394
fezf2FEZ family zinc finger 20.340
rdh10aretinol dehydrogenase 10a0.297
flot1flotillin 10.291
nrp2bneuropilin 2b0.260
ascl1aachaete-scute complex-like 1a (Drosophila)0.258
wnt3wingless-type MMTV integration site family, member 30.235
cdkn1ccyclin-dependent kinase inhibitor 1C (p57, Kip2)0.230
itgavintegrin, alpha V0.223
mecomMDS1 and EVI1 complex locus0.213
twist3twist30.213
ntn1bnetrin 1b0.207
grem2gremlin 2, cysteine knot superfamily0.196
crestincrestin0.195
dlx2adistal-less homeobox gene 2a0.195
foxp2forkhead box P20.186
wnt3awingless-type MMTV integration site family, member 3A0.179
sema3dsemaphorin 3d0.163
lhx3LIM homeobox 30.162
shhasonic hedgehog a0.157
eng1aengrailed 1a0.149
fgf3fibroblast growth factor 30.147
vcanbversican b0.135
myf5myogenic factor 50.119
tbx2bT-box 2b0.118
esrrgaestrogen-related receptor gamma a0.116
lhx6LIM homeobox 60.116
lmx1b.1LIM homeobox transcription factor 1, beta 10.112
isl2aislet2a0.110
vax2ventral anterior homeobox 20.106
rx3retinal homeobox gene 30.106
mafbav-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)0.101
ret1receptor tyrosine kinase0.100
tbx2aT-box gene 2a0.097
vcanaversican a0.095
sulf1sulfatase 10.095
tcf7transcription factor 7 (T-cell specific, HMG-box)0.090
slit2slit (Drosophila) homolog 20.089
ntn1anetrin 1a0.083
barhl2BarH-like 20.081
tbx4T-box 40.077
spry4sprouty (Drosophila) homolog 40.075
phox2apaired-like homeobox 2a0.074
wnt7bawingless-type MMTV integration site family, member 7Ba0.074
mapk14amitogen-activated protein kinase 14a0.073
arxaristaless related homeobox0.073
dbx1adeveloping brain homeobox 1a0.072
wnt7aawingless-type MMTV integration site family, member 7Aa0.069
sema3esema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E0.069
mmp2matrix metalloproteinase 20.067
her15.1hairy and enhancer of split-related 15.10.064
slit1aslit homolog 1a (Drosophila)0.062
dlddeltaD0.061
zgc:77752zgc:777520.060
flhfloating head0.059
wlswntless homolog (Drosophila)0.059
lmo4aLIM domain only 4a0.058
osr2odd-skipped related 2 (Drosophila)0.057
nrp1aneuropilin 1a0.055
efnb2aephrin B2a0.055
bocbrother of CDO0.054
klf4aKruppel-like transcription factor 4a0.052
foxd3forkhead box D30.052
gfra1agdnf family receptor alpha 1a0.052
cdh2cadherin 2, neuronal0.051
wnt9bwingless-type MMTV integration site family, member 9B0.050
sox2SRY-box containing gene 20.050
fzd7afrizzled homolog 7a0.050
etv2ets variant gene 20.048
tbx5aT-box 5a0.047
gli1GLI-Kruppel family member 10.047
myod1myogenic differentiation 10.047
epb4.1l4erythrocyte protein band 4.1-like 40.047
pcdh10bprotocadherin 10b0.047
neo1neogenin 10.047
hoxa13bhomeo box A13b0.046
pcdh19protocadherin 190.045
wnt10awingless-type MMTV integration site family, member 10a0.045
cntn2contactin 20.044
exorhextra-ocular rhodopsin0.044
vax1ventral anterior homeobox 10.044
sox4bSRY-box containing gene 4b0.043
epha4aeph receptor A4a0.043
ndel1anudE nuclear distribution gene E homolog like 1 (A. nidulans) A0.042
slit1bslit homolog 1b (Drosophila)0.042
rxrabretinoid x receptor, alpha b0.042
gli2aGLI-Kruppel family member GLI2a0.042
msxdmuscle segment homeobox D0.040
zic2azic family member 2 (odd-paired homolog, Drosophila), a0.039
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Drosophila melanogaster
NameDescriptionProbabilityFunc Analog Organism
unc-5CG8166 gene product from transcript CG8166-RA0.994
roboroundabout0.992
Sema-2aCG4700 gene product from transcript CG4700-RC0.992
trioCG18214 gene product from transcript CG18214-RA0.992
DscamDown syndrome cell adhesion molecule0.987
NetBNetrin-B0.985
frafrazzled0.976
atoatonal0.961
tutlturtle0.958
commcommissureless0.954
Wnt5Wnt oncogene analog 50.948
lealeak0.901
Sema-1aCG18405 gene product from transcript CG18405-RD0.900
Ptp69DProtein tyrosine phosphatase 69D0.889
robo3CG5423 gene product from transcript CG5423-RA0.885
plexBplexin B0.838
plexAplexin A0.836
dockdreadlocks0.746
slislit0.683
E(spl)Enhancer of split0.620
amosabsent MD neurons and olfactory sensilla0.585
LIMK1LIM-kinase10.546
MicalMolecule interacting with CasL0.513
CapsCalcium activated protein for secretion0.499
stanstarry night0.453
futschCG34387 gene product from transcript CG34387-RC0.384
PakPAK-kinase0.379
nvynervy0.374
gogogolden goal0.372
Liprin-alphaCG11199 gene product from transcript CG11199-RB0.353
emsempty spiracles0.342
gcmglial cells missing0.312
enaenabled0.268
NrtNeurotactin0.253
rgrugose0.253
retnretained0.252
HLHm7E(spl) region transcript m70.244
senssenseless0.239
AblAbl tyrosine kinase0.238
HGTXCG13475 gene product from transcript CG13475-RB0.226
babobaboon0.214
Gyc76CGuanylyl cyclase at 76C0.194
EphEph receptor tyrosine kinase0.186
exexextra-extra0.182
CG12424CG12424 gene product from transcript CG12424-RC0.180
salmspalt major0.177
Hr51Hormone receptor 510.177
otkoff-track0.176
beat-Iabeaten path Ia0.170
pod1CG4532 gene product from transcript CG4532-RF0.158
Sra-1specifically Rac1-associated protein 10.157
Trim9CG31721 gene product from transcript CG31721-RB0.142
tlltailless0.137
acachaete0.132
HLHmgammaE(spl) region transcript mgamma0.125
CG33960CG33960 gene product from transcript CG33960-RB0.119
CadNCadherin-N0.106
vndventral nervous system defective0.098
SdcSyndecan0.090
EphrinCG1862 gene product from transcript CG1862-RA0.087
RhoGAPp190CG32555 gene product from transcript CG32555-RB0.082
VGlutVesicular glutamate transporter0.079
RhoGAP93BCG3421 gene product from transcript CG3421-RA0.078
toktolkin0.078
btlbreathless0.077
nerfin-1nervous fingers 10.076
KrKruppel0.074
midmidline0.072
Ptp52FCG18243 gene product from transcript CG18243-RB0.072
sidesidestep0.070
rorough0.069
drlderailed0.067
DAAMDishevelled Associated Activator of Morphogenesis0.067
beat-Icbeaten path Ic0.065
CaMKIICalcium/calmodulin-dependent protein kinase II0.064
grimCG4345 gene product from transcript CG4345-RA0.063
Fas3Fasciclin 30.062
Fak56DFocal Adhesion Kinase0.062
malphaE(spl) region transcript malpha0.059
jingCG9397 gene product from transcript CG9397-RI0.057
Fas2Fasciclin 20.056
mammastermind0.056
ococelliless0.054
sqzsqueeze0.052
hkbhuckebein0.052
eyeyeless0.051
nubnubbin0.049
m2E(spl) region transcript m20.046
Wnt2Wnt oncogene analog 20.043
Lim3CG10699 gene product from transcript CG10699-RB0.042
reporeversed polarity0.041
HLHm5E(spl) region transcript m50.040
jebjelly belly0.039
stumpsCG31317 gene product from transcript CG31317-RC0.038
NotumCG13076 gene product from transcript CG13076-RB0.037
dawdawdle0.036
HLHmdeltaE(spl) region transcript mdelta0.036
gsbgooseberry0.035
CBPsarcoplasmic calcium-binding protein0.032
pdm3pou domain motif 30.032
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Mus musculus
NameDescriptionProbabilityFunc Analog Organism
Sema6asema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A0.962
Robo1roundabout homolog 1 (Drosophila)0.908
Gli3GLI-Kruppel family member GLI30.881
Ednraendothelin receptor type A0.852
Slit2slit homolog 2 (Drosophila)0.851
Plxna1plexin A10.850
Pax2paired box gene 20.849
Tgfbr2transforming growth factor, beta receptor II0.811
Fgf8fibroblast growth factor 80.785
Zfpm2zinc finger protein, multitype 20.765
AxlAXL receptor tyrosine kinase0.762
Tbx3T-box 30.744
Epha4Eph receptor A40.738
Fzd1frizzled homolog 1 (Drosophila)0.662
Fgfr2fibroblast growth factor receptor 20.632
Ephb2Eph receptor B20.600
Acvr1activin A receptor, type 10.570
Kdrkinase insert domain protein receptor0.567
Rargretinoic acid receptor, gamma0.563
Gdf11growth differentiation factor 110.553
Shhsonic hedgehog0.539
Pdgfraplatelet derived growth factor receptor, alpha polypeptide0.534
Gab1growth factor receptor bound protein 2-associated protein 10.524
Pou3f3POU domain, class 3, transcription factor 30.512
Arhgef11Rho guanine nucleotide exchange factor (GEF) 110.490
Dccdeleted in colorectal carcinoma0.487
Gnaqguanine nucleotide binding protein, alpha q polypeptide0.476
Gfra2glial cell line derived neurotrophic factor family receptor alpha 20.465
Mgat3mannoside acetylglucosaminyltransferase 30.421
Nrp1neuropilin 10.417
Unc5cunc-5 homolog C (C. elegans)0.389
Tyro3TYRO3 protein tyrosine kinase 30.383
Ptf1apancreas specific transcription factor, 1a0.378
Otx2orthodenticle homolog 2 (Drosophila)0.348
Pax3paired box gene 30.338
Wnt2bwingless related MMTV integration site 2b0.336
Flt4FMS-like tyrosine kinase 40.304
Ror1receptor tyrosine kinase-like orphan receptor 10.299
Fgf10fibroblast growth factor 100.295
Sdc3syndecan 30.293
Emp2epithelial membrane protein 20.293
Fzd8frizzled homolog 8 (Drosophila)0.283
Tbx1T-box 10.276
Retret proto-oncogene0.274
Sema6dsema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D0.260
Grb10growth factor receptor bound protein 100.249
Tbx2T-box 20.228
Robo2roundabout homolog 2 (Drosophila)0.216
Tgfbr1transforming growth factor, beta receptor I0.215
Cyp26a1cytochrome P450, family 26, subfamily a, polypeptide 10.209
Engendoglin0.207
Flt1FMS-like tyrosine kinase 10.204
Ptprbprotein tyrosine phosphatase, receptor type, B0.202
Pax6paired box gene 60.199
Apcadenomatosis polyposis coli0.193
Igdcc3immunoglobulin superfamily, DCC subclass, member 30.185
Hoxd11homeobox D110.183
Tgfbr3transforming growth factor, beta receptor III0.177
Slit3slit homolog 3 (Drosophila)0.172
Lmx1aLIM homeobox transcription factor 1 alpha0.172
Rararetinoic acid receptor, alpha0.162
Gdnfglial cell line derived neurotrophic factor0.156
Cdh6cadherin 60.155
Lhx1LIM homeobox protein 10.155
Neurog1neurogenin 10.154
Wnt4wingless-related MMTV integration site 40.152
Gpr27G protein-coupled receptor 270.150
Six3sine oculis-related homeobox 3 homolog (Drosophila)0.150
Epha3Eph receptor A30.147
Nognoggin0.146
Rarbretinoic acid receptor, beta0.145
Mid2midline 20.145
Fgf5fibroblast growth factor 50.145
Nrp2neuropilin 20.144
Ptk7PTK7 protein tyrosine kinase 70.134
Hmx3H6 homeobox 30.132
Fgf15fibroblast growth factor 150.131
Fzd7frizzled homolog 7 (Drosophila)0.127
Mycnv-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian)0.124
Foxc1forkhead box C10.123
Pcdh12protocadherin 120.119
Wnt3awingless-related MMTV integration site 3A0.116
Cacna2d1calcium channel, voltage-dependent, alpha2/delta subunit 10.116
Ephb3Eph receptor B30.115
Sox7SRY-box containing gene 70.115
Cntn4contactin 40.114
Wnt7awingless-related MMTV integration site 7A0.113
Mmp15matrix metallopeptidase 150.111
Dkk1dickkopf homolog 1 (Xenopus laevis)0.110
Efnb2ephrin B20.109
Kcnd3potassium voltage-gated channel, Shal-related family, member 30.107
Adra2aadrenergic receptor, alpha 2a0.106
Bmp5bone morphogenetic protein 50.106
Slit1slit homolog 1 (Drosophila)0.105
Msi1Musashi homolog 1(Drosophila)0.103
Ednrbendothelin receptor type B0.100
Sult4a1sulfotransferase family 4A, member 10.096
Cdh13cadherin 130.096
Foxb1forkhead box B10.096
Pdgfrbplatelet derived growth factor receptor, beta polypeptide0.096
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Rattus norvegicus
NameDescriptionProbabilityFunc Analog Organism
Grip1glutamate receptor interacting protein 10.011
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Saccharomyces cerevisiae
NameDescriptionProbabilityFunc Analog Organism